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The map label for this gene is mrpD [H]

Identifier: 121998811

GI number: 121998811

Start: 2234576

End: 2236090

Strand: Reverse

Name: mrpD [H]

Synonym: Hhal_2032

Alternate gene names: 121998811

Gene position: 2236090-2234576 (Counterclockwise)

Preceding gene: 121998812

Following gene: 121998810

Centisome position: 83.48

GC content: 66.6

Gene sequence:

>1515_bases
GTGAGTCTGCAAGTCGCCATACCGGTACTGCTGCCCCTGCTGCTGGGCGCCGTCTCGCTGGCGGCCCACCGCCACCTGAC
CGTGCAGCGTTGGCTCGGGGTGCTCGGCACCGGCGCGCTGCTGGTCAGCACCCTGTGGCTGCTGCