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The map label for this gene is sam1 [H]

Identifier: 123967047

GI number: 123967047

Start: 1597597

End: 1599036

Strand: Reverse

Name: sam1 [H]

Synonym: P9515_18141

Alternate gene names: 123967047

Gene position: 1599036-1597597 (Counterclockwise)

Preceding gene: 123967049

Following gene: 123967046

Centisome position: 93.83

GC content: 34.51

Gene sequence:

>1440_bases
ATGATAAGAATTTTTTTAGAAATGGTTATTGCTAACTCGATTAAAACATCTATACCAAACTACGTTATTACAGATATTTC
TCTATCTGATTTCGGACGTAAAGAGATTAAAATTGCTGAAACTGAAATGCCTGGATTAATGGCACTAAGAGAGAAGCATC
ATTCTGATAAGCCTCTCAAAGGTGCAAAAATAGCAGGTAGTTTGCATATGACTATTCAAACTGCTGTTTTGATTGAGACG
CTTGTTGAACTTGGTGCACAAGTCAAATGGGCCTCATGTAATATTTTTTCAACCCAAGATCATGCTGCTGCAGCTATTGC
AGAACAAGGAATTGCCGTTTATGCAAAAAAAGGTGAGAGCTTAGATGAATATTGGCAATACACACACTACATTTTAGATT
GGGGTACAGATTCTCCCAACATGATCTTGGATGATGGTGGAGATGCAACAGGTTTATTAATACTAGGTAGCAAAGCAGAA
AAAGATTTGTCAGTTTTAGATAATCCTAGTAATGAAGAGGAAATAGCTTTGTTTAAATCAATCAAGGCTAAATTGCTAGA
GGATAGTAATTTTTATTCTCGTATTAAGGGAAATATTATTGGGGTAACTGAAGAAACTACGACAGGTGTTGCAAGATTGT
ATCAATTGCAAAAACAAAATGCATTACCATTTCCAGCTATAAACGTAAATGATTCAGTTACTAAGAGTAAATTTGATAAT
TTATATGGCTGTAGAGAATCTCTAGTTGACAGCATAAAGCGTGCTACAGATGTAATGATTGCAGGAAAAGTTGCTTTAGT
CATTGGTTTTGGTGATGTTGGAAAAGGTTCTGCTCAATCATTAAGAGGACTTGGAGCAATAGTTAAAGTTGCGGAGGTAG
ACCCAATATGTGCTCTTCAAGCAGCTATGGAGGGATTTAGCGTTGTAACATTAGAGGATGTTGTTGAAGATATAGATATA
TTTGTTACTGCTACTGGTAATTATCAAGTTATAACTAACGATAATCTCGTAAGGATGAAGGATGAGGCGATAGTTTGCAA
TATTGGACATTTTGATAACGAAATTGATGTTGCTTCCTTAAAAGATTACCCATGGGAAAATATTAAGCCTCAAGTCGATC
ATATTACTTTGCCAAGTGGGAATAAAATTATTCTTTTAGCGGAGGGAAGACTTGTTAATTTAGGTTGTGCAACAGGCCAT
CCAAGTTTCGTTATGAGTAATTCTTTTACTAATCAAGTATTGGCTCAAATCGAACTCTTCAATAAGTCAGAAGAATATTC
AAAAGAAGTCTATGTATTGCCAAAACATTTAGACGAAATGGTTGCTAGATTACATTTAGATAAAATTGGTGCCAAGTTAA
CAAAATTAACTAAGGAGCAAGCTGACTATATCAATGTTTCTGTTGAAGGACCTTATAAACCAGAACTATATAGATACTAA

Upstream 100 bases:

>100_bases
ATTTTGGATTTAATTCTTGAGCGAATTTTTTTCCTAATTGAATTGTCTCTATTAAATTCCCAATAAACACAAAATTACAT
AAAAATCATTTATAGTTTAA

Downstream 100 bases:

>100_bases
AGTTGAGTTTAATTTTTATTAATTTACTCACTTCCATTCCTGAATATATCAGTAAGGCTGTAGAAACAAACTCATTAATT
GCTTACCTTACGATAGGTTT

Product: S-adenosyl-L-homocysteine hydrolase

Products: NA

Alternate protein names: S-adenosyl-L-homocysteine hydrolase; AdoHcyase [H]

Number of amino acids: Translated: 479; Mature: 479

Protein sequence:

>479_residues
MIRIFLEMVIANSIKTSIPNYVITDISLSDFGRKEIKIAETEMPGLMALREKHHSDKPLKGAKIAGSLHMTIQTAVLIET
LVELGAQVKWASCNIFSTQDHAAAAIAEQGIAVYAKKGESLDEYWQYTHYILDWGTDSPNMILDDGGDATGLLILGSKAE
KDLSVLDNPSNEEEIALFKSIKAKLLEDSNFYSRIKGNIIGVTEETTTGVARLYQLQKQNALPFPAINVNDSVTKSKFDN
LYGCRESLVDSIKRATDVMIAGKVALVIGFGDVGKGSAQSLRGLGAIVKVAEVDPICALQAAMEGFSVVTLEDVVEDIDI
FVTATGNYQVITNDNLVRMKDEAIVCNIGHFDNEIDVASLKDYPWENIKPQVDHITLPSGNKIILLAEGRLVNLGCATGH
PSFVMSNSFTNQVLAQIELFNKSEEYSKEVYVLPKHLDEMVARLHLDKIGAKLTKLTKEQADYINVSVEGPYKPELYRY

Sequences:

>Translated_479_residues
MIRIFLEMVIANSIKTSIPNYVITDISLSDFGRKEIKIAETEMPGLMALREKHHSDKPLKGAKIAGSLHMTIQTAVLIET
LVELGAQVKWASCNIFSTQDHAAAAIAEQGIAVYAKKGESLDEYWQYTHYILDWGTDSPNMILDDGGDATGLLILGSKAE
KDLSVLDNPSNEEEIALFKSIKAKLLEDSNFYSRIKGNIIGVTEETTTGVARLYQLQKQNALPFPAINVNDSVTKSKFDN
LYGCRESLVDSIKRATDVMIAGKVALVIGFGDVGKGSAQSLRGLGAIVKVAEVDPICALQAAMEGFSVVTLEDVVEDIDI
FVTATGNYQVITNDNLVRMKDEAIVCNIGHFDNEIDVASLKDYPWENIKPQVDHITLPSGNKIILLAEGRLVNLGCATGH
PSFVMSNSFTNQVLAQIELFNKSEEYSKEVYVLPKHLDEMVARLHLDKIGAKLTKLTKEQADYINVSVEGPYKPELYRY
>Mature_479_residues
MIRIFLEMVIANSIKTSIPNYVITDISLSDFGRKEIKIAETEMPGLMALREKHHSDKPLKGAKIAGSLHMTIQTAVLIET
LVELGAQVKWASCNIFSTQDHAAAAIAEQGIAVYAKKGESLDEYWQYTHYILDWGTDSPNMILDDGGDATGLLILGSKAE
KDLSVLDNPSNEEEIALFKSIKAKLLEDSNFYSRIKGNIIGVTEETTTGVARLYQLQKQNALPFPAINVNDSVTKSKFDN
LYGCRESLVDSIKRATDVMIAGKVALVIGFGDVGKGSAQSLRGLGAIVKVAEVDPICALQAAMEGFSVVTLEDVVEDIDI
FVTATGNYQVITNDNLVRMKDEAIVCNIGHFDNEIDVASLKDYPWENIKPQVDHITLPSGNKIILLAEGRLVNLGCATGH
PSFVMSNSFTNQVLAQIELFNKSEEYSKEVYVLPKHLDEMVARLHLDKIGAKLTKLTKEQADYINVSVEGPYKPELYRY

Specific function: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine [H]

COG id: COG0499

COG function: function code H; S-adenosylhomocysteine hydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenosylhomocysteinase family [H]

Homologues:

Organism=Homo sapiens, GI9951915, Length=461, Percent_Identity=57.4837310195228, Blast_Score=503, Evalue=1e-142,
Organism=Homo sapiens, GI239937451, Length=439, Percent_Identity=57.8587699316629, Blast_Score=480, Evalue=1e-135,
Organism=Homo sapiens, GI298286489, Length=463, Percent_Identity=49.6760259179266, Blast_Score=460, Evalue=1e-129,
Organism=Homo sapiens, GI195539337, Length=463, Percent_Identity=49.6760259179266, Blast_Score=460, Evalue=1e-129,
Organism=Homo sapiens, GI24308043, Length=463, Percent_Identity=49.6760259179266, Blast_Score=460, Evalue=1e-129,
Organism=Homo sapiens, GI195539349, Length=463, Percent_Identity=49.6760259179266, Blast_Score=459, Evalue=1e-129,
Organism=Homo sapiens, GI21361647, Length=463, Percent_Identity=48.8120950323974, Blast_Score=437, Evalue=1e-123,
Organism=Caenorhabditis elegans, GI17506425, Length=473, Percent_Identity=57.7167019027484, Blast_Score=505, Evalue=1e-143,
Organism=Saccharomyces cerevisiae, GI6320882, Length=478, Percent_Identity=56.2761506276151, Blast_Score=486, Evalue=1e-138,
Organism=Drosophila melanogaster, GI24642172, Length=466, Percent_Identity=60.5150214592275, Blast_Score=518, Evalue=1e-147,
Organism=Drosophila melanogaster, GI24656245, Length=452, Percent_Identity=51.3274336283186, Blast_Score=459, Evalue=1e-129,
Organism=Drosophila melanogaster, GI45553387, Length=466, Percent_Identity=50.6437768240343, Blast_Score=436, Evalue=1e-122,
Organism=Drosophila melanogaster, GI45553385, Length=465, Percent_Identity=50.5376344086022, Blast_Score=434, Evalue=1e-122,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000043
- InterPro:   IPR015878
- InterPro:   IPR020082 [H]

Pfam domain/function: PF05221 AdoHcyase; PF00670 AdoHcyase_NAD [H]

EC number: =3.3.1.1 [H]

Molecular weight: Translated: 52722; Mature: 52722

Theoretical pI: Translated: 4.86; Mature: 4.86

Prosite motif: PS00738 ADOHCYASE_1 ; PS00739 ADOHCYASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIRIFLEMVIANSIKTSIPNYVITDISLSDFGRKEIKIAETEMPGLMALREKHHSDKPLK
CCEEEEHHHHHHHHHHCCCCEEEEECCHHHCCCCEEEEEECCCCHHHHHHHHCCCCCCCC
GAKIAGSLHMTIQTAVLIETLVELGAQVKWASCNIFSTQDHAAAAIAEQGIAVYAKKGES
CCEEECEEEEHHHHHHHHHHHHHHCCCEEEEEEEEECCCCHHHHHHHHCCEEEEEECCCC
LDEYWQYTHYILDWGTDSPNMILDDGGDATGLLILGSKAEKDLSVLDNPSNEEEIALFKS
HHHHHHHEEEEEEECCCCCCEEEECCCCEEEEEEECCCCCCCHHHHCCCCCHHHHHHHHH
IKAKLLEDSNFYSRIKGNIIGVTEETTTGVARLYQLQKQNALPFPAINVNDSVTKSKFDN
HHHHHHCCCCHHHHHCCCEEEEECCHHHHHHHHHHHHHCCCCCCCEECCCCCHHHHHHHH
LYGCRESLVDSIKRATDVMIAGKVALVIGFGDVGKGSAQSLRGLGAIVKVAEVDPICALQ
HHHHHHHHHHHHHHHHHEEEECEEEEEEEECCCCCCCHHHHHHHHHHEEEECCCCHHHHH
AAMEGFSVVTLEDVVEDIDIFVTATGNYQVITNDNLVRMKDEAIVCNIGHFDNEIDVASL
HHHCCCEEEEHHHHHCCCEEEEEECCCEEEEECCCEEEEECCEEEEEECCCCCCCCEEEC
KDYPWENIKPQVDHITLPSGNKIILLAEGRLVNLGCATGHPSFVMSNSFTNQVLAQIELF
CCCCCCCCCCCCCEEECCCCCEEEEEECCEEEEEEECCCCCCEEEECCHHHHHHHHHHHH
NKSEEYSKEVYVLPKHLDEMVARLHLDKIGAKLTKLTKEQADYINVSVEGPYKPELYRY
CCCHHHCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCC
>Mature Secondary Structure
MIRIFLEMVIANSIKTSIPNYVITDISLSDFGRKEIKIAETEMPGLMALREKHHSDKPLK
CCEEEEHHHHHHHHHHCCCCEEEEECCHHHCCCCEEEEEECCCCHHHHHHHHCCCCCCCC
GAKIAGSLHMTIQTAVLIETLVELGAQVKWASCNIFSTQDHAAAAIAEQGIAVYAKKGES
CCEEECEEEEHHHHHHHHHHHHHHCCCEEEEEEEEECCCCHHHHHHHHCCEEEEEECCCC
LDEYWQYTHYILDWGTDSPNMILDDGGDATGLLILGSKAEKDLSVLDNPSNEEEIALFKS
HHHHHHHEEEEEEECCCCCCEEEECCCCEEEEEEECCCCCCCHHHHCCCCCHHHHHHHHH
IKAKLLEDSNFYSRIKGNIIGVTEETTTGVARLYQLQKQNALPFPAINVNDSVTKSKFDN
HHHHHHCCCCHHHHHCCCEEEEECCHHHHHHHHHHHHHCCCCCCCEECCCCCHHHHHHHH
LYGCRESLVDSIKRATDVMIAGKVALVIGFGDVGKGSAQSLRGLGAIVKVAEVDPICALQ
HHHHHHHHHHHHHHHHHEEEECEEEEEEEECCCCCCCHHHHHHHHHHEEEECCCCHHHHH
AAMEGFSVVTLEDVVEDIDIFVTATGNYQVITNDNLVRMKDEAIVCNIGHFDNEIDVASL
HHHCCCEEEEHHHHHCCCEEEEEECCCEEEEECCCEEEEECCEEEEEECCCCCCCCEEEC
KDYPWENIKPQVDHITLPSGNKIILLAEGRLVNLGCATGHPSFVMSNSFTNQVLAQIELF
CCCCCCCCCCCCCEEECCCCCEEEEEECCEEEEEEECCCCCCEEEECCHHHHHHHHHHHH
NKSEEYSKEVYVLPKHLDEMVARLHLDKIGAKLTKLTKEQADYINVSVEGPYKPELYRY
CCCHHHCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA