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The map label for this gene is glmS [H]

Identifier: 123967027

GI number: 123967027

Start: 1580020

End: 1581915

Strand: Reverse

Name: glmS [H]

Synonym: P9515_17941

Alternate gene names: 123967027

Gene position: 1581915-1580020 (Counterclockwise)

Preceding gene: 123967028

Following gene: 123967025

Centisome position: 92.83

GC content: 33.23

Gene sequence:

>1896_bases
ATGTGTGGAATAGTTGCTGTTACTGGTTATAAAAAAGCGTTACCGTTATTAATAAATGGTTTAGAAAAACTTGAATACAG
AGGTTACGATTCTGCAGGAATAGCTGTAATAAGCTCTGAAACAAAAAATATAGTTTGTAATAAGGCAGAGGGAAAACTTA
ATAATTTAAAAAATAATTTAAAAAATGCCGAAATACCAGGAACTGTAGGAATAGGTCATACTCGTTGGGCGACTCACGGA
AAACCGGAGGTCAAAAATGCACATCCACATCTTGATAGCTTAGGAAAAGTTGCAGTTGTACAAAATGGGATAATAGAAAA
TTATCAGGAATTAAAAAGTAAGTTAGAAAAAGAAGGAATTTCTTTTGATTCTGATACTGACACAGAAGTTATTCCACACT
TAATTCAAAAAGAATTAATTGCTTTAAGTCAACTCAATCTTGAAAATAACGGCTCAACTTTGCTAGTAGCTGTAAGAAAT
GTAATTTCTGATTTGGAAGGGTCTTATGCTTTAGCGGTAATTTGGTCTGGCGCCCCAGATTCATTAGTAGTTGCTAGGAG
GCAGGCGCCTTTAATAATTGGTTTAGGAGAAGGAGAATTTATATGCGCAAGTGATACCCCAGCTATAGCAAGTTTCACAA
AGATTATTTTACCTTTGGAAGATGGGGAAATAGCTCTTTTAACACCTTTAGGAATAGAAATTTATGATTCAAATAATGAA
AGACAATATCGAAATCCGATTTCTTTACAAATTGCAGAGCAGGTAATTGATAAAAACAATTTCAGACATTACATGTTAAA
AGAAATCTACGATCAGCCTGAAATTGCAAAATATTGGTTAGAAAAATATTTAATTAAAGATTTAAAGACTAGTAAATTTC
AAATAAAATACCCCTTTGATACAAAGTTTTTTGAATCAATTGAAAGGATTGAAATTGTTGCTTGTGGTACTAGTAAGCAT
GCTGCGATGGTTGGTAAATTTTTGTTAGAGCAATTTTCAGGTATACCTACAAATGTTTTTTTTGCAAGTGAATTTAGATA
TTCACCACCACCATTACTTCCTAATACTTTAACGATCGGAGTAACTCAGTCAGGAGAAACAGCTGATACTATCGCCGCTA
TAAAGATGGAAATTCAAAGAAGAGCCTCAATGGGAGATGAAAGTTACAAACCAAATTTAGTTGCGATTACAAATAGAATT
GAAAGTTCAATTGGTAGACAGATATCAAATATAATTGATATCGGTGCTGGAATTGAAATTGGAGTTGCTGCTACAAAAAC
TTTCTTTGCGCAACTACTTTCTTTTTATGGCTTAGCTATTAAATTTGCTCAAATTAAACAAAGTCAAAGTAATGAAACTA
TTAGTCAATTAATCTCAGAATTAACTAAACTACCCCCATTAGTTGAAGAACTTTTAGAAAAACATAATCAATCTTCAGAA
AAACTTGCGCATGAGTTTTTTAATATTAAAGATGTTATTTTTTTGGGAAGAGGAATAAATTATCCTATTGCACTTGAGGG
GGCTTTAAAGTTAAAGGAAATTAGTTATATTCATGCTGCAGGATATCCTGCTGGTGAAATGAAGCATGGACCAATAGCTT
TATTAGATAAAAAAGTACCTGTAATTTCAATAGCTTTTCCTGGAGAAGTATTTGATAAGGTCATCAGTAATGCGCAAGAA
GCTAAAGCGAGAGATGCATATTTAATTGGTGTTGCCCCCAAATGTAAGGGAACTGAAATCTTTGATTATTTAATGGCCAT
CCCTTCAACAAATGAGTGGATTTCACCATTGCTTGCTATAGTCCCTCTCCAATTATTGAGTTACCACATAGCTGCTCATC
GAGGCCTCGATGTAGATCAACCAAGAAATTTAGCTAAAAGTGTAACAGTGGAATAG

Upstream 100 bases:

>100_bases
TATGGGTTTAGCTTATTAATTTTATAGTGCAGTTTTAAGACAGTCCATATTTTGTTGAATACTTAATTTATTTCAATTAT
TATTGGAAAAAATTAGATAT

Downstream 100 bases:

>100_bases
CTCTTGGGTGGGATTCATTAAAATGAATTTCCCATGAAGTTTCATAATTCTAAAAGGCCTGGCGGAGGAGTAATTATTAA
AAATTTATTCTTTATATCAA

Product: glucosamine--fructose-6-phosphate aminotransferase

Products: NA

Alternate protein names: D-fructose-6-phosphate amidotransferase; GFAT; Glucosamine-6-phosphate synthase; Hexosephosphate aminotransferase; L-glutamine-D-fructose-6-phosphate amidotransferase [H]

Number of amino acids: Translated: 631; Mature: 631

Protein sequence:

>631_residues
MCGIVAVTGYKKALPLLINGLEKLEYRGYDSAGIAVISSETKNIVCNKAEGKLNNLKNNLKNAEIPGTVGIGHTRWATHG
KPEVKNAHPHLDSLGKVAVVQNGIIENYQELKSKLEKEGISFDSDTDTEVIPHLIQKELIALSQLNLENNGSTLLVAVRN
VISDLEGSYALAVIWSGAPDSLVVARRQAPLIIGLGEGEFICASDTPAIASFTKIILPLEDGEIALLTPLGIEIYDSNNE
RQYRNPISLQIAEQVIDKNNFRHYMLKEIYDQPEIAKYWLEKYLIKDLKTSKFQIKYPFDTKFFESIERIEIVACGTSKH
AAMVGKFLLEQFSGIPTNVFFASEFRYSPPPLLPNTLTIGVTQSGETADTIAAIKMEIQRRASMGDESYKPNLVAITNRI
ESSIGRQISNIIDIGAGIEIGVAATKTFFAQLLSFYGLAIKFAQIKQSQSNETISQLISELTKLPPLVEELLEKHNQSSE
KLAHEFFNIKDVIFLGRGINYPIALEGALKLKEISYIHAAGYPAGEMKHGPIALLDKKVPVISIAFPGEVFDKVISNAQE
AKARDAYLIGVAPKCKGTEIFDYLMAIPSTNEWISPLLAIVPLQLLSYHIAAHRGLDVDQPRNLAKSVTVE

Sequences:

>Translated_631_residues
MCGIVAVTGYKKALPLLINGLEKLEYRGYDSAGIAVISSETKNIVCNKAEGKLNNLKNNLKNAEIPGTVGIGHTRWATHG
KPEVKNAHPHLDSLGKVAVVQNGIIENYQELKSKLEKEGISFDSDTDTEVIPHLIQKELIALSQLNLENNGSTLLVAVRN
VISDLEGSYALAVIWSGAPDSLVVARRQAPLIIGLGEGEFICASDTPAIASFTKIILPLEDGEIALLTPLGIEIYDSNNE
RQYRNPISLQIAEQVIDKNNFRHYMLKEIYDQPEIAKYWLEKYLIKDLKTSKFQIKYPFDTKFFESIERIEIVACGTSKH
AAMVGKFLLEQFSGIPTNVFFASEFRYSPPPLLPNTLTIGVTQSGETADTIAAIKMEIQRRASMGDESYKPNLVAITNRI
ESSIGRQISNIIDIGAGIEIGVAATKTFFAQLLSFYGLAIKFAQIKQSQSNETISQLISELTKLPPLVEELLEKHNQSSE
KLAHEFFNIKDVIFLGRGINYPIALEGALKLKEISYIHAAGYPAGEMKHGPIALLDKKVPVISIAFPGEVFDKVISNAQE
AKARDAYLIGVAPKCKGTEIFDYLMAIPSTNEWISPLLAIVPLQLLSYHIAAHRGLDVDQPRNLAKSVTVE
>Mature_631_residues
MCGIVAVTGYKKALPLLINGLEKLEYRGYDSAGIAVISSETKNIVCNKAEGKLNNLKNNLKNAEIPGTVGIGHTRWATHG
KPEVKNAHPHLDSLGKVAVVQNGIIENYQELKSKLEKEGISFDSDTDTEVIPHLIQKELIALSQLNLENNGSTLLVAVRN
VISDLEGSYALAVIWSGAPDSLVVARRQAPLIIGLGEGEFICASDTPAIASFTKIILPLEDGEIALLTPLGIEIYDSNNE
RQYRNPISLQIAEQVIDKNNFRHYMLKEIYDQPEIAKYWLEKYLIKDLKTSKFQIKYPFDTKFFESIERIEIVACGTSKH
AAMVGKFLLEQFSGIPTNVFFASEFRYSPPPLLPNTLTIGVTQSGETADTIAAIKMEIQRRASMGDESYKPNLVAITNRI
ESSIGRQISNIIDIGAGIEIGVAATKTFFAQLLSFYGLAIKFAQIKQSQSNETISQLISELTKLPPLVEELLEKHNQSSE
KLAHEFFNIKDVIFLGRGINYPIALEGALKLKEISYIHAAGYPAGEMKHGPIALLDKKVPVISIAFPGEVFDKVISNAQE
AKARDAYLIGVAPKCKGTEIFDYLMAIPSTNEWISPLLAIVPLQLLSYHIAAHRGLDVDQPRNLAKSVTVE

Specific function: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source [H]

COG id: COG0449

COG function: function code M; Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 SIS domains [H]

Homologues:

Organism=Homo sapiens, GI4826742, Length=710, Percent_Identity=34.2253521126761, Blast_Score=352, Evalue=5e-97,
Organism=Homo sapiens, GI205277386, Length=705, Percent_Identity=33.4751773049645, Blast_Score=344, Evalue=1e-94,
Organism=Homo sapiens, GI29570798, Length=180, Percent_Identity=30, Blast_Score=75, Evalue=2e-13,
Organism=Escherichia coli, GI1790167, Length=637, Percent_Identity=41.1302982731554, Blast_Score=448, Evalue=1e-127,
Organism=Escherichia coli, GI87082251, Length=320, Percent_Identity=23.125, Blast_Score=80, Evalue=4e-16,
Organism=Escherichia coli, GI1788651, Length=246, Percent_Identity=26.4227642276423, Blast_Score=72, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI17532899, Length=444, Percent_Identity=34.9099099099099, Blast_Score=243, Evalue=2e-64,
Organism=Caenorhabditis elegans, GI17532897, Length=444, Percent_Identity=34.9099099099099, Blast_Score=243, Evalue=2e-64,
Organism=Caenorhabditis elegans, GI17539970, Length=447, Percent_Identity=33.7807606263982, Blast_Score=241, Evalue=7e-64,
Organism=Caenorhabditis elegans, GI17554892, Length=276, Percent_Identity=28.9855072463768, Blast_Score=68, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6322745, Length=454, Percent_Identity=33.2599118942731, Blast_Score=234, Evalue=2e-62,
Organism=Saccharomyces cerevisiae, GI6323731, Length=451, Percent_Identity=27.2727272727273, Blast_Score=142, Evalue=1e-34,
Organism=Saccharomyces cerevisiae, GI6323730, Length=208, Percent_Identity=37.9807692307692, Blast_Score=121, Evalue=3e-28,
Organism=Drosophila melanogaster, GI21357745, Length=703, Percent_Identity=34.1394025604552, Blast_Score=365, Evalue=1e-101,
Organism=Drosophila melanogaster, GI24659598, Length=259, Percent_Identity=25.4826254826255, Blast_Score=79, Evalue=8e-15,
Organism=Drosophila melanogaster, GI24659604, Length=239, Percent_Identity=25.5230125523013, Blast_Score=79, Evalue=1e-14,
Organism=Drosophila melanogaster, GI28573187, Length=238, Percent_Identity=26.4705882352941, Blast_Score=67, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000583
- InterPro:   IPR017932
- InterPro:   IPR005855
- InterPro:   IPR001347 [H]

Pfam domain/function: PF00310 GATase_2; PF01380 SIS [H]

EC number: =2.6.1.16 [H]

Molecular weight: Translated: 69499; Mature: 69499

Theoretical pI: Translated: 6.22; Mature: 6.22

Prosite motif: PS00443 GATASE_TYPE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCGIVAVTGYKKALPLLINGLEKLEYRGYDSAGIAVISSETKNIVCNKAEGKLNNLKNNL
CCCEEEECCHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCEEEECCCCHHHHHHHHC
KNAEIPGTVGIGHTRWATHGKPEVKNAHPHLDSLGKVAVVQNGIIENYQELKSKLEKEGI
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHCCC
SFDSDTDTEVIPHLIQKELIALSQLNLENNGSTLLVAVRNVISDLEGSYALAVIWSGAPD
CCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEHHHHHHHCCCCEEEEEEECCCCC
SLVVARRQAPLIIGLGEGEFICASDTPAIASFTKIILPLEDGEIALLTPLGIEIYDSNNE
CEEEEECCCCEEEECCCCCEEEECCCCHHHHHEEEEEEECCCCEEEEEECCEEEEECCCC
RQYRNPISLQIAEQVIDKNNFRHYMLKEIYDQPEIAKYWLEKYLIKDLKTSKFQIKYPFD
CCCCCCCHHHHHHHHHCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCEEEEECCCC
TKFFESIERIEIVACGTSKHAAMVGKFLLEQFSGIPTNVFFASEFRYSPPPLLPNTLTIG
CHHHHHHHHEEEEEECCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCEEEE
VTQSGETADTIAAIKMEIQRRASMGDESYKPNLVAITNRIESSIGRQISNIIDIGAGIEI
EECCCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHCCCCCEE
GVAATKTFFAQLLSFYGLAIKFAQIKQSQSNETISQLISELTKLPPLVEELLEKHNQSSE
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCHHHHHHHHHCCCHHH
KLAHEFFNIKDVIFLGRGINYPIALEGALKLKEISYIHAAGYPAGEMKHGPIALLDKKVP
HHHHHHHCHHEEEEECCCCCCCEEECCCEEEHHEEEEEECCCCCCCCCCCCEEEEECCCC
VISIAFPGEVFDKVISNAQEAKARDAYLIGVAPKCKGTEIFDYLMAIPSTNEWISPLLAI
EEEEECCHHHHHHHHCCHHHHCCCCEEEEEECCCCCCHHHHHHHHHCCCCHHHHHHHHHH
VPLQLLSYHIAAHRGLDVDQPRNLAKSVTVE
HHHHHHHHHHHHHCCCCCCCCHHHHHHCCCC
>Mature Secondary Structure
MCGIVAVTGYKKALPLLINGLEKLEYRGYDSAGIAVISSETKNIVCNKAEGKLNNLKNNL
CCCEEEECCHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCEEEECCCCHHHHHHHHC
KNAEIPGTVGIGHTRWATHGKPEVKNAHPHLDSLGKVAVVQNGIIENYQELKSKLEKEGI
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHCCC
SFDSDTDTEVIPHLIQKELIALSQLNLENNGSTLLVAVRNVISDLEGSYALAVIWSGAPD
CCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEHHHHHHHCCCCEEEEEEECCCCC
SLVVARRQAPLIIGLGEGEFICASDTPAIASFTKIILPLEDGEIALLTPLGIEIYDSNNE
CEEEEECCCCEEEECCCCCEEEECCCCHHHHHEEEEEEECCCCEEEEEECCEEEEECCCC
RQYRNPISLQIAEQVIDKNNFRHYMLKEIYDQPEIAKYWLEKYLIKDLKTSKFQIKYPFD
CCCCCCCHHHHHHHHHCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCEEEEECCCC
TKFFESIERIEIVACGTSKHAAMVGKFLLEQFSGIPTNVFFASEFRYSPPPLLPNTLTIG
CHHHHHHHHEEEEEECCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCEEEE
VTQSGETADTIAAIKMEIQRRASMGDESYKPNLVAITNRIESSIGRQISNIIDIGAGIEI
EECCCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHCCCCCEE
GVAATKTFFAQLLSFYGLAIKFAQIKQSQSNETISQLISELTKLPPLVEELLEKHNQSSE
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCHHHHHHHHHCCCHHH
KLAHEFFNIKDVIFLGRGINYPIALEGALKLKEISYIHAAGYPAGEMKHGPIALLDKKVP
HHHHHHHCHHEEEEECCCCCCCEEECCCEEEHHEEEEEECCCCCCCCCCCCEEEEECCCC
VISIAFPGEVFDKVISNAQEAKARDAYLIGVAPKCKGTEIFDYLMAIPSTNEWISPLLAI
EEEEECCHHHHHHHHCCHHHHCCCCEEEEEECCCCCCHHHHHHHHHCCCCHHHHHHHHHH
VPLQLLSYHIAAHRGLDVDQPRNLAKSVTVE
HHHHHHHHHHHHHCCCCCCCCHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12240834 [H]