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The map label for this gene is coaBC [H]

Identifier: 121999077

GI number: 121999077

Start: 2526851

End: 2528080

Strand: Reverse

Name: coaBC [H]

Synonym: Hhal_2299

Alternate gene names: 121999077

Gene position: 2528080-2526851 (Counterclockwise)

Preceding gene: 121999080

Following gene: 121999076

Centisome position: 94.39

GC content: 72.93

Gene sequence:

>1230_bases
ATGTCTTTGCCGAGCCGACCGATCCGCATCCTGCTCGTGGTGACCGGCGGGATCGCCGCCTACAAGGCCGCTGACCTGGT
GCGCGAGCTGCGCCGCGGCGGTGCCGACGTGCGCGTGGTGATGACCGCGGCCGCGCAGCACTTCGTCACCCCGCTGACCT
TCCAGGCCCTGTCCGGCCACCGCGTCCATACCGATCTGCTGGATCCGGATGCCGAGGCGGGGATGGGCCATATCGAGCTG
GCGCGCTGGCCGGATCGCATCGTCGTGGCACCCGCCACCGCGGATTTCCTGGCACGCCTGGCCCAGGGGCGCGCGGACGA
CCTGCCGGCGGCGCTGTGCCTGGCCTCGCGGGCGCCGATCATGGTGGCCCCGGCCATGAACCACGTCATGTGGGAGGCGG
GGGCGACCCGCGAAAACCTGGCGACCCTGCACCGCCGCGGCGTGGCGTGTATCGGCCCCGAGGTTGGTGAACAGGCCTGC
GGGGAGTCTGGCGAGGGGCGCATGTCCGATCCGGCGGCCATCGCCGCGGCCCTCCTCGATGCCGGGGGCGCCGCCGGGCC
GTGGGCCGGGCGCACGGTGCTGATCACCGCCGGCCCCACCCGCGAGCCCCTCGACCCGGTACGGTACCTGACCAATCGCA
GCTCCGGCCGGATGGGCTTCGCCCTGGCGGCCGCCGCCCGTGAGGCTGGCGCCCGGGTGATCCTCGTGGCCGGCCCCACG
GCGCTGGCCACGCCCCCGGGCGTGGAGCGAGTCGATGTCGAGCGGGCCGGGCAGATGTACGATGCCGTGCTCGGTTGTAT
CGATGAGGCGGACTGCTTCATCGCCGCCGCAGCCGTGAGCGACTATCGGCCCGAGCGCGAGGCGCCTGAGAAGATCAAGA
AAGGCGGGGACGCCCTGACCCTGGCCCTGGAGCCCACGCCGGATACCTTGCGGGCCGTGGCGGCCCGCTCGCCCCGGCCC
TTCGTGGTGGGGTTCGCCGCCGAGACCGAGCGCGTCAGCGAGTACGCCCGGCGCAAGCTCAACGACAAGGATCTCGACCT
GATCGCCGCCAACCGCGTCGGTCCGGGTCAGGGGTTCGATACCGACGACAACGCCCTGGAAGTCCTCTGGCGCGACGGCA
GCGTCGCCCTGGCCGAGCAGCCCAAGACGGCACTGGCCCGGGAGCTGCTGCAGATCGTGGCCGAGCGCGCCGGGTTCGCG
GAGGCAACGAGGAGCCACCATGCACCGTAG

Upstream 100 bases:

>100_bases
AATGGGATGAAACGATAGAATGCGGCCCATGATGGAACCCCATCGGCTAGCGGTGTAGCGCAGTCGCGCGCCGCCTGCAC
GGATCTGCGACAATACGCGT

Downstream 100 bases:

>100_bases
GATCGAAGCACGCATCGTCGATGCACGTCTCGGCAGCGAGATCCCGCTGCCTGACTACGCCACCGACGGCTCGGCCGCCA
TCGACCTGCGGGCCTGCCTG

Product: phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase

Products: NA

Alternate protein names: DNA/pantothenate metabolism flavoprotein; Phosphopantothenoylcysteine decarboxylase; PPCDC; CoaC; Phosphopantothenate--cysteine ligase; CoaB; PPC synthetase; PPCS; Phosphopantothenoylcysteine synthase [H]

Number of amino acids: Translated: 409; Mature: 408

Protein sequence:

>409_residues
MSLPSRPIRILLVVTGGIAAYKAADLVRELRRGGADVRVVMTAAAQHFVTPLTFQALSGHRVHTDLLDPDAEAGMGHIEL
ARWPDRIVVAPATADFLARLAQGRADDLPAALCLASRAPIMVAPAMNHVMWEAGATRENLATLHRRGVACIGPEVGEQAC
GESGEGRMSDPAAIAAALLDAGGAAGPWAGRTVLITAGPTREPLDPVRYLTNRSSGRMGFALAAAAREAGARVILVAGPT
ALATPPGVERVDVERAGQMYDAVLGCIDEADCFIAAAAVSDYRPEREAPEKIKKGGDALTLALEPTPDTLRAVAARSPRP
FVVGFAAETERVSEYARRKLNDKDLDLIAANRVGPGQGFDTDDNALEVLWRDGSVALAEQPKTALARELLQIVAERAGFA
EATRSHHAP

Sequences:

>Translated_409_residues
MSLPSRPIRILLVVTGGIAAYKAADLVRELRRGGADVRVVMTAAAQHFVTPLTFQALSGHRVHTDLLDPDAEAGMGHIEL
ARWPDRIVVAPATADFLARLAQGRADDLPAALCLASRAPIMVAPAMNHVMWEAGATRENLATLHRRGVACIGPEVGEQAC
GESGEGRMSDPAAIAAALLDAGGAAGPWAGRTVLITAGPTREPLDPVRYLTNRSSGRMGFALAAAAREAGARVILVAGPT
ALATPPGVERVDVERAGQMYDAVLGCIDEADCFIAAAAVSDYRPEREAPEKIKKGGDALTLALEPTPDTLRAVAARSPRP
FVVGFAAETERVSEYARRKLNDKDLDLIAANRVGPGQGFDTDDNALEVLWRDGSVALAEQPKTALARELLQIVAERAGFA
EATRSHHAP
>Mature_408_residues
SLPSRPIRILLVVTGGIAAYKAADLVRELRRGGADVRVVMTAAAQHFVTPLTFQALSGHRVHTDLLDPDAEAGMGHIELA
RWPDRIVVAPATADFLARLAQGRADDLPAALCLASRAPIMVAPAMNHVMWEAGATRENLATLHRRGVACIGPEVGEQACG
ESGEGRMSDPAAIAAALLDAGGAAGPWAGRTVLITAGPTREPLDPVRYLTNRSSGRMGFALAAAAREAGARVILVAGPTA
LATPPGVERVDVERAGQMYDAVLGCIDEADCFIAAAAVSDYRPEREAPEKIKKGGDALTLALEPTPDTLRAVAARSPRPF
VVGFAAETERVSEYARRKLNDKDLDLIAANRVGPGQGFDTDDNALEVLWRDGSVALAEQPKTALARELLQIVAERAGFAE
ATRSHHAP

Specific function: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine [H]

COG id: COG0452

COG function: function code H; Phosphopantothenoylcysteine synthetase/decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PPC synthetase family [H]

Homologues:

Organism=Homo sapiens, GI71725351, Length=180, Percent_Identity=31.6666666666667, Blast_Score=74, Evalue=2e-13,
Organism=Escherichia coli, GI87082301, Length=409, Percent_Identity=51.8337408312958, Blast_Score=373, Evalue=1e-104,
Organism=Caenorhabditis elegans, GI17560194, Length=180, Percent_Identity=31.6666666666667, Blast_Score=69, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005252
- InterPro:   IPR007085
- InterPro:   IPR003382 [H]

Pfam domain/function: PF04127 DFP; PF02441 Flavoprotein [H]

EC number: =4.1.1.36; =6.3.2.5 [H]

Molecular weight: Translated: 43120; Mature: 42988

Theoretical pI: Translated: 5.91; Mature: 5.91

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLPSRPIRILLVVTGGIAAYKAADLVRELRRGGADVRVVMTAAAQHFVTPLTFQALSGH
CCCCCCCEEEEEEEECCHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHCHHHHHHCCCC
RVHTDLLDPDAEAGMGHIELARWPDRIVVAPATADFLARLAQGRADDLPAALCLASRAPI
EEECCCCCCCHHCCCCEEEEECCCCEEEEECCHHHHHHHHHCCCCCCCHHHHHHHCCCCE
MVAPAMNHVMWEAGATRENLATLHRRGVACIGPEVGEQACGESGEGRMSDPAAIAAALLD
EEECCHHHHHHCCCCCHHHHHHHHHCCCEEECCHHHHHHCCCCCCCCCCCHHHHHHHHHH
AGGAAGPWAGRTVLITAGPTREPLDPVRYLTNRSSGRMGFALAAAAREAGARVILVAGPT
CCCCCCCCCCCEEEEECCCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHCCCEEEEEECCC
ALATPPGVERVDVERAGQMYDAVLGCIDEADCFIAAAAVSDYRPEREAPEKIKKGGDALT
CCCCCCCCCEECHHHHHHHHHHHHHHHCCCHHHEEHHHHHHCCCCCCCHHHHHCCCCEEE
LALEPTPDTLRAVAARSPRPFVVGFAAETERVSEYARRKLNDKDLDLIAANRVGPGQGFD
EEECCCHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCC
TDDNALEVLWRDGSVALAEQPKTALARELLQIVAERAGFAEATRSHHAP
CCCCEEEEEEECCCEEECCCCHHHHHHHHHHHHHHHCCHHHHHHHCCCC
>Mature Secondary Structure 
SLPSRPIRILLVVTGGIAAYKAADLVRELRRGGADVRVVMTAAAQHFVTPLTFQALSGH
CCCCCCEEEEEEEECCHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHCHHHHHHCCCC
RVHTDLLDPDAEAGMGHIELARWPDRIVVAPATADFLARLAQGRADDLPAALCLASRAPI
EEECCCCCCCHHCCCCEEEEECCCCEEEEECCHHHHHHHHHCCCCCCCHHHHHHHCCCCE
MVAPAMNHVMWEAGATRENLATLHRRGVACIGPEVGEQACGESGEGRMSDPAAIAAALLD
EEECCHHHHHHCCCCCHHHHHHHHHCCCEEECCHHHHHHCCCCCCCCCCCHHHHHHHHHH
AGGAAGPWAGRTVLITAGPTREPLDPVRYLTNRSSGRMGFALAAAAREAGARVILVAGPT
CCCCCCCCCCCEEEEECCCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHCCCEEEEEECCC
ALATPPGVERVDVERAGQMYDAVLGCIDEADCFIAAAAVSDYRPEREAPEKIKKGGDALT
CCCCCCCCCEECHHHHHHHHHHHHHHHCCCHHHEEHHHHHHCCCCCCCHHHHHCCCCEEE
LALEPTPDTLRAVAARSPRPFVVGFAAETERVSEYARRKLNDKDLDLIAANRVGPGQGFD
EEECCCHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCC
TDDNALEVLWRDGSVALAEQPKTALARELLQIVAERAGFAEATRSHHAP
CCCCEEEEEEECCCEEECCCCHHHHHHHHHHHHHHHCCHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]