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The map label for this gene is clpP1 [H]

Identifier: 123966075

GI number: 123966075

Start: 763600

End: 764190

Strand: Reverse

Name: clpP1 [H]

Synonym: P9515_08421

Alternate gene names: 123966075

Gene position: 764190-763600 (Counterclockwise)

Preceding gene: 123966079

Following gene: 123966073

Centisome position: 44.84

GC content: 33.33

Gene sequence:

>591_bases
ATGATCCCTTTAGTTTTGGAAGAATCTGGTGGAAGTGAAAGAGTATTTGATATTTACTCAAGACTTTTAAGAGAGAGGAT
TATATTTCTAGGAGAACAAGTCACGAGTGATACTGCTAACAGAATTGTTGCTCAATTACTTTTTCTAGAAGCAGAAGATC
CTGAAAAAGATATATATATGTATATAAATTCACCGGGAGGCTCTGTTTATGATGGCTTAGGTATATTTGATACTATGCAA
CATGTAAAGCCTGATATTCATACAGTTTGCGTTGGATTAGCAGCAAGTATGGGAGCTTTTTTACTTGCAGCAGGAACAAA
GGGTAAAAGAAGTAGTTTGAGACATTCAAGAATTATGATTCATCAACCACTTGGTGGTGCAAGAGGACAAGCAAGTGATA
TAAGAATTCAAGCAGATGAAATCTTATATTTAAAAGAAAGATTAAATTCTGAATTATCTGAAAGAACTGGCAAAAATTTA
GAAACTATTAAAGAGGATACAGATAGGGATTTTTATATGTCTCCTCTAGAAGCCGTTGAATATGGCTTAATTGACTTAGT
TTTGGATAAAAAACCTATCAGAGGAACTTAA

Upstream 100 bases:

>100_bases
ACAGTCAAATTTTCTTTCAATTTTTTATATGTAAACCTTAATAACCATAGCGTATGTTGACTCAATATCGCTAGGATCTT
ATAAACAGATAAATATTATT

Downstream 100 bases:

>100_bases
TTCAATAATTGTGGGGTTCTTTCTTTCTCAGGAACAGTTGTAAATTCGGAAAGTATTTTTACAAATTCTTCACCATCTAA
AGTTTCTCTTTCTATTAAAA

Product: ATP-dependent Clp protease proteolytic subunit

Products: NA

Alternate protein names: Endopeptidase Clp 1 [H]

Number of amino acids: Translated: 196; Mature: 196

Protein sequence:

>196_residues
MIPLVLEESGGSERVFDIYSRLLRERIIFLGEQVTSDTANRIVAQLLFLEAEDPEKDIYMYINSPGGSVYDGLGIFDTMQ
HVKPDIHTVCVGLAASMGAFLLAAGTKGKRSSLRHSRIMIHQPLGGARGQASDIRIQADEILYLKERLNSELSERTGKNL
ETIKEDTDRDFYMSPLEAVEYGLIDLVLDKKPIRGT

Sequences:

>Translated_196_residues
MIPLVLEESGGSERVFDIYSRLLRERIIFLGEQVTSDTANRIVAQLLFLEAEDPEKDIYMYINSPGGSVYDGLGIFDTMQ
HVKPDIHTVCVGLAASMGAFLLAAGTKGKRSSLRHSRIMIHQPLGGARGQASDIRIQADEILYLKERLNSELSERTGKNL
ETIKEDTDRDFYMSPLEAVEYGLIDLVLDKKPIRGT
>Mature_196_residues
MIPLVLEESGGSERVFDIYSRLLRERIIFLGEQVTSDTANRIVAQLLFLEAEDPEKDIYMYINSPGGSVYDGLGIFDTMQ
HVKPDIHTVCVGLAASMGAFLLAAGTKGKRSSLRHSRIMIHQPLGGARGQASDIRIQADEILYLKERLNSELSERTGKNL
ETIKEDTDRDFYMSPLEAVEYGLIDLVLDKKPIRGT

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins [H]

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family [H]

Homologues:

Organism=Homo sapiens, GI5174419, Length=195, Percent_Identity=54.8717948717949, Blast_Score=217, Evalue=6e-57,
Organism=Escherichia coli, GI1786641, Length=191, Percent_Identity=60.2094240837696, Blast_Score=244, Evalue=3e-66,
Organism=Caenorhabditis elegans, GI17538017, Length=186, Percent_Identity=51.0752688172043, Blast_Score=190, Evalue=5e-49,
Organism=Drosophila melanogaster, GI20129427, Length=192, Percent_Identity=52.0833333333333, Blast_Score=204, Evalue=4e-53,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001907
- InterPro:   IPR018215 [H]

Pfam domain/function: PF00574 CLP_protease [H]

EC number: =3.4.21.92 [H]

Molecular weight: Translated: 21874; Mature: 21874

Theoretical pI: Translated: 4.96; Mature: 4.96

Prosite motif: PS00381 CLP_PROTEASE_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIPLVLEESGGSERVFDIYSRLLRERIIFLGEQVTSDTANRIVAQLLFLEAEDPEKDIYM
CCCEEEECCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCEEEE
YINSPGGSVYDGLGIFDTMQHVKPDIHTVCVGLAASMGAFLLAAGTKGKRSSLRHSRIMI
EEECCCCCHHCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHEEECCCCCCHHHHHHCEEEE
HQPLGGARGQASDIRIQADEILYLKERLNSELSERTGKNLETIKEDTDRDFYMSPLEAVE
ECCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCHHCCHHHHHH
YGLIDLVLDKKPIRGT
HHHHHEEECCCCCCCC
>Mature Secondary Structure
MIPLVLEESGGSERVFDIYSRLLRERIIFLGEQVTSDTANRIVAQLLFLEAEDPEKDIYM
CCCEEEECCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCEEEE
YINSPGGSVYDGLGIFDTMQHVKPDIHTVCVGLAASMGAFLLAAGTKGKRSSLRHSRIMI
EEECCCCCHHCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHEEECCCCCCHHHHHHCEEEE
HQPLGGARGQASDIRIQADEILYLKERLNSELSERTGKNLETIKEDTDRDFYMSPLEAVE
ECCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCHHCCHHHHHH
YGLIDLVLDKKPIRGT
HHHHHEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12917642 [H]