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The map label for this gene is thiD [H]

Identifier: 123965638

GI number: 123965638

Start: 365111

End: 365899

Strand: Direct

Name: thiD [H]

Synonym: P9515_04031

Alternate gene names: 123965638

Gene position: 365111-365899 (Clockwise)

Preceding gene: 123965637

Following gene: 123965639

Centisome position: 21.42

GC content: 33.33

Gene sequence:

>789_bases
ATGTATTCAAAAATTGCTCTTTCTATTGGTGGTAGTGATTCCGGGGGAGGTGCAGGAATTCAAGCTGATTTGAAAACTTT
TATGGCTCTAAATGTTCATGGATGCTCAGCCATAACATGTATTACTGCTCAAAATAGTTTTGAAGTAAGCTGCGTAGAAG
CGGTCCAAAAGGAAACTTTAATAAGCCAAATTGATACTTTGTTCTCGGATTTTGATATTAATGCTTTAAAAACTGGCATG
CTTTTGAATGAGAGTATTATTGATACTACGGCTTTAAAACTAAAATCTTATTCTATACCCAAGATTATAGACCCTGTAAT
GGTTTCAAGAACTGGGTCAAAATTACTTGAGGATGCTGCAATTAATGCTTACAAAAAATTGCTTTTGCCAATAGCTGATA
TTGTTACTCCAAATATTTTCGAAGCAAATCTTTTATCAAATATTGAAATCAAAAATAAGAAAGATATAGAGCTCGCAGCA
CATAATATTATTGAACTTGGAGCCAAAGCAGTATTAATAAAGGGTGGAGGATTAAAAGAGATGCAAGGAAAGGATTTTTA
TTTTGATGTCACAGGAAAAAGCAAATGGTTTATTAATAAATTTATAAATACTAAAAATACGCATGGAAGTGGATGTACTT
TAAGTTCGGCAATTTGCGGTTATCAAGCCTTGGGATTTGAATTGATAGAATCAATTGAAAGAGCGAAAGCATTTATTGAA
AGATCCTTGGAGAAATCTTATAAAATTGGTTCTGGTCCAGGCCCCCTTGGACATTATCAATCACTTTAG

Upstream 100 bases:

>100_bases
AGCGAATTATTTATATAAGAGAGCAATGGAATTGGAATTAGAATTTTTTAATGCTTATTCCAACTACTAATAAAGAAACT
TTTAAATTTTAAATAAAACT

Downstream 100 bases:

>100_bases
ACAAATAATAAGAGAATTTTGTAGCCTAAATTTTTTTGAAATTTTTTTAAAAATCGTTTTTTTATATTTATTATTTTTAT
AAATCAATAAATTTTTATTT

Product: phosphomethylpyrimidine kinase

Products: NA

Alternate protein names: Hydroxymethylpyrimidine kinase; HMP kinase; Hydroxymethylpyrimidine phosphate kinase; HMP-P kinase; HMP-phosphate kinase; HMPP kinase [H]

Number of amino acids: Translated: 262; Mature: 262

Protein sequence:

>262_residues
MYSKIALSIGGSDSGGGAGIQADLKTFMALNVHGCSAITCITAQNSFEVSCVEAVQKETLISQIDTLFSDFDINALKTGM
LLNESIIDTTALKLKSYSIPKIIDPVMVSRTGSKLLEDAAINAYKKLLLPIADIVTPNIFEANLLSNIEIKNKKDIELAA
HNIIELGAKAVLIKGGGLKEMQGKDFYFDVTGKSKWFINKFINTKNTHGSGCTLSSAICGYQALGFELIESIERAKAFIE
RSLEKSYKIGSGPGPLGHYQSL

Sequences:

>Translated_262_residues
MYSKIALSIGGSDSGGGAGIQADLKTFMALNVHGCSAITCITAQNSFEVSCVEAVQKETLISQIDTLFSDFDINALKTGM
LLNESIIDTTALKLKSYSIPKIIDPVMVSRTGSKLLEDAAINAYKKLLLPIADIVTPNIFEANLLSNIEIKNKKDIELAA
HNIIELGAKAVLIKGGGLKEMQGKDFYFDVTGKSKWFINKFINTKNTHGSGCTLSSAICGYQALGFELIESIERAKAFIE
RSLEKSYKIGSGPGPLGHYQSL
>Mature_262_residues
MYSKIALSIGGSDSGGGAGIQADLKTFMALNVHGCSAITCITAQNSFEVSCVEAVQKETLISQIDTLFSDFDINALKTGM
LLNESIIDTTALKLKSYSIPKIIDPVMVSRTGSKLLEDAAINAYKKLLLPIADIVTPNIFEANLLSNIEIKNKKDIELAA
HNIIELGAKAVLIKGGGLKEMQGKDFYFDVTGKSKWFINKFINTKNTHGSGCTLSSAICGYQALGFELIESIERAKAFIE
RSLEKSYKIGSGPGPLGHYQSL

Specific function: Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P [H]

COG id: COG0351

COG function: function code H; Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiD family [H]

Homologues:

Organism=Escherichia coli, GI1788420, Length=260, Percent_Identity=36.5384615384615, Blast_Score=185, Evalue=3e-48,
Organism=Saccharomyces cerevisiae, GI6325378, Length=273, Percent_Identity=31.1355311355311, Blast_Score=117, Evalue=1e-27,
Organism=Saccharomyces cerevisiae, GI6324517, Length=251, Percent_Identity=34.6613545816733, Blast_Score=98, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6324997, Length=252, Percent_Identity=34.1269841269841, Blast_Score=96, Evalue=4e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013749
- InterPro:   IPR004399 [H]

Pfam domain/function: PF08543 Phos_pyr_kin [H]

EC number: =2.7.1.49; =2.7.4.7 [H]

Molecular weight: Translated: 28235; Mature: 28235

Theoretical pI: Translated: 7.41; Mature: 7.41

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYSKIALSIGGSDSGGGAGIQADLKTFMALNVHGCSAITCITAQNSFEVSCVEAVQKETL
CCCEEEEEECCCCCCCCCCHHHHHHHHHEEEECCCCEEEEEECCCCCCHHHHHHHHHHHH
ISQIDTLFSDFDINALKTGMLLNESIIDTTALKLKSYSIPKIIDPVMVSRTGSKLLEDAA
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCHHHHHHHHH
INAYKKLLLPIADIVTPNIFEANLLSNIEIKNKKDIELAAHNIIELGAKAVLIKGGGLKE
HHHHHHHHHHHHHHHCCCCCHHHHHCCCEECCCCCHHHHHHHHHHHCCCEEEEECCCCCC
MQGKDFYFDVTGKSKWFINKFINTKNTHGSGCTLSSAICGYQALGFELIESIERAKAFIE
CCCCCEEEEECCCCHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
RSLEKSYKIGSGPGPLGHYQSL
HHHHHHCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MYSKIALSIGGSDSGGGAGIQADLKTFMALNVHGCSAITCITAQNSFEVSCVEAVQKETL
CCCEEEEEECCCCCCCCCCHHHHHHHHHEEEECCCCEEEEEECCCCCCHHHHHHHHHHHH
ISQIDTLFSDFDINALKTGMLLNESIIDTTALKLKSYSIPKIIDPVMVSRTGSKLLEDAA
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCHHHHHHHHH
INAYKKLLLPIADIVTPNIFEANLLSNIEIKNKKDIELAAHNIIELGAKAVLIKGGGLKE
HHHHHHHHHHHHHHHCCCCCHHHHHCCCEECCCCCHHHHHHHHHHHCCCEEEEECCCCCC
MQGKDFYFDVTGKSKWFINKFINTKNTHGSGCTLSSAICGYQALGFELIESIERAKAFIE
CCCCCEEEEECCCCHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
RSLEKSYKIGSGPGPLGHYQSL
HHHHHHCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA