Definition Prochlorococcus marinus str. MIT 9515, complete genome.
Accession NC_008817
Length 1,704,176

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The map label for this gene is dxs [H]

Identifier: 123966223

GI number: 123966223

Start: 883800

End: 885695

Strand: Reverse

Name: dxs [H]

Synonym: P9515_09901

Alternate gene names: 123966223

Gene position: 885695-883800 (Counterclockwise)

Preceding gene: 123966227

Following gene: 123966220

Centisome position: 51.97

GC content: 35.6

Gene sequence:

>1896_bases
ATGCTTTTAAGTGAGTTAAGCCATCCAAATCAATTACATGGCTTAACGGTATCACAATTAGAAGAAATTGCCTGTCAGAT
AAGAGAAAGACATTTGCAGGTAGTTTCAACAAGTGGAGGTCATTTAGGTCCTGGACTAGGCGTAGTTGAATTAACACTTG
CTTTATATCAAACATTAGATCTTGATTTCGACAAAGTTGTTTGGGATGTTGGTCATCAAGCTTATCCACATAAATTAGTT
ACTGGACGTTTTAATGAATTCGATTCTTTACGTCAACAAAAAGGCATAGCAGGTTATCTAAAACGCTCTGAAAGTATTTT
CGACCATTTTGGAGCAGGTCATGCAAGTACCTCTATTTCAGCAGCTTTGGGAATGGCAATTGCAAGAGATGCTAAAGGTG
AAAATCATAAATGCGTTGCTGTTATAGGAGATGGAGCACTAACAGGTGGAATGGCTTTAGAAGCTATAAATCATGCAGGG
ACCTTACCAGAGACTCCTTTTTTAGTAATACTTAACGATAATGACATGTCTATCTCTCCACCTGTTGGAGCCCTTTCTAC
CTATCTAAATAAAGTTAGATTAAGTCCTCCTTTACAATTTTTATCAAATAGTGTTCAAGAAAGTGTTAAAAATATTCCGC
TTATAGGCAAGGATCTACCTGAAGAATTAAAAACTATAAAAGGAAGCGTGAGAAGATTAGCTGTTCCTAAAGTTGGTGCA
GTTTTTGAAGAACTTGGTTTTACATATATGGGTCCAATTCAAGGTCATGATATTTCTAATCTTATTAATACTTTTAATGC
TGCTCATAGACTTAAAAAACCTGTACTTGTTCACGTGGTTACAACTAAAGGAAAGGGATATCCATACGCTGAAGCGGATC
AAGTAGGTTATCATGCTCAGTCATCCTTCAATTTAACAACTGGAAAATCTATCCCATCAAGTAAACCTAAACCAGTTAGT
TATAGTAAAATATTTGGCCAAACTCTTTTGAAAATTTGTGAACAAGACAGTAAAGTAATTGGTATCACAGCTGCTATGGC
TACAGGAACAGGCCTTGATTTGTTACAGAAGAATATTCCTGAACAATATATAGATGTTGGTATAGCAGAACAACATGCTG
TTACTCTTGCTGCAGGCATGTCATGCGATGGTCTAAAACCTGTAGTTGCTATTTACAGCACCTTCCTACAACGTGCTTTT
GATCAATTAATTCATGATGTTGGTATTCAAAATTTGCCAGTCTCTTTTGTTCTTGACCGGGCGGGTATCGTAGGTGCTGA
TGGTCCTACACACCAAGGTCAGTACGATATTAGCTATATGAGATCAATTCCAAATTTTGTCTTGATGGCACCAAAGGATG
AAGCCGAATTGCAGAGAATGTTAATTACTTCAATTAATCATAAAGGTCCTACTGCATTACGTATCCCTAGAGGTTCAGGG
CGTGGTGTTGCAGTTATGGATGAAGGATGGGAACCTTTAAATATTGGTGAAGGCGAAATATTAGAAGATGGGGAGGATAT
TCTTATAGTTGCTTATGGATCTATGGTTTCCTCAGCTATTGAAACATCAAAATTATTAAAAGATAAAAATATATCACCTT
GTGTCATTAATGCTAGGTTTGTAAGACCTCTTGATAAAGACTTAATACTACCTTTAGCAAATAAAATTAAAAAAGTTGTA
ACTATGGAAGAGGGTACTTTGATTGGAGGATTTGGCTCTGCAATCGTTGAATTATTAAATGATAATGATATTAACATTCC
TGTTTTTAGAATTGGAATACCAGATGTATTAGTTGACCATGCTTCACCTGATCAAAGCAAAACACAATTAGGTCTTATGC
CCAATCAGATGTCTGAGAATATTATTAATAGATTCAATTTAATAAAAAATTTCTAA

Upstream 100 bases:

>100_bases
TTAATTATTAATCTAATAAAACATTACATAATCTATTTCAAAAAAAATACTCATTTTGCACCTTAACGTCTTAGATTATA
TAAGATAATATTTTTTTATA

Downstream 100 bases:

>100_bases
ATATAACTTTTTACAAAACTCCTCTTGAAGCAAGACCCAATATGGAACCCACTCCTAATAAATGACCTAAACAATTAGCT
CCTACAAAAGCACCATGACT

Product: 1-deoxy-D-xylulose-5-phosphate synthase

Products: NA

Alternate protein names: 1-deoxyxylulose-5-phosphate synthase; DXP synthase; DXPS [H]

Number of amino acids: Translated: 631; Mature: 631

Protein sequence:

>631_residues
MLLSELSHPNQLHGLTVSQLEEIACQIRERHLQVVSTSGGHLGPGLGVVELTLALYQTLDLDFDKVVWDVGHQAYPHKLV
TGRFNEFDSLRQQKGIAGYLKRSESIFDHFGAGHASTSISAALGMAIARDAKGENHKCVAVIGDGALTGGMALEAINHAG
TLPETPFLVILNDNDMSISPPVGALSTYLNKVRLSPPLQFLSNSVQESVKNIPLIGKDLPEELKTIKGSVRRLAVPKVGA
VFEELGFTYMGPIQGHDISNLINTFNAAHRLKKPVLVHVVTTKGKGYPYAEADQVGYHAQSSFNLTTGKSIPSSKPKPVS
YSKIFGQTLLKICEQDSKVIGITAAMATGTGLDLLQKNIPEQYIDVGIAEQHAVTLAAGMSCDGLKPVVAIYSTFLQRAF
DQLIHDVGIQNLPVSFVLDRAGIVGADGPTHQGQYDISYMRSIPNFVLMAPKDEAELQRMLITSINHKGPTALRIPRGSG
RGVAVMDEGWEPLNIGEGEILEDGEDILIVAYGSMVSSAIETSKLLKDKNISPCVINARFVRPLDKDLILPLANKIKKVV
TMEEGTLIGGFGSAIVELLNDNDINIPVFRIGIPDVLVDHASPDQSKTQLGLMPNQMSENIINRFNLIKNF

Sequences:

>Translated_631_residues
MLLSELSHPNQLHGLTVSQLEEIACQIRERHLQVVSTSGGHLGPGLGVVELTLALYQTLDLDFDKVVWDVGHQAYPHKLV
TGRFNEFDSLRQQKGIAGYLKRSESIFDHFGAGHASTSISAALGMAIARDAKGENHKCVAVIGDGALTGGMALEAINHAG
TLPETPFLVILNDNDMSISPPVGALSTYLNKVRLSPPLQFLSNSVQESVKNIPLIGKDLPEELKTIKGSVRRLAVPKVGA
VFEELGFTYMGPIQGHDISNLINTFNAAHRLKKPVLVHVVTTKGKGYPYAEADQVGYHAQSSFNLTTGKSIPSSKPKPVS
YSKIFGQTLLKICEQDSKVIGITAAMATGTGLDLLQKNIPEQYIDVGIAEQHAVTLAAGMSCDGLKPVVAIYSTFLQRAF
DQLIHDVGIQNLPVSFVLDRAGIVGADGPTHQGQYDISYMRSIPNFVLMAPKDEAELQRMLITSINHKGPTALRIPRGSG
RGVAVMDEGWEPLNIGEGEILEDGEDILIVAYGSMVSSAIETSKLLKDKNISPCVINARFVRPLDKDLILPLANKIKKVV
TMEEGTLIGGFGSAIVELLNDNDINIPVFRIGIPDVLVDHASPDQSKTQLGLMPNQMSENIINRFNLIKNF
>Mature_631_residues
MLLSELSHPNQLHGLTVSQLEEIACQIRERHLQVVSTSGGHLGPGLGVVELTLALYQTLDLDFDKVVWDVGHQAYPHKLV
TGRFNEFDSLRQQKGIAGYLKRSESIFDHFGAGHASTSISAALGMAIARDAKGENHKCVAVIGDGALTGGMALEAINHAG
TLPETPFLVILNDNDMSISPPVGALSTYLNKVRLSPPLQFLSNSVQESVKNIPLIGKDLPEELKTIKGSVRRLAVPKVGA
VFEELGFTYMGPIQGHDISNLINTFNAAHRLKKPVLVHVVTTKGKGYPYAEADQVGYHAQSSFNLTTGKSIPSSKPKPVS
YSKIFGQTLLKICEQDSKVIGITAAMATGTGLDLLQKNIPEQYIDVGIAEQHAVTLAAGMSCDGLKPVVAIYSTFLQRAF
DQLIHDVGIQNLPVSFVLDRAGIVGADGPTHQGQYDISYMRSIPNFVLMAPKDEAELQRMLITSINHKGPTALRIPRGSG
RGVAVMDEGWEPLNIGEGEILEDGEDILIVAYGSMVSSAIETSKLLKDKNISPCVINARFVRPLDKDLILPLANKIKKVV
TMEEGTLIGGFGSAIVELLNDNDINIPVFRIGIPDVLVDHASPDQSKTQLGLMPNQMSENIINRFNLIKNF

Specific function: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) [H]

COG id: COG1154

COG function: function code HI; Deoxyxylulose-5-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family. DXPS subfamily [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=488, Percent_Identity=22.3360655737705, Blast_Score=110, Evalue=5e-24,
Organism=Homo sapiens, GI4507521, Length=488, Percent_Identity=22.3360655737705, Blast_Score=110, Evalue=5e-24,
Organism=Homo sapiens, GI225637459, Length=397, Percent_Identity=25.4408060453401, Blast_Score=96, Evalue=1e-19,
Organism=Homo sapiens, GI225637461, Length=397, Percent_Identity=25.4408060453401, Blast_Score=96, Evalue=2e-19,
Organism=Homo sapiens, GI225637463, Length=397, Percent_Identity=25.4408060453401, Blast_Score=95, Evalue=2e-19,
Organism=Homo sapiens, GI133778974, Length=656, Percent_Identity=21.4939024390244, Blast_Score=91, Evalue=3e-18,
Organism=Homo sapiens, GI4557353, Length=268, Percent_Identity=22.7611940298507, Blast_Score=70, Evalue=5e-12,
Organism=Homo sapiens, GI34101272, Length=268, Percent_Identity=22.7611940298507, Blast_Score=70, Evalue=5e-12,
Organism=Escherichia coli, GI1786622, Length=613, Percent_Identity=43.5562805872757, Blast_Score=503, Evalue=1e-143,
Organism=Caenorhabditis elegans, GI17539652, Length=408, Percent_Identity=27.2058823529412, Blast_Score=118, Evalue=8e-27,
Organism=Caenorhabditis elegans, GI17538422, Length=259, Percent_Identity=25.8687258687259, Blast_Score=65, Evalue=7e-11,
Organism=Saccharomyces cerevisiae, GI6319698, Length=348, Percent_Identity=24.4252873563218, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI45551847, Length=651, Percent_Identity=23.963133640553, Blast_Score=124, Evalue=3e-28,
Organism=Drosophila melanogaster, GI45550715, Length=651, Percent_Identity=23.963133640553, Blast_Score=124, Evalue=3e-28,
Organism=Drosophila melanogaster, GI24645119, Length=607, Percent_Identity=24.3822075782537, Blast_Score=120, Evalue=3e-27,
Organism=Drosophila melanogaster, GI24666278, Length=673, Percent_Identity=23.7741456166419, Blast_Score=118, Evalue=1e-26,
Organism=Drosophila melanogaster, GI21358145, Length=332, Percent_Identity=24.3975903614458, Blast_Score=73, Evalue=7e-13,
Organism=Drosophila melanogaster, GI24650940, Length=332, Percent_Identity=24.3975903614458, Blast_Score=73, Evalue=7e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001017
- InterPro:   IPR005477
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474 [H]

Pfam domain/function: PF00676 E1_dh; PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: =2.2.1.7 [H]

Molecular weight: Translated: 68277; Mature: 68277

Theoretical pI: Translated: 6.47; Mature: 6.47

Prosite motif: PS00801 TRANSKETOLASE_1 ; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure: 

>Translated Secondary Structure
MLLSELSHPNQLHGLTVSQLEEIACQIRERHLQVVSTSGGHLGPGLGVVELTLALYQTLD
CCCCCCCCCCHHCCCCHHHHHHHHHHHHHHHHEEEECCCCCCCCCCHHHHHHHHHHHHHC
LDFDKVVWDVGHQAYPHKLVTGRFNEFDSLRQQKGIAGYLKRSESIFDHFGAGHASTSIS
CCHHHHHHHCCCCCCCCHHHCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCHHHH
AALGMAIARDAKGENHKCVAVIGDGALTGGMALEAINHAGTLPETPFLVILNDNDMSISP
HHHHHHHHHCCCCCCCEEEEEECCCCCCCCHHHHHHHHCCCCCCCCEEEEECCCCCCCCC
PVGALSTYLNKVRLSPPLQFLSNSVQESVKNIPLIGKDLPEELKTIKGSVRRLAVPKVGA
CHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCHHHH
VFEELGFTYMGPIQGHDISNLINTFNAAHRLKKPVLVHVVTTKGKGYPYAEADQVGYHAQ
HHHHCCCEEECCCCCCCHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCHHHCCCCCC
SSFNLTTGKSIPSSKPKPVSYSKIFGQTLLKICEQDSKVIGITAAMATGTGLDLLQKNIP
CCCCEECCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEEEHHCCCCHHHHHHCCC
EQYIDVGIAEQHAVTLAAGMSCDGLKPVVAIYSTFLQRAFDQLIHDVGIQNLPVSFVLDR
HHHHHCCCCCHHHEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHEEEC
AGIVGADGPTHQGQYDISYMRSIPNFVLMAPKDEAELQRMLITSINHKGPTALRIPRGSG
CCEECCCCCCCCCCCHHHHHHCCCCEEEECCCCHHHHHHHHHHHCCCCCCCEEEECCCCC
RGVAVMDEGWEPLNIGEGEILEDGEDILIVAYGSMVSSAIETSKLLKDKNISPCVINARF
CEEEEECCCCCCCCCCCCCEEECCCCEEEEEEHHHHHHHHHHHHHHHCCCCCCEEEEEHC
VRPLDKDLILPLANKIKKVVTMEEGTLIGGFGSAIVELLNDNDINIPVFRIGIPDVLVDH
CCCCCHHHHHHHHHHHHHHEEECCCCEEECHHHHHHHHHCCCCCCEEEEEECCCHHHHCC
ASPDQSKTQLGLMPNQMSENIINRFNLIKNF
CCCCCCCCEECCCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MLLSELSHPNQLHGLTVSQLEEIACQIRERHLQVVSTSGGHLGPGLGVVELTLALYQTLD
CCCCCCCCCCHHCCCCHHHHHHHHHHHHHHHHEEEECCCCCCCCCCHHHHHHHHHHHHHC
LDFDKVVWDVGHQAYPHKLVTGRFNEFDSLRQQKGIAGYLKRSESIFDHFGAGHASTSIS
CCHHHHHHHCCCCCCCCHHHCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCHHHH
AALGMAIARDAKGENHKCVAVIGDGALTGGMALEAINHAGTLPETPFLVILNDNDMSISP
HHHHHHHHHCCCCCCCEEEEEECCCCCCCCHHHHHHHHCCCCCCCCEEEEECCCCCCCCC
PVGALSTYLNKVRLSPPLQFLSNSVQESVKNIPLIGKDLPEELKTIKGSVRRLAVPKVGA
CHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCHHHH
VFEELGFTYMGPIQGHDISNLINTFNAAHRLKKPVLVHVVTTKGKGYPYAEADQVGYHAQ
HHHHCCCEEECCCCCCCHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCHHHCCCCCC
SSFNLTTGKSIPSSKPKPVSYSKIFGQTLLKICEQDSKVIGITAAMATGTGLDLLQKNIP
CCCCEECCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEEEHHCCCCHHHHHHCCC
EQYIDVGIAEQHAVTLAAGMSCDGLKPVVAIYSTFLQRAFDQLIHDVGIQNLPVSFVLDR
HHHHHCCCCCHHHEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHEEEC
AGIVGADGPTHQGQYDISYMRSIPNFVLMAPKDEAELQRMLITSINHKGPTALRIPRGSG
CCEECCCCCCCCCCCHHHHHHCCCCEEEECCCCHHHHHHHHHHHCCCCCCCEEEECCCCC
RGVAVMDEGWEPLNIGEGEILEDGEDILIVAYGSMVSSAIETSKLLKDKNISPCVINARF
CEEEEECCCCCCCCCCCCCEEECCCCEEEEEEHHHHHHHHHHHHHHHCCCCCCEEEEEHC
VRPLDKDLILPLANKIKKVVTMEEGTLIGGFGSAIVELLNDNDINIPVFRIGIPDVLVDH
CCCCCHHHHHHHHHHHHHHEEECCCCEEECHHHHHHHHHCCCCCCEEEEEECCCHHHHCC
ASPDQSKTQLGLMPNQMSENIINRFNLIKNF
CCCCCCCCEECCCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12917642 [H]