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The map label for this gene is hhoA [H]

Identifier: 123965337

GI number: 123965337

Start: 104759

End: 105910

Strand: Reverse

Name: hhoA [H]

Synonym: P9515_01021

Alternate gene names: 123965337

Gene position: 105910-104759 (Counterclockwise)

Preceding gene: 123965341

Following gene: 123965334

Centisome position: 6.21

GC content: 30.56

Gene sequence:

>1152_bases
ATGTTTTTTAAGGCATTAAGAAAAATAAAAACAAGGAAATACTCTTTTAATAGACTAATGTTTATATCCTATTTAACTTT
TGGTTTACTAAATAAACCGCAAGTAATATCACAGCCGATAAGAAATCAAACTCTTGATGAAAAATCTAAAATTGCAAATA
TATCGTTCATAACAAAAGCAATTAAGAAAACAGGGGCATCTGTAGTAACTATTGACACTCAAAGATTAGTAAAAAATAAA
CAATTTTCCAGAGATTCAGGAATTTTCATTGACCCATATTTCGAAAGATTTTTTGGATTACAATTACCTCGCGAATATCA
ACCAAGAATAGAACAGAGTCAGGGAAGTGGATTTATATTCGAAGATGGTCTAGTAATGACAAATGCGCATGTTGTTAATG
GCTCTAAAAAAGTAATAGTTGGCTTATCAAATGGGACAAAATATGAAGGGAAGTTAATAGGACAAGATTCACTTACTGAT
CTAGCTGTGATTAAGCTCCAAGGTCGAGGTCCTTGGCCAAAAGCAAAATTAGGTGACTCTTCAAAAATAGAAGTCGGTGA
TTGGGCCATAGCTGTGGGAAACCCTTTTGGACTCGAAAATACAGTCACTCTAGGAATAATTAGTAATTTAAATAGAAATG
TCTCAGAATTAGGAATATACGATAAAAAATTTGAATTAATCCAGACAGATGCTGCAATTAACCCCGGCAATTCTGGAGGA
CCATTATTAAATAGTGCTGGAGAGGTCATTGGAATTAATACTTTGATTAGATCAGGACCTGGAGCAGGTCTCAGTTTTGC
CATTCCAATAAATAAAGCTAAAGATATCGCTTCACAACTAATCAACAATGGGCGAGTAATTCATCCTATGATTGGAATTA
ATTTAATAGATCAAAATTCTTTTGAGATTAAAAAAAATATTGTGAAAGTAGGATATGTTGTCCCAAATAGTCCTGCCGAT
AAAAGTGGATTCTATATTAATGACGTAATTATTAAAGTGGGTAAAAAAGATGTTCAAAATTCTTCAGATGTTATAAATGA
AATAACTAATAATGGAATTAATAATTATTTAAATATAATCATCAAAAGAAAAAATAAACTTATTAAATTAAAAGTTAAAC
CAACTGATATAAGTAATTTATCAGGAAAATAA

Upstream 100 bases:

>100_bases
AATAAATTTAGTTATTTTTATGCAACAATATCTTCTTTATTCCAAATAATTATGCCTATTTATATAATTATGATTAACAA
TCAATATAAAAATACAAAGA

Downstream 100 bases:

>100_bases
AAAGTTTTTAACTTTCATCATCTCTTAGTATTTCTACACATTTTGAGATGCAAATACCATCAGTAATATCACAGCTAGAA
ATACATTCAAAATAACTTTC

Product: serine protease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 383; Mature: 383

Protein sequence:

>383_residues
MFFKALRKIKTRKYSFNRLMFISYLTFGLLNKPQVISQPIRNQTLDEKSKIANISFITKAIKKTGASVVTIDTQRLVKNK
QFSRDSGIFIDPYFERFFGLQLPREYQPRIEQSQGSGFIFEDGLVMTNAHVVNGSKKVIVGLSNGTKYEGKLIGQDSLTD
LAVIKLQGRGPWPKAKLGDSSKIEVGDWAIAVGNPFGLENTVTLGIISNLNRNVSELGIYDKKFELIQTDAAINPGNSGG
PLLNSAGEVIGINTLIRSGPGAGLSFAIPINKAKDIASQLINNGRVIHPMIGINLIDQNSFEIKKNIVKVGYVVPNSPAD
KSGFYINDVIIKVGKKDVQNSSDVINEITNNGINNYLNIIIKRKNKLIKLKVKPTDISNLSGK

Sequences:

>Translated_383_residues
MFFKALRKIKTRKYSFNRLMFISYLTFGLLNKPQVISQPIRNQTLDEKSKIANISFITKAIKKTGASVVTIDTQRLVKNK
QFSRDSGIFIDPYFERFFGLQLPREYQPRIEQSQGSGFIFEDGLVMTNAHVVNGSKKVIVGLSNGTKYEGKLIGQDSLTD
LAVIKLQGRGPWPKAKLGDSSKIEVGDWAIAVGNPFGLENTVTLGIISNLNRNVSELGIYDKKFELIQTDAAINPGNSGG
PLLNSAGEVIGINTLIRSGPGAGLSFAIPINKAKDIASQLINNGRVIHPMIGINLIDQNSFEIKKNIVKVGYVVPNSPAD
KSGFYINDVIIKVGKKDVQNSSDVINEITNNGINNYLNIIIKRKNKLIKLKVKPTDISNLSGK
>Mature_383_residues
MFFKALRKIKTRKYSFNRLMFISYLTFGLLNKPQVISQPIRNQTLDEKSKIANISFITKAIKKTGASVVTIDTQRLVKNK
QFSRDSGIFIDPYFERFFGLQLPREYQPRIEQSQGSGFIFEDGLVMTNAHVVNGSKKVIVGLSNGTKYEGKLIGQDSLTD
LAVIKLQGRGPWPKAKLGDSSKIEVGDWAIAVGNPFGLENTVTLGIISNLNRNVSELGIYDKKFELIQTDAAINPGNSGG
PLLNSAGEVIGINTLIRSGPGAGLSFAIPINKAKDIASQLINNGRVIHPMIGINLIDQNSFEIKKNIVKVGYVVPNSPAD
KSGFYINDVIIKVGKKDVQNSSDVINEITNNGINNYLNIIIKRKNKLIKLKVKPTDISNLSGK

Specific function: A putative protease, its function overlaps that of the related putative proteases HhoB and HtrA [H]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PDZ (DHR) domain [H]

Homologues:

Organism=Homo sapiens, GI4506141, Length=283, Percent_Identity=40.2826855123675, Blast_Score=179, Evalue=3e-45,
Organism=Homo sapiens, GI7019477, Length=338, Percent_Identity=33.4319526627219, Blast_Score=159, Evalue=6e-39,
Organism=Homo sapiens, GI22129776, Length=283, Percent_Identity=37.4558303886926, Blast_Score=154, Evalue=2e-37,
Organism=Homo sapiens, GI24308541, Length=281, Percent_Identity=35.2313167259786, Blast_Score=145, Evalue=4e-35,
Organism=Escherichia coli, GI1789629, Length=300, Percent_Identity=36.3333333333333, Blast_Score=159, Evalue=2e-40,
Organism=Escherichia coli, GI1786356, Length=270, Percent_Identity=37.7777777777778, Blast_Score=154, Evalue=7e-39,
Organism=Escherichia coli, GI1789630, Length=274, Percent_Identity=36.4963503649635, Blast_Score=149, Evalue=2e-37,
Organism=Drosophila melanogaster, GI24646839, Length=321, Percent_Identity=35.202492211838, Blast_Score=155, Evalue=4e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 42123; Mature: 42123

Theoretical pI: Translated: 10.53; Mature: 10.53

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFFKALRKIKTRKYSFNRLMFISYLTFGLLNKPQVISQPIRNQTLDEKSKIANISFITKA
CHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHH
IKKTGASVVTIDTQRLVKNKQFSRDSGIFIDPYFERFFGLQLPREYQPRIEQSQGSGFIF
HHHCCCEEEEEEHHHHHHCCCCCCCCCEEECHHHHHHHCCCCCHHHCCCHHCCCCCEEEE
EDGLVMTNAHVVNGSKKVIVGLSNGTKYEGKLIGQDSLTDLAVIKLQGRGPWPKAKLGDS
ECCEEEEEEEEECCCCEEEEECCCCCEECCEEECCCCCCEEEEEEEECCCCCCCCCCCCC
SKIEVGDWAIAVGNPFGLENTVTLGIISNLNRNVSELGIYDKKFELIQTDAAINPGNSGG
CEEEECCEEEEECCCCCCCCEEEEEEHHCCCCCHHHHCCCCCCEEEEEECCCCCCCCCCC
PLLNSAGEVIGINTLIRSGPGAGLSFAIPINKAKDIASQLINNGRVIHPMIGINLIDQNS
CCCCCCCCEEEEHHHHHCCCCCCEEEEEECCHHHHHHHHHHHCCCEEEEEECEEEECCCC
FEIKKNIVKVGYVVPNSPADKSGFYINDVIIKVGKKDVQNSSDVINEITNNGINNYLNII
HHHHHCEEEEEEEECCCCCCCCCEEEEEEEEECCCHHCCCHHHHHHHHHCCCHHHHHEEE
IKRKNKLIKLKVKPTDISNLSGK
EEECCCEEEEEECCCCCCCCCCC
>Mature Secondary Structure
MFFKALRKIKTRKYSFNRLMFISYLTFGLLNKPQVISQPIRNQTLDEKSKIANISFITKA
CHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHH
IKKTGASVVTIDTQRLVKNKQFSRDSGIFIDPYFERFFGLQLPREYQPRIEQSQGSGFIF
HHHCCCEEEEEEHHHHHHCCCCCCCCCEEECHHHHHHHCCCCCHHHCCCHHCCCCCEEEE
EDGLVMTNAHVVNGSKKVIVGLSNGTKYEGKLIGQDSLTDLAVIKLQGRGPWPKAKLGDS
ECCEEEEEEEEECCCCEEEEECCCCCEECCEEECCCCCCEEEEEEEECCCCCCCCCCCCC
SKIEVGDWAIAVGNPFGLENTVTLGIISNLNRNVSELGIYDKKFELIQTDAAINPGNSGG
CEEEECCEEEEECCCCCCCCEEEEEEHHCCCCCHHHHCCCCCCEEEEEECCCCCCCCCCC
PLLNSAGEVIGINTLIRSGPGAGLSFAIPINKAKDIASQLINNGRVIHPMIGINLIDQNS
CCCCCCCCEEEEHHHHHCCCCCCEEEEEECCHHHHHHHHHHHCCCEEEEEECEEEECCCC
FEIKKNIVKVGYVVPNSPADKSGFYINDVIIKVGKKDVQNSSDVINEITNNGINNYLNII
HHHHHCEEEEEEEECCCCCCCCCEEEEEEEEECCCHHCCCHHHHHHHHHCCCHHHHHEEE
IKRKNKLIKLKVKPTDISNLSGK
EEECCCEEEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]