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The map label for this gene is met3 [H]

Identifier: 123965494

GI number: 123965494

Start: 240978

End: 242153

Strand: Reverse

Name: met3 [H]

Synonym: P9515_02591

Alternate gene names: 123965494

Gene position: 242153-240978 (Counterclockwise)

Preceding gene: 123965495

Following gene: 123965493

Centisome position: 14.21

GC content: 33.5

Gene sequence:

>1176_bases
ATGAACTCACAAAAAGAATCTATAAGAGATTCAAAAGGTATCATCCTTCCTTATGGAGGAGAACTAAAAGATTTAATTAT
CAAAGATAAAAAACTTATAACAAAACTTTTTTCTCAAGTTTCATATGAGCATGAATGCAGTGATAGAAATGCATGCGATG
TAGAACTTTTAATGGTTGGAGGCTTTTCTCCTCTAGAGGGATTTATGGATAAAGAAGATTACAAATCTGTAATTAAAAGC
CATCGAAACACAAAGGGTTTACTGTTTGGATTGCCAATTGTATTTGATACTAATAAAGAAGAAATTAGAGAAGGCGAAAC
GATATTGCTCACATACAAAAAACAAAAACTAGCATTTTTGGAAGTTAGTTCAAAATGGGAGCCAGATAAATCCGTTGAAG
CAGAATTTTGTTACGGCACTAATTCATTGGATCATCCCGCAGTAAAAATGATTTTTAATGAAAGAGGTAGATACTACATA
GGAGGTAAGATTTACGGGTTGGAGCTCCCAAATAGAGATTTTCCATGTAAAACACCAGAAGAAGTAAGAGATTTATTACC
TGCTAATTTTGATGTGGTTGCTTTTCAATGCAGAAATCCCATTCATAGAGCTCATTATGAATTATTTACTAATGCCTTAC
AATCGGATAATGTTTCCTCAAATTCAGTAGTTTTAGTTCACCCAACATGCGGGCCAACACAACAAGATGACATTCCAGGA
AAAGTAAGATACTTAACATATAAAAAATTAGAAGAAGAAATTTCTAATGAGAATATCAAATGGGCATTTTTACCATACTC
AATGCATATGGCAGGACCTAGGGAGGCACTTCAACACATGATTATCAGAAGAAATTATGGCTGTACACATTTCATAATCG
GTAGGGATATGGCTGGATGCAAATCATCCTCCACTGGTGAAGATTTTTACGGTCCTTATGATGCACAGAATTTTGCCAAT
AAATGTTCGAAAGAGTTAATGATGCAAACTGTCCCTTCTAGAAATCTAGTTTACACATTAGAAAAAGGTTATATAACTGC
AGAAGAAGCAAAAGAAAAAAACTATCAGATAATGAAACTTAGCGGTACAGAATTTAGAAAAAAATTGAGGAATGGTGATT
CAATACCTGAATGGTTCGCATTTAAAAGTGTAGTAGATGTTCTAAGAAAGTCTTAA

Upstream 100 bases:

>100_bases
GTGAGCTTTACGGAAGAAAAGCTTAATTCTAAATAAAGAAAAAAAAGAGGGTTAAAACCCTCTTTTTTTTTTTTCATAAT
TTGTCTTATAAAATCATAAA

Downstream 100 bases:

>100_bases
TATTGTTTTATTATTAGTATTATATATTTACTAAAGATTTTTTATCGTGAACAAACGTTGGAGAAACGTAGGACTTTATG
TTCTAGCAGTAATAACAGTT

Product: ATP-sulfurylase

Products: NA

Alternate protein names: Sulfate adenylyltransferase; ATP-sulfurylase; Sulfate adenylate transferase; SAT; Adenylyl-sulfate kinase; APS kinase; ATP adenosine-5'-phosphosulfate 3'-phosphotransferase; Adenosine-5'-phosphosulfate kinase [H]

Number of amino acids: Translated: 391; Mature: 391

Protein sequence:

>391_residues
MNSQKESIRDSKGIILPYGGELKDLIIKDKKLITKLFSQVSYEHECSDRNACDVELLMVGGFSPLEGFMDKEDYKSVIKS
HRNTKGLLFGLPIVFDTNKEEIREGETILLTYKKQKLAFLEVSSKWEPDKSVEAEFCYGTNSLDHPAVKMIFNERGRYYI
GGKIYGLELPNRDFPCKTPEEVRDLLPANFDVVAFQCRNPIHRAHYELFTNALQSDNVSSNSVVLVHPTCGPTQQDDIPG
KVRYLTYKKLEEEISNENIKWAFLPYSMHMAGPREALQHMIIRRNYGCTHFIIGRDMAGCKSSSTGEDFYGPYDAQNFAN
KCSKELMMQTVPSRNLVYTLEKGYITAEEAKEKNYQIMKLSGTEFRKKLRNGDSIPEWFAFKSVVDVLRKS

Sequences:

>Translated_391_residues
MNSQKESIRDSKGIILPYGGELKDLIIKDKKLITKLFSQVSYEHECSDRNACDVELLMVGGFSPLEGFMDKEDYKSVIKS
HRNTKGLLFGLPIVFDTNKEEIREGETILLTYKKQKLAFLEVSSKWEPDKSVEAEFCYGTNSLDHPAVKMIFNERGRYYI
GGKIYGLELPNRDFPCKTPEEVRDLLPANFDVVAFQCRNPIHRAHYELFTNALQSDNVSSNSVVLVHPTCGPTQQDDIPG
KVRYLTYKKLEEEISNENIKWAFLPYSMHMAGPREALQHMIIRRNYGCTHFIIGRDMAGCKSSSTGEDFYGPYDAQNFAN
KCSKELMMQTVPSRNLVYTLEKGYITAEEAKEKNYQIMKLSGTEFRKKLRNGDSIPEWFAFKSVVDVLRKS
>Mature_391_residues
MNSQKESIRDSKGIILPYGGELKDLIIKDKKLITKLFSQVSYEHECSDRNACDVELLMVGGFSPLEGFMDKEDYKSVIKS
HRNTKGLLFGLPIVFDTNKEEIREGETILLTYKKQKLAFLEVSSKWEPDKSVEAEFCYGTNSLDHPAVKMIFNERGRYYI
GGKIYGLELPNRDFPCKTPEEVRDLLPANFDVVAFQCRNPIHRAHYELFTNALQSDNVSSNSVVLVHPTCGPTQQDDIPG
KVRYLTYKKLEEEISNENIKWAFLPYSMHMAGPREALQHMIIRRNYGCTHFIIGRDMAGCKSSSTGEDFYGPYDAQNFAN
KCSKELMMQTVPSRNLVYTLEKGYITAEEAKEKNYQIMKLSGTEFRKKLRNGDSIPEWFAFKSVVDVLRKS

Specific function: Unknown

COG id: COG2046

COG function: function code P; ATP sulfurylase (sulfate adenylyltransferase)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the APS kinase family [H]

Homologues:

Organism=Homo sapiens, GI46094058, Length=390, Percent_Identity=27.6923076923077, Blast_Score=120, Evalue=3e-27,
Organism=Homo sapiens, GI34447231, Length=360, Percent_Identity=27.5, Blast_Score=112, Evalue=4e-25,
Organism=Homo sapiens, GI62912492, Length=363, Percent_Identity=26.7217630853994, Blast_Score=112, Evalue=8e-25,
Organism=Caenorhabditis elegans, GI17542422, Length=425, Percent_Identity=26.5882352941176, Blast_Score=108, Evalue=3e-24,
Organism=Saccharomyces cerevisiae, GI6322469, Length=389, Percent_Identity=38.560411311054, Blast_Score=269, Evalue=5e-73,
Organism=Drosophila melanogaster, GI24667032, Length=389, Percent_Identity=26.9922879177378, Blast_Score=102, Evalue=4e-22,
Organism=Drosophila melanogaster, GI24667028, Length=389, Percent_Identity=26.9922879177378, Blast_Score=102, Evalue=4e-22,
Organism=Drosophila melanogaster, GI24667036, Length=389, Percent_Identity=26.9922879177378, Blast_Score=102, Evalue=4e-22,
Organism=Drosophila melanogaster, GI116007838, Length=389, Percent_Identity=26.9922879177378, Blast_Score=102, Evalue=5e-22,
Organism=Drosophila melanogaster, GI24667044, Length=389, Percent_Identity=26.9922879177378, Blast_Score=102, Evalue=5e-22,
Organism=Drosophila melanogaster, GI24667040, Length=349, Percent_Identity=28.080229226361, Blast_Score=102, Evalue=6e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002891
- InterPro:   IPR015947
- InterPro:   IPR014729
- InterPro:   IPR020792
- InterPro:   IPR002650 [H]

Pfam domain/function: PF01583 APS_kinase; PF01747 ATP-sulfurylase [H]

EC number: =2.7.7.4; =2.7.1.25 [H]

Molecular weight: Translated: 44811; Mature: 44811

Theoretical pI: Translated: 7.47; Mature: 7.47

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSQKESIRDSKGIILPYGGELKDLIIKDKKLITKLFSQVSYEHECSDRNACDVELLMVG
CCCHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEC
GFSPLEGFMDKEDYKSVIKSHRNTKGLLFGLPIVFDTNKEEIREGETILLTYKKQKLAFL
CCCHHHHHCCHHHHHHHHHHCCCCCCEEEECCEEEECCHHHHHCCCEEEEEEECCEEEEE
EVSSKWEPDKSVEAEFCYGTNSLDHPAVKMIFNERGRYYIGGKIYGLELPNRDFPCKTPE
EECCCCCCCCCCCEEEEECCCCCCCHHHHHHHHCCCCEEECCEEEEEECCCCCCCCCCHH
EVRDLLPANFDVVAFQCRNPIHRAHYELFTNALQSDNVSSNSVVLVHPTCGPTQQDDIPG
HHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCCCC
KVRYLTYKKLEEEISNENIKWAFLPYSMHMAGPREALQHMIIRRNYGCTHFIIGRDMAGC
CEEEEHHHHHHHHHCCCCEEEEEECEEEECCCHHHHHHHHHHHCCCCCEEEEECCCCCCC
KSSSTGEDFYGPYDAQNFANKCSKELMMQTVPSRNLVYTLEKGYITAEEAKEKNYQIMKL
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEECCEEEHHHHHCCCEEEEEE
SGTEFRKKLRNGDSIPEWFAFKSVVDVLRKS
CCHHHHHHHHCCCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNSQKESIRDSKGIILPYGGELKDLIIKDKKLITKLFSQVSYEHECSDRNACDVELLMVG
CCCHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEC
GFSPLEGFMDKEDYKSVIKSHRNTKGLLFGLPIVFDTNKEEIREGETILLTYKKQKLAFL
CCCHHHHHCCHHHHHHHHHHCCCCCCEEEECCEEEECCHHHHHCCCEEEEEEECCEEEEE
EVSSKWEPDKSVEAEFCYGTNSLDHPAVKMIFNERGRYYIGGKIYGLELPNRDFPCKTPE
EECCCCCCCCCCCEEEEECCCCCCCHHHHHHHHCCCCEEECCEEEEEECCCCCCCCCCHH
EVRDLLPANFDVVAFQCRNPIHRAHYELFTNALQSDNVSSNSVVLVHPTCGPTQQDDIPG
HHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCCCC
KVRYLTYKKLEEEISNENIKWAFLPYSMHMAGPREALQHMIIRRNYGCTHFIIGRDMAGC
CEEEEHHHHHHHHHCCCCEEEEEECEEEECCCHHHHHHHHHHHCCCCCEEEEECCCCCCC
KSSSTGEDFYGPYDAQNFANKCSKELMMQTVPSRNLVYTLEKGYITAEEAKEKNYQIMKL
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEECCEEEHHHHHCCCEEEEEE
SGTEFRKKLRNGDSIPEWFAFKSVVDVLRKS
CCHHHHHHHHCCCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9537320 [H]