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The map label for this gene is umuC [H]

Identifier: 123966253

GI number: 123966253

Start: 911430

End: 912722

Strand: Direct

Name: umuC [H]

Synonym: P9515_10201

Alternate gene names: 123966253

Gene position: 911430-912722 (Clockwise)

Preceding gene: 123966252

Following gene: 123966254

Centisome position: 53.48

GC content: 29.0

Gene sequence:

>1293_bases
ATGAAAAGCAAAAGCTCAATTACTGAAGCAATAGCTCTCATAGATGCTAATAATTTTTACGCATCATGCGAACAAAGTAT
TAATCCACATTTAAGGAATAAACCAGTAGTAATCCTATCTAATAATGATGGATGCATTATCGCAAGAAGTCCTGAAGCTC
GTGCTTTGAGAATCAAAATGGGAATTCCTTATTTTAAAGTAAAAAAAAAATTGAATAGCTTAGGAGTAGCAGTTTTAAGT
TCAAATTACTCTCTCTATGGAGATATGAGCAAGAGATTAATGAATTTATTAAAGGATTATTCTGAAGAGATCGAGATTTA
CTCTATAGATGAAGCCTTTGTCTCAATTCTGAGACCTAAAGATAAAAATTTAAATCCTTGGGCAAGAAAAGTAAGGTGCT
TAATATATCAAAATTTAGGAATAACTTTAACAATCGGAATAGCAGAAAACAAAGTAAGAGCAAAAATTGCTAATAAACTA
GCTAAGAATATAGATTCTTCAGCAGGAATATTTGATTTAGTCAGAATCCATGATGAGACTAATTACTTAAGAAAAATTAG
TGTGGGAAAGGTATGGGGTGTCGGGAAACAAACATCTAATTGGTTACAGAGCAAAGGGATTAAAAATGTCAATGAATTAA
GAGATATGGATGAAAATGAAATCATTAAGAAATTAGGTATTATCGGGAAAAGATTACAACTTGAATTAAGAGGAGAGAAA
TGTCTTCCGATAGAAACAAGTAAGAAGCCAAAGAAAGAGATTCAAGTAAGTAGAAGCTTTGGTAAGCCAATTACAAAATT
AGAAGATTTGACTCAAGCATTAGCAATTTATGCAATAAAGGCATCCGAGAAAATGAGAAATCAAAATTTAAAATCATCTA
CCATTACTATATTTACAAGAACTAGTCATTATTCAAATCATGCTTATCAAAAAAGTGCTTATAAAAAACTTATCAATGCA
ACAGATAACACAAGTACTATTTTAAAAATAGTAGTTGAATTATCTAAAGAGATTTATACGCCGGGATATAAATTATCTAA
AGCTGGAGTTTTAATGCAGGATTTAACTAATTGCAAATATTTACAAAAATCAATTATCAATAATGAATTTCAAGAAGACT
CAAAAAAAACTATACGACTTATGAAAACAATTGACTCCTTGAATAAAAGATATAATAATGAAGTAATTACTTGGGCAATT
GCAAAAAAACAACAAGTATGGGCAATGAATAGAAATTCATTAAGTTCCGGATCTACAACAGATATTAAAAAAATTCCAAA
TATAATTAAATAA

Upstream 100 bases:

>100_bases
ATTTAAAAGCAGAAAATCATAATTACCCGGACTTCAGTTTTAGGAATCATGTTGATATACAGATTTGGGGAGTTGTAATT
TATTCAATACATAGTTACTT

Downstream 100 bases:

>100_bases
AAAGGAATATGTTTGAATTTATATTATTTATAAACAAAATTGATAAAGAAATAATAGAACTAATCAATAAATCAAATCAT
TCAATAGAGGAAAATACAGA

Product: putative UmuC protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 430; Mature: 430

Protein sequence:

>430_residues
MKSKSSITEAIALIDANNFYASCEQSINPHLRNKPVVILSNNDGCIIARSPEARALRIKMGIPYFKVKKKLNSLGVAVLS
SNYSLYGDMSKRLMNLLKDYSEEIEIYSIDEAFVSILRPKDKNLNPWARKVRCLIYQNLGITLTIGIAENKVRAKIANKL
AKNIDSSAGIFDLVRIHDETNYLRKISVGKVWGVGKQTSNWLQSKGIKNVNELRDMDENEIIKKLGIIGKRLQLELRGEK
CLPIETSKKPKKEIQVSRSFGKPITKLEDLTQALAIYAIKASEKMRNQNLKSSTITIFTRTSHYSNHAYQKSAYKKLINA
TDNTSTILKIVVELSKEIYTPGYKLSKAGVLMQDLTNCKYLQKSIINNEFQEDSKKTIRLMKTIDSLNKRYNNEVITWAI
AKKQQVWAMNRNSLSSGSTTDIKKIPNIIK

Sequences:

>Translated_430_residues
MKSKSSITEAIALIDANNFYASCEQSINPHLRNKPVVILSNNDGCIIARSPEARALRIKMGIPYFKVKKKLNSLGVAVLS
SNYSLYGDMSKRLMNLLKDYSEEIEIYSIDEAFVSILRPKDKNLNPWARKVRCLIYQNLGITLTIGIAENKVRAKIANKL
AKNIDSSAGIFDLVRIHDETNYLRKISVGKVWGVGKQTSNWLQSKGIKNVNELRDMDENEIIKKLGIIGKRLQLELRGEK
CLPIETSKKPKKEIQVSRSFGKPITKLEDLTQALAIYAIKASEKMRNQNLKSSTITIFTRTSHYSNHAYQKSAYKKLINA
TDNTSTILKIVVELSKEIYTPGYKLSKAGVLMQDLTNCKYLQKSIINNEFQEDSKKTIRLMKTIDSLNKRYNNEVITWAI
AKKQQVWAMNRNSLSSGSTTDIKKIPNIIK
>Mature_430_residues
MKSKSSITEAIALIDANNFYASCEQSINPHLRNKPVVILSNNDGCIIARSPEARALRIKMGIPYFKVKKKLNSLGVAVLS
SNYSLYGDMSKRLMNLLKDYSEEIEIYSIDEAFVSILRPKDKNLNPWARKVRCLIYQNLGITLTIGIAENKVRAKIANKL
AKNIDSSAGIFDLVRIHDETNYLRKISVGKVWGVGKQTSNWLQSKGIKNVNELRDMDENEIIKKLGIIGKRLQLELRGEK
CLPIETSKKPKKEIQVSRSFGKPITKLEDLTQALAIYAIKASEKMRNQNLKSSTITIFTRTSHYSNHAYQKSAYKKLINA
TDNTSTILKIVVELSKEIYTPGYKLSKAGVLMQDLTNCKYLQKSIINNEFQEDSKKTIRLMKTIDSLNKRYNNEVITWAI
AKKQQVWAMNRNSLSSGSTTDIKKIPNIIK

Specific function: Involved in UV protection and mutation. Essential for induced (or SOS) mutagenesis. May modify the DNA replication machinery to allow bypass synthesis across a damaged template [H]

COG id: COG0389

COG function: function code L; Nucleotidyltransferase/DNA polymerase involved in DNA repair

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 umuC domain [H]

Homologues:

Organism=Escherichia coli, GI1787432, Length=414, Percent_Identity=37.6811594202899, Blast_Score=279, Evalue=3e-76,
Organism=Escherichia coli, GI1786425, Length=223, Percent_Identity=24.2152466367713, Blast_Score=73, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017961
- InterPro:   IPR001126
- InterPro:   IPR017963 [H]

Pfam domain/function: PF00817 IMS [H]

EC number: NA

Molecular weight: Translated: 48757; Mature: 48757

Theoretical pI: Translated: 10.43; Mature: 10.43

Prosite motif: PS50173 UMUC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSKSSITEAIALIDANNFYASCEQSINPHLRNKPVVILSNNDGCIIARSPEARALRIKM
CCCHHHHHHHHHEEECCCHHHHHHHCCCCCCCCCCEEEEECCCCEEEEECCCCEEEEEEE
GIPYFKVKKKLNSLGVAVLSSNYSLYGDMSKRLMNLLKDYSEEIEIYSIDEAFVSILRPK
CCCHHHHHHHHHHHCEEEEECCCEEEHHHHHHHHHHHHHHHHCEEEEEHHHHHHHHHCCC
DKNLNPWARKVRCLIYQNLGITLTIGIAENKVRAKIANKLAKNIDSSAGIFDLVRIHDET
CCCCCHHHHHHHHHEEECCCEEEEEEECCCHHHHHHHHHHHHHCCCCCCCEEEEEEECCH
NYLRKISVGKVWGVGKQTSNWLQSKGIKNVNELRDMDENEIIKKLGIIGKRLQLELRGEK
HHHHEECCCCEECCCCHHHHHHHHCCCCCHHHHHCCCHHHHHHHHCCCCCEEEEEECCCE
CLPIETSKKPKKEIQVSRSFGKPITKLEDLTQALAIYAIKASEKMRNQNLKSSTITIFTR
ECCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEE
TSHYSNHAYQKSAYKKLINATDNTSTILKIVVELSKEIYTPGYKLSKAGVLMQDLTNCKY
CCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHH
LQKSIINNEFQEDSKKTIRLMKTIDSLNKRYNNEVITWAIAKKQQVWAMNRNSLSSGSTT
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCHHHEEECCCCCCCCCCC
DIKKIPNIIK
HHHHCCHHCC
>Mature Secondary Structure
MKSKSSITEAIALIDANNFYASCEQSINPHLRNKPVVILSNNDGCIIARSPEARALRIKM
CCCHHHHHHHHHEEECCCHHHHHHHCCCCCCCCCCEEEEECCCCEEEEECCCCEEEEEEE
GIPYFKVKKKLNSLGVAVLSSNYSLYGDMSKRLMNLLKDYSEEIEIYSIDEAFVSILRPK
CCCHHHHHHHHHHHCEEEEECCCEEEHHHHHHHHHHHHHHHHCEEEEEHHHHHHHHHCCC
DKNLNPWARKVRCLIYQNLGITLTIGIAENKVRAKIANKLAKNIDSSAGIFDLVRIHDET
CCCCCHHHHHHHHHEEECCCEEEEEEECCCHHHHHHHHHHHHHCCCCCCCEEEEEEECCH
NYLRKISVGKVWGVGKQTSNWLQSKGIKNVNELRDMDENEIIKKLGIIGKRLQLELRGEK
HHHHEECCCCEECCCCHHHHHHHHCCCCCHHHHHCCCHHHHHHHHCCCCCEEEEEECCCE
CLPIETSKKPKKEIQVSRSFGKPITKLEDLTQALAIYAIKASEKMRNQNLKSSTITIFTR
ECCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEE
TSHYSNHAYQKSAYKKLINATDNTSTILKIVVELSKEIYTPGYKLSKAGVLMQDLTNCKY
CCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHH
LQKSIINNEFQEDSKKTIRLMKTIDSLNKRYNNEVITWAIAKKQQVWAMNRNSLSSGSTT
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCHHHEEECCCCCCCCCCC
DIKKIPNIIK
HHHHCCHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases); Serine endopeptidases [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2989817; 2989816; 8905232; 9278503; 1320188 [H]