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The map label for this gene is fabG [H]

Identifier: 123965656

GI number: 123965656

Start: 377373

End: 378137

Strand: Reverse

Name: fabG [H]

Synonym: P9515_04211

Alternate gene names: 123965656

Gene position: 378137-377373 (Counterclockwise)

Preceding gene: 123965657

Following gene: 123965653

Centisome position: 22.19

GC content: 32.29

Gene sequence:

>765_bases
ATGAATTTACAAATAAAAGAACAGACTGTTTTAATAACAGGAGCTGGAAGAGGCTTAGGTTCCGAAATAGCAAAATCTTT
TCATCGAGAGGGAGCAAAAGTAGTAATCAATTATAGAAAGTCATTTAAAAGTGCCCAAAAACTATCTGCTTCATTGGGAG
AAAATGTAATTTTAATCCAAGGTGATATTAGAGAAAAAGATCAAGTTTCTAAAATGCATGATGAATTGCATAATAAAGAT
ATCAAAGTGGATACAGTAGTTCATAATGCAATAAATGATTTTGTTTTTAATGGTGATCAAAGAAAAAAAATTGATACTAT
AGAGTGGCAAGATTTCCAAAACCAAATTGAAACTTCTCAGAAAGGATTTTTAAATCTGCTGAATATTTTTAACCCAAACA
TGAAAAAAAATTCTTTTGGAAGATTCATATCTATTGGAACTAACTTATTTCAAAATCCAGTGATCCCATATCACGATTAT
ACTGCCGCCAAAGGGGGTTTATTATCACTTACGAGAACTGCGGCAATAGATCTAGGACAATTTAATATCACAGTAAATAT
GGTTTCAGGAGGTTTATTAAAAGTTACTGATGCTAGCAAAGGAACTCCCGATAGTGTTTTTGAGTATATTTCAAGCATCA
CACCTTTAAGAAAAGTAACTACCACTGAGGACTTTTCTGATGCTGTATTATTTTTTGCCTCCCCTTGGTCAAGGGCAGTT
ACTGGGCAAAATTTAGTAGTTGATGGAGGATTAGTTCTAAATTAA

Upstream 100 bases:

>100_bases
ACAATTATAAGATATATATATTATGGGAAAAAGTAGAACCTAAATTTAATAAACAAATTTTCAGTTATTTCCTTTTTAAA
TACCCTTTTCAGAAAAACTT

Downstream 100 bases:

>100_bases
TTACTCTGAAATACTGGAGTTAAAATACCGCCATCAAAATCATCATCATCATCATTACTATCATCTGAGAAAATTAATTG
TCCTACTTCTAATCCAAAAT

Product: putative dehydrogenase

Products: NA

Alternate protein names: 3-ketoacyl-acyl carrier protein reductase [H]

Number of amino acids: Translated: 254; Mature: 254

Protein sequence:

>254_residues
MNLQIKEQTVLITGAGRGLGSEIAKSFHREGAKVVINYRKSFKSAQKLSASLGENVILIQGDIREKDQVSKMHDELHNKD
IKVDTVVHNAINDFVFNGDQRKKIDTIEWQDFQNQIETSQKGFLNLLNIFNPNMKKNSFGRFISIGTNLFQNPVIPYHDY
TAAKGGLLSLTRTAAIDLGQFNITVNMVSGGLLKVTDASKGTPDSVFEYISSITPLRKVTTTEDFSDAVLFFASPWSRAV
TGQNLVVDGGLVLN

Sequences:

>Translated_254_residues
MNLQIKEQTVLITGAGRGLGSEIAKSFHREGAKVVINYRKSFKSAQKLSASLGENVILIQGDIREKDQVSKMHDELHNKD
IKVDTVVHNAINDFVFNGDQRKKIDTIEWQDFQNQIETSQKGFLNLLNIFNPNMKKNSFGRFISIGTNLFQNPVIPYHDY
TAAKGGLLSLTRTAAIDLGQFNITVNMVSGGLLKVTDASKGTPDSVFEYISSITPLRKVTTTEDFSDAVLFFASPWSRAV
TGQNLVVDGGLVLN
>Mature_254_residues
MNLQIKEQTVLITGAGRGLGSEIAKSFHREGAKVVINYRKSFKSAQKLSASLGENVILIQGDIREKDQVSKMHDELHNKD
IKVDTVVHNAINDFVFNGDQRKKIDTIEWQDFQNQIETSQKGFLNLLNIFNPNMKKNSFGRFISIGTNLFQNPVIPYHDY
TAAKGGLLSLTRTAAIDLGQFNITVNMVSGGLLKVTDASKGTPDSVFEYISSITPLRKVTTTEDFSDAVLFFASPWSRAV
TGQNLVVDGGLVLN

Specific function: 7-Alpha-Dehydroxylation Of Cholic Acid, Yielding Deoxycholic Acid And Lithocholic Acid, Respectively. Highest Affinity With Taurochenodeoxycholic Acid. [C]

COG id: COG1028

COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI10190704, Length=255, Percent_Identity=23.921568627451, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI5031737, Length=253, Percent_Identity=28.0632411067194, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI19923817, Length=259, Percent_Identity=26.2548262548263, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI32483357, Length=256, Percent_Identity=24.21875, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI40254992, Length=249, Percent_Identity=25.3012048192771, Blast_Score=66, Evalue=3e-11,
Organism=Escherichia coli, GI1787905, Length=256, Percent_Identity=32.8125, Blast_Score=101, Evalue=5e-23,
Organism=Escherichia coli, GI1787335, Length=253, Percent_Identity=28.4584980237154, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI87082100, Length=261, Percent_Identity=24.5210727969349, Blast_Score=77, Evalue=8e-16,
Organism=Escherichia coli, GI1789057, Length=268, Percent_Identity=28.3582089552239, Blast_Score=74, Evalue=8e-15,
Organism=Escherichia coli, GI1787820, Length=232, Percent_Identity=24.5689655172414, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI1787545, Length=258, Percent_Identity=26.7441860465116, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI1786812, Length=254, Percent_Identity=25.5905511811024, Blast_Score=71, Evalue=6e-14,
Organism=Escherichia coli, GI1788459, Length=260, Percent_Identity=26.1538461538462, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1790717, Length=255, Percent_Identity=25.0980392156863, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1789208, Length=261, Percent_Identity=24.5210727969349, Blast_Score=63, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17555706, Length=249, Percent_Identity=26.9076305220884, Blast_Score=80, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI17562910, Length=270, Percent_Identity=27.037037037037, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17560332, Length=271, Percent_Identity=28.4132841328413, Blast_Score=71, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17544670, Length=270, Percent_Identity=25.5555555555556, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17559104, Length=260, Percent_Identity=27.3076923076923, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI115534694, Length=256, Percent_Identity=25.78125, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17562908, Length=275, Percent_Identity=27.6363636363636, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24639444, Length=251, Percent_Identity=25.8964143426295, Blast_Score=75, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011284
- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: =1.1.1.100 [H]

Molecular weight: Translated: 28096; Mature: 28096

Theoretical pI: Translated: 9.32; Mature: 9.32

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLQIKEQTVLITGAGRGLGSEIAKSFHREGAKVVINYRKSFKSAQKLSASLGENVILIQ
CCCEEECEEEEEEECCCCCHHHHHHHHHHCCCEEEEEEHHHHHHHHHHHHHHCCCEEEEE
GDIREKDQVSKMHDELHNKDIKVDTVVHNAINDFVFNGDQRKKIDTIEWQDFQNQIETSQ
CCCCCHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHH
KGFLNLLNIFNPNMKKNSFGRFISIGTNLFQNPVIPYHDYTAAKGGLLSLTRTAAIDLGQ
HHHHHHHHHHCCCCCCCCCCCEEEECCHHHHCCCCCCCCCCCCCCCEEEEHHHHEEECCE
FNITVNMVSGGLLKVTDASKGTPDSVFEYISSITPLRKVTTTEDFSDAVLFFASPWSRAV
EEEEEEEECCCEEEEECCCCCCHHHHHHHHHHCCCHHHHCCCCCCCCEEEEEECCCCCCC
TGQNLVVDGGLVLN
CCCEEEEECCEEEC
>Mature Secondary Structure
MNLQIKEQTVLITGAGRGLGSEIAKSFHREGAKVVINYRKSFKSAQKLSASLGENVILIQ
CCCEEECEEEEEEECCCCCHHHHHHHHHHCCCEEEEEEHHHHHHHHHHHHHHCCCEEEEE
GDIREKDQVSKMHDELHNKDIKVDTVVHNAINDFVFNGDQRKKIDTIEWQDFQNQIETSQ
CCCCCHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHH
KGFLNLLNIFNPNMKKNSFGRFISIGTNLFQNPVIPYHDYTAAKGGLLSLTRTAAIDLGQ
HHHHHHHHHHCCCCCCCCCCCEEEECCHHHHCCCCCCCCCCCCCCCEEEEHHHHEEECCE
FNITVNMVSGGLLKVTDASKGTPDSVFEYISSITPLRKVTTTEDFSDAVLFFASPWSRAV
EEEEEEEECCCEEEEECCCCCCHHHHHHHHHHCCCHHHHCCCCCCCCEEEEEECCCCCCC
TGQNLVVDGGLVLN
CCCEEEEECCEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8759840; 9384377; 9534248; 8654983 [H]