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The map label for this gene is cbbA [H]

Identifier: 123966036

GI number: 123966036

Start: 723412

End: 724485

Strand: Direct

Name: cbbA [H]

Synonym: P9515_08011

Alternate gene names: 123966036

Gene position: 723412-724485 (Clockwise)

Preceding gene: 123966035

Following gene: 123966042

Centisome position: 42.45

GC content: 39.29

Gene sequence:

>1074_bases
ATGGCCCTTGTTCCACTGAGATTACTTTTAGATCACGCTGCCGAGAATGGTTACGGTATACCAGCTTTTAACGTTAACAA
TCTTGAACAAGTTCAAGCGATTATGGAGGCTGCTTATGAAACTGATAGTCCTGTCATTCTTCAAGCCTCAAGAGGAGCGA
GAAATTATGCTGGAGAAATTTTCCTTCGTCACCTAATCCTTGCCGCAACCGAAACTTATCCTAATATTCCAGTCGTAATG
CATCAGGATCATGGAAATGAGCCATCAACTTGTTATTCAGCTGCAATAAATGGTTTCACATCAGTAATGATGGATGGTTC
TCTTGAGGCAGATGCAAAAACACCTGCAAGTTACGAGTATAATGTGGCAGTAACAAAAAAAGTAGTCGACTTTGCTCACT
CTGTTGGAGTGAGTGTTGAGGGAGAACTAGGATGTTTAGGTTCATTAGAAACTGGAAAAGGCGAAGCTGAAGATGGACAT
GGATTTGAAGGTGAGCTTTCAACAGATATGCTTTTAACTGATCCGGAAGAAGCCGCAGATTTTGTAACTAAAACGAATGT
TGATGCTTTAGCTATCGCTATAGGAACAAGTCATGGAGCATATAAATTCACAAGAAAGCCAACAGGAGAGGTTCTTGCAA
TAAGTAGGATTTCTGAAATCCATAACGCTATTCCAAATACTCATCTTGTAATGCATGGATCTAGTTCAGTACCACAGGAA
TGGTTAGATATCATAAATAAATACGGGGGAGAGATTCCGCAAACATATGGCGTGCCTGTTGAAGAAATTCAAGAAGGTAT
CAGAAATGGAGTAAGGAAAGTTAATATCGATACTGATAATAGACTTGCCTTTACAGCAGCAGTTAGAGAAGCGGCTTTTT
CAGACACAGCAAACTTCGATCCAAGACATTTCAATAAACCTGCCAGAAATTATATGAAGCAAGTTTGTCTTGATAGATAC
AGACAATTCTGGTGTGAAGGTCAAGCAGGTAGGATCAAGCAAAGCAGTACAAATTATTATGCTGATCTTTATGCAAAAGG
TAACTTAGGTTCAAAGGTAAAAGCAAAAGTTTAG

Upstream 100 bases:

>100_bases
GCACTTAATTTAATTATTAACGTGACATTTGATACCTTCGTATATTAAACTCTCGGAACATATTGCTTATTTATTTTAAG
CATTTAATTAAATTTTAATT

Downstream 100 bases:

>100_bases
TTCAATAAGTTATTCCCAAATAAAAAAGACCTTCAATATATGAAGGTCTTTTTTTTTATTAATTAAATCATTAATGACTT
CAAAGTATATAGTCCATCTG

Product: fructose-1,6-bisphosphate aldolase

Products: NA

Alternate protein names: FBP aldolase; FBPA; Fructose-1,6-bisphosphate aldolase; Fructose-bisphosphate aldolase class II [H]

Number of amino acids: Translated: 357; Mature: 356

Protein sequence:

>357_residues
MALVPLRLLLDHAAENGYGIPAFNVNNLEQVQAIMEAAYETDSPVILQASRGARNYAGEIFLRHLILAATETYPNIPVVM
HQDHGNEPSTCYSAAINGFTSVMMDGSLEADAKTPASYEYNVAVTKKVVDFAHSVGVSVEGELGCLGSLETGKGEAEDGH
GFEGELSTDMLLTDPEEAADFVTKTNVDALAIAIGTSHGAYKFTRKPTGEVLAISRISEIHNAIPNTHLVMHGSSSVPQE
WLDIINKYGGEIPQTYGVPVEEIQEGIRNGVRKVNIDTDNRLAFTAAVREAAFSDTANFDPRHFNKPARNYMKQVCLDRY
RQFWCEGQAGRIKQSSTNYYADLYAKGNLGSKVKAKV

Sequences:

>Translated_357_residues
MALVPLRLLLDHAAENGYGIPAFNVNNLEQVQAIMEAAYETDSPVILQASRGARNYAGEIFLRHLILAATETYPNIPVVM
HQDHGNEPSTCYSAAINGFTSVMMDGSLEADAKTPASYEYNVAVTKKVVDFAHSVGVSVEGELGCLGSLETGKGEAEDGH
GFEGELSTDMLLTDPEEAADFVTKTNVDALAIAIGTSHGAYKFTRKPTGEVLAISRISEIHNAIPNTHLVMHGSSSVPQE
WLDIINKYGGEIPQTYGVPVEEIQEGIRNGVRKVNIDTDNRLAFTAAVREAAFSDTANFDPRHFNKPARNYMKQVCLDRY
RQFWCEGQAGRIKQSSTNYYADLYAKGNLGSKVKAKV
>Mature_356_residues
ALVPLRLLLDHAAENGYGIPAFNVNNLEQVQAIMEAAYETDSPVILQASRGARNYAGEIFLRHLILAATETYPNIPVVMH
QDHGNEPSTCYSAAINGFTSVMMDGSLEADAKTPASYEYNVAVTKKVVDFAHSVGVSVEGELGCLGSLETGKGEAEDGHG
FEGELSTDMLLTDPEEAADFVTKTNVDALAIAIGTSHGAYKFTRKPTGEVLAISRISEIHNAIPNTHLVMHGSSSVPQEW
LDIINKYGGEIPQTYGVPVEEIQEGIRNGVRKVNIDTDNRLAFTAAVREAAFSDTANFDPRHFNKPARNYMKQVCLDRYR
QFWCEGQAGRIKQSSTNYYADLYAKGNLGSKVKAKV

Specific function: Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3- phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis [H]

COG id: COG0191

COG function: function code G; Fructose/tagatose bisphosphate aldolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class II fructose-bisphosphate aldolase family [H]

Homologues:

Organism=Escherichia coli, GI1789526, Length=335, Percent_Identity=34.9253731343284, Blast_Score=161, Evalue=5e-41,
Organism=Escherichia coli, GI87082041, Length=329, Percent_Identity=31.6109422492401, Blast_Score=148, Evalue=5e-37,
Organism=Escherichia coli, GI1788072, Length=330, Percent_Identity=30.6060606060606, Blast_Score=127, Evalue=1e-30,
Organism=Escherichia coli, GI1789293, Length=340, Percent_Identity=24.4117647058824, Blast_Score=74, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6322790, Length=318, Percent_Identity=27.6729559748428, Blast_Score=71, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006412
- InterPro:   IPR000771 [H]

Pfam domain/function: PF01116 F_bP_aldolase [H]

EC number: =4.1.2.13 [H]

Molecular weight: Translated: 38936; Mature: 38805

Theoretical pI: Translated: 5.12; Mature: 5.12

Prosite motif: PS00602 ALDOLASE_CLASS_II_1 ; PS00806 ALDOLASE_CLASS_II_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALVPLRLLLDHAAENGYGIPAFNVNNLEQVQAIMEAAYETDSPVILQASRGARNYAGEI
CCCCHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHH
FLRHLILAATETYPNIPVVMHQDHGNEPSTCYSAAINGFTSVMMDGSLEADAKTPASYEY
HHHHHHHHHHCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEE
NVAVTKKVVDFAHSVGVSVEGELGCLGSLETGKGEAEDGHGFEGELSTDMLLTDPEEAAD
EEHHHHHHHHHHHHCCCEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECHHHHHH
FVTKTNVDALAIAIGTSHGAYKFTRKPTGEVLAISRISEIHNAIPNTHLVMHGSSSVPQE
HHHHCCCCEEEEEEECCCCCEEECCCCCCCEEHHHHHHHHHHHCCCCEEEEECCCCCCHH
WLDIINKYGGEIPQTYGVPVEEIQEGIRNGVRKVNIDTDNRLAFTAAVREAAFSDTANFD
HHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCEEEECCCCCCEEHHHHHHHHHHCCCCCCC
PRHFNKPARNYMKQVCLDRYRQFWCEGQAGRIKQSSTNYYADLYAKGNLGSKVKAKV
CHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEEECCCCCCEEECC
>Mature Secondary Structure 
ALVPLRLLLDHAAENGYGIPAFNVNNLEQVQAIMEAAYETDSPVILQASRGARNYAGEI
CCCHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHH
FLRHLILAATETYPNIPVVMHQDHGNEPSTCYSAAINGFTSVMMDGSLEADAKTPASYEY
HHHHHHHHHHCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEE
NVAVTKKVVDFAHSVGVSVEGELGCLGSLETGKGEAEDGHGFEGELSTDMLLTDPEEAAD
EEHHHHHHHHHHHHCCCEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECHHHHHH
FVTKTNVDALAIAIGTSHGAYKFTRKPTGEVLAISRISEIHNAIPNTHLVMHGSSSVPQE
HHHHCCCCEEEEEEECCCCCEEECCCCCCCEEHHHHHHHHHHHCCCCEEEEECCCCCCHH
WLDIINKYGGEIPQTYGVPVEEIQEGIRNGVRKVNIDTDNRLAFTAAVREAAFSDTANFD
HHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCEEEECCCCCCEEHHHHHHHHHHCCCCCCC
PRHFNKPARNYMKQVCLDRYRQFWCEGQAGRIKQSSTNYYADLYAKGNLGSKVKAKV
CHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEEECCCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231; 9298645 [H]