Click here to switch to the map view.

The map label for this gene is hemH [H]

Identifier: 123965824

GI number: 123965824

Start: 526707

End: 527882

Strand: Direct

Name: hemH [H]

Synonym: P9515_05891

Alternate gene names: 123965824

Gene position: 526707-527882 (Clockwise)

Preceding gene: 123965818

Following gene: 123965825

Centisome position: 30.91

GC content: 34.95

Gene sequence:

>1176_bases
ATGGAAAAAATAGGCGTCTTATTGATGAATCTTGGAGGCCCTGAACGCATTACAGATGTGGGTCCATTTTTATATAATTT
ATTTTCCGACCCTGAAATAATAAGGCTCCCAGTACCAGCTTTTCAGAAACCTTTAGCCTGGCTAATAAGCACACTTCGAA
GTACTACTTCACAACAGGCCTACCTTTCGATTGGTGGTGGATCTCCTATTAGAAGAATTACTGAACAACAAGCCAGAGAA
TTGCAAAGTAAATTAAGAGATAAAGGTTTAAATGTCACAACTTATATAGCTATGAGATATTGGCATCCTTTCACAGAATC
TGCAATAGCAGATATGAAAGCAGATGGGATAGATCAAATTGTTGTACTGCCTCTTTACCCTCATTTTTCTATAAGTACAA
GTGGTTCTAGCTTTAGAGAATTAAAAAAATTACGAGACTCGGATTCCGATTTTAAAAAAATACCAATGAGATGTGTAAGA
AGCTGGTTTAGTCAATCAGGTTATTTAAAATCTATGGTTGAACTTATTTCAGAGCAAATTTCACTTTGCGAATCACCTGC
TGATGCACATATATTTTTTACCGCTCACGGTGTTCCAAAAAGTTATGTAGAGGAAGCTGGAGATCCATATAAAGAACAAA
TTGAAGATTGTTCATTACTAATTATTAATGAACTTGAAAAATATTTAGGCCATAGTAATTCATATACTCTCTCATATCAA
AGTAGAGTCGGTCCTGTTGAATGGTTGAAACCTTATACTGAAGAAGTTTTGACAGACCTTGGTAAAGCGAAAGTAAATGA
TTTAATTGTAGTGCCCATAAGTTTTGTAGGTGAACATATTGAGACTTTGCAGGAAATTGATATTGAGTATAAAGAAATTG
CCGAGAAAGCAGGGATTGTTAATTTCAGAAGAGTAAAGGCTCTAAATACACATCCTACATTCATTGAGGGTCTTAGTGAT
CTCGTTGTTTCTAGCCTAAATGGACCAGTTGTCAATATAGAAAAAGCTTCTGAGTTACCTGAAAAAGTTAAACTTTATCC
TCAGGAAAAATGGCAATGGGGCTGGAATAATAGTTCAGAAGTTTGGAATGGGAGGGTTGCAATGATTGTTTTCCTAATAC
TTTTTATTGAACTAATATCAGGCTCTGGACCTCTTCATAAATTAGGTATTTTATAA

Upstream 100 bases:

>100_bases
TCATTGACATTATTGATTTCGTGAATTATGTTCATTAACTTATATAATTGACCTTATAATGACGTTTCTAATGTTTATTT
TCAATATCCATATACTTTAA

Downstream 100 bases:

>100_bases
ATTACACTCCATAAATAAAAATCTAAACTACATTTAAAAATATTTAATTTAGAAGTGGTTCCTGACATTACGTTTCTAAA
TTAGGCAAAATTTTTTAATT

Product: ferrochelatase

Products: NA

Alternate protein names: Heme synthase; Protoheme ferro-lyase [H]

Number of amino acids: Translated: 391; Mature: 391

Protein sequence:

>391_residues
MEKIGVLLMNLGGPERITDVGPFLYNLFSDPEIIRLPVPAFQKPLAWLISTLRSTTSQQAYLSIGGGSPIRRITEQQARE
LQSKLRDKGLNVTTYIAMRYWHPFTESAIADMKADGIDQIVVLPLYPHFSISTSGSSFRELKKLRDSDSDFKKIPMRCVR
SWFSQSGYLKSMVELISEQISLCESPADAHIFFTAHGVPKSYVEEAGDPYKEQIEDCSLLIINELEKYLGHSNSYTLSYQ
SRVGPVEWLKPYTEEVLTDLGKAKVNDLIVVPISFVGEHIETLQEIDIEYKEIAEKAGIVNFRRVKALNTHPTFIEGLSD
LVVSSLNGPVVNIEKASELPEKVKLYPQEKWQWGWNNSSEVWNGRVAMIVFLILFIELISGSGPLHKLGIL

Sequences:

>Translated_391_residues
MEKIGVLLMNLGGPERITDVGPFLYNLFSDPEIIRLPVPAFQKPLAWLISTLRSTTSQQAYLSIGGGSPIRRITEQQARE
LQSKLRDKGLNVTTYIAMRYWHPFTESAIADMKADGIDQIVVLPLYPHFSISTSGSSFRELKKLRDSDSDFKKIPMRCVR
SWFSQSGYLKSMVELISEQISLCESPADAHIFFTAHGVPKSYVEEAGDPYKEQIEDCSLLIINELEKYLGHSNSYTLSYQ
SRVGPVEWLKPYTEEVLTDLGKAKVNDLIVVPISFVGEHIETLQEIDIEYKEIAEKAGIVNFRRVKALNTHPTFIEGLSD
LVVSSLNGPVVNIEKASELPEKVKLYPQEKWQWGWNNSSEVWNGRVAMIVFLILFIELISGSGPLHKLGIL
>Mature_391_residues
MEKIGVLLMNLGGPERITDVGPFLYNLFSDPEIIRLPVPAFQKPLAWLISTLRSTTSQQAYLSIGGGSPIRRITEQQARE
LQSKLRDKGLNVTTYIAMRYWHPFTESAIADMKADGIDQIVVLPLYPHFSISTSGSSFRELKKLRDSDSDFKKIPMRCVR
SWFSQSGYLKSMVELISEQISLCESPADAHIFFTAHGVPKSYVEEAGDPYKEQIEDCSLLIINELEKYLGHSNSYTLSYQ
SRVGPVEWLKPYTEEVLTDLGKAKVNDLIVVPISFVGEHIETLQEIDIEYKEIAEKAGIVNFRRVKALNTHPTFIEGLSD
LVVSSLNGPVVNIEKASELPEKVKLYPQEKWQWGWNNSSEVWNGRVAMIVFLILFIELISGSGPLHKLGIL

Specific function: Catalyzes the ferrous insertion into protoporphyrin IX [H]

COG id: COG0276

COG function: function code H; Protoheme ferro-lyase (ferrochelatase)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ferrochelatase family [H]

Homologues:

Organism=Homo sapiens, GI60499021, Length=331, Percent_Identity=34.441087613293, Blast_Score=186, Evalue=4e-47,
Organism=Homo sapiens, GI60499025, Length=331, Percent_Identity=34.441087613293, Blast_Score=186, Evalue=4e-47,
Organism=Escherichia coli, GI1786681, Length=327, Percent_Identity=30.5810397553517, Blast_Score=125, Evalue=4e-30,
Organism=Saccharomyces cerevisiae, GI6324750, Length=330, Percent_Identity=37.5757575757576, Blast_Score=195, Evalue=1e-50,
Organism=Drosophila melanogaster, GI17864156, Length=330, Percent_Identity=33.9393939393939, Blast_Score=191, Evalue=1e-48,
Organism=Drosophila melanogaster, GI24651774, Length=260, Percent_Identity=31.1538461538462, Blast_Score=132, Evalue=6e-31,
Organism=Drosophila melanogaster, GI45552018, Length=171, Percent_Identity=36.2573099415205, Blast_Score=112, Evalue=4e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001015
- InterPro:   IPR019772 [H]

Pfam domain/function: PF00762 Ferrochelatase [H]

EC number: =4.99.1.1 [H]

Molecular weight: Translated: 44109; Mature: 44109

Theoretical pI: Translated: 5.69; Mature: 5.69

Prosite motif: PS00534 FERROCHELATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKIGVLLMNLGGPERITDVGPFLYNLFSDPEIIRLPVPAFQKPLAWLISTLRSTTSQQA
CCCCEEEEEECCCCHHHHHHHHHHHHHCCCCCEEEECCHHHHHHHHHHHHHHHHCCCCCE
YLSIGGGSPIRRITEQQARELQSKLRDKGLNVTTYIAMRYWHPFTESAIADMKADGIDQI
EEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHCCCHHHHHHHHHCCCCCCCE
VVLPLYPHFSISTSGSSFRELKKLRDSDSDFKKIPMRCVRSWFSQSGYLKSMVELISEQI
EEEECCCCCEEECCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
SLCESPADAHIFFTAHGVPKSYVEEAGDPYKEQIEDCSLLIINELEKYLGHSNSYTLSYQ
HHHCCCCCCEEEEEECCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEC
SRVGPVEWLKPYTEEVLTDLGKAKVNDLIVVPISFVGEHIETLQEIDIEYKEIAEKAGIV
CCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHCCHHHHHHHHCCCC
NFRRVKALNTHPTFIEGLSDLVVSSLNGPVVNIEKASELPEKVKLYPQEKWQWGWNNSSE
CHHHHEECCCCCHHHHHHHHHHHHHCCCCEEEEHHHHCCHHHHCCCCCHHCCCCCCCCCH
VWNGRVAMIVFLILFIELISGSGPLHKLGIL
HHCCHHHHHHHHHHHHHHHCCCCCCHHCCCC
>Mature Secondary Structure
MEKIGVLLMNLGGPERITDVGPFLYNLFSDPEIIRLPVPAFQKPLAWLISTLRSTTSQQA
CCCCEEEEEECCCCHHHHHHHHHHHHHCCCCCEEEECCHHHHHHHHHHHHHHHHCCCCCE
YLSIGGGSPIRRITEQQARELQSKLRDKGLNVTTYIAMRYWHPFTESAIADMKADGIDQI
EEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHCCCHHHHHHHHHCCCCCCCE
VVLPLYPHFSISTSGSSFRELKKLRDSDSDFKKIPMRCVRSWFSQSGYLKSMVELISEQI
EEEECCCCCEEECCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
SLCESPADAHIFFTAHGVPKSYVEEAGDPYKEQIEDCSLLIINELEKYLGHSNSYTLSYQ
HHHCCCCCCEEEEEECCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEC
SRVGPVEWLKPYTEEVLTDLGKAKVNDLIVVPISFVGEHIETLQEIDIEYKEIAEKAGIV
CCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHCCHHHHHHHHCCCC
NFRRVKALNTHPTFIEGLSDLVVSSLNGPVVNIEKASELPEKVKLYPQEKWQWGWNNSSE
CHHHHEECCCCCHHHHHHHHHHHHHCCCCEEEEHHHHCCHHHHCCCCCHHCCCCCCCCCH
VWNGRVAMIVFLILFIELISGSGPLHKLGIL
HHCCHHHHHHHHHHHHHHHCCCCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA