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The map label for this gene is tetA [H]

Identifier: 123967119

GI number: 123967119

Start: 1675343

End: 1676593

Strand: Direct

Name: tetA [H]

Synonym: P9515_18861

Alternate gene names: 123967119

Gene position: 1675343-1676593 (Clockwise)

Preceding gene: 123967117

Following gene: 123967120

Centisome position: 98.31

GC content: 31.57

Gene sequence:

>1251_bases
GTGAAAAAAAGTTTATTTAAGCCAAGTAGGAAATTCACATTATTCAGTGCTTTTATAACTCTCTTAAATGATCGTTTAAG
TGAAAGTATTCTTTTGCCTATTTTACCTTCTTTTGTTTTACTTTTTGATTCAAAAGCAAGTACTTACGGTTTACTATCCT
GTACTTATCAATTAGCACAATTTACAGCTTCACCATTTATTGGGCTTATGAGTGACAGATATGGTAGAAGACCTGTAACA
CTATTTTGTATAACTGGCTCAATAATCGGAATCTCAATACTATCATTTACAGTTTTATTTGATTGGTCAAATTCAATAGC
TACTATTCCCTTATTTTTATTATTTATAGCAAGACTTATAGACGGGCTCAGTGGTGGGACTGCAGCAACAGCGACTACCA
TCCTTGCAGATATTTCTAGCCCTGAAAAAAGAGCCAAAACATTTGGACTTATTGGGGTTGCCTTTGGATTAAGTTTTTTC
TTAGGAAATATATTTGTTGTAATTTTTGCTAAAAATACAAATAATAATTTCATTATTCCCGTAATAATAGCTTCAATTAT
TCCAATTATTAACTTTATACTAGTCCTTTTTTATTTACCAGAAACTAAACCTCAAAACGAATTAAACAAATCACCCCAAA
TGTTGAAAAATCCTTTAAAAAAATTATTTAAAGTATTTAAAGAAGATAAAATCAGAAAACTATCTCTAGCTTTTTTTATA
TATTTCATAGCTTTTACTGGACTAACGAACATTTTAATATTCTTCCTTCAAGAGTCTCTTAATTGGACAACTAAGGCATC
AAGTGGAACTCTTGTCGTCGTAGGCGTGATAGCAATAATTGTACAGGGTGGACTAATTGGTCCCTTAGTAAAAAGATTTG
GCGAAATGAAACTCACCTTAATTGGTTCAGGTTTTATTCTTCTAGCATGTATCCTTTTGATAACTACCCCTAAAGAAAAT
GCGGCAATAAATATTTATTCTGCAGTATCATTTTTAGCCATAGGTGCAGGATTAATTACACCTACCTTGAGAGCATTAAT
ATCTAAAAAATTAGACGGAGATAACCAAGGATCGATATTAAGTAATTTACAAGGTCTTCAAAGTCTTGGAGGGGTATTAG
GTATCGGTATGGCTGGGAGAGTTTATGACGATTTTGGTCCTAAAGCACCATTTATTGCAGGATCAATTATCTTAATTTTT
ATGATTTACCTTATTGCTGAAGGGAGAGGTAACAAAATTTCTTATAATTAA

Upstream 100 bases:

>100_bases
GATCACCAGGCCCTGCGCCAACTAAATAAACTATTCCGGGCACATTAATCTCCATTAACAAGTATGGTAGTAGAAGAAAA
TCGTATTGTAGATAAATATC

Downstream 100 bases:

>100_bases
CTAATTAAACCACCTTAATGAAATACGAAGCTAATAACTACATTAATAGGGAATTAAGTTGGATTGACTTTAATAAAAGA
GTTCTTTTGACTGGTATGGA

Product: major facilitator superfamily multidrug-efflux transporter

Products: NA

Alternate protein names: TetA(C) [H]

Number of amino acids: Translated: 416; Mature: 416

Protein sequence:

>416_residues
MKKSLFKPSRKFTLFSAFITLLNDRLSESILLPILPSFVLLFDSKASTYGLLSCTYQLAQFTASPFIGLMSDRYGRRPVT
LFCITGSIIGISILSFTVLFDWSNSIATIPLFLLFIARLIDGLSGGTAATATTILADISSPEKRAKTFGLIGVAFGLSFF
LGNIFVVIFAKNTNNNFIIPVIIASIIPIINFILVLFYLPETKPQNELNKSPQMLKNPLKKLFKVFKEDKIRKLSLAFFI
YFIAFTGLTNILIFFLQESLNWTTKASSGTLVVVGVIAIIVQGGLIGPLVKRFGEMKLTLIGSGFILLACILLITTPKEN
AAINIYSAVSFLAIGAGLITPTLRALISKKLDGDNQGSILSNLQGLQSLGGVLGIGMAGRVYDDFGPKAPFIAGSIILIF
MIYLIAEGRGNKISYN

Sequences:

>Translated_416_residues
MKKSLFKPSRKFTLFSAFITLLNDRLSESILLPILPSFVLLFDSKASTYGLLSCTYQLAQFTASPFIGLMSDRYGRRPVT
LFCITGSIIGISILSFTVLFDWSNSIATIPLFLLFIARLIDGLSGGTAATATTILADISSPEKRAKTFGLIGVAFGLSFF
LGNIFVVIFAKNTNNNFIIPVIIASIIPIINFILVLFYLPETKPQNELNKSPQMLKNPLKKLFKVFKEDKIRKLSLAFFI
YFIAFTGLTNILIFFLQESLNWTTKASSGTLVVVGVIAIIVQGGLIGPLVKRFGEMKLTLIGSGFILLACILLITTPKEN
AAINIYSAVSFLAIGAGLITPTLRALISKKLDGDNQGSILSNLQGLQSLGGVLGIGMAGRVYDDFGPKAPFIAGSIILIF
MIYLIAEGRGNKISYN
>Mature_416_residues
MKKSLFKPSRKFTLFSAFITLLNDRLSESILLPILPSFVLLFDSKASTYGLLSCTYQLAQFTASPFIGLMSDRYGRRPVT
LFCITGSIIGISILSFTVLFDWSNSIATIPLFLLFIARLIDGLSGGTAATATTILADISSPEKRAKTFGLIGVAFGLSFF
LGNIFVVIFAKNTNNNFIIPVIIASIIPIINFILVLFYLPETKPQNELNKSPQMLKNPLKKLFKVFKEDKIRKLSLAFFI
YFIAFTGLTNILIFFLQESLNWTTKASSGTLVVVGVIAIIVQGGLIGPLVKRFGEMKLTLIGSGFILLACILLITTPKEN
AAINIYSAVSFLAIGAGLITPTLRALISKKLDGDNQGSILSNLQGLQSLGGVLGIGMAGRVYDDFGPKAPFIAGSIILIF
MIYLIAEGRGNKISYN

Specific function: Resistance to tetracycline by an active tetracycline efflux. This is an energy-dependent process that decreases the accumulation of the antibiotic in whole cells. This protein functions as a metal-tetracycline/H(+) antiporter [H]

COG id: COG0477

COG function: function code GEPR; Permeases of the major facilitator superfamily

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. TCR/tet family [H]

Homologues:

Organism=Homo sapiens, GI225703104, Length=378, Percent_Identity=25.3968253968254, Blast_Score=86, Evalue=7e-17,
Organism=Homo sapiens, GI225703102, Length=378, Percent_Identity=25.3968253968254, Blast_Score=86, Evalue=7e-17,
Organism=Homo sapiens, GI39753965, Length=363, Percent_Identity=22.038567493113, Blast_Score=79, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17551570, Length=366, Percent_Identity=24.0437158469945, Blast_Score=94, Evalue=9e-20,
Organism=Caenorhabditis elegans, GI71996331, Length=338, Percent_Identity=20.1183431952663, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI17738085, Length=384, Percent_Identity=26.3020833333333, Blast_Score=121, Evalue=8e-28,
Organism=Drosophila melanogaster, GI24652011, Length=380, Percent_Identity=24.4736842105263, Blast_Score=69, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR005829
- InterPro:   IPR001958 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 45250; Mature: 45250

Theoretical pI: Translated: 10.39; Mature: 10.39

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKSLFKPSRKFTLFSAFITLLNDRLSESILLPILPSFVLLFDSKASTYGLLSCTYQLAQ
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHH
FTASPFIGLMSDRYGRRPVTLFCITGSIIGISILSFTVLFDWSNSIATIPLFLLFIARLI
HHHCCHHHHHHCCCCCCCEEEEEECCHHHHHHHHHHHHEEECCCCHHHHHHHHHHHHHHH
DGLSGGTAATATTILADISSPEKRAKTFGLIGVAFGLSFFLGNIFVVIFAKNTNNNFIIP
CCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCEEEEEEEECCCCCEEHH
VIIASIIPIINFILVLFYLPETKPQNELNKSPQMLKNPLKKLFKVFKEDKIRKLSLAFFI
HHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YFIAFTGLTNILIFFLQESLNWTTKASSGTLVVVGVIAIIVQGGLIGPLVKRFGEMKLTL
HHHHHHHHHHHHHHHHHHHCCCEECCCCCCCHHHHHHHHHHCCCCHHHHHHHHCCEEEEE
IGSGFILLACILLITTPKENAAINIYSAVSFLAIGAGLITPTLRALISKKLDGDNQGSIL
ECCCHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHH
SNLQGLQSLGGVLGIGMAGRVYDDFGPKAPFIAGSIILIFMIYLIAEGRGNKISYN
HHHHHHHHHHHHHHCCCCCCHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MKKSLFKPSRKFTLFSAFITLLNDRLSESILLPILPSFVLLFDSKASTYGLLSCTYQLAQ
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHH
FTASPFIGLMSDRYGRRPVTLFCITGSIIGISILSFTVLFDWSNSIATIPLFLLFIARLI
HHHCCHHHHHHCCCCCCCEEEEEECCHHHHHHHHHHHHEEECCCCHHHHHHHHHHHHHHH
DGLSGGTAATATTILADISSPEKRAKTFGLIGVAFGLSFFLGNIFVVIFAKNTNNNFIIP
CCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCEEEEEEEECCCCCEEHH
VIIASIIPIINFILVLFYLPETKPQNELNKSPQMLKNPLKKLFKVFKEDKIRKLSLAFFI
HHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YFIAFTGLTNILIFFLQESLNWTTKASSGTLVVVGVIAIIVQGGLIGPLVKRFGEMKLTL
HHHHHHHHHHHHHHHHHHHCCCEECCCCCCCHHHHHHHHHHCCCCHHHHHHHHCCEEEEE
IGSGFILLACILLITTPKENAAINIYSAVSFLAIGAGLITPTLRALISKKLDGDNQGSIL
ECCCHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHH
SNLQGLQSLGGVLGIGMAGRVYDDFGPKAPFIAGSIILIFMIYLIAEGRGNKISYN
HHHHHHHHHHHHHHCCCCCCHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 383387; 6337373; 6307828; 1517220 [H]