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The map label for this gene is ribH

Identifier: 123967066

GI number: 123967066

Start: 1617045

End: 1617521

Strand: Reverse

Name: ribH

Synonym: P9515_18331

Alternate gene names: 123967066

Gene position: 1617521-1617045 (Counterclockwise)

Preceding gene: 123967067

Following gene: 123967065

Centisome position: 94.92

GC content: 33.54

Gene sequence:

>477_bases
ATGGCTATCTTTGAGGGATCTTTTACTACTGCTTCAAACTTGAAAGTGGGCATAGTTGTTGCAAGGTTTAATGATTTAAT
TACTAATAAAATATTATCTGGTTGCCTTGATTGTTTGAAAAGGCATGGTTTAGATACCTCAGAAACAAGTGAAACACTTG
ATATAGTCTGGGTACCTGGATCATTCGAACTACCAATAGCAGCGAAAACACTTTTGAAAAAATCAAACTACGATGTTTTA
ATTTCTCTTGGAGCTGTTATTAGAGGAGAAACCTCTCATTATGATGTTGTTATTTCTGAGGCAAGTAAGGGAATTGCGCA
AGTTTCATATGATTATGATGTTCCAATTATTTTTGGTGTTTTAACGACTGATAGTATGCAGCAGGCTTTAGAAAGAGCTG
GTATAAAAAATAATCTTGGTTGGAATTATGCTTTACAGGCAATAGAAATGGGTTCTCTAATCAAAAATTTAAATTAG

Upstream 100 bases:

>100_bases
AGTTTGGGTGGTTTTAGTTTTTGCTACAGGGATTGTTTCATCTTTAGTTTGAACTTAATACCTTTTCATGAGAGTCTAGT
TATATAACGAAGAAAATTTA

Downstream 100 bases:

>100_bases
TTTCAAAAAAAGTAAGATTATGTTCATTTCATTCCTTTTTTAAGATAAAATAATAGAGTTGTGCGGATGTAGCTCAGTGG
TAGAGCATCTCCTTGCCAAG

Product: 6,7-dimethyl-8-ribityllumazine synthase

Products: NA

Alternate protein names: DMRL synthase; Lumazine synthase; Riboflavin synthase beta chain

Number of amino acids: Translated: 158; Mature: 157

Protein sequence:

>158_residues
MAIFEGSFTTASNLKVGIVVARFNDLITNKILSGCLDCLKRHGLDTSETSETLDIVWVPGSFELPIAAKTLLKKSNYDVL
ISLGAVIRGETSHYDVVISEASKGIAQVSYDYDVPIIFGVLTTDSMQQALERAGIKNNLGWNYALQAIEMGSLIKNLN

Sequences:

>Translated_158_residues
MAIFEGSFTTASNLKVGIVVARFNDLITNKILSGCLDCLKRHGLDTSETSETLDIVWVPGSFELPIAAKTLLKKSNYDVL
ISLGAVIRGETSHYDVVISEASKGIAQVSYDYDVPIIFGVLTTDSMQQALERAGIKNNLGWNYALQAIEMGSLIKNLN
>Mature_157_residues
AIFEGSFTTASNLKVGIVVARFNDLITNKILSGCLDCLKRHGLDTSETSETLDIVWVPGSFELPIAAKTLLKKSNYDVLI
SLGAVIRGETSHYDVVISEASKGIAQVSYDYDVPIIFGVLTTDSMQQALERAGIKNNLGWNYALQAIEMGSLIKNLN

Specific function: Riboflavin synthase is a bifunctional enzyme complex catalyzing the formation of riboflavin from 5-amino-6-(1'-D)- ribityl-amino-2,4(1H,3H)-pyrimidinedione and L-3,4-dihydrohy-2- butanone-4-phosphate via 6,7-dimethyl-8-lumazine. The beta subunit catalyzes

COG id: COG0054

COG function: function code H; Riboflavin synthase beta-chain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DMRL synthase family

Homologues:

Organism=Escherichia coli, GI1786617, Length=156, Percent_Identity=46.1538461538462, Blast_Score=142, Evalue=1e-35,
Organism=Saccharomyces cerevisiae, GI6324429, Length=150, Percent_Identity=30.6666666666667, Blast_Score=82, Evalue=5e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RISB_PROM5 (A2BZ29)

Other databases:

- EMBL:   CP000552
- RefSeq:   YP_001012147.1
- ProteinModelPortal:   A2BZ29
- SMR:   A2BZ29
- STRING:   A2BZ29
- GeneID:   4720411
- GenomeReviews:   CP000552_GR
- KEGG:   pmc:P9515_18331
- eggNOG:   COG0054
- HOGENOM:   HBG311126
- OMA:   KAGNKGW
- ProtClustDB:   PRK00061
- BioCyc:   PMAR167542:P9515ORF_1915-MONOMER
- HAMAP:   MF_00178
- InterPro:   IPR002180
- Gene3D:   G3DSA:3.40.50.960
- PANTHER:   PTHR21058
- TIGRFAMs:   TIGR00114

Pfam domain/function: PF00885 DMRL_synthase; SSF52121 DMRL_synthase

EC number: =2.5.1.9

Molecular weight: Translated: 17186; Mature: 17055

Theoretical pI: Translated: 4.88; Mature: 4.88

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIFEGSFTTASNLKVGIVVARFNDLITNKILSGCLDCLKRHGLDTSETSETLDIVWVPG
CEEECCCCCCCCCCEEEEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCC
SFELPIAAKTLLKKSNYDVLISLGAVIRGETSHYDVVISEASKGIAQVSYDYDVPIIFGV
CCCCCHHHHHHHHCCCCEEEEEECCEEECCCCCEEEEEECCCCCEEEEECCCCCCEEEEE
LTTDSMQQALERAGIKNNLGWNYALQAIEMGSLIKNLN
ECCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
AIFEGSFTTASNLKVGIVVARFNDLITNKILSGCLDCLKRHGLDTSETSETLDIVWVPG
EEECCCCCCCCCCEEEEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCC
SFELPIAAKTLLKKSNYDVLISLGAVIRGETSHYDVVISEASKGIAQVSYDYDVPIIFGV
CCCCCHHHHHHHHCCCCEEEEEECCEEECCCCCEEEEEECCCCCEEEEECCCCCCEEEEE
LTTDSMQQALERAGIKNNLGWNYALQAIEMGSLIKNLN
ECCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA