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The map label for this gene is gnd [H]

Identifier: 123966048

GI number: 123966048

Start: 731774

End: 733192

Strand: Reverse

Name: gnd [H]

Synonym: P9515_08131

Alternate gene names: 123966048

Gene position: 733192-731774 (Counterclockwise)

Preceding gene: 123966049

Following gene: 123966047

Centisome position: 43.02

GC content: 36.5

Gene sequence:

>1419_bases
ATGTCCAAGGCACATTTTGGTTTAATCGGTCTTGGAGTCATGGGGGAGAATTTAGTTCTAAATGCAGAAAGGAATGGATT
TTCTAGTGTGGTTTTTAATAGAACTTATTCAAAAACCGAAGAGTTTCTAAAGGGAAGAGGTTTAGGAAAAAATATAGAAG
GAGCTAAAACACTTCAAGAATTTGTTAATAAGCTCGAGAGACCAAGAAGAATTTTAATGATGGTAAAAGCTGGTTCTCCC
ACAGATGCTGTGATTGACAATATTTCTGAATATCTTGAAGAAGGAGATTTATTAATAGATGGAGGCAATTCTCAATTTAA
AGATACGGAAAGAAGAGTTAAGACTCTTGAAAGTAAAAGTTTTGGATATATTGGGATGGGTGTCTCCGGAGGGGCTAAAG
GTGCTCTAGAAGGTCCCAGTATGATGCCAGGAGGTACTAAGGCTTCTTACGACGCAATAGAAAGCTTATTGACTAAAATG
GCTGCGAAAGTAGAAGACGGTCCTTGTGTTGCTTATGTTGGCCCTGGTGGTTCAGGCCATTTCGTCAAAACTGTTCATAA
CGGTATTGAATATGGTATTGAGCAAATACTTGCAGAAGCCTATGACCTTATGAAGAGAGTTAAAAATATGAATGGTTCAC
AAATGTCAGAAGTCTTTGGTATTTGGAATAATACAGATGAGTTAGCCTCGTATCTTGTCGAAATAACAGAGATCTGTTTA
AACACTAAAGATGAAATAACTGGTGAAGATGTTGTTGAGAAAATATTGGATAAAGCTGGCCAAAAAGGTACTGGCTTATG
GACGGTGGTTAGTGCGTTAGAACTTGGTGTGTCAGTTCCAACTATTTATGCCTCTTTAAATGCAAGGGTTATGAGTTCAC
TGAAAGACCAACGTAGTGAAATTGAGAAAACACTCCCAATAAAAGCTTTTAATGATTTTGATTTAGGAGATATTTCTAAT
GGAATGAAACCTTTGTTTGATGCCGTGGTTCTTGCTACTATCGCTAGTTACGCTCAAGGCATGGACATATTAAGTGAAGC
ATCATCCGTATATAAATATGATTTGAATATGCCGTCAATTGCTCAAATATGGAAAGGTGGGTGCATTATAAGATCAAAAT
TATTAAGAAAAATTCAGGATGCATACCAAAAGGAGCCTAACTTAAAAAATTTAATATTTGATGATTGGTTCAATATGGAA
ATTTCTTCGAGGATAGATAATTTAGCTAATGTTGTTTCTTCCTCAACAAAAGCTGGCATCCCTGTGCCCTGTTTATCAAG
TACCCTTGATTATTTAAATAGTTACAGAACAAACAGACTTCCACAAAACCTGGTGCAGGCTATGAGAGATTGTTTTGGCT
CTCATACTTACGAGAGAATTGATAAAGAGGGGAGTTTTCATACTGAATGGATGAAATGA

Upstream 100 bases:

>100_bases
AATTTTATATTTCGATCATTTTTCGCTGACAAAAGGAATCTTTTTTAAGCAATTTCTCTTAGTTACATGCAATATATAAA
TATTGCGTTTTTTATTTTTT

Downstream 100 bases:

>100_bases
TTAAGAAATCTGTTGATGGATACGATTTAAACATATATAAAGATAAATTAGAACTTTCATCTAAAGTTTCTAAATTTATA
GAAAATCAAATTATCCAAAC

Product: 6-phosphogluconate dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 472; Mature: 471

Protein sequence:

>472_residues
MSKAHFGLIGLGVMGENLVLNAERNGFSSVVFNRTYSKTEEFLKGRGLGKNIEGAKTLQEFVNKLERPRRILMMVKAGSP
TDAVIDNISEYLEEGDLLIDGGNSQFKDTERRVKTLESKSFGYIGMGVSGGAKGALEGPSMMPGGTKASYDAIESLLTKM
AAKVEDGPCVAYVGPGGSGHFVKTVHNGIEYGIEQILAEAYDLMKRVKNMNGSQMSEVFGIWNNTDELASYLVEITEICL
NTKDEITGEDVVEKILDKAGQKGTGLWTVVSALELGVSVPTIYASLNARVMSSLKDQRSEIEKTLPIKAFNDFDLGDISN
GMKPLFDAVVLATIASYAQGMDILSEASSVYKYDLNMPSIAQIWKGGCIIRSKLLRKIQDAYQKEPNLKNLIFDDWFNME
ISSRIDNLANVVSSSTKAGIPVPCLSSTLDYLNSYRTNRLPQNLVQAMRDCFGSHTYERIDKEGSFHTEWMK

Sequences:

>Translated_472_residues
MSKAHFGLIGLGVMGENLVLNAERNGFSSVVFNRTYSKTEEFLKGRGLGKNIEGAKTLQEFVNKLERPRRILMMVKAGSP
TDAVIDNISEYLEEGDLLIDGGNSQFKDTERRVKTLESKSFGYIGMGVSGGAKGALEGPSMMPGGTKASYDAIESLLTKM
AAKVEDGPCVAYVGPGGSGHFVKTVHNGIEYGIEQILAEAYDLMKRVKNMNGSQMSEVFGIWNNTDELASYLVEITEICL
NTKDEITGEDVVEKILDKAGQKGTGLWTVVSALELGVSVPTIYASLNARVMSSLKDQRSEIEKTLPIKAFNDFDLGDISN
GMKPLFDAVVLATIASYAQGMDILSEASSVYKYDLNMPSIAQIWKGGCIIRSKLLRKIQDAYQKEPNLKNLIFDDWFNME
ISSRIDNLANVVSSSTKAGIPVPCLSSTLDYLNSYRTNRLPQNLVQAMRDCFGSHTYERIDKEGSFHTEWMK
>Mature_471_residues
SKAHFGLIGLGVMGENLVLNAERNGFSSVVFNRTYSKTEEFLKGRGLGKNIEGAKTLQEFVNKLERPRRILMMVKAGSPT
DAVIDNISEYLEEGDLLIDGGNSQFKDTERRVKTLESKSFGYIGMGVSGGAKGALEGPSMMPGGTKASYDAIESLLTKMA
AKVEDGPCVAYVGPGGSGHFVKTVHNGIEYGIEQILAEAYDLMKRVKNMNGSQMSEVFGIWNNTDELASYLVEITEICLN
TKDEITGEDVVEKILDKAGQKGTGLWTVVSALELGVSVPTIYASLNARVMSSLKDQRSEIEKTLPIKAFNDFDLGDISNG
MKPLFDAVVLATIASYAQGMDILSEASSVYKYDLNMPSIAQIWKGGCIIRSKLLRKIQDAYQKEPNLKNLIFDDWFNMEI
SSRIDNLANVVSSSTKAGIPVPCLSSTLDYLNSYRTNRLPQNLVQAMRDCFGSHTYERIDKEGSFHTEWMK

Specific function: Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH [H]

COG id: COG0362

COG function: function code G; 6-phosphogluconate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 6-phosphogluconate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI40068518, Length=472, Percent_Identity=46.1864406779661, Blast_Score=409, Evalue=1e-114,
Organism=Escherichia coli, GI1788341, Length=472, Percent_Identity=48.5169491525424, Blast_Score=444, Evalue=1e-126,
Organism=Caenorhabditis elegans, GI17542558, Length=472, Percent_Identity=45.7627118644068, Blast_Score=428, Evalue=1e-120,
Organism=Saccharomyces cerevisiae, GI6321695, Length=469, Percent_Identity=43.9232409381663, Blast_Score=416, Evalue=1e-117,
Organism=Saccharomyces cerevisiae, GI6321977, Length=455, Percent_Identity=45.4945054945055, Blast_Score=409, Evalue=1e-115,
Organism=Drosophila melanogaster, GI24639279, Length=470, Percent_Identity=43.6170212765958, Blast_Score=384, Evalue=1e-107,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR006114
- InterPro:   IPR006113
- InterPro:   IPR006115
- InterPro:   IPR006184
- InterPro:   IPR013328
- InterPro:   IPR012284
- InterPro:   IPR016040
- InterPro:   IPR006183 [H]

Pfam domain/function: PF00393 6PGD; PF03446 NAD_binding_2 [H]

EC number: =1.1.1.44 [H]

Molecular weight: Translated: 51905; Mature: 51774

Theoretical pI: Translated: 5.26; Mature: 5.26

Prosite motif: PS00461 6PGD

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKAHFGLIGLGVMGENLVLNAERNGFSSVVFNRTYSKTEEFLKGRGLGKNIEGAKTLQE
CCCCCCCEEEECCCCCCEEEECCCCCCHHHHHHCHHHHHHHHHHCCCCCCCCCHHHHHHH
FVNKLERPRRILMMVKAGSPTDAVIDNISEYLEEGDLLIDGGNSQFKDTERRVKTLESKS
HHHHHHCCCEEEEEEECCCCHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHCCC
FGYIGMGVSGGAKGALEGPSMMPGGTKASYDAIESLLTKMAAKVEDGPCVAYVGPGGSGH
CCEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCC
FVKTVHNGIEYGIEQILAEAYDLMKRVKNMNGSQMSEVFGIWNNTDELASYLVEITEICL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHH
NTKDEITGEDVVEKILDKAGQKGTGLWTVVSALELGVSVPTIYASLNARVMSSLKDQRSE
CCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
IEKTLPIKAFNDFDLGDISNGMKPLFDAVVLATIASYAQGMDILSEASSVYKYDLNMPSI
HHHHCCCCCCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCHH
AQIWKGGCIIRSKLLRKIQDAYQKEPNLKNLIFDDWFNMEISSRIDNLANVVSSSTKAGI
HHHHCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCC
PVPCLSSTLDYLNSYRTNRLPQNLVQAMRDCFGSHTYERIDKEGSFHTEWMK
CCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure 
SKAHFGLIGLGVMGENLVLNAERNGFSSVVFNRTYSKTEEFLKGRGLGKNIEGAKTLQE
CCCCCCEEEECCCCCCEEEECCCCCCHHHHHHCHHHHHHHHHHCCCCCCCCCHHHHHHH
FVNKLERPRRILMMVKAGSPTDAVIDNISEYLEEGDLLIDGGNSQFKDTERRVKTLESKS
HHHHHHCCCEEEEEEECCCCHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHCCC
FGYIGMGVSGGAKGALEGPSMMPGGTKASYDAIESLLTKMAAKVEDGPCVAYVGPGGSGH
CCEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCC
FVKTVHNGIEYGIEQILAEAYDLMKRVKNMNGSQMSEVFGIWNNTDELASYLVEITEICL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHH
NTKDEITGEDVVEKILDKAGQKGTGLWTVVSALELGVSVPTIYASLNARVMSSLKDQRSE
CCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
IEKTLPIKAFNDFDLGDISNGMKPLFDAVVLATIASYAQGMDILSEASSVYKYDLNMPSI
HHHHCCCCCCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCHH
AQIWKGGCIIRSKLLRKIQDAYQKEPNLKNLIFDDWFNMEISSRIDNLANVVSSSTKAGI
HHHHCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCC
PVPCLSSTLDYLNSYRTNRLPQNLVQAMRDCFGSHTYERIDKEGSFHTEWMK
CCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2113917 [H]