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The map label for this gene is ubiB [C]

Identifier: 123966406

GI number: 123966406

Start: 1027885

End: 1029543

Strand: Reverse

Name: ubiB [C]

Synonym: P9515_11731

Alternate gene names: 123966406

Gene position: 1029543-1027885 (Counterclockwise)

Preceding gene: 123966409

Following gene: 123966405

Centisome position: 60.41

GC content: 29.84

Gene sequence:

>1659_bases
ATGGCAGCTTCTTATACAAAATATTCACCCAAAAAAGATTTGCTTTGGTTACTTTTGAGGCCATGGATCTTATTTCCAAG
AATTTTATATATCCTATTAACTTTAATATTTCTTTTAGTAAGAATACTTTTTCAAGGTAACAGTAATAGCAATAATGTAC
AGAAAAATCTTTCTAAATATCTTTTTGAAGTTATTACAAATTTGGGCCCATGTTTTATTAAATTAGGACAAGCACTTTCA
ACGAGACCTGATCTTGTAAGGCAAGATTGGTTAACAGAACTGACTAATTTACAAGATAATCTTCCACCTTTTGATCACAA
AATTGCTCTAAAAATAATTGAGGAGGAACTTGGAGCTCCTGCTAATGAATTATTTGATGATTTTCCAGATAAACCTATTG
CTTCAGCTAGCTTAGGAATAGTTTATAAAGCAAAAATAAAAAATAATTCTTTATGTGCGGTAAAAGTACAAAGACCTAAT
CTATTTTTTCTTATTAGAAGAGATATTGTGATACTAAAAATTTTAGCAAATACATTTGGATCATTATTACCACTAAATAT
TGGTGTTGGAATTGGAGAAATAATAGATGAATTTGGTAAAGCCCTTTTTGAAGAAATTGACTACGAAAAAGAAGGGGAAA
ATGCATTAAAATTTGCAGAATATTTTAAAGCAAATCCCAATGTATTTATACCAAAATTAGAAAAAGATTTTTCCTCAAAA
AGGGTAATTACAACATCTTGGATTGAAGGAGTTAAGTTAAGAGACAGAGAAATATTAGAGCAAAATAATTTGATACCTTC
CTCTTACATAAGAACTTGCGTGATAAGTGGACTACAGCAATTATTCGAATATGGTTATTTCCATGCGGATCCTCATCCTG
GAAATATGTTTGCTCTTAAAGGTGGAAGTTCAGATTTCGGACACTTAGCTTACGTTGATTTTGGAATGATGGATACTATT
ACTAATTCAGATAGGCTTACACTTATAAAAGCAATTGTTCATTTAATAAATCAAGAGTATTTATTAATGGCTAAAGATTT
TCAGAAATTAGGCTTTTTAACAAAAGACCAAGATCTTGAACAACTTGTAGAACCACTAAAAGAGGTTCTTGGTGGAGCTT
TTGGCGCTGAGGTTGGCAATTTTAATTTAAAAAATGTAACTGATAAATTCTCAAAACTTATGTATTCTTATCCTTTTAGA
GTTCCAAGTAGGTTTGCCTTAATAATAAGAGCTGTTGTTAGTCAAGAAGGTTTAGCTTTAAGACTTGATCCTGAATTTAA
AATTTTGAAAATTGCATATCCATATATTGCAAAAAAACTTTTAACAGATAATTCAGATGAAATTGTAGATATTCTTCTTG
AAGTTGTATTTGATAGTGAAGGTAGAATTCAGATTGATAAGCTTGAAAGTTTATTAAACACCTTATTTAAGGATACTGAA
AACATTAATTCAGATCTAATACCAGTCGCCAATGCAGGGTTAAAACTATTTGTAAGTGAAAAAGGATCTGAAGTTAGAAA
AAACCTTTTATTGAGCCTTGTTAAAGATGACAAATTAGAACTCAAAGACGCTGAAAAACTCTTAAGTTTATTGAGGGATA
CTTTTAGTCCTTTAAAATTAGCTAAAAGTGCCGTTCAAAATATTATCTCTGCAGTTTAG

Upstream 100 bases:

>100_bases
TAAAAACTTTTTAGTTAGAAAAGAAGAAATACTCATAAAGTATTATTGGCACATATAGAATGTATTGAAAATGAATTCTT
CTTTAATATTTTAAATTTTA

Downstream 100 bases:

>100_bases
TTTTTTATCAATTCCTCAAATTATAATTTTTGATTTATGAATTGATTAATACAATACAAACCATTAATTAGATGCCATTA
TTAAGTAGCTAAATTTAAAT

Product: kinase

Products: 2-octaprenyl-6-hydroxyphenol [C]

Alternate protein names: NA

Number of amino acids: Translated: 552; Mature: 551

Protein sequence:

>552_residues
MAASYTKYSPKKDLLWLLLRPWILFPRILYILLTLIFLLVRILFQGNSNSNNVQKNLSKYLFEVITNLGPCFIKLGQALS
TRPDLVRQDWLTELTNLQDNLPPFDHKIALKIIEEELGAPANELFDDFPDKPIASASLGIVYKAKIKNNSLCAVKVQRPN
LFFLIRRDIVILKILANTFGSLLPLNIGVGIGEIIDEFGKALFEEIDYEKEGENALKFAEYFKANPNVFIPKLEKDFSSK
RVITTSWIEGVKLRDREILEQNNLIPSSYIRTCVISGLQQLFEYGYFHADPHPGNMFALKGGSSDFGHLAYVDFGMMDTI
TNSDRLTLIKAIVHLINQEYLLMAKDFQKLGFLTKDQDLEQLVEPLKEVLGGAFGAEVGNFNLKNVTDKFSKLMYSYPFR
VPSRFALIIRAVVSQEGLALRLDPEFKILKIAYPYIAKKLLTDNSDEIVDILLEVVFDSEGRIQIDKLESLLNTLFKDTE
NINSDLIPVANAGLKLFVSEKGSEVRKNLLLSLVKDDKLELKDAEKLLSLLRDTFSPLKLAKSAVQNIISAV

Sequences:

>Translated_552_residues
MAASYTKYSPKKDLLWLLLRPWILFPRILYILLTLIFLLVRILFQGNSNSNNVQKNLSKYLFEVITNLGPCFIKLGQALS
TRPDLVRQDWLTELTNLQDNLPPFDHKIALKIIEEELGAPANELFDDFPDKPIASASLGIVYKAKIKNNSLCAVKVQRPN
LFFLIRRDIVILKILANTFGSLLPLNIGVGIGEIIDEFGKALFEEIDYEKEGENALKFAEYFKANPNVFIPKLEKDFSSK
RVITTSWIEGVKLRDREILEQNNLIPSSYIRTCVISGLQQLFEYGYFHADPHPGNMFALKGGSSDFGHLAYVDFGMMDTI
TNSDRLTLIKAIVHLINQEYLLMAKDFQKLGFLTKDQDLEQLVEPLKEVLGGAFGAEVGNFNLKNVTDKFSKLMYSYPFR
VPSRFALIIRAVVSQEGLALRLDPEFKILKIAYPYIAKKLLTDNSDEIVDILLEVVFDSEGRIQIDKLESLLNTLFKDTE
NINSDLIPVANAGLKLFVSEKGSEVRKNLLLSLVKDDKLELKDAEKLLSLLRDTFSPLKLAKSAVQNIISAV
>Mature_551_residues
AASYTKYSPKKDLLWLLLRPWILFPRILYILLTLIFLLVRILFQGNSNSNNVQKNLSKYLFEVITNLGPCFIKLGQALST
RPDLVRQDWLTELTNLQDNLPPFDHKIALKIIEEELGAPANELFDDFPDKPIASASLGIVYKAKIKNNSLCAVKVQRPNL
FFLIRRDIVILKILANTFGSLLPLNIGVGIGEIIDEFGKALFEEIDYEKEGENALKFAEYFKANPNVFIPKLEKDFSSKR
VITTSWIEGVKLRDREILEQNNLIPSSYIRTCVISGLQQLFEYGYFHADPHPGNMFALKGGSSDFGHLAYVDFGMMDTIT
NSDRLTLIKAIVHLINQEYLLMAKDFQKLGFLTKDQDLEQLVEPLKEVLGGAFGAEVGNFNLKNVTDKFSKLMYSYPFRV
PSRFALIIRAVVSQEGLALRLDPEFKILKIAYPYIAKKLLTDNSDEIVDILLEVVFDSEGRIQIDKLESLLNTLFKDTEN
INSDLIPVANAGLKLFVSEKGSEVRKNLLLSLVKDDKLELKDAEKLLSLLRDTFSPLKLAKSAVQNIISAV

Specific function: Required, Probably Indirectly, For The Hydroxylation Of 2-Octaprenylphenol To 2-Octaprenyl-6-Hydroxy-Phenol, The Fourth Step In Ubiquinone Biosynthesis. Specific For Aerobically Grown Log-Phase Cells. [C]

COG id: COG0661

COG function: function code R; Predicted unusual protein kinase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the protein kinase superfamily. ADCK protein kinase family [H]

Homologues:

Organism=Homo sapiens, GI40254938, Length=294, Percent_Identity=27.2108843537415, Blast_Score=125, Evalue=1e-28,
Organism=Homo sapiens, GI41393593, Length=281, Percent_Identity=29.5373665480427, Blast_Score=119, Evalue=7e-27,
Organism=Homo sapiens, GI217035081, Length=279, Percent_Identity=26.5232974910394, Blast_Score=109, Evalue=5e-24,
Organism=Homo sapiens, GI34147522, Length=333, Percent_Identity=25.8258258258258, Blast_Score=82, Evalue=9e-16,
Organism=Escherichia coli, GI2367309, Length=384, Percent_Identity=28.125, Blast_Score=164, Evalue=1e-41,
Organism=Caenorhabditis elegans, GI17559152, Length=274, Percent_Identity=29.5620437956204, Blast_Score=129, Evalue=4e-30,
Organism=Caenorhabditis elegans, GI32565180, Length=210, Percent_Identity=30.952380952381, Blast_Score=80, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6323282, Length=259, Percent_Identity=28.5714285714286, Blast_Score=99, Evalue=3e-21,
Organism=Saccharomyces cerevisiae, GI6325148, Length=447, Percent_Identity=22.1476510067114, Blast_Score=80, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6321319, Length=226, Percent_Identity=27.8761061946903, Blast_Score=77, Evalue=8e-15,
Organism=Drosophila melanogaster, GI22024280, Length=351, Percent_Identity=25.3561253561254, Blast_Score=117, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24662575, Length=379, Percent_Identity=24.802110817942, Blast_Score=117, Evalue=3e-26,
Organism=Drosophila melanogaster, GI18859849, Length=356, Percent_Identity=25.561797752809, Blast_Score=86, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004147
- InterPro:   IPR011009
- InterPro:   IPR000719 [H]

Pfam domain/function: PF03109 ABC1 [H]

EC number: NA

Molecular weight: Translated: 62480; Mature: 62348

Theoretical pI: Translated: 6.41; Mature: 6.41

Prosite motif: PS50011 PROTEIN_KINASE_DOM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAASYTKYSPKKDLLWLLLRPWILFPRILYILLTLIFLLVRILFQGNSNSNNVQKNLSKY
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
LFEVITNLGPCFIKLGQALSTRPDLVRQDWLTELTNLQDNLPPFDHKIALKIIEEELGAP
HHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCC
ANELFDDFPDKPIASASLGIVYKAKIKNNSLCAVKVQRPNLFFLIRRDIVILKILANTFG
HHHHHHHCCCCCCCCCCCCEEEEEEECCCCEEEEEEECCCEEEEEHHHHHHHHHHHHHHC
SLLPLNIGVGIGEIIDEFGKALFEEIDYEKEGENALKFAEYFKANPNVFIPKLEKDFSSK
CCEEHHCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCEECCCHHCCCCCC
RVITTSWIEGVKLRDREILEQNNLIPSSYIRTCVISGLQQLFEYGYFHADPHPGNMFALK
CEEEHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCEECCCCCCCEEEEC
GGSSDFGHLAYVDFGMMDTITNSDRLTLIKAIVHLINQEYLLMAKDFQKLGFLTKDQDLE
CCCCCCCCEEEEECCHHHHCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCHHHH
QLVEPLKEVLGGAFGAEVGNFNLKNVTDKFSKLMYSYPFRVPSRFALIIRAVVSQEGLAL
HHHHHHHHHHCCHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCEE
RLDPEFKILKIAYPYIAKKLLTDNSDEIVDILLEVVFDSEGRIQIDKLESLLNTLFKDTE
EECCCEEEEEEHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHH
NINSDLIPVANAGLKLFVSEKGSEVRKNLLLSLVKDDKLELKDAEKLLSLLRDTFSPLKL
CCCCCCCEECCCCEEEEEECCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
AKSAVQNIISAV
HHHHHHHHHHCC
>Mature Secondary Structure 
AASYTKYSPKKDLLWLLLRPWILFPRILYILLTLIFLLVRILFQGNSNSNNVQKNLSKY
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
LFEVITNLGPCFIKLGQALSTRPDLVRQDWLTELTNLQDNLPPFDHKIALKIIEEELGAP
HHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCC
ANELFDDFPDKPIASASLGIVYKAKIKNNSLCAVKVQRPNLFFLIRRDIVILKILANTFG
HHHHHHHCCCCCCCCCCCCEEEEEEECCCCEEEEEEECCCEEEEEHHHHHHHHHHHHHHC
SLLPLNIGVGIGEIIDEFGKALFEEIDYEKEGENALKFAEYFKANPNVFIPKLEKDFSSK
CCEEHHCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCEECCCHHCCCCCC
RVITTSWIEGVKLRDREILEQNNLIPSSYIRTCVISGLQQLFEYGYFHADPHPGNMFALK
CEEEHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCEECCCCCCCEEEEC
GGSSDFGHLAYVDFGMMDTITNSDRLTLIKAIVHLINQEYLLMAKDFQKLGFLTKDQDLE
CCCCCCCCEEEEECCHHHHCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCHHHH
QLVEPLKEVLGGAFGAEVGNFNLKNVTDKFSKLMYSYPFRVPSRFALIIRAVVSQEGLAL
HHHHHHHHHHCCHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCEE
RLDPEFKILKIAYPYIAKKLLTDNSDEIVDILLEVVFDSEGRIQIDKLESLLNTLFKDTE
EECCCEEEEEEHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHH
NINSDLIPVANAGLKLFVSEKGSEVRKNLLLSLVKDDKLELKDAEKLLSLLRDTFSPLKL
CCCCCCCEECCCCEEEEEECCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
AKSAVQNIISAV
HHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2 2-octaprenylphenol; O2 [C]

Specific reaction: 2 2-octaprenylphenol + O2 = 2 2-octaprenyl-6-hydroxyphenol [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]