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The map label for this gene is argG

Identifier: 123967131

GI number: 123967131

Start: 1691117

End: 1692331

Strand: Reverse

Name: argG

Synonym: P9515_18981

Alternate gene names: 123967131

Gene position: 1692331-1691117 (Counterclockwise)

Preceding gene: 123967132

Following gene: 123967128

Centisome position: 99.3

GC content: 34.07

Gene sequence:

>1215_bases
ATGCAGCACCCAAAAAAAGTTGTTCTTGCCTATTCTGGTGGAGTTGATACTAGTGTTTGTATTCCATATCTTAAAAATGA
ATACGGAATTTCAGAAGTTATTACTTTTGTGGCAGATCTTGGTCAAGGAGACGATATAGAGAGTATTAGTCAAAAAGCTT
TAAATTCCGGAGCAACAAAATCGGTGATTGGAAATTTAGTAGAGGATTTTGTTGAGAAGTATGCTTTTCCTGCTATAAGA
GCAAACGCACTTTATGGAGAAAAGTATCCTTTATCAACAGCTTTGGCCAGACCTTTAATAGCTGAAAATCTTGTCAAATT
AGCAAGAAAATTAAATGCTGGCGCAGTTGCGCACGGTTGTACAGGAAAAGGAAATGATCAAGTAAGATTTGACTTGGCTA
TTAATGCTTTAGGACCTGATTTGGAGATAATTACACCTGCTCGAGAATGGAAGATGAGTAGAGAAGAAGCTATTTTATAT
GGAGAAAAATTTGGAATTCCTGCTCCGGTTTCTAAGAAATCACCATACTCGATTGATGTCAATCTTCTTGGCCGTAGTGT
CGAAGCTGGTTTTTTGGAAGATCCGATGCAAGAACCTAATGAAGAAGTTTTTGCGATGACTTCATCTATTGATGATTCGC
CAAATTATCCAAAGGATATAGAAATTACATTTAAAAATGGATTTCCTATTGCTATTGGGAACGAATCTCTAAGCCCTTTA
AAGATTATTCAAAAGGTTAATTACTTAGCAGGAAAAAATGGTTTTGGTAGGATTGATATGATTGAAGATAGAGTAGTTGG
CATTAAAAGTAGAGAAATATATGAGGCTCCTGGTCTTTTACTGCTTATAAAAGCTCATAAAGAATTAGAAAGCATAACGT
TAAATCCAGATGTATTAGATTTTAAAAATTTAGTCGAAAAAAAATGGGCCCAACTTGTATATCAGGGATTTTGGTTCGGC
CCTCTTAAGAAAGCATTAGATGGTTTTATTGATGCAACACAAACTTCTGTTAATGGAAAGGTGAAAATAAGATTACATAA
AGGAAATGCAATAATAATTGGTAGGTCCTCTGAAAATAATTCTCTTTATAGGGAAGATTTAGCAACCTATAGTAAAGATG
ATATTTTTGACCACAAGCAAGCAGAAGGATTCATCTATATGTGGGGTATGTCTAATAAAATATGGGCAGAATTAAATTCA
AAAATGAATAATTAA

Upstream 100 bases:

>100_bases
TTTGGTCCAGGACTTGTAGTTACAATAATATTAGTTTTCAATAAAATTTTGAAAGCTAAATGAAATTTAGATTTTAGACT
GTTACCTGAGGGAAATTTTA

Downstream 100 bases:

>100_bases
AACTTAAGATTTTACTTGCTCTTCTAATTCTGGAGTAGAAGATTCTAAGGTTATTTTCTTTTTATTATCCGTTTCGTCTG
CTTTAGGCTCAGATTTATTG

Product: argininosuccinate synthase

Products: NA

Alternate protein names: Citrulline--aspartate ligase

Number of amino acids: Translated: 404; Mature: 404

Protein sequence:

>404_residues
MQHPKKVVLAYSGGVDTSVCIPYLKNEYGISEVITFVADLGQGDDIESISQKALNSGATKSVIGNLVEDFVEKYAFPAIR
ANALYGEKYPLSTALARPLIAENLVKLARKLNAGAVAHGCTGKGNDQVRFDLAINALGPDLEIITPAREWKMSREEAILY
GEKFGIPAPVSKKSPYSIDVNLLGRSVEAGFLEDPMQEPNEEVFAMTSSIDDSPNYPKDIEITFKNGFPIAIGNESLSPL
KIIQKVNYLAGKNGFGRIDMIEDRVVGIKSREIYEAPGLLLLIKAHKELESITLNPDVLDFKNLVEKKWAQLVYQGFWFG
PLKKALDGFIDATQTSVNGKVKIRLHKGNAIIIGRSSENNSLYREDLATYSKDDIFDHKQAEGFIYMWGMSNKIWAELNS
KMNN

Sequences:

>Translated_404_residues
MQHPKKVVLAYSGGVDTSVCIPYLKNEYGISEVITFVADLGQGDDIESISQKALNSGATKSVIGNLVEDFVEKYAFPAIR
ANALYGEKYPLSTALARPLIAENLVKLARKLNAGAVAHGCTGKGNDQVRFDLAINALGPDLEIITPAREWKMSREEAILY
GEKFGIPAPVSKKSPYSIDVNLLGRSVEAGFLEDPMQEPNEEVFAMTSSIDDSPNYPKDIEITFKNGFPIAIGNESLSPL
KIIQKVNYLAGKNGFGRIDMIEDRVVGIKSREIYEAPGLLLLIKAHKELESITLNPDVLDFKNLVEKKWAQLVYQGFWFG
PLKKALDGFIDATQTSVNGKVKIRLHKGNAIIIGRSSENNSLYREDLATYSKDDIFDHKQAEGFIYMWGMSNKIWAELNS
KMNN
>Mature_404_residues
MQHPKKVVLAYSGGVDTSVCIPYLKNEYGISEVITFVADLGQGDDIESISQKALNSGATKSVIGNLVEDFVEKYAFPAIR
ANALYGEKYPLSTALARPLIAENLVKLARKLNAGAVAHGCTGKGNDQVRFDLAINALGPDLEIITPAREWKMSREEAILY
GEKFGIPAPVSKKSPYSIDVNLLGRSVEAGFLEDPMQEPNEEVFAMTSSIDDSPNYPKDIEITFKNGFPIAIGNESLSPL
KIIQKVNYLAGKNGFGRIDMIEDRVVGIKSREIYEAPGLLLLIKAHKELESITLNPDVLDFKNLVEKKWAQLVYQGFWFG
PLKKALDGFIDATQTSVNGKVKIRLHKGNAIIIGRSSENNSLYREDLATYSKDDIFDHKQAEGFIYMWGMSNKIWAELNS
KMNN

Specific function: Arginine biosynthesis; seventh step. [C]

COG id: COG0137

COG function: function code E; Argininosuccinate synthase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the argininosuccinate synthase family. Type 1 subfamily

Homologues:

Organism=Homo sapiens, GI53759107, Length=416, Percent_Identity=39.1826923076923, Blast_Score=277, Evalue=1e-74,
Organism=Homo sapiens, GI16950633, Length=416, Percent_Identity=39.1826923076923, Blast_Score=277, Evalue=1e-74,
Organism=Escherichia coli, GI1789563, Length=392, Percent_Identity=27.5510204081633, Blast_Score=125, Evalue=7e-30,
Organism=Saccharomyces cerevisiae, GI6324514, Length=412, Percent_Identity=39.0776699029126, Blast_Score=283, Evalue=4e-77,
Organism=Drosophila melanogaster, GI21358151, Length=396, Percent_Identity=38.3838383838384, Blast_Score=265, Evalue=3e-71,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): ASSY_PROM5 (A2BZ94)

Other databases:

- EMBL:   CP000552
- RefSeq:   YP_001012212.1
- ProteinModelPortal:   A2BZ94
- SMR:   A2BZ94
- STRING:   A2BZ94
- GeneID:   4720131
- GenomeReviews:   CP000552_GR
- KEGG:   pmc:P9515_18981
- eggNOG:   COG0137
- HOGENOM:   HBG335267
- OMA:   VAVDVGQ
- ProtClustDB:   PRK00509
- BioCyc:   PMAR167542:P9515ORF_1981-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00005
- InterPro:   IPR001518
- InterPro:   IPR018223
- InterPro:   IPR014729
- Gene3D:   G3DSA:3.40.50.620
- PANTHER:   PTHR11587
- TIGRFAMs:   TIGR00032

Pfam domain/function: PF00764 Arginosuc_synth

EC number: =6.3.4.5

Molecular weight: Translated: 44715; Mature: 44715

Theoretical pI: Translated: 5.81; Mature: 5.81

Prosite motif: PS00564 ARGININOSUCCIN_SYN_1; PS00565 ARGININOSUCCIN_SYN_2

Important sites: BINDING 38-38 BINDING 89-89 BINDING 119-119 BINDING 121-121 BINDING 125-125 BINDING 125-125 BINDING 126-126 BINDING 129-129 BINDING 177-177 BINDING 186-186 BINDING 262-262 BINDING 274-274

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQHPKKVVLAYSGGVDTSVCIPYLKNEYGISEVITFVADLGQGDDIESISQKALNSGATK
CCCCCEEEEEECCCCCCCEEHHHHHCCCCHHHHHHHHHHCCCCCCHHHHHHHHHCCCCHH
SVIGNLVEDFVEKYAFPAIRANALYGEKYPLSTALARPLIAENLVKLARKLNAGAVAHGC
HHHHHHHHHHHHHHCCCHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEECC
TGKGNDQVRFDLAINALGPDLEIITPAREWKMSREEAILYGEKFGIPAPVSKKSPYSIDV
CCCCCCEEEEEEEEECCCCCCEEECCHHHHCCCCHHEEEEEHHCCCCCCCCCCCCCEEEE
NLLGRSVEAGFLEDPMQEPNEEVFAMTSSIDDSPNYPKDIEITFKNGFPIAIGNESLSPL
EEECCCCCCCCCCCHHCCCCHHEEEEECCCCCCCCCCCCEEEEEECCCEEEECCCCCCHH
KIIQKVNYLAGKNGFGRIDMIEDRVVGIKSREIYEAPGLLLLIKAHKELESITLNPDVLD
HHHHHHHHHHCCCCCCCEEEECCCEECCCCCHHCCCCCEEEEEECHHCHHHEECCCCHHH
FKNLVEKKWAQLVYQGFWFGPLKKALDGFIDATQTSVNGKVKIRLHKGNAIIIGRSSENN
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCEEEEEEECCCEEEEECCCCCC
SLYREDLATYSKDDIFDHKQAEGFIYMWGMSNKIWAELNSKMNN
CHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHCCC
>Mature Secondary Structure
MQHPKKVVLAYSGGVDTSVCIPYLKNEYGISEVITFVADLGQGDDIESISQKALNSGATK
CCCCCEEEEEECCCCCCCEEHHHHHCCCCHHHHHHHHHHCCCCCCHHHHHHHHHCCCCHH
SVIGNLVEDFVEKYAFPAIRANALYGEKYPLSTALARPLIAENLVKLARKLNAGAVAHGC
HHHHHHHHHHHHHHCCCHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEECC
TGKGNDQVRFDLAINALGPDLEIITPAREWKMSREEAILYGEKFGIPAPVSKKSPYSIDV
CCCCCCEEEEEEEEECCCCCCEEECCHHHHCCCCHHEEEEEHHCCCCCCCCCCCCCEEEE
NLLGRSVEAGFLEDPMQEPNEEVFAMTSSIDDSPNYPKDIEITFKNGFPIAIGNESLSPL
EEECCCCCCCCCCCHHCCCCHHEEEEECCCCCCCCCCCCEEEEEECCCEEEECCCCCCHH
KIIQKVNYLAGKNGFGRIDMIEDRVVGIKSREIYEAPGLLLLIKAHKELESITLNPDVLD
HHHHHHHHHHCCCCCCCEEEECCCEECCCCCHHCCCCCEEEEEECHHCHHHEECCCCHHH
FKNLVEKKWAQLVYQGFWFGPLKKALDGFIDATQTSVNGKVKIRLHKGNAIIIGRSSENN
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCEEEEEEECCCEEEEECCCCCC
SLYREDLATYSKDDIFDHKQAEGFIYMWGMSNKIWAELNSKMNN
CHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA