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The map label for this gene is dapA

Identifier: 123967076

GI number: 123967076

Start: 1630190

End: 1631098

Strand: Reverse

Name: dapA

Synonym: P9515_18431

Alternate gene names: 123967076

Gene position: 1631098-1630190 (Counterclockwise)

Preceding gene: 123967077

Following gene: 123967075

Centisome position: 95.71

GC content: 36.08

Gene sequence:

>909_bases
ATGATTCCCAACAATACACAATTTTCTAATCCAATATTTGGAAGAATATTAACTGCGATGGTTACTCCATTTAAAGAAAA
TGGGGGGGTTGATTATGAGTTAGCTATTAAACTTGCTAATCACCTTTGTGAAAATGGCTCTGATGGCATTGTGCTTTGTG
GTACCACAGGAGAATCTCCAACTCTTTCATGGGATGAACAGCATAATTTATTCGTTGCAGTAAAAAGTTCTTTAAATTCT
AGATCGAAAGTTATTGTTGGTACAGGTAGTAATTGTACAAGTGAGGCTATAGAAGCCACCAAAAAAGCTTATGAATTTGG
TGCTGATGGTGCTTTAGTGGTTGTTCCCTATTATAATAAGCCTCCTCAAGAAGGTCTTTATAACCACTTTAGTTCTATAG
CTACTGCCGCAAGTGATTTACCTTTAATGTTATATAACATTCCCGGAAGAACTGGTTGTAATTTATTACCTACGACTGTA
AACAAACTTATGAATTTTCCCAATATTCTCAGTATTAAAGCAGCAAGCGGTAGAATAGAAGAAGTGACTGAGTTAAGGGC
AGCGTGCGGCCCTAAACTTTTTATATATAGTGGCGATGATTCATTATTGCTTCCTATGCTATCAGTAGGTGCTGTTGGTG
TAGTAAGCGTTGCTAGCCACATTGTTGGGTTGCAGCTAAAAATGATGATTGAATCGTTTCAAAAAGGAGAATTCTCTATT
GCCCTTGATATTCATGAAAAGCTGCAACCACTTTTTAAAGCACTATTTGAAACGACAAATCCAATTCCCATCAAAGCTGC
TTTAGAACTAACAGGTTGGCAAGTAGGTTCTCCTAGGAATCCATTAACACCTCTTATTAAAGAAAAGAAAGACAATTTAT
TTCAGATAATTCAAAATCTGTCTTTGTAA

Upstream 100 bases:

>100_bases
GTAATCCGAATGGATTAGAATTGTGGTTATGTGGAGATCAAATAAGGAAAGGAGCAGCACTAAATGCTGTTCAAATAGCT
GAACTATTGATTGCAAAAAA

Downstream 100 bases:

>100_bases
ATGCTTCTCTTAGAGCTTTAATAAAGTTACTTTGAATAAAATGCCCACAATTTTAGTTTGTTAAAATACTCTTATCATGA
ATTCAAATCAAACCAAATCA

Product: dihydrodipicolinate synthase

Products: NA

Alternate protein names: DHDPS

Number of amino acids: Translated: 302; Mature: 302

Protein sequence:

>302_residues
MIPNNTQFSNPIFGRILTAMVTPFKENGGVDYELAIKLANHLCENGSDGIVLCGTTGESPTLSWDEQHNLFVAVKSSLNS
RSKVIVGTGSNCTSEAIEATKKAYEFGADGALVVVPYYNKPPQEGLYNHFSSIATAASDLPLMLYNIPGRTGCNLLPTTV
NKLMNFPNILSIKAASGRIEEVTELRAACGPKLFIYSGDDSLLLPMLSVGAVGVVSVASHIVGLQLKMMIESFQKGEFSI
ALDIHEKLQPLFKALFETTNPIPIKAALELTGWQVGSPRNPLTPLIKEKKDNLFQIIQNLSL

Sequences:

>Translated_302_residues
MIPNNTQFSNPIFGRILTAMVTPFKENGGVDYELAIKLANHLCENGSDGIVLCGTTGESPTLSWDEQHNLFVAVKSSLNS
RSKVIVGTGSNCTSEAIEATKKAYEFGADGALVVVPYYNKPPQEGLYNHFSSIATAASDLPLMLYNIPGRTGCNLLPTTV
NKLMNFPNILSIKAASGRIEEVTELRAACGPKLFIYSGDDSLLLPMLSVGAVGVVSVASHIVGLQLKMMIESFQKGEFSI
ALDIHEKLQPLFKALFETTNPIPIKAALELTGWQVGSPRNPLTPLIKEKKDNLFQIIQNLSL
>Mature_302_residues
MIPNNTQFSNPIFGRILTAMVTPFKENGGVDYELAIKLANHLCENGSDGIVLCGTTGESPTLSWDEQHNLFVAVKSSLNS
RSKVIVGTGSNCTSEAIEATKKAYEFGADGALVVVPYYNKPPQEGLYNHFSSIATAASDLPLMLYNIPGRTGCNLLPTTV
NKLMNFPNILSIKAASGRIEEVTELRAACGPKLFIYSGDDSLLLPMLSVGAVGVVSVASHIVGLQLKMMIESFQKGEFSI
ALDIHEKLQPLFKALFETTNPIPIKAALELTGWQVGSPRNPLTPLIKEKKDNLFQIIQNLSL

Specific function: Biosynthesis of diaminopimelate and lysine from aspartate semialdehyde; first step. [C]

COG id: COG0329

COG function: function code EM; Dihydrodipicolinate synthase/N-acetylneuraminate lyase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHDPS family

Homologues:

Organism=Homo sapiens, GI13540533, Length=288, Percent_Identity=28.125, Blast_Score=99, Evalue=6e-21,
Organism=Homo sapiens, GI31543060, Length=284, Percent_Identity=25.7042253521127, Blast_Score=92, Evalue=7e-19,
Organism=Escherichia coli, GI1788823, Length=292, Percent_Identity=37.6712328767123, Blast_Score=201, Evalue=6e-53,
Organism=Escherichia coli, GI1789620, Length=243, Percent_Identity=25.1028806584362, Blast_Score=108, Evalue=6e-25,
Organism=Escherichia coli, GI1786463, Length=289, Percent_Identity=28.0276816608997, Blast_Score=102, Evalue=2e-23,
Organism=Escherichia coli, GI87082415, Length=272, Percent_Identity=27.2058823529412, Blast_Score=101, Evalue=5e-23,

Paralogues:

None

Copy number: 840 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): DAPA_PROM5 (A2BZ39)

Other databases:

- EMBL:   CP000552
- RefSeq:   YP_001012157.1
- ProteinModelPortal:   A2BZ39
- SMR:   A2BZ39
- STRING:   A2BZ39
- GeneID:   4720421
- GenomeReviews:   CP000552_GR
- KEGG:   pmc:P9515_18431
- eggNOG:   COG0329
- HOGENOM:   HBG358848
- OMA:   HFETIAS
- ProtClustDB:   PRK03170
- BioCyc:   PMAR167542:P9515ORF_1925-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00418
- InterPro:   IPR013785
- InterPro:   IPR005263
- InterPro:   IPR002220
- InterPro:   IPR020625
- InterPro:   IPR020624
- Gene3D:   G3DSA:3.20.20.70
- PANTHER:   PTHR12128
- PRINTS:   PR00146
- TIGRFAMs:   TIGR00674

Pfam domain/function: PF00701 DHDPS

EC number: =4.2.1.52

Molecular weight: Translated: 32683; Mature: 32683

Theoretical pI: Translated: 6.36; Mature: 6.36

Prosite motif: PS00665 DHDPS_1; PS00666 DHDPS_2

Important sites: ACT_SITE 173-173 BINDING 117-117

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIPNNTQFSNPIFGRILTAMVTPFKENGGVDYELAIKLANHLCENGSDGIVLCGTTGESP
CCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEECCCCCC
TLSWDEQHNLFVAVKSSLNSRSKVIVGTGSNCTSEAIEATKKAYEFGADGALVVVPYYNK
CCCCCCCCCEEEEEECCCCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCCCEEEEECCCC
PPQEGLYNHFSSIATAASDLPLMLYNIPGRTGCNLLPTTVNKLMNFPNILSIKAASGRIE
CCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCHHHHHHHHCCCCEEEEECCCCCHH
EVTELRAACGPKLFIYSGDDSLLLPMLSVGAVGVVSVASHIVGLQLKMMIESFQKGEFSI
HHHHHHHHCCCEEEEEECCCCHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEE
ALDIHEKLQPLFKALFETTNPIPIKAALELTGWQVGSPRNPLTPLIKEKKDNLFQIIQNL
EEEHHHHHHHHHHHHHHCCCCCCEEEEEEECCEECCCCCCCCCHHHHHHHHHHHHHHHHC
SL
CC
>Mature Secondary Structure
MIPNNTQFSNPIFGRILTAMVTPFKENGGVDYELAIKLANHLCENGSDGIVLCGTTGESP
CCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEECCCCCC
TLSWDEQHNLFVAVKSSLNSRSKVIVGTGSNCTSEAIEATKKAYEFGADGALVVVPYYNK
CCCCCCCCCEEEEEECCCCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCCCEEEEECCCC
PPQEGLYNHFSSIATAASDLPLMLYNIPGRTGCNLLPTTVNKLMNFPNILSIKAASGRIE
CCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCHHHHHHHHCCCCEEEEECCCCCHH
EVTELRAACGPKLFIYSGDDSLLLPMLSVGAVGVVSVASHIVGLQLKMMIESFQKGEFSI
HHHHHHHHCCCEEEEEECCCCHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEE
ALDIHEKLQPLFKALFETTNPIPIKAALELTGWQVGSPRNPLTPLIKEKKDNLFQIIQNL
EEEHHHHHHHHHHHHHHCCCCCCEEEEEEECCEECCCCCCCCCHHHHHHHHHHHHHHHHC
SL
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA