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The map label for this gene is cobW [H]

Identifier: 123966040

GI number: 123966040

Start: 725794

End: 726846

Strand: Reverse

Name: cobW [H]

Synonym: P9515_08051

Alternate gene names: 123966040

Gene position: 726846-725794 (Counterclockwise)

Preceding gene: 123966041

Following gene: 123966039

Centisome position: 42.65

GC content: 27.54

Gene sequence:

>1053_bases
ATGAATAAAAGAACACCTGTAATTGTAATCTCTGGATTTCTTGGTTCAGGGAAAACAACCTTTTTAAGGTATTTATTAAA
AAATAGTAATAAAAAATTTGGTTTAATAATTAATGAATTTGGAGATGTTGGAATTGATGGTGATTTGGTTAAAAGTTGTA
ATGGCTGCGATGATTCAGATACAGATTGCATTATTGAATTAAATAATGGGTGTCTATGTTGCACTGTTCAAGATGATTTT
ATTCCCTCGATTAAATCACTTCTAAATTTTAATCCTGATATTGATGCAATAATTATTGAGACAAGTGGACTAGCCTTACC
CTTACCTTTGTTACAAGCACTTAATTGGCCTGAGATAAGGACCTCAATATATCTTGATCAAGTTATAGGAATAGTTAATG
GAGAATCAATGCTTAAGGGCTCTCCAATAAATGACTTAAGTGAAATAACTAATCAATACGATTCTCTTAATAAAATTGAC
CATAAATCATCGATTGACGAACTTTTTGAAGAACAGTTAGAAGTTTCTGATCTCGTTTTAATTTCGAGAGGTGATGTTTT
AAATGAACAAGAATTTAAATCTATAAAAAATATAATCAAAAATAAGTTTAATTCAACTGTTCCTATTCTGAAATCTATTA
ATGGAATAGTTGATTTAAAATACATATTTGATTTTGAATTAAAAAAGGATAATTATAAAAAATTTATTACAGAGGAACAT
GATCATAATCATATTGAACTCGTCTCTGATTCAATAAAATTAAATTATTTTCTTGATAAAAAGGAATTTGAAAAAGAGAT
GGTAAACGTTTTAAGTGATAGTAATATTCTTCGAATTAAAGGACGTTTATGGATCCCAAAGAAATCATTACCTTTACAAA
TACAAATTGTTGGAAAGAAAATTAACACTTGGTATGAGGAGGCACCTTTAAATTGTTGGAGACCAATAGATAGTGGTGGA
CTTGACTTGGTTATAATTTCTTTTGATGATGTATCAATTAAAAAACTCATAAAAAAAATTAAAGAGAAATTTAAGATTTT
AAATGGCCCATAA

Upstream 100 bases:

>100_bases
TAGTCGGATTCAACAAAAGGAATTATGTGCAATAGCTAATGGCACAAATAGTTCAACAGGAGAAAGTACTGAATATAGTC
TTGGTTGTTAAAACTAATTT

Downstream 100 bases:

>100_bases
ATAAGGATTTGACTTTATAGTTACTTACCAGAATGATTTCCCTTATTTCAAAACTGAAAATGGAAGATTCAAAAATAACT
TACAAAGCTAACATAATAAA

Product: putative cobalamin synthesis protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 350; Mature: 350

Protein sequence:

>350_residues
MNKRTPVIVISGFLGSGKTTFLRYLLKNSNKKFGLIINEFGDVGIDGDLVKSCNGCDDSDTDCIIELNNGCLCCTVQDDF
IPSIKSLLNFNPDIDAIIIETSGLALPLPLLQALNWPEIRTSIYLDQVIGIVNGESMLKGSPINDLSEITNQYDSLNKID
HKSSIDELFEEQLEVSDLVLISRGDVLNEQEFKSIKNIIKNKFNSTVPILKSINGIVDLKYIFDFELKKDNYKKFITEEH
DHNHIELVSDSIKLNYFLDKKEFEKEMVNVLSDSNILRIKGRLWIPKKSLPLQIQIVGKKINTWYEEAPLNCWRPIDSGG
LDLVIISFDDVSIKKLIKKIKEKFKILNGP

Sequences:

>Translated_350_residues
MNKRTPVIVISGFLGSGKTTFLRYLLKNSNKKFGLIINEFGDVGIDGDLVKSCNGCDDSDTDCIIELNNGCLCCTVQDDF
IPSIKSLLNFNPDIDAIIIETSGLALPLPLLQALNWPEIRTSIYLDQVIGIVNGESMLKGSPINDLSEITNQYDSLNKID
HKSSIDELFEEQLEVSDLVLISRGDVLNEQEFKSIKNIIKNKFNSTVPILKSINGIVDLKYIFDFELKKDNYKKFITEEH
DHNHIELVSDSIKLNYFLDKKEFEKEMVNVLSDSNILRIKGRLWIPKKSLPLQIQIVGKKINTWYEEAPLNCWRPIDSGG
LDLVIISFDDVSIKKLIKKIKEKFKILNGP
>Mature_350_residues
MNKRTPVIVISGFLGSGKTTFLRYLLKNSNKKFGLIINEFGDVGIDGDLVKSCNGCDDSDTDCIIELNNGCLCCTVQDDF
IPSIKSLLNFNPDIDAIIIETSGLALPLPLLQALNWPEIRTSIYLDQVIGIVNGESMLKGSPINDLSEITNQYDSLNKID
HKSSIDELFEEQLEVSDLVLISRGDVLNEQEFKSIKNIIKNKFNSTVPILKSINGIVDLKYIFDFELKKDNYKKFITEEH
DHNHIELVSDSIKLNYFLDKKEFEKEMVNVLSDSNILRIKGRLWIPKKSLPLQIQIVGKKINTWYEEAPLNCWRPIDSGG
LDLVIISFDDVSIKKLIKKIKEKFKILNGP

Specific function: Might be involved in cobalt reduction leading to cobalt(I) corrinoids [H]

COG id: COG0523

COG function: function code R; Putative GTPases (G3E family)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 cobW C-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI33469141, Length=340, Percent_Identity=29.1176470588235, Blast_Score=102, Evalue=4e-22,
Organism=Homo sapiens, GI126722884, Length=340, Percent_Identity=29.1176470588235, Blast_Score=102, Evalue=4e-22,
Organism=Homo sapiens, GI148727351, Length=340, Percent_Identity=28.8235294117647, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI223941779, Length=331, Percent_Identity=29.0030211480363, Blast_Score=100, Evalue=4e-21,
Organism=Homo sapiens, GI146231952, Length=338, Percent_Identity=28.698224852071, Blast_Score=99, Evalue=6e-21,
Organism=Homo sapiens, GI223941776, Length=325, Percent_Identity=28.6153846153846, Blast_Score=89, Evalue=8e-18,
Organism=Homo sapiens, GI119120938, Length=167, Percent_Identity=34.1317365269461, Blast_Score=88, Evalue=1e-17,
Organism=Escherichia coli, GI87082430, Length=325, Percent_Identity=28, Blast_Score=92, Evalue=5e-20,
Organism=Escherichia coli, GI1788499, Length=241, Percent_Identity=26.9709543568465, Blast_Score=81, Evalue=8e-17,
Organism=Saccharomyces cerevisiae, GI6324356, Length=214, Percent_Identity=29.9065420560748, Blast_Score=92, Evalue=8e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012824
- InterPro:   IPR003495
- InterPro:   IPR011629 [H]

Pfam domain/function: PF02492 cobW; PF07683 CobW_C [H]

EC number: NA

Molecular weight: Translated: 39670; Mature: 39670

Theoretical pI: Translated: 5.05; Mature: 5.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKRTPVIVISGFLGSGKTTFLRYLLKNSNKKFGLIINEFGDVGIDGDLVKSCNGCDDSD
CCCCCCEEEEECCCCCCHHHHHHHHHHCCCCEEEEEEECCCCCCCCHHHHHHCCCCCCCC
TDCIIELNNGCLCCTVQDDFIPSIKSLLNFNPDIDAIIIETSGLALPLPLLQALNWPEIR
CCEEEEECCCEEEEEECHHHHHHHHHHHCCCCCCCEEEEECCCCEECHHHHHHCCCCHHH
TSIYLDQVIGIVNGESMLKGSPINDLSEITNQYDSLNKIDHKSSIDELFEEQLEVSDLVL
HHHHHHHHHHHCCCCHHCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCHHHEEE
ISRGDVLNEQEFKSIKNIIKNKFNSTVPILKSINGIVDLKYIFDFELKKDNYKKFITEEH
EECCCCCCHHHHHHHHHHHHHHCCCCHHHHHHCCCEEEEEEEEEEEECCCCHHHHCCCCC
DHNHIELVSDSIKLNYFLDKKEFEKEMVNVLSDSNILRIKGRLWIPKKSLPLQIQIVGKK
CCCEEEEEECCEEEEEEECHHHHHHHHHHHHCCCCEEEEECEEECCCCCCCEEEEEECCH
INTWYEEAPLNCWRPIDSGGLDLVIISFDDVSIKKLIKKIKEKFKILNGP
HHHHHHHCCCCCCCCCCCCCEEEEEEEECCHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MNKRTPVIVISGFLGSGKTTFLRYLLKNSNKKFGLIINEFGDVGIDGDLVKSCNGCDDSD
CCCCCCEEEEECCCCCCHHHHHHHHHHCCCCEEEEEEECCCCCCCCHHHHHHCCCCCCCC
TDCIIELNNGCLCCTVQDDFIPSIKSLLNFNPDIDAIIIETSGLALPLPLLQALNWPEIR
CCEEEEECCCEEEEEECHHHHHHHHHHHCCCCCCCEEEEECCCCEECHHHHHHCCCCHHH
TSIYLDQVIGIVNGESMLKGSPINDLSEITNQYDSLNKIDHKSSIDELFEEQLEVSDLVL
HHHHHHHHHHHCCCCHHCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCHHHEEE
ISRGDVLNEQEFKSIKNIIKNKFNSTVPILKSINGIVDLKYIFDFELKKDNYKKFITEEH
EECCCCCCHHHHHHHHHHHHHHCCCCHHHHHHCCCEEEEEEEEEEEECCCCHHHHCCCCC
DHNHIELVSDSIKLNYFLDKKEFEKEMVNVLSDSNILRIKGRLWIPKKSLPLQIQIVGKK
CCCEEEEEECCEEEEEEECHHHHHHHHHHHHCCCCEEEEECEEECCCCCCCEEEEEECCH
INTWYEEAPLNCWRPIDSGGLDLVIISFDDVSIKKLIKKIKEKFKILNGP
HHHHHHHCCCCCCCCCCCCCEEEEEEEECCHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1655697 [H]