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The map label for this gene is bioA [H]

Identifier: 123966885

GI number: 123966885

Start: 1443983

End: 1445284

Strand: Direct

Name: bioA [H]

Synonym: P9515_16521

Alternate gene names: 123966885

Gene position: 1443983-1445284 (Clockwise)

Preceding gene: 123966884

Following gene: 123966888

Centisome position: 84.73

GC content: 32.8

Gene sequence:

>1302_bases
ATGAAATCTCAGATATCAACAAACATTAATCAAGATTGGCACCCTCATATATGGCCACCTTTTACTCAGATTACAAATAG
CAAACCCCAAATAGAAGTTACTCATGGAAAAAATGCTTTAATTTATACTAAAAATCCACAACAAGAACTTATTGATGGAA
TAAGCAGTTGGTGGGTTACCCTACATGGACATAGTAACGATTACATAGCAAATGCAATTTTTCACCAAGCCAAGACTCTT
GAACAAATTATATTTGCCGATTTCTTACATCCACAGGCTAAATTATTATCAGAGAGACTCAGCAGCTTAACAAAATTAGA
AAGACTATTTTTTTCTGATAATGGGTCTACGGCTGTTGAAGTAGCTTTAAAAATTGCCTATCAATCTTGGCAAAATCAAG
GTGAAATAAGAAACCAAATCATTGCTTTTGATGGAGCTTATCATGGTGATACCTTTGGAGCAATGGCTTTAGGGGAAAGA
AATATTTTTAATGAGAATTTTGACAATCTCATGTTTCCCGTCAAAAGGGTCCCCTGGCCTTCAACATGGATAGATGATGA
AAAGGTTAAAATAAAAGAGAAACAAGCAATCCAAATATTAAATAACCTTCTTAAAAAACCAACAGTAGCTGTCATAATCG
AACCATTAGTACAAGGGGCTGGGGGAATGAATATGGTTAGGCCTGAATTTATTAAAAAAGTTTCAGAAGTAGTAAAAAAT
AATAACTCTTTATTAATAGCTGATGAAGTATTAACAGGATTTGGGAGATGTGGAAGTCTCTTTGCATTTCAAAAGGCAAA
TATAATTCCTGATTTAATTTCTATTTCCAAGGGATTAACTGGAGGATTCCTACCTATGGGAATAACATTAGCTAAAGAGA
CAATTTTCCAAGCTTTTATTAGCGACTCGCCTAAAAAAACTTTTTGGCATGGTCATAGCTTCACAGCAAACCCTTTAGGA
TGTGCAGCAGCTAATGCAAGCCTTGACTTATTAGAAAATGATCCAGTTAAATATATTTCTTTTGAGGCAAAGCACTCTTA
TCACCTAAAGAAAATCAAGAAATTACCTTTCGTAAAAAACATAAGATTCACAGGAACTATTGCCGCATTTGATATTGAAA
TTGGGAATAATGAAGGTTATCTAAACAATATTGGTAAAAAGATAAAAGCCTTAGCAATTAAAAAAGGTTTATTTATAAGA
CCACTTGGTAATGTCATATATCTATTGCCCCCTCTTTGTATTACAGACAAACAATTAGAAAAAAGTTACAGAATTATTTT
TGAAATTTTAAGTGATCTTTAA

Upstream 100 bases:

>100_bases
CATTGATTCAGAACATTGGTTCCCATAATTTAGATATAATTTGGGAAGAGTTAAAAATTAAAAATAGATTGATCACCTTA
TTAAGTTCAAAAAATAATTA

Downstream 100 bases:

>100_bases
AATTTAAGGTTATGGTCCTTGTAAAATAGCATTTTCAATATCTTCTCTATTTATACAATAAGAAAATAGTCTTTTAGTTA
ATTTACCTCCACTCTCCCAA

Product: putative diaminopelargonic acid synthase

Products: NA

Alternate protein names: 7,8-diamino-pelargonic acid aminotransferase; DAPA AT; DAPA aminotransferase; Diaminopelargonic acid synthase [H]

Number of amino acids: Translated: 433; Mature: 433

Protein sequence:

>433_residues
MKSQISTNINQDWHPHIWPPFTQITNSKPQIEVTHGKNALIYTKNPQQELIDGISSWWVTLHGHSNDYIANAIFHQAKTL
EQIIFADFLHPQAKLLSERLSSLTKLERLFFSDNGSTAVEVALKIAYQSWQNQGEIRNQIIAFDGAYHGDTFGAMALGER
NIFNENFDNLMFPVKRVPWPSTWIDDEKVKIKEKQAIQILNNLLKKPTVAVIIEPLVQGAGGMNMVRPEFIKKVSEVVKN
NNSLLIADEVLTGFGRCGSLFAFQKANIIPDLISISKGLTGGFLPMGITLAKETIFQAFISDSPKKTFWHGHSFTANPLG
CAAANASLDLLENDPVKYISFEAKHSYHLKKIKKLPFVKNIRFTGTIAAFDIEIGNNEGYLNNIGKKIKALAIKKGLFIR
PLGNVIYLLPPLCITDKQLEKSYRIIFEILSDL

Sequences:

>Translated_433_residues
MKSQISTNINQDWHPHIWPPFTQITNSKPQIEVTHGKNALIYTKNPQQELIDGISSWWVTLHGHSNDYIANAIFHQAKTL
EQIIFADFLHPQAKLLSERLSSLTKLERLFFSDNGSTAVEVALKIAYQSWQNQGEIRNQIIAFDGAYHGDTFGAMALGER
NIFNENFDNLMFPVKRVPWPSTWIDDEKVKIKEKQAIQILNNLLKKPTVAVIIEPLVQGAGGMNMVRPEFIKKVSEVVKN
NNSLLIADEVLTGFGRCGSLFAFQKANIIPDLISISKGLTGGFLPMGITLAKETIFQAFISDSPKKTFWHGHSFTANPLG
CAAANASLDLLENDPVKYISFEAKHSYHLKKIKKLPFVKNIRFTGTIAAFDIEIGNNEGYLNNIGKKIKALAIKKGLFIR
PLGNVIYLLPPLCITDKQLEKSYRIIFEILSDL
>Mature_433_residues
MKSQISTNINQDWHPHIWPPFTQITNSKPQIEVTHGKNALIYTKNPQQELIDGISSWWVTLHGHSNDYIANAIFHQAKTL
EQIIFADFLHPQAKLLSERLSSLTKLERLFFSDNGSTAVEVALKIAYQSWQNQGEIRNQIIAFDGAYHGDTFGAMALGER
NIFNENFDNLMFPVKRVPWPSTWIDDEKVKIKEKQAIQILNNLLKKPTVAVIIEPLVQGAGGMNMVRPEFIKKVSEVVKN
NNSLLIADEVLTGFGRCGSLFAFQKANIIPDLISISKGLTGGFLPMGITLAKETIFQAFISDSPKKTFWHGHSFTANPLG
CAAANASLDLLENDPVKYISFEAKHSYHLKKIKKLPFVKNIRFTGTIAAFDIEIGNNEGYLNNIGKKIKALAIKKGLFIR
PLGNVIYLLPPLCITDKQLEKSYRIIFEILSDL

Specific function: Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor [H]

COG id: COG0161

COG function: function code H; Adenosylmethionine-8-amino-7-oxononanoate aminotransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily [H]

Homologues:

Organism=Homo sapiens, GI13994255, Length=315, Percent_Identity=28.2539682539683, Blast_Score=104, Evalue=1e-22,
Organism=Homo sapiens, GI4557809, Length=391, Percent_Identity=25.0639386189258, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI37574042, Length=431, Percent_Identity=26.2180974477958, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI284507298, Length=323, Percent_Identity=26.0061919504644, Blast_Score=94, Evalue=3e-19,
Organism=Homo sapiens, GI226442705, Length=431, Percent_Identity=25.9860788863109, Blast_Score=93, Evalue=5e-19,
Organism=Homo sapiens, GI226442709, Length=384, Percent_Identity=26.3020833333333, Blast_Score=92, Evalue=7e-19,
Organism=Homo sapiens, GI24119277, Length=409, Percent_Identity=22.0048899755501, Blast_Score=74, Evalue=3e-13,
Organism=Escherichia coli, GI1786991, Length=416, Percent_Identity=34.375, Blast_Score=239, Evalue=3e-64,
Organism=Escherichia coli, GI145693181, Length=395, Percent_Identity=30.379746835443, Blast_Score=154, Evalue=1e-38,
Organism=Escherichia coli, GI1789759, Length=325, Percent_Identity=30.4615384615385, Blast_Score=134, Evalue=1e-32,
Organism=Escherichia coli, GI1788044, Length=378, Percent_Identity=27.5132275132275, Blast_Score=127, Evalue=1e-30,
Organism=Escherichia coli, GI1789016, Length=401, Percent_Identity=28.428927680798, Blast_Score=125, Evalue=5e-30,
Organism=Escherichia coli, GI1787560, Length=397, Percent_Identity=27.9596977329975, Blast_Score=118, Evalue=8e-28,
Organism=Escherichia coli, GI1786349, Length=319, Percent_Identity=25.3918495297806, Blast_Score=78, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI25144271, Length=416, Percent_Identity=25, Blast_Score=114, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI32564660, Length=449, Percent_Identity=26.5033407572383, Blast_Score=108, Evalue=8e-24,
Organism=Caenorhabditis elegans, GI25144274, Length=232, Percent_Identity=31.4655172413793, Blast_Score=105, Evalue=4e-23,
Organism=Caenorhabditis elegans, GI71992977, Length=397, Percent_Identity=22.9219143576826, Blast_Score=82, Evalue=5e-16,
Organism=Saccharomyces cerevisiae, GI6324386, Length=468, Percent_Identity=29.4871794871795, Blast_Score=196, Evalue=6e-51,
Organism=Saccharomyces cerevisiae, GI6323470, Length=410, Percent_Identity=26.8292682926829, Blast_Score=124, Evalue=3e-29,
Organism=Saccharomyces cerevisiae, GI6324432, Length=418, Percent_Identity=27.511961722488, Blast_Score=119, Evalue=1e-27,
Organism=Drosophila melanogaster, GI21357415, Length=406, Percent_Identity=25.1231527093596, Blast_Score=101, Evalue=1e-21,
Organism=Drosophila melanogaster, GI161085790, Length=409, Percent_Identity=24.6943765281174, Blast_Score=101, Evalue=1e-21,
Organism=Drosophila melanogaster, GI28574759, Length=396, Percent_Identity=25.2525252525253, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI21356575, Length=422, Percent_Identity=23.4597156398104, Blast_Score=92, Evalue=8e-19,
Organism=Drosophila melanogaster, GI281366494, Length=162, Percent_Identity=30.2469135802469, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24667139, Length=162, Percent_Identity=30.2469135802469, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24667143, Length=162, Percent_Identity=30.2469135802469, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005814
- InterPro:   IPR005815
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.62 [H]

Molecular weight: Translated: 48646; Mature: 48646

Theoretical pI: Translated: 9.48; Mature: 9.48

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSQISTNINQDWHPHIWPPFTQITNSKPQIEVTHGKNALIYTKNPQQELIDGISSWWVT
CCCCCCCCCCCCCCCCCCCCHHHHCCCCCCEEEECCCEEEEEECCCHHHHHHHHHEEEEE
LHGHSNDYIANAIFHQAKTLEQIIFADFLHPQAKLLSERLSSLTKLERLFFSDNGSTAVE
EECCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHH
VALKIAYQSWQNQGEIRNQIIAFDGAYHGDTFGAMALGERNIFNENFDNLMFPVKRVPWP
HHHHHHHHHHCCCCCHHCEEEEECCCCCCCCCCHHCCCCCCCCCCCCHHHHHHHHCCCCC
STWIDDEKVKIKEKQAIQILNNLLKKPTVAVIIEPLVQGAGGMNMVRPEFIKKVSEVVKN
CCCCCCCCEEHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHC
NNSLLIADEVLTGFGRCGSLFAFQKANIIPDLISISKGLTGGFLPMGITLAKETIFQAFI
CCCEEEEHHHHHHHCCCCHHHHHHHCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHH
SDSPKKTFWHGHSFTANPLGCAAANASLDLLENDPVKYISFEAKHSYHLKKIKKLPFVKN
CCCCCCEEECCCCCCCCCCCCEECCCCEEECCCCCEEEEEEECCCHHHHHHHHHCCCEEC
IRFTGTIAAFDIEIGNNEGYLNNIGKKIKALAIKKGLFIRPLGNVIYLLPPLCITDKQLE
EEEEEEEEEEEEEECCCCCHHHHHHHHHHHHHHHCCCEEEECCCCCEECCCCCCCHHHHH
KSYRIIFEILSDL
HHHHHHHHHHHCC
>Mature Secondary Structure
MKSQISTNINQDWHPHIWPPFTQITNSKPQIEVTHGKNALIYTKNPQQELIDGISSWWVT
CCCCCCCCCCCCCCCCCCCCHHHHCCCCCCEEEECCCEEEEEECCCHHHHHHHHHEEEEE
LHGHSNDYIANAIFHQAKTLEQIIFADFLHPQAKLLSERLSSLTKLERLFFSDNGSTAVE
EECCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHH
VALKIAYQSWQNQGEIRNQIIAFDGAYHGDTFGAMALGERNIFNENFDNLMFPVKRVPWP
HHHHHHHHHHCCCCCHHCEEEEECCCCCCCCCCHHCCCCCCCCCCCCHHHHHHHHCCCCC
STWIDDEKVKIKEKQAIQILNNLLKKPTVAVIIEPLVQGAGGMNMVRPEFIKKVSEVVKN
CCCCCCCCEEHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHC
NNSLLIADEVLTGFGRCGSLFAFQKANIIPDLISISKGLTGGFLPMGITLAKETIFQAFI
CCCEEEEHHHHHHHCCCCHHHHHHHCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHH
SDSPKKTFWHGHSFTANPLGCAAANASLDLLENDPVKYISFEAKHSYHLKKIKKLPFVKN
CCCCCCEEECCCCCCCCCCCCEECCCCEEECCCCCEEEEEEECCCHHHHHHHHHCCCEEC
IRFTGTIAAFDIEIGNNEGYLNNIGKKIKALAIKKGLFIRPLGNVIYLLPPLCITDKQLE
EEEEEEEEEEEEEECCCCCHHHHHHHHHHHHHHHCCCEEEECCCCCEECCCCCCCHHHHH
KSYRIIFEILSDL
HHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2110099 [H]