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The map label for this gene is gmk [H]

Identifier: 123965766

GI number: 123965766

Start: 475049

End: 475603

Strand: Direct

Name: gmk [H]

Synonym: P9515_05311

Alternate gene names: 123965766

Gene position: 475049-475603 (Clockwise)

Preceding gene: 123965762

Following gene: 123965769

Centisome position: 27.88

GC content: 30.99

Gene sequence:

>555_bases
ATGAAAAATTTAAAAAAACTCATTATTATCACAGGCCCAAGTGGAGTTGGGAAAGGTACTGTTGTTAAACAACTTTTAGA
TAGTAAAAAAGATATATGGCTTTCTATCTCTGCGACAACAAGAAACCCCAGAATGGGAGAGAAAGATGGTGTGAATTATT
ACTTTATTAGTGATGAAAAGTTTAAAGATATGGTCGATAAAAAAGAATTTCTTGAATGGGCTCAATTCGCAGGTAATTAT
TATGGAACTCCACTATCTACTGTAAATGAAAAGATTGAAAGTGGATTTATTGTTTTACTGGAAATTGAAGTTGAAGGTGC
CAAACAAATTAAAGAAAAGTTCCCAGAAGCTTTATCAATATTTCTTCTTCCTCCTAGCGATGAGGAATTAGAAAAAAGAA
TAAGAAATAGAGGTACTGAAAAAGAAGAGGCAATAAAAATGAGACTTAGGAGAGCTAAATACGAAATTGCTTCCTCAGAT
AGATTTGATTTTGTTTTAACAAATTATCATGTTGATGAGACAGTTAAAAGAATTTTCGAAATAATTAAGTCTTGA

Upstream 100 bases:

>100_bases
ACAGATTTTATAGATGTAATATCCATAATCTGAGGTACACCTTTTTGCATTATTTCTTGTAGTTAATCACCAAAACCCAC
TTTACTGTAAAAATTTTAAT

Downstream 100 bases:

>100_bases
AATTTTTTTGAAAATCTCAGCTCATTGGATGGAATAATAAATCAGGAAAAAATCTATTAAATTCAATAATTATTCCAGCG
GTGAGGCTTATCCAAATTGC

Product: guanylate kinase

Products: NA

Alternate protein names: GMP kinase [H]

Number of amino acids: Translated: 184; Mature: 184

Protein sequence:

>184_residues
MKNLKKLIIITGPSGVGKGTVVKQLLDSKKDIWLSISATTRNPRMGEKDGVNYYFISDEKFKDMVDKKEFLEWAQFAGNY
YGTPLSTVNEKIESGFIVLLEIEVEGAKQIKEKFPEALSIFLLPPSDEELEKRIRNRGTEKEEAIKMRLRRAKYEIASSD
RFDFVLTNYHVDETVKRIFEIIKS

Sequences:

>Translated_184_residues
MKNLKKLIIITGPSGVGKGTVVKQLLDSKKDIWLSISATTRNPRMGEKDGVNYYFISDEKFKDMVDKKEFLEWAQFAGNY
YGTPLSTVNEKIESGFIVLLEIEVEGAKQIKEKFPEALSIFLLPPSDEELEKRIRNRGTEKEEAIKMRLRRAKYEIASSD
RFDFVLTNYHVDETVKRIFEIIKS
>Mature_184_residues
MKNLKKLIIITGPSGVGKGTVVKQLLDSKKDIWLSISATTRNPRMGEKDGVNYYFISDEKFKDMVDKKEFLEWAQFAGNY
YGTPLSTVNEKIESGFIVLLEIEVEGAKQIKEKFPEALSIFLLPPSDEELEKRIRNRGTEKEEAIKMRLRRAKYEIASSD
RFDFVLTNYHVDETVKRIFEIIKS

Specific function: Essential for recycling GMP and indirectly, cGMP [H]

COG id: COG0194

COG function: function code F; Guanylate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 guanylate kinase-like domain [H]

Homologues:

Organism=Homo sapiens, GI226874833, Length=179, Percent_Identity=36.3128491620112, Blast_Score=121, Evalue=4e-28,
Organism=Homo sapiens, GI4504221, Length=179, Percent_Identity=36.3128491620112, Blast_Score=121, Evalue=4e-28,
Organism=Homo sapiens, GI226874831, Length=179, Percent_Identity=36.3128491620112, Blast_Score=121, Evalue=4e-28,
Organism=Homo sapiens, GI262118259, Length=177, Percent_Identity=30.5084745762712, Blast_Score=84, Evalue=6e-17,
Organism=Homo sapiens, GI262118255, Length=177, Percent_Identity=31.0734463276836, Blast_Score=84, Evalue=6e-17,
Organism=Homo sapiens, GI4505237, Length=177, Percent_Identity=30.5084745762712, Blast_Score=84, Evalue=6e-17,
Organism=Homo sapiens, GI262118263, Length=177, Percent_Identity=31.0734463276836, Blast_Score=84, Evalue=7e-17,
Organism=Homo sapiens, GI38570142, Length=183, Percent_Identity=28.4153005464481, Blast_Score=84, Evalue=7e-17,
Organism=Homo sapiens, GI186972120, Length=187, Percent_Identity=27.2727272727273, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI186700629, Length=187, Percent_Identity=27.2727272727273, Blast_Score=76, Evalue=1e-14,
Organism=Homo sapiens, GI186700627, Length=187, Percent_Identity=27.2727272727273, Blast_Score=76, Evalue=1e-14,
Organism=Homo sapiens, GI21389483, Length=182, Percent_Identity=25.2747252747253, Blast_Score=69, Evalue=2e-12,
Organism=Homo sapiens, GI14780902, Length=189, Percent_Identity=21.6931216931217, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI111154074, Length=114, Percent_Identity=30.7017543859649, Blast_Score=65, Evalue=3e-11,
Organism=Escherichia coli, GI1790080, Length=180, Percent_Identity=38.8888888888889, Blast_Score=150, Evalue=5e-38,
Organism=Caenorhabditis elegans, GI193203132, Length=181, Percent_Identity=38.121546961326, Blast_Score=128, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI17508835, Length=181, Percent_Identity=38.121546961326, Blast_Score=127, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI71988048, Length=187, Percent_Identity=26.2032085561497, Blast_Score=75, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI71988041, Length=187, Percent_Identity=26.2032085561497, Blast_Score=75, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17556244, Length=117, Percent_Identity=35.042735042735, Blast_Score=67, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17557440, Length=182, Percent_Identity=25.8241758241758, Blast_Score=66, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6320662, Length=184, Percent_Identity=41.8478260869565, Blast_Score=146, Evalue=2e-36,
Organism=Drosophila melanogaster, GI21356141, Length=166, Percent_Identity=40.9638554216867, Blast_Score=122, Evalue=2e-28,
Organism=Drosophila melanogaster, GI161077626, Length=182, Percent_Identity=25.8241758241758, Blast_Score=79, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24640542, Length=182, Percent_Identity=25.8241758241758, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI45554489, Length=182, Percent_Identity=25.8241758241758, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI45554481, Length=182, Percent_Identity=25.8241758241758, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI85724806, Length=182, Percent_Identity=25.8241758241758, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI116007136, Length=182, Percent_Identity=25.8241758241758, Blast_Score=78, Evalue=3e-15,
Organism=Drosophila melanogaster, GI85816281, Length=214, Percent_Identity=28.0373831775701, Blast_Score=77, Evalue=8e-15,
Organism=Drosophila melanogaster, GI85816106, Length=214, Percent_Identity=28.0373831775701, Blast_Score=77, Evalue=8e-15,
Organism=Drosophila melanogaster, GI45551002, Length=214, Percent_Identity=28.0373831775701, Blast_Score=76, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008144
- InterPro:   IPR008145
- InterPro:   IPR017665 [H]

Pfam domain/function: PF00625 Guanylate_kin [H]

EC number: =2.7.4.8 [H]

Molecular weight: Translated: 21247; Mature: 21247

Theoretical pI: Translated: 9.20; Mature: 9.20

Prosite motif: PS00856 GUANYLATE_KINASE_1 ; PS50052 GUANYLATE_KINASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNLKKLIIITGPSGVGKGTVVKQLLDSKKDIWLSISATTRNPRMGEKDGVNYYFISDEK
CCCCEEEEEEECCCCCCCHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCCEEEEECCHH
FKDMVDKKEFLEWAQFAGNYYGTPLSTVNEKIESGFIVLLEIEVEGAKQIKEKFPEALSI
HHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCEEEEEEEECCCHHHHHHHCHHHEEE
FLLPPSDEELEKRIRNRGTEKEEAIKMRLRRAKYEIASSDRFDFVLTNYHVDETVKRIFE
EEECCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHH
IIKS
HHCC
>Mature Secondary Structure
MKNLKKLIIITGPSGVGKGTVVKQLLDSKKDIWLSISATTRNPRMGEKDGVNYYFISDEK
CCCCEEEEEEECCCCCCCHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCCEEEEECCHH
FKDMVDKKEFLEWAQFAGNYYGTPLSTVNEKIESGFIVLLEIEVEGAKQIKEKFPEALSI
HHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCEEEEEEEECCCHHHHHHHCHHHEEE
FLLPPSDEELEKRIRNRGTEKEEAIKMRLRRAKYEIASSDRFDFVLTNYHVDETVKRIFE
EEECCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHH
IIKS
HHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12917642 [H]