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The map label for this gene is zwf [H]

Identifier: 123966397

GI number: 123966397

Start: 1017903

End: 1019426

Strand: Reverse

Name: zwf [H]

Synonym: P9515_11641

Alternate gene names: 123966397

Gene position: 1019426-1017903 (Counterclockwise)

Preceding gene: 123966398

Following gene: 123966396

Centisome position: 59.82

GC content: 35.43

Gene sequence:

>1524_bases
ATGCTAAAAACTATAAGTAATCCTCTTAGATTAGGATTACGTCAAGAAAGAGTGATATCTCCACAATGTCTAATAATCTT
TGGTGCTAGTGGAGATCTTACTCATAGGAAACTTATACCTGCTTTATTTGAACTGTATTTACAAAGAAGAATACCAAGTG
AATTTGCCATAGTTGGTTGTGCTAGAAGAACTTGGACTGATCAAGAGTTTAAGGAGAAAATGAAAGCTAAATTGGGTGAT
CAAATAACTGGTAATGAAAAAGAATGGGAACTTTTTTCTAATTATCTTTTCTATGAGCCAGTTGATCTACAACAAAGTGA
GCATGTTGTAAGGCTCTCCAAAAGATTAAATGAAATTGATAAATCACAGGCTACTCATGGAAACAAGACCTTCTACTTAT
CAGTATCTCCAAACTTCTACGGAAGTGGCTGTAAAGCCCTTAAGTCTGCTGGATTATTGGAAGACCCTAAGAAAAGTCGA
ATCGTTATTGAAAAACCTTTTGGAAGAGATTATTCAAGTGCAAAAAAACTGAATAAAATTGTTCAAAGTTGTGCAGATGA
AAGTCAGATATATCGTATAGATCATTATTTAGGAAAAGAGACTGTTCAGAACATACTTGTTATGCGCTTTGCTAATACTA
TTTTTGAACCCATATGGAATAGAAATTATATTTCAAGTATTCAAATAACATCATCAGAGACAGTTGGGGTTGAAGATAGA
GCTGGCTATTATGAAAGCTCTGGGGCTTTAAGAGATATGCTCCAAAATCATTTAACTCAAATGCTTGCTGTTACTGCAAT
GGAGCCACCAGGTAAATTCGAACCTGAGGCAATAAGGAATGAAAAAGCGAAAGTTCTTCAAGCGTCAAAACTTGCTGATG
AGAATCAACCATGGAATTGCTGTATAAGAGGGCAGTATGCAAAAGGAGGAAATAGTCTAAAAAGACTTAAAGGTTACAGG
GACGAGAATGGAGTGGATTTAAATAGTACAACAGAAACTTATATCGCCACAAAAGTTTTTATTGATAATTGGCGTTGGCA
AGGAGTTCCTTTTTACTTAAGAACAGGTAAAAGGCTACCTAAAAGACTTGGGGAGATTGTATTAACATTTAAAGATGTTC
CTGTACACTTGTTTGAATCAACAATAATTAATCCATCTCCAAATCAGCTTATTCTTAGAATTCAGCCAAATGAAGGAGCT
ACTTTTAAATTTGAAGTCAAATCACCCGGTTCAGGGATGAAATCAAGACCAGTTGAGATGGAATTTTCTTACGATGAATC
TTTTGGAGAACCTTCTGATGAAGGTTATGTAAGATTGTTGGCTGATGCTATGCTTTCTGATCCAACATTATTCACAAGAA
GTGATGAGGTAGAAGCTGCTTGGAAACTTTATACACCACTAATAGAGTTAATGGAGAATGCTCCTTGGAAGTTACCTATT
CACAAATACGAATCAATGACTTGGGGGCCTCCTGAATCAGATCAATTACTTTCTAAAGATAATATTTTCTGGCGCAGACC
CTAA

Upstream 100 bases:

>100_bases
AGGTTTTAAATTATAATTTCAAGACTTTTTTGGTTTAGACACAAAATGTAGCTAATTAGCTAAAAAAAGACGATTTTATT
TATATAAGACTAATAAAAAT

Downstream 100 bases:

>100_bases
CCTTATAATGAAACCACAATTAACACTTCAAACCCCACTAGAACTTCCTCCTCAAGAAATATCTAATTACTTAAATCAAT
TATGGATTTCTGAAGATGAA

Product: glucose-6-phosphate 1-dehydrogenase

Products: NA

Alternate protein names: G6PD [H]

Number of amino acids: Translated: 507; Mature: 507

Protein sequence:

>507_residues
MLKTISNPLRLGLRQERVISPQCLIIFGASGDLTHRKLIPALFELYLQRRIPSEFAIVGCARRTWTDQEFKEKMKAKLGD
QITGNEKEWELFSNYLFYEPVDLQQSEHVVRLSKRLNEIDKSQATHGNKTFYLSVSPNFYGSGCKALKSAGLLEDPKKSR
IVIEKPFGRDYSSAKKLNKIVQSCADESQIYRIDHYLGKETVQNILVMRFANTIFEPIWNRNYISSIQITSSETVGVEDR
AGYYESSGALRDMLQNHLTQMLAVTAMEPPGKFEPEAIRNEKAKVLQASKLADENQPWNCCIRGQYAKGGNSLKRLKGYR
DENGVDLNSTTETYIATKVFIDNWRWQGVPFYLRTGKRLPKRLGEIVLTFKDVPVHLFESTIINPSPNQLILRIQPNEGA
TFKFEVKSPGSGMKSRPVEMEFSYDESFGEPSDEGYVRLLADAMLSDPTLFTRSDEVEAAWKLYTPLIELMENAPWKLPI
HKYESMTWGPPESDQLLSKDNIFWRRP

Sequences:

>Translated_507_residues
MLKTISNPLRLGLRQERVISPQCLIIFGASGDLTHRKLIPALFELYLQRRIPSEFAIVGCARRTWTDQEFKEKMKAKLGD
QITGNEKEWELFSNYLFYEPVDLQQSEHVVRLSKRLNEIDKSQATHGNKTFYLSVSPNFYGSGCKALKSAGLLEDPKKSR
IVIEKPFGRDYSSAKKLNKIVQSCADESQIYRIDHYLGKETVQNILVMRFANTIFEPIWNRNYISSIQITSSETVGVEDR
AGYYESSGALRDMLQNHLTQMLAVTAMEPPGKFEPEAIRNEKAKVLQASKLADENQPWNCCIRGQYAKGGNSLKRLKGYR
DENGVDLNSTTETYIATKVFIDNWRWQGVPFYLRTGKRLPKRLGEIVLTFKDVPVHLFESTIINPSPNQLILRIQPNEGA
TFKFEVKSPGSGMKSRPVEMEFSYDESFGEPSDEGYVRLLADAMLSDPTLFTRSDEVEAAWKLYTPLIELMENAPWKLPI
HKYESMTWGPPESDQLLSKDNIFWRRP
>Mature_507_residues
MLKTISNPLRLGLRQERVISPQCLIIFGASGDLTHRKLIPALFELYLQRRIPSEFAIVGCARRTWTDQEFKEKMKAKLGD
QITGNEKEWELFSNYLFYEPVDLQQSEHVVRLSKRLNEIDKSQATHGNKTFYLSVSPNFYGSGCKALKSAGLLEDPKKSR
IVIEKPFGRDYSSAKKLNKIVQSCADESQIYRIDHYLGKETVQNILVMRFANTIFEPIWNRNYISSIQITSSETVGVEDR
AGYYESSGALRDMLQNHLTQMLAVTAMEPPGKFEPEAIRNEKAKVLQASKLADENQPWNCCIRGQYAKGGNSLKRLKGYR
DENGVDLNSTTETYIATKVFIDNWRWQGVPFYLRTGKRLPKRLGEIVLTFKDVPVHLFESTIINPSPNQLILRIQPNEGA
TFKFEVKSPGSGMKSRPVEMEFSYDESFGEPSDEGYVRLLADAMLSDPTLFTRSDEVEAAWKLYTPLIELMENAPWKLPI
HKYESMTWGPPESDQLLSKDNIFWRRP

Specific function: Pentose phosphate pathway; first step. [C]

COG id: COG0364

COG function: function code G; Glucose-6-phosphate 1-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-6-phosphate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI109389365, Length=482, Percent_Identity=36.0995850622407, Blast_Score=286, Evalue=3e-77,
Organism=Homo sapiens, GI108773793, Length=482, Percent_Identity=36.0995850622407, Blast_Score=286, Evalue=4e-77,
Organism=Homo sapiens, GI52145310, Length=493, Percent_Identity=28.3975659229209, Blast_Score=170, Evalue=3e-42,
Organism=Escherichia coli, GI1788158, Length=489, Percent_Identity=37.4233128834356, Blast_Score=335, Evalue=3e-93,
Organism=Caenorhabditis elegans, GI17538218, Length=485, Percent_Identity=35.2577319587629, Blast_Score=303, Evalue=1e-82,
Organism=Saccharomyces cerevisiae, GI6324088, Length=473, Percent_Identity=34.6723044397463, Blast_Score=268, Evalue=1e-72,
Organism=Drosophila melanogaster, GI24643350, Length=486, Percent_Identity=34.5679012345679, Blast_Score=275, Evalue=5e-74,
Organism=Drosophila melanogaster, GI24643352, Length=486, Percent_Identity=34.5679012345679, Blast_Score=275, Evalue=7e-74,
Organism=Drosophila melanogaster, GI221513548, Length=470, Percent_Identity=27.4468085106383, Blast_Score=188, Evalue=6e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001282
- InterPro:   IPR019796
- InterPro:   IPR022675
- InterPro:   IPR022674
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02781 G6PD_C; PF00479 G6PD_N [H]

EC number: =1.1.1.49 [H]

Molecular weight: Translated: 58111; Mature: 58111

Theoretical pI: Translated: 8.50; Mature: 8.50

Prosite motif: PS00069 G6P_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKTISNPLRLGLRQERVISPQCLIIFGASGDLTHRKLIPALFELYLQRRIPSEFAIVGC
CCCCCCCHHHHCCCHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCHHEEEEC
ARRTWTDQEFKEKMKAKLGDQITGNEKEWELFSNYLFYEPVDLQQSEHVVRLSKRLNEID
HHCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHCCEEECCCCCCCHHHHHHHHHHHHHHH
KSQATHGNKTFYLSVSPNFYGSGCKALKSAGLLEDPKKSRIVIEKPFGRDYSSAKKLNKI
HHHCCCCCEEEEEEECCCCCCCHHHHHHHCCCCCCCCCCEEEEECCCCCCHHHHHHHHHH
VQSCADESQIYRIDHYLGKETVQNILVMRFANTIFEPIWNRNYISSIQITSSETVGVEDR
HHHHCCCCCEEEHHHHHCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCC
AGYYESSGALRDMLQNHLTQMLAVTAMEPPGKFEPEAIRNEKAKVLQASKLADENQPWNC
CCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCEE
CIRGQYAKGGNSLKRLKGYRDENGVDLNSTTETYIATKVFIDNWRWQGVPFYLRTGKRLP
EEEECCCCCCCHHHHHCCCCCCCCCCCCCCCHHEEEEEEEEECCEECCCCCEECCCHHHH
KRLGEIVLTFKDVPVHLFESTIINPSPNQLILRIQPNEGATFKFEVKSPGSGMKSRPVEM
HHHHHEEEEECCCCHHHHHHHCCCCCCCEEEEEEECCCCCEEEEEECCCCCCCCCCCEEE
EFSYDESFGEPSDEGYVRLLADAMLSDPTLFTRSDEVEAAWKLYTPLIELMENAPWKLPI
EECCCCCCCCCCCCHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCH
HKYESMTWGPPESDQLLSKDNIFWRRP
HHHCCCCCCCCCCCCHHCCCCEEEECC
>Mature Secondary Structure
MLKTISNPLRLGLRQERVISPQCLIIFGASGDLTHRKLIPALFELYLQRRIPSEFAIVGC
CCCCCCCHHHHCCCHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCHHEEEEC
ARRTWTDQEFKEKMKAKLGDQITGNEKEWELFSNYLFYEPVDLQQSEHVVRLSKRLNEID
HHCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHCCEEECCCCCCCHHHHHHHHHHHHHHH
KSQATHGNKTFYLSVSPNFYGSGCKALKSAGLLEDPKKSRIVIEKPFGRDYSSAKKLNKI
HHHCCCCCEEEEEEECCCCCCCHHHHHHHCCCCCCCCCCEEEEECCCCCCHHHHHHHHHH
VQSCADESQIYRIDHYLGKETVQNILVMRFANTIFEPIWNRNYISSIQITSSETVGVEDR
HHHHCCCCCEEEHHHHHCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCC
AGYYESSGALRDMLQNHLTQMLAVTAMEPPGKFEPEAIRNEKAKVLQASKLADENQPWNC
CCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCEE
CIRGQYAKGGNSLKRLKGYRDENGVDLNSTTETYIATKVFIDNWRWQGVPFYLRTGKRLP
EEEECCCCCCCHHHHHCCCCCCCCCCCCCCCHHEEEEEEEEECCEECCCCCEECCCHHHH
KRLGEIVLTFKDVPVHLFESTIINPSPNQLILRIQPNEGATFKFEVKSPGSGMKSRPVEM
HHHHHEEEEECCCCHHHHHHHCCCCCCCEEEEEEECCCCCEEEEEECCCCCCCCCCCEEE
EFSYDESFGEPSDEGYVRLLADAMLSDPTLFTRSDEVEAAWKLYTPLIELMENAPWKLPI
EECCCCCCCCCCCCHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCH
HKYESMTWGPPESDQLLSKDNIFWRRP
HHHCCCCCCCCCCCCHHCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1643289 [H]