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The map label for this gene is lon [H]

Identifier: 123966919

GI number: 123966919

Start: 1482737

End: 1483393

Strand: Reverse

Name: lon [H]

Synonym: P9515_16861

Alternate gene names: 123966919

Gene position: 1483393-1482737 (Counterclockwise)

Preceding gene: 123966920

Following gene: 123966918

Centisome position: 87.04

GC content: 35.01

Gene sequence:

>657_bases
ATGGGAGAGCTTTCAGTAAGGGAATTACCATTATTCCCTCTCCCAGAAGTTGTTCTTTTCCCTCAAGAAGTTTTACCTCT
ACACATATTTGAATCAAGATACAGAATTATGCTTAAATCTGTTCTTGAATCAGATTCAATGTTTGGGGTAATTAAATGGG
ATCCTAATACTAAAAGTATGGCTAACGTTGGCTGCTGTGCTCAAATAATTAAACATCAAACAGCCGATGATGGAAGAAGT
AATATAGTCACGTTGGGACAGCAAAGATTCCAAGTCTTAGAAGTTGTACGTTCAACACCATATTGCTCAGCGATTGTTAG
TTGGATTACTGATGAAAATATCGAAAGTTTCCAAAGTTTAGATCTTTTAAGAGATTCTGTTACTGAAGCATTAAATGATG
TAGTTAAATTAACTAGTAAACTAACTAATTCTCAAAAAGTTCTTCCTGATAAATTACCTGAAAACCCTATGGAACTCTCT
TTTTGGATTGGTGCTCATTTAGGTGGACCGGTGGCTGAAGAGCAGCAGAAACTTTTAGAAGAGAGGAGTACATATACACG
TTTGCAAAGAGAGTTTGAAATGTTAGATCATACGAGAAAACAATTGGCAGCTAGAACAGCTTTAAAAGAAAGTTTTCCAG
ATATCAAAGAAAATTAA

Upstream 100 bases:

>100_bases
ACTAGATCTTCCTAGCGGTGTAGATATAGAAGTTAAACTATAAGATTGCCCGAATAGTGCCTAAATTTACTAATATGTAG
TTATAGATTTTGAGGTTTAA

Downstream 100 bases:

>100_bases
ATGTCCTTATTCTTAACATCTTTTATTTTTTTAGTTTTAATTCTATTTTTCTTGTATTTAGTACTTTGGAGGATTAATAC
TAGAAAATATATCTCTTCGG

Product: ATP-dependent protease La

Products: NA

Alternate protein names: ATP-dependent protease La [H]

Number of amino acids: Translated: 218; Mature: 217

Protein sequence:

>218_residues
MGELSVRELPLFPLPEVVLFPQEVLPLHIFESRYRIMLKSVLESDSMFGVIKWDPNTKSMANVGCCAQIIKHQTADDGRS
NIVTLGQQRFQVLEVVRSTPYCSAIVSWITDENIESFQSLDLLRDSVTEALNDVVKLTSKLTNSQKVLPDKLPENPMELS
FWIGAHLGGPVAEEQQKLLEERSTYTRLQREFEMLDHTRKQLAARTALKESFPDIKEN

Sequences:

>Translated_218_residues
MGELSVRELPLFPLPEVVLFPQEVLPLHIFESRYRIMLKSVLESDSMFGVIKWDPNTKSMANVGCCAQIIKHQTADDGRS
NIVTLGQQRFQVLEVVRSTPYCSAIVSWITDENIESFQSLDLLRDSVTEALNDVVKLTSKLTNSQKVLPDKLPENPMELS
FWIGAHLGGPVAEEQQKLLEERSTYTRLQREFEMLDHTRKQLAARTALKESFPDIKEN
>Mature_217_residues
GELSVRELPLFPLPEVVLFPQEVLPLHIFESRYRIMLKSVLESDSMFGVIKWDPNTKSMANVGCCAQIIKHQTADDGRSN
IVTLGQQRFQVLEVVRSTPYCSAIVSWITDENIESFQSLDLLRDSVTEALNDVVKLTSKLTNSQKVLPDKLPENPMELSF
WIGAHLGGPVAEEQQKLLEERSTYTRLQREFEMLDHTRKQLAARTALKESFPDIKEN

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG2802

COG function: function code R; Uncharacterized protein, similar to the N-terminal domain of Lon protease

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Lon domain [H]

Homologues:

Organism=Homo sapiens, GI148528975, Length=183, Percent_Identity=30.0546448087432, Blast_Score=72, Evalue=3e-13,
Organism=Homo sapiens, GI87080813, Length=131, Percent_Identity=31.2977099236641, Blast_Score=69, Evalue=5e-12,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR003111
- InterPro:   IPR008268
- InterPro:   IPR001984
- InterPro:   IPR015947
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C [H]

EC number: =3.4.21.53 [H]

Molecular weight: Translated: 24846; Mature: 24715

Theoretical pI: Translated: 4.99; Mature: 4.99

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGELSVRELPLFPLPEVVLFPQEVLPLHIFESRYRIMLKSVLESDSMFGVIKWDPNTKSM
CCCCCCCCCCCCCCCHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCHHH
ANVGCCAQIIKHQTADDGRSNIVTLGQQRFQVLEVVRSTPYCSAIVSWITDENIESFQSL
HHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHH
DLLRDSVTEALNDVVKLTSKLTNSQKVLPDKLPENPMELSFWIGAHLGGPVAEEQQKLLE
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEHHHHHHHCCCCCHHHHHHHHH
ERSTYTRLQREFEMLDHTRKQLAARTALKESFPDIKEN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
GELSVRELPLFPLPEVVLFPQEVLPLHIFESRYRIMLKSVLESDSMFGVIKWDPNTKSM
CCCCCCCCCCCCCCHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCHHH
ANVGCCAQIIKHQTADDGRSNIVTLGQQRFQVLEVVRSTPYCSAIVSWITDENIESFQSL
HHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHH
DLLRDSVTEALNDVVKLTSKLTNSQKVLPDKLPENPMELSFWIGAHLGGPVAEEQQKLLE
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEHHHHHHHCCCCCHHHHHHHHH
ERSTYTRLQREFEMLDHTRKQLAARTALKESFPDIKEN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA