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The map label for this gene is acoA [H]

Identifier: 123966682

GI number: 123966682

Start: 1284254

End: 1285291

Strand: Direct

Name: acoA [H]

Synonym: P9515_14491

Alternate gene names: 123966682

Gene position: 1284254-1285291 (Clockwise)

Preceding gene: 123966676

Following gene: 123966685

Centisome position: 75.36

GC content: 39.21

Gene sequence:

>1038_bases
TTGGAAACACACTTAGAGAGAATTTCAAATCTTCAGGATTTCAAAAAAGCGAAGTTAGATCGTGAAACAGGATTATTTCT
CTATGAAGATATGACGCTTGGTCGAAGATTTGAAGATAAATGTGCAGAGATGTACTACAGAGGCAAGATGTTTGGATTCG
TACATCTTTACAATGGCCAAGAAGCTATTAGCACTGGTGTCATAGGTGCAATGAAAAGGAAGCACGACTGGTTTTGTAGT
ACCTACCGCGATCATGTTCATGCTCTAAGTGCAGGTGTCCCTTCTTTTGAAGTGATGAGTGAATTATTCGGCAAGGCCAC
AGGATGCAGTAAAGGCAGAGGCGGTTCTATGCATTTGTTCTCAAAAGAACATCATCTCTTAGGAGGATATGCTTTTATTG
GTGAGGGCATTCCAGTTGCTTTAGGGTCAGCTTTTTCAAGTAAATATAAAAAAGTAGTTGCAGGTGACAGCCAAAGCGAC
TCTGTAACAGCTGCTTTCTTTGGAGATGGGACTTGTAATAATGGGCAGTTTTTTGAATGTTTAAATATGGCTCAATTATG
GAAACTTCCAATAATTTTTGTAGTTGAAAACAATAAATGGGCTATAGGCATGGCTCATGACAGAGCTACAAGCGACCCGG
AAATATGGAGAAAAGCATCGGCTTTCGGGATGCATGGTGAAGAAGTTGATGGAATGGACGTATTAGCCGTGAGAGGGGCG
GCACAAAGAGCAGTAGAAAGAGCTAGAGCAGGTGAGGGTCCTACTCTACTCGAATGCTTAACTTACAGATTTAGAGGTCA
TTCTTTGGCAGATCCAGATGAATTAAGAGCTGAAGAAGAAAAAGAATTCTGGGGGAAAAGAGATCCTATTAAGAAATTAG
CAAAACTTATGATAGAGGGAGATTTTGCGAAAGAAGAGGAATTAAAGAGTATAGAAAAGAAAATAGATTTAGAAATTTCT
GAATCTGTTAAAAATGCTCTTGAAGCTCCTGAACCTCCTGCTAATGAATTAACAAAATATATTTGGGCAGAAGATTAA

Upstream 100 bases:

>100_bases
TTTTTTTCATAAGGTCTTGGAGAGTTATTAAAAAAAAACATAAAAATTGTCCATTGAAGCTTAGAATGTTAACAAATCAA
AACTTCATTAAGGTATTTTC

Downstream 100 bases:

>100_bases
ATTAAATTCCACTAGGTAATTTTCTGGTTAAGTTTCTTAATTTTCTAAGAGCCTTCAGTTCTACCTGTCTTACCCTTTCT
CTAGAGACTTCAAGTAATCT

Product: pyruvate dehydrogenase E1 alpha subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 345; Mature: 345

Protein sequence:

>345_residues
METHLERISNLQDFKKAKLDRETGLFLYEDMTLGRRFEDKCAEMYYRGKMFGFVHLYNGQEAISTGVIGAMKRKHDWFCS
TYRDHVHALSAGVPSFEVMSELFGKATGCSKGRGGSMHLFSKEHHLLGGYAFIGEGIPVALGSAFSSKYKKVVAGDSQSD
SVTAAFFGDGTCNNGQFFECLNMAQLWKLPIIFVVENNKWAIGMAHDRATSDPEIWRKASAFGMHGEEVDGMDVLAVRGA
AQRAVERARAGEGPTLLECLTYRFRGHSLADPDELRAEEEKEFWGKRDPIKKLAKLMIEGDFAKEEELKSIEKKIDLEIS
ESVKNALEAPEPPANELTKYIWAED

Sequences:

>Translated_345_residues
METHLERISNLQDFKKAKLDRETGLFLYEDMTLGRRFEDKCAEMYYRGKMFGFVHLYNGQEAISTGVIGAMKRKHDWFCS
TYRDHVHALSAGVPSFEVMSELFGKATGCSKGRGGSMHLFSKEHHLLGGYAFIGEGIPVALGSAFSSKYKKVVAGDSQSD
SVTAAFFGDGTCNNGQFFECLNMAQLWKLPIIFVVENNKWAIGMAHDRATSDPEIWRKASAFGMHGEEVDGMDVLAVRGA
AQRAVERARAGEGPTLLECLTYRFRGHSLADPDELRAEEEKEFWGKRDPIKKLAKLMIEGDFAKEEELKSIEKKIDLEIS
ESVKNALEAPEPPANELTKYIWAED
>Mature_345_residues
METHLERISNLQDFKKAKLDRETGLFLYEDMTLGRRFEDKCAEMYYRGKMFGFVHLYNGQEAISTGVIGAMKRKHDWFCS
TYRDHVHALSAGVPSFEVMSELFGKATGCSKGRGGSMHLFSKEHHLLGGYAFIGEGIPVALGSAFSSKYKKVVAGDSQSD
SVTAAFFGDGTCNNGQFFECLNMAQLWKLPIIFVVENNKWAIGMAHDRATSDPEIWRKASAFGMHGEEVDGMDVLAVRGA
AQRAVERARAGEGPTLLECLTYRFRGHSLADPDELRAEEEKEFWGKRDPIKKLAKLMIEGDFAKEEELKSIEKKIDLEIS
ESVKNALEAPEPPANELTKYIWAED

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG1071

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4885543, Length=329, Percent_Identity=37.6899696048632, Blast_Score=221, Evalue=6e-58,
Organism=Homo sapiens, GI4505685, Length=329, Percent_Identity=38.2978723404255, Blast_Score=208, Evalue=5e-54,
Organism=Homo sapiens, GI291084742, Length=329, Percent_Identity=38.2978723404255, Blast_Score=208, Evalue=5e-54,
Organism=Homo sapiens, GI291084744, Length=336, Percent_Identity=37.5, Blast_Score=201, Evalue=6e-52,
Organism=Homo sapiens, GI291084757, Length=329, Percent_Identity=34.9544072948328, Blast_Score=172, Evalue=5e-43,
Organism=Homo sapiens, GI11386135, Length=328, Percent_Identity=27.7439024390244, Blast_Score=114, Evalue=9e-26,
Organism=Homo sapiens, GI258645172, Length=333, Percent_Identity=27.9279279279279, Blast_Score=112, Evalue=4e-25,
Organism=Caenorhabditis elegans, GI32564172, Length=326, Percent_Identity=37.7300613496933, Blast_Score=214, Evalue=6e-56,
Organism=Caenorhabditis elegans, GI17536047, Length=326, Percent_Identity=37.7300613496933, Blast_Score=214, Evalue=7e-56,
Organism=Caenorhabditis elegans, GI86563357, Length=313, Percent_Identity=28.4345047923323, Blast_Score=117, Evalue=8e-27,
Organism=Caenorhabditis elegans, GI86563355, Length=313, Percent_Identity=28.4345047923323, Blast_Score=117, Evalue=9e-27,
Organism=Saccharomyces cerevisiae, GI6321026, Length=316, Percent_Identity=37.3417721518987, Blast_Score=202, Evalue=5e-53,
Organism=Drosophila melanogaster, GI24639748, Length=331, Percent_Identity=38.9728096676737, Blast_Score=215, Evalue=3e-56,
Organism=Drosophila melanogaster, GI24639744, Length=310, Percent_Identity=38.0645161290323, Blast_Score=207, Evalue=1e-53,
Organism=Drosophila melanogaster, GI28571106, Length=310, Percent_Identity=38.0645161290323, Blast_Score=207, Evalue=1e-53,
Organism=Drosophila melanogaster, GI24639740, Length=332, Percent_Identity=36.4457831325301, Blast_Score=207, Evalue=1e-53,
Organism=Drosophila melanogaster, GI24639746, Length=313, Percent_Identity=37.0607028753994, Blast_Score=199, Evalue=2e-51,
Organism=Drosophila melanogaster, GI21355903, Length=337, Percent_Identity=25.2225519287834, Blast_Score=95, Evalue=7e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001017
- InterPro:   IPR017597 [H]

Pfam domain/function: PF00676 E1_dh [H]

EC number: =1.2.4.1 [H]

Molecular weight: Translated: 38659; Mature: 38659

Theoretical pI: Translated: 5.99; Mature: 5.99

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
METHLERISNLQDFKKAKLDRETGLFLYEDMTLGRRFEDKCAEMYYRGKMFGFVHLYNGQ
CCCHHHHHHHHHHHHHHHCCHHCCEEEEECCHHCCHHHHHHHHHHHHCCEEEEEEEECCH
EAISTGVIGAMKRKHDWFCSTYRDHVHALSAGVPSFEVMSELFGKATGCSKGRGGSMHLF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCCCEEEE
SKEHHLLGGYAFIGEGIPVALGSAFSSKYKKVVAGDSQSDSVTAAFFGDGTCNNGQFFEC
CCCCHHCCCEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCHHHHH
LNMAQLWKLPIIFVVENNKWAIGMAHDRATSDPEIWRKASAFGMHGEEVDGMDVLAVRGA
HHHHHHHCCCEEEEEECCEEEEEECCCCCCCCHHHHHHHHHCCCCCCCCCCCCCEEHHHH
AQRAVERARAGEGPTLLECLTYRFRGHSLADPDELRAEEEKEFWGKRDPIKKLAKLMIEG
HHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHCC
DFAKEEELKSIEKKIDLEISESVKNALEAPEPPANELTKYIWAED
CCCCHHHHHHHHHHHCCHHHHHHHHHHCCCCCCHHHHHHHHCCCC
>Mature Secondary Structure
METHLERISNLQDFKKAKLDRETGLFLYEDMTLGRRFEDKCAEMYYRGKMFGFVHLYNGQ
CCCHHHHHHHHHHHHHHHCCHHCCEEEEECCHHCCHHHHHHHHHHHHCCEEEEEEEECCH
EAISTGVIGAMKRKHDWFCSTYRDHVHALSAGVPSFEVMSELFGKATGCSKGRGGSMHLF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCCCEEEE
SKEHHLLGGYAFIGEGIPVALGSAFSSKYKKVVAGDSQSDSVTAAFFGDGTCNNGQFFEC
CCCCHHCCCEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCHHHHH
LNMAQLWKLPIIFVVENNKWAIGMAHDRATSDPEIWRKASAFGMHGEEVDGMDVLAVRGA
HHHHHHHCCCEEEEEECCEEEEEECCCCCCCCHHHHHHHHHCCCCCCCCCCCCCEEHHHH
AQRAVERARAGEGPTLLECLTYRFRGHSLADPDELRAEEEKEFWGKRDPIKKLAKLMIEG
HHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHCC
DFAKEEELKSIEKKIDLEISESVKNALEAPEPPANELTKYIWAED
CCCCHHHHHHHHHHHCCHHHHHHHHHHCCCCCCHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA