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The map label for this gene is accC [H]

Identifier: 121999113

GI number: 121999113

Start: 2560860

End: 2562203

Strand: Reverse

Name: accC [H]

Synonym: Hhal_2335

Alternate gene names: 121999113

Gene position: 2562203-2560860 (Counterclockwise)

Preceding gene: 121999114

Following gene: 121999112

Centisome position: 95.66

GC content: 67.19

Gene sequence:

>1344_bases
ATGCAGAAGATCCTCATCGCCAACCGCGGCGAGATCGCGCTGCGCATCCTGCGCGCCTGTCGTGAGCTGGGTATCCGCAG
TGTCGCCGTCCACTCCGCGGCCGATCGCGAGCTCAAGCACGTGCGTCTGGCCGACGAGTCGGTCTGCATCGGGCCGAACA
ACGTCCGCGACAGCTACCTCAACATCCCGGCGATCATCGCCGCCGCCGAGGTCACCGATTCCACTGCTATCCACCCCGGC
TACGGCTTCCTCTCCGAGAACGCCGATTTCGCCGAGCGGGTCGAGCAGTCGGGCTTCGTGTTCATCGGACCGCGGGCGGA
GAGCATCCGCACCATGGGCGACAAGGTCTCGGCGATCCGCGCCATGAAGGAGGCTGGCGTGCCGTGCGTGCCCGGCTCCA
ATGGCCCGGTCCCTGACGACGATCCCGATGAGACGCTGCGCATCGCCTCCGAGATCGGCTATCCGATCATGATCAAGGCA
GCCTCGGGCGGCGGCGGCCGGGGCATGCGCGTGGTGCGCAGCGAGGCGGCGCTGCTCAATGCCGTGTCGTTGACCCGCGG
CGAGGCCGAGAACGCCTTCGGCGACGGTACCGTCTACATGGAGAAGTACCTGGAGAAGCCGCGCCATATCGAGGTGCAGG
TGCTCGCCGACCACCACGGCAACGCCATCCACCTCGGTGAGCGCGACTGCTCCATGCAGCGGCGGCATCAGAAGGTGGTC
GAGGAGGCCCCGGCCCCGGGGATCACCGAGGCGCAGCGGCGCGACATCGGGGAACGCTGCGCCGAGGCGTGCCGGCAGAT
GGGCTATCGCGGCGCGGGCACCTTCGAGTTCCTGTACGAGAACGGCGAGTTCTACTTCATCGAGATGAACACCCGCATCC
AGGTCGAGCACCCGGTCACCGAGATGGTCACCGGCTGCGATCTGGTTGCCGAGCAGATCCGCATCGCCTCGGGCGAGCCG
CTGAGCTGGCGCCAGGAAGACATCCAGGTGCGGGGCCACGCGGTGGAGTGTCGGATCAACGCCGAGGATCCGAAGACGCT
GATGCCCTGCCCGGGCACCATCGATCACTTCCACGCCCCGGGCGGCCCCGGGGTGCGGGTCGATTCCCACGTCTACACCG
GCTACGCGGTGCCGCCGTATTTCGACTCCATGATCGGTAAGCTGATCACCCACGGTCCGAGCCGTGACAGCGCCCTGGCG
CGGATGCGCACGGCGCTCTCCGAGATCGTGGTCAGCGGTATCGGTACCAATATCTCGCTGCAGCAGGAGATCATCGGGGA
TGCCGCGTTCCGCGCCGGCGGGACCGACATCCACTATCTGGAGAAGAAGCTCGCCCTCGATTGA

Upstream 100 bases:

>100_bases
GGCCGACCGCGACGGGGTCATCACCGCCGTTCTGGTCGAGAATGGTCAGCCCGTCGAGTACGACCAGCCGCTGTTCCTGA
TCTCCGACTGAGTGAGCACC

Downstream 100 bases:

>100_bases
GGCTTGCACCACGGTGCGGCGACGCCCTGTAATGGGGGCAGGCGGGCAAACCCGGTGGGGAGACGAGCATGATCAAGCGG
ATCGCGGCGGTGGCGGCCCT

Product: acetyl-CoA carboxylase, biotin carboxylase

Products: NA

Alternate protein names: Acetyl-CoA carboxylase subunit A; ACC [H]

Number of amino acids: Translated: 447; Mature: 447

Protein sequence:

>447_residues
MQKILIANRGEIALRILRACRELGIRSVAVHSAADRELKHVRLADESVCIGPNNVRDSYLNIPAIIAAAEVTDSTAIHPG
YGFLSENADFAERVEQSGFVFIGPRAESIRTMGDKVSAIRAMKEAGVPCVPGSNGPVPDDDPDETLRIASEIGYPIMIKA
ASGGGGRGMRVVRSEAALLNAVSLTRGEAENAFGDGTVYMEKYLEKPRHIEVQVLADHHGNAIHLGERDCSMQRRHQKVV
EEAPAPGITEAQRRDIGERCAEACRQMGYRGAGTFEFLYENGEFYFIEMNTRIQVEHPVTEMVTGCDLVAEQIRIASGEP
LSWRQEDIQVRGHAVECRINAEDPKTLMPCPGTIDHFHAPGGPGVRVDSHVYTGYAVPPYFDSMIGKLITHGPSRDSALA
RMRTALSEIVVSGIGTNISLQQEIIGDAAFRAGGTDIHYLEKKLALD

Sequences:

>Translated_447_residues
MQKILIANRGEIALRILRACRELGIRSVAVHSAADRELKHVRLADESVCIGPNNVRDSYLNIPAIIAAAEVTDSTAIHPG
YGFLSENADFAERVEQSGFVFIGPRAESIRTMGDKVSAIRAMKEAGVPCVPGSNGPVPDDDPDETLRIASEIGYPIMIKA
ASGGGGRGMRVVRSEAALLNAVSLTRGEAENAFGDGTVYMEKYLEKPRHIEVQVLADHHGNAIHLGERDCSMQRRHQKVV
EEAPAPGITEAQRRDIGERCAEACRQMGYRGAGTFEFLYENGEFYFIEMNTRIQVEHPVTEMVTGCDLVAEQIRIASGEP
LSWRQEDIQVRGHAVECRINAEDPKTLMPCPGTIDHFHAPGGPGVRVDSHVYTGYAVPPYFDSMIGKLITHGPSRDSALA
RMRTALSEIVVSGIGTNISLQQEIIGDAAFRAGGTDIHYLEKKLALD
>Mature_447_residues
MQKILIANRGEIALRILRACRELGIRSVAVHSAADRELKHVRLADESVCIGPNNVRDSYLNIPAIIAAAEVTDSTAIHPG
YGFLSENADFAERVEQSGFVFIGPRAESIRTMGDKVSAIRAMKEAGVPCVPGSNGPVPDDDPDETLRIASEIGYPIMIKA
ASGGGGRGMRVVRSEAALLNAVSLTRGEAENAFGDGTVYMEKYLEKPRHIEVQVLADHHGNAIHLGERDCSMQRRHQKVV
EEAPAPGITEAQRRDIGERCAEACRQMGYRGAGTFEFLYENGEFYFIEMNTRIQVEHPVTEMVTGCDLVAEQIRIASGEP
LSWRQEDIQVRGHAVECRINAEDPKTLMPCPGTIDHFHAPGGPGVRVDSHVYTGYAVPPYFDSMIGKLITHGPSRDSALA
RMRTALSEIVVSGIGTNISLQQEIIGDAAFRAGGTDIHYLEKKLALD

Specific function: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA [H]

COG id: COG0439

COG function: function code I; Biotin carboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotin carboxylation domain [H]

Homologues:

Organism=Homo sapiens, GI116805327, Length=444, Percent_Identity=47.2972972972973, Blast_Score=416, Evalue=1e-116,
Organism=Homo sapiens, GI189095269, Length=442, Percent_Identity=48.868778280543, Blast_Score=416, Evalue=1e-116,
Organism=Homo sapiens, GI65506442, Length=442, Percent_Identity=48.868778280543, Blast_Score=416, Evalue=1e-116,
Organism=Homo sapiens, GI295821183, Length=442, Percent_Identity=48.868778280543, Blast_Score=416, Evalue=1e-116,
Organism=Homo sapiens, GI106049528, Length=450, Percent_Identity=45.1111111111111, Blast_Score=372, Evalue=1e-103,
Organism=Homo sapiens, GI106049295, Length=450, Percent_Identity=45.1111111111111, Blast_Score=372, Evalue=1e-103,
Organism=Homo sapiens, GI106049292, Length=450, Percent_Identity=45.1111111111111, Blast_Score=372, Evalue=1e-103,
Organism=Homo sapiens, GI38679974, Length=508, Percent_Identity=31.496062992126, Blast_Score=248, Evalue=1e-65,
Organism=Homo sapiens, GI38679977, Length=508, Percent_Identity=31.496062992126, Blast_Score=248, Evalue=1e-65,
Organism=Homo sapiens, GI38679967, Length=508, Percent_Identity=31.496062992126, Blast_Score=248, Evalue=1e-65,
Organism=Homo sapiens, GI38679960, Length=508, Percent_Identity=31.496062992126, Blast_Score=248, Evalue=1e-65,
Organism=Homo sapiens, GI38679971, Length=508, Percent_Identity=31.496062992126, Blast_Score=248, Evalue=1e-65,
Organism=Homo sapiens, GI134142062, Length=510, Percent_Identity=31.5686274509804, Blast_Score=237, Evalue=2e-62,
Organism=Escherichia coli, GI1789654, Length=446, Percent_Identity=71.52466367713, Blast_Score=648, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71987519, Length=444, Percent_Identity=46.8468468468468, Blast_Score=396, Evalue=1e-110,
Organism=Caenorhabditis elegans, GI17567343, Length=442, Percent_Identity=45.0226244343891, Blast_Score=387, Evalue=1e-108,
Organism=Caenorhabditis elegans, GI17562816, Length=449, Percent_Identity=44.7661469933185, Blast_Score=355, Evalue=2e-98,
Organism=Caenorhabditis elegans, GI71997168, Length=515, Percent_Identity=27.7669902912621, Blast_Score=202, Evalue=2e-52,
Organism=Caenorhabditis elegans, GI71997163, Length=515, Percent_Identity=27.7669902912621, Blast_Score=202, Evalue=3e-52,
Organism=Caenorhabditis elegans, GI133931226, Length=490, Percent_Identity=28.3673469387755, Blast_Score=199, Evalue=3e-51,
Organism=Saccharomyces cerevisiae, GI6319685, Length=430, Percent_Identity=43.4883720930233, Blast_Score=355, Evalue=8e-99,
Organism=Saccharomyces cerevisiae, GI6319695, Length=441, Percent_Identity=45.3514739229025, Blast_Score=339, Evalue=4e-94,
Organism=Saccharomyces cerevisiae, GI6321376, Length=441, Percent_Identity=45.3514739229025, Blast_Score=332, Evalue=8e-92,
Organism=Saccharomyces cerevisiae, GI6324343, Length=492, Percent_Identity=33.5365853658537, Blast_Score=239, Evalue=7e-64,
Organism=Saccharomyces cerevisiae, GI6323863, Length=455, Percent_Identity=33.6263736263736, Blast_Score=228, Evalue=2e-60,
Organism=Drosophila melanogaster, GI24651757, Length=449, Percent_Identity=46.1024498886414, Blast_Score=401, Evalue=1e-112,
Organism=Drosophila melanogaster, GI24652212, Length=449, Percent_Identity=46.3251670378619, Blast_Score=370, Evalue=1e-102,
Organism=Drosophila melanogaster, GI24652210, Length=449, Percent_Identity=46.3251670378619, Blast_Score=370, Evalue=1e-102,
Organism=Drosophila melanogaster, GI24652214, Length=449, Percent_Identity=46.3251670378619, Blast_Score=370, Evalue=1e-102,
Organism=Drosophila melanogaster, GI19921944, Length=449, Percent_Identity=46.3251670378619, Blast_Score=370, Evalue=1e-102,
Organism=Drosophila melanogaster, GI24652216, Length=449, Percent_Identity=46.3251670378619, Blast_Score=370, Evalue=1e-102,
Organism=Drosophila melanogaster, GI281363050, Length=449, Percent_Identity=46.3251670378619, Blast_Score=370, Evalue=1e-102,
Organism=Drosophila melanogaster, GI24652224, Length=449, Percent_Identity=46.3251670378619, Blast_Score=370, Evalue=1e-102,
Organism=Drosophila melanogaster, GI24652222, Length=449, Percent_Identity=46.3251670378619, Blast_Score=370, Evalue=1e-102,
Organism=Drosophila melanogaster, GI24652220, Length=449, Percent_Identity=46.3251670378619, Blast_Score=370, Evalue=1e-102,
Organism=Drosophila melanogaster, GI24652218, Length=449, Percent_Identity=46.3251670378619, Blast_Score=370, Evalue=1e-102,
Organism=Drosophila melanogaster, GI24651759, Length=410, Percent_Identity=45.3658536585366, Blast_Score=360, Evalue=1e-99,
Organism=Drosophila melanogaster, GI161076409, Length=503, Percent_Identity=30.0198807157058, Blast_Score=219, Evalue=2e-57,
Organism=Drosophila melanogaster, GI24586458, Length=503, Percent_Identity=30.0198807157058, Blast_Score=219, Evalue=3e-57,
Organism=Drosophila melanogaster, GI161076407, Length=503, Percent_Identity=30.0198807157058, Blast_Score=219, Evalue=3e-57,
Organism=Drosophila melanogaster, GI24586460, Length=503, Percent_Identity=30.0198807157058, Blast_Score=219, Evalue=3e-57,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004549
- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2 [H]

