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The map label for this gene is lpxC

Identifier: 121998863

GI number: 121998863

Start: 2287625

End: 2288527

Strand: Reverse

Name: lpxC

Synonym: Hhal_2084

Alternate gene names: 121998863

Gene position: 2288527-2287625 (Counterclockwise)

Preceding gene: 121998864

Following gene: 121998862

Centisome position: 85.44

GC content: 64.56

Gene sequence:

>903_bases
ATGATCCGTCAACGCACCTTGAAGAACAGCATCCGCGCGACCGGCGTGGGCCTGCACACCGGCGAGAAGGTCTACCTGAC
CCTCCGTCCGGCTCCGGCCAATGCGGGGATCATATTCCGGCGCACTGATCTCGACCGCGAGATCAAGGCAACCGCCGCTG
CCGTGGGCGACACCCGCCTGTCCACCTGCCTGGTGGAAGACGGGGTGCGGGTTTCCACCGTCGAGCACCTGCTGTCGGCG
CTGGCCGGGCTGGGGATCGACAACTGCTATGTCGATCTCTCCGCGGCCGAGGTGCCGATCATGGACGGCAGTGCGGCGCC
CTTTGTCTTCCTGGTGCGCTCCGCAGGGATCAAGGAGCAGGAGGCGCCCAAGCGCTTCGTGCGCATCCTGGAGCCGGTCC
AGGTTGTTGATGGTGACAAGTGGGTGGCCTTCGAGCCCTTCGAGGGCTTCAAGGTCAGCTTCACCATCGATTTCGACCAC
CCGGTCTTCCTCGATCAGCACGCCCGTGCCGAGGTGGATTTCTCCTCGACCTCCTTCATCAAGGAGGTCAGCCGTGCGCG
GACCTTCGGCTTCATGAAGGAGATCGAGGCCCTGCGGGCCTCCCGGCTGGCCCTCGGTGGCAGCCTCGACAACGCCATCG
TGGTCGACGACTACCGGGTGCTGAACGAGGACGGGTTGCGGTACCGGGACGAGTTCGTCAAGCACAAGATCCTCGACGCC
ATCGGCGACCTTTACCTCTTGGGTAGCAGCCTGATCGGCTCGTTCCACGGGCACAAGTCCGGGCACGCCCTCAATAACCG
CCTCCTGCGCAAGCTGCTCGAGCACGAGCACGCCTGGGAGGAGGTGACCTTTGAGGAGCTGGACGAATTGCCCATCGCCT
ACGATCAGCCGGTGGTGGCCTGA

Upstream 100 bases:

>100_bases
ACGTCTTGCCGCTACCAAAGGGTGAAGGCGGTGTGTCCGGTCGCGCGGGTTGCGTCTGAGCACACAAGTAGCCGCATGAG
CAGTGGAGCCGAGCCGAGCC

Downstream 100 bases:

>100_bases
GCGCCGCAGCAGCTTGCGGTCCAGGCCGGCCAGCCGGTAGGGTGTAGCTTTCTACCTGAAAGCTGGCTATGGATCTCTCG
CTAACCCGCGCGATTCTCTT

Product: UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase

Products: NA

Alternate protein names: UDP-3-O-acyl-GlcNAc deacetylase

Number of amino acids: Translated: 300; Mature: 300

Protein sequence:

>300_residues
MIRQRTLKNSIRATGVGLHTGEKVYLTLRPAPANAGIIFRRTDLDREIKATAAAVGDTRLSTCLVEDGVRVSTVEHLLSA
LAGLGIDNCYVDLSAAEVPIMDGSAAPFVFLVRSAGIKEQEAPKRFVRILEPVQVVDGDKWVAFEPFEGFKVSFTIDFDH
PVFLDQHARAEVDFSSTSFIKEVSRARTFGFMKEIEALRASRLALGGSLDNAIVVDDYRVLNEDGLRYRDEFVKHKILDA
IGDLYLLGSSLIGSFHGHKSGHALNNRLLRKLLEHEHAWEEVTFEELDELPIAYDQPVVA

Sequences:

>Translated_300_residues
MIRQRTLKNSIRATGVGLHTGEKVYLTLRPAPANAGIIFRRTDLDREIKATAAAVGDTRLSTCLVEDGVRVSTVEHLLSA
LAGLGIDNCYVDLSAAEVPIMDGSAAPFVFLVRSAGIKEQEAPKRFVRILEPVQVVDGDKWVAFEPFEGFKVSFTIDFDH
PVFLDQHARAEVDFSSTSFIKEVSRARTFGFMKEIEALRASRLALGGSLDNAIVVDDYRVLNEDGLRYRDEFVKHKILDA
IGDLYLLGSSLIGSFHGHKSGHALNNRLLRKLLEHEHAWEEVTFEELDELPIAYDQPVVA
>Mature_300_residues
MIRQRTLKNSIRATGVGLHTGEKVYLTLRPAPANAGIIFRRTDLDREIKATAAAVGDTRLSTCLVEDGVRVSTVEHLLSA
LAGLGIDNCYVDLSAAEVPIMDGSAAPFVFLVRSAGIKEQEAPKRFVRILEPVQVVDGDKWVAFEPFEGFKVSFTIDFDH
PVFLDQHARAEVDFSSTSFIKEVSRARTFGFMKEIEALRASRLALGGSLDNAIVVDDYRVLNEDGLRYRDEFVKHKILDA
IGDLYLLGSSLIGSFHGHKSGHALNNRLLRKLLEHEHAWEEVTFEELDELPIAYDQPVVA

Specific function: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell

COG id: COG0774

COG function: function code M; UDP-3-O-acyl-N-acetylglucosamine deacetylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxC family

Homologues:

Organism=Escherichia coli, GI1786285, Length=300, Percent_Identity=60.3333333333333, Blast_Score=377, Evalue=1e-106,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXC_HALHL (A1WYT6)

Other databases:

- EMBL:   CP000544
- RefSeq:   YP_001003650.1
- ProteinModelPortal:   A1WYT6
- SMR:   A1WYT6
- STRING:   A1WYT6
- GeneID:   4710088
- GenomeReviews:   CP000544_GR
- KEGG:   hha:Hhal_2084
- eggNOG:   COG0774
- HOGENOM:   HBG482342
- OMA:   KAYKSGH
- PhylomeDB:   A1WYT6
- ProtClustDB:   PRK13186
- BioCyc:   HHAL349124:HHAL_2084-MONOMER
- HAMAP:   MF_00388
- InterPro:   IPR020568
- InterPro:   IPR004463
- InterPro:   IPR011334
- InterPro:   IPR015870
- Gene3D:   G3DSA:3.30.1700.10
- Gene3D:   G3DSA:3.30.230.20
- TIGRFAMs:   TIGR00325

Pfam domain/function: PF03331 LpxC; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: 3.5.1.-

Molecular weight: Translated: 33333; Mature: 33333

Theoretical pI: Translated: 5.60; Mature: 5.60

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIRQRTLKNSIRATGVGLHTGEKVYLTLRPAPANAGIIFRRTDLDREIKATAAAVGDTRL
CCCHHHHHHHHHHCCCEEECCCEEEEEEECCCCCCCEEEEECCCCHHHHHHHHHHCCHHH
STCLVEDGVRVSTVEHLLSALAGLGIDNCYVDLSAAEVPIMDGSAAPFVFLVRSAGIKEQ
HHHHHHCCCCHHHHHHHHHHHHHCCCCCEEEEECCCEEEEECCCCCCCEEEEECCCCCHH
EAPKRFVRILEPVQVVDGDKWVAFEPFEGFKVSFTIDFDHPVFLDQHARAEVDFSSTSFI
HHHHHHHHHHCCHHEECCCEEEEECCCCCEEEEEEEECCCCEEECCCCCCEECCCHHHHH
KEVSRARTFGFMKEIEALRASRLALGGSLDNAIVVDDYRVLNEDGLRYRDEFVKHKILDA
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECEEEECCCCCHHHHHHHHHHHHHH
IGDLYLLGSSLIGSFHGHKSGHALNNRLLRKLLEHEHAWEEVTFEELDELPIAYDQPVVA
HHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCCCCCC
>Mature Secondary Structure
MIRQRTLKNSIRATGVGLHTGEKVYLTLRPAPANAGIIFRRTDLDREIKATAAAVGDTRL
CCCHHHHHHHHHHCCCEEECCCEEEEEEECCCCCCCEEEEECCCCHHHHHHHHHHCCHHH
STCLVEDGVRVSTVEHLLSALAGLGIDNCYVDLSAAEVPIMDGSAAPFVFLVRSAGIKEQ
HHHHHHCCCCHHHHHHHHHHHHHCCCCCEEEEECCCEEEEECCCCCCCEEEEECCCCCHH
EAPKRFVRILEPVQVVDGDKWVAFEPFEGFKVSFTIDFDHPVFLDQHARAEVDFSSTSFI
HHHHHHHHHHCCHHEECCCEEEEECCCCCEEEEEEEECCCCEEECCCCCCEECCCHHHHH
KEVSRARTFGFMKEIEALRASRLALGGSLDNAIVVDDYRVLNEDGLRYRDEFVKHKILDA
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECEEEECCCCCHHHHHHHHHHHHHH
IGDLYLLGSSLIGSFHGHKSGHALNNRLLRKLLEHEHAWEEVTFEELDELPIAYDQPVVA
HHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on carbon-nitrogen bonds, other than peptide bonds; In linear amides [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA