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The map label for this gene is acrA [H]

Identifier: 123966536

GI number: 123966536

Start: 1143152

End: 1144213

Strand: Direct

Name: acrA [H]

Synonym: P9515_13031

Alternate gene names: 123966536

Gene position: 1143152-1144213 (Clockwise)

Preceding gene: 123966534

Following gene: 123966537

Centisome position: 67.08

GC content: 28.63

Gene sequence:

>1062_bases
ATGCTTAATTTAATAAAAAGATTTTTAAATATAAAAAATGGAATCATATTAATTGTACTAACAACTTTTTTTGTCTTTTT
AAGTAATTCCTTTAAGAAAAACAAATCAAAAGACATATCCAATTTTGTAGTTCCCGTTGAAAAAGGAATTCTTTCTGAAT
CAATTAACACTAGTGGAGAAGTAAAGGCAACAAGAACAAGCAATATCGGTCCAAGAAAACAAGGAATAATAAAAGAATTA
AAAGTAAAAGAAGGTGATCTTGTAAAAAAAGGCCAGATTTTGGCTACTCTTGATGATGAAGATTTCATCTATAAACTTGA
AGAACTTGAATTAAATTTAAAAAAACAAAAGTCTCAATACTTGAGAAGAGAATTTTTATATAAAGAGGGGGCAGTGAGTA
GAGAGGATTATGAAAGCTATAAAAATAATTACAATACAAGTGAAGCTAAATTTAGTGATGCAAAAGCTGAAGAAAATTTT
TATTTAATAAAAGCTCCATATCCAGGGAAGATAACAGCTAAATATGCAGAGATTGGGGCATATGTTACACCCAGTACAAA
TTTAAGTTCAGACTCTAAAAATAAAAACTTTATTTTTGAATTATCCGAGGGTCTTGAAATAATTGCTAAAGTTCCGGAGA
GTGATATTGGAAGGATAAAAAAAGGTCAAGAGGCCTCTGTAAGGATAGAAGCTTATCCCTCAAATAAATATAGTGCAATA
GTAAAAAAAATAGCTGAGAGGGCAGTTAAGGATAATAATGTCACTTCATTTGAAGTAACGTTGAAATTCAAAGAAATTTC
TGAAGAAATAAAAATTGGTATGACAGCAGATCTTGAATTTAAAGTCAAAAGTAATGAAGAAAAGATCTTAGTTCCAACAG
TTTCTATTGTCACTGAAAAAGGTGAAAAAGGTATTTTAAAAGTAGATAAAAATAATTATCCTAAATTTGAAAAAATAGAA
ATAGGTATTAGCAGCGGTAATAAGACTTCAATAATTGATGGTTTAAAACCAGGAGAACAAATCTTTATTGATATTCCACC
TTGGGCGAATAAAAGAAAATGA

Upstream 100 bases:

>100_bases
TATAGAGTTTACTTAACCAATCATGGATAAGTTAATCATAATCGTTTCGATTATTCACTATAGTTTCTACATATCCTTAT
TGCCTGCCTAAACAAAAGAT

Downstream 100 bases:

>100_bases
GTTTGAAATCACAAGACTCAAAAAAACCAGTTTTACTTTTAGTTGATGGACATTCTCTCGCTTTTAGAAGTTTCTATGCG
TTTAGCAAAGGAGTTGATGG

Product: membrane fusion protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 353; Mature: 353

Protein sequence:

>353_residues
MLNLIKRFLNIKNGIILIVLTTFFVFLSNSFKKNKSKDISNFVVPVEKGILSESINTSGEVKATRTSNIGPRKQGIIKEL
KVKEGDLVKKGQILATLDDEDFIYKLEELELNLKKQKSQYLRREFLYKEGAVSREDYESYKNNYNTSEAKFSDAKAEENF
YLIKAPYPGKITAKYAEIGAYVTPSTNLSSDSKNKNFIFELSEGLEIIAKVPESDIGRIKKGQEASVRIEAYPSNKYSAI
VKKIAERAVKDNNVTSFEVTLKFKEISEEIKIGMTADLEFKVKSNEEKILVPTVSIVTEKGEKGILKVDKNNYPKFEKIE
IGISSGNKTSIIDGLKPGEQIFIDIPPWANKRK

Sequences:

>Translated_353_residues
MLNLIKRFLNIKNGIILIVLTTFFVFLSNSFKKNKSKDISNFVVPVEKGILSESINTSGEVKATRTSNIGPRKQGIIKEL
KVKEGDLVKKGQILATLDDEDFIYKLEELELNLKKQKSQYLRREFLYKEGAVSREDYESYKNNYNTSEAKFSDAKAEENF
YLIKAPYPGKITAKYAEIGAYVTPSTNLSSDSKNKNFIFELSEGLEIIAKVPESDIGRIKKGQEASVRIEAYPSNKYSAI
VKKIAERAVKDNNVTSFEVTLKFKEISEEIKIGMTADLEFKVKSNEEKILVPTVSIVTEKGEKGILKVDKNNYPKFEKIE
IGISSGNKTSIIDGLKPGEQIFIDIPPWANKRK
>Mature_353_residues
MLNLIKRFLNIKNGIILIVLTTFFVFLSNSFKKNKSKDISNFVVPVEKGILSESINTSGEVKATRTSNIGPRKQGIIKEL
KVKEGDLVKKGQILATLDDEDFIYKLEELELNLKKQKSQYLRREFLYKEGAVSREDYESYKNNYNTSEAKFSDAKAEENF
YLIKAPYPGKITAKYAEIGAYVTPSTNLSSDSKNKNFIFELSEGLEIIAKVPESDIGRIKKGQEASVRIEAYPSNKYSAI
VKKIAERAVKDNNVTSFEVTLKFKEISEEIKIGMTADLEFKVKSNEEKILVPTVSIVTEKGEKGILKVDKNNYPKFEKIE
IGISSGNKTSIIDGLKPGEQIFIDIPPWANKRK

Specific function: Efflux transporter for macrolide antibiotics [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI87081796, Length=327, Percent_Identity=22.0183486238532, Blast_Score=79, Evalue=5e-16,
Organism=Escherichia coli, GI87082036, Length=310, Percent_Identity=22.258064516129, Blast_Score=62, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 39880; Mature: 39880

Theoretical pI: Translated: 9.81; Mature: 9.81

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
0.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
0.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLNLIKRFLNIKNGIILIVLTTFFVFLSNSFKKNKSKDISNFVVPVEKGILSESINTSGE
CHHHHHHHHCCCCCEEEEHHHHHHHHHCCCCCCCCCCCHHHEEEEHHHHHHHHCCCCCCC
VKATRTSNIGPRKQGIIKELKVKEGDLVKKGQILATLDDEDFIYKLEELELNLKKQKSQY
EEEEECCCCCCHHHHHHHHHCCCCCCCEECCCEEEEECCCHHEEEEEHHHCCHHHHHHHH
LRREFLYKEGAVSREDYESYKNNYNTSEAKFSDAKAEENFYLIKAPYPGKITAKYAEIGA
HHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEECCCCCCEEEEHHHCCE
YVTPSTNLSSDSKNKNFIFELSEGLEIIAKVPESDIGRIKKGQEASVRIEAYPSNKYSAI
EECCCCCCCCCCCCCCEEEEECCCCEEEHCCCCHHHHHCCCCCCCEEEEEEECCCHHHHH
VKKIAERAVKDNNVTSFEVTLKFKEISEEIKIGMTADLEFKVKSNEEKILVPTVSIVTEK
HHHHHHHHHCCCCCEEEEEEEEEHHHHHHHEECEEEEEEEEEECCCCEEEEEEEEEEECC
GEKGILKVDKNNYPKFEKIEIGISSGNKTSIIDGLKPGEQIFIDIPPWANKRK
CCCCEEEECCCCCCCEEEEEEEECCCCCEEEECCCCCCCEEEEECCCCCCCCC
>Mature Secondary Structure
MLNLIKRFLNIKNGIILIVLTTFFVFLSNSFKKNKSKDISNFVVPVEKGILSESINTSGE
CHHHHHHHHCCCCCEEEEHHHHHHHHHCCCCCCCCCCCHHHEEEEHHHHHHHHCCCCCCC
VKATRTSNIGPRKQGIIKELKVKEGDLVKKGQILATLDDEDFIYKLEELELNLKKQKSQY
EEEEECCCCCCHHHHHHHHHCCCCCCCEECCCEEEEECCCHHEEEEEHHHCCHHHHHHHH
LRREFLYKEGAVSREDYESYKNNYNTSEAKFSDAKAEENFYLIKAPYPGKITAKYAEIGA
HHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEECCCCCCEEEEHHHCCE
YVTPSTNLSSDSKNKNFIFELSEGLEIIAKVPESDIGRIKKGQEASVRIEAYPSNKYSAI
EECCCCCCCCCCCCCCEEEEECCCCEEEHCCCCHHHHHCCCCCCCEEEEEEECCCHHHHH
VKKIAERAVKDNNVTSFEVTLKFKEISEEIKIGMTADLEFKVKSNEEKILVPTVSIVTEK
HHHHHHHHHCCCCCEEEEEEEEEHHHHHHHEECEEEEEEEEEECCCCEEEEEEEEEEECC
GEKGILKVDKNNYPKFEKIEIGISSGNKTSIIDGLKPGEQIFIDIPPWANKRK
CCCCEEEECCCCCCCEEEEEEEECCCCCEEEECCCCCCCEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430 [H]