EC number: =6.3.4.14; =6.4.1.2 [H]

Molecular weight: Translated: 48724; Mature: 48724

Theoretical pI: Translated: 5.73; Mature: 5.73

Prosite motif: PS50975 ATP_GRASP ; PS00866 CPSASE_1 ; PS00867 CPSASE_2 ; PS50979 BC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQKILIANRGEIALRILRACRELGIRSVAVHSAADRELKHVRLADESVCIGPNNVRDSYL
CCEEEEECCCHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHEEECCCEEEECCCCCCHHHC
NIPAIIAAAEVTDSTAIHPGYGFLSENADFAERVEQSGFVFIGPRAESIRTMGDKVSAIR
CCCHHEEEECCCCCCEECCCCCCCCCCCHHHHHHHHCCEEEECCCHHHHHHHHHHHHHHH
AMKEAGVPCVPGSNGPVPDDDPDETLRIASEIGYPIMIKAASGGGGRGMRVVRSEAALLN
HHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCEEEEEEECCCCCCCHHHHHHHHHHHH
AVSLTRGEAENAFGDGTVYMEKYLEKPRHIEVQVLADHHGNAIHLGERDCSMQRRHQKVV
HHHHCCCCCCCCCCCCHHHHHHHHCCCCCEEEEEEECCCCCEEEECCCCHHHHHHHHHHH
EEAPAPGITEAQRRDIGERCAEACRQMGYRGAGTFEFLYENGEFYFIEMNTRIQVEHPVT
HHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCEEEEEECCEEEECCCHH
EMVTGCDLVAEQIRIASGEPLSWRQEDIQVRGHAVECRINAEDPKTLMPCPGTIDHFHAP
HHHHHHHHHHHHHHHCCCCCCCCCCCCCEEECEEEEEEECCCCCCEECCCCCCCCCCCCC
GGPGVRVDSHVYTGYAVPPYFDSMIGKLITHGPSRDSALARMRTALSEIVVSGIGTNISL
CCCCCEECCEEEECCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCH
QQEIIGDAAFRAGGTDIHYLEKKLALD
HHHHHHHHHHCCCCCCHHHHHHHHCCC
>Mature Secondary Structure
MQKILIANRGEIALRILRACRELGIRSVAVHSAADRELKHVRLADESVCIGPNNVRDSYL
CCEEEEECCCHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHEEECCCEEEECCCCCCHHHC
NIPAIIAAAEVTDSTAIHPGYGFLSENADFAERVEQSGFVFIGPRAESIRTMGDKVSAIR
CCCHHEEEECCCCCCEECCCCCCCCCCCHHHHHHHHCCEEEECCCHHHHHHHHHHHHHHH
AMKEAGVPCVPGSNGPVPDDDPDETLRIASEIGYPIMIKAASGGGGRGMRVVRSEAALLN
HHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCEEEEEEECCCCCCCHHHHHHHHHHHH
AVSLTRGEAENAFGDGTVYMEKYLEKPRHIEVQVLADHHGNAIHLGERDCSMQRRHQKVV
HHHHCCCCCCCCCCCCHHHHHHHHCCCCCEEEEEEECCCCCEEEECCCCHHHHHHHHHHH
EEAPAPGITEAQRRDIGERCAEACRQMGYRGAGTFEFLYENGEFYFIEMNTRIQVEHPVT
HHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCEEEEEECCEEEECCCHH
EMVTGCDLVAEQIRIASGEPLSWRQEDIQVRGHAVECRINAEDPKTLMPCPGTIDHFHAP
HHHHHHHHHHHHHHHCCCCCCCCCCCCCEEECEEEEEEECCCCCCEECCCCCCCCCCCCC
GGPGVRVDSHVYTGYAVPPYFDSMIGKLITHGPSRDSALARMRTALSEIVVSGIGTNISL
CCCCCEECCEEEECCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCH
QQEIIGDAAFRAGGTDIHYLEKKLALD
HHHHHHHHHHCCCCCCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9560425 [H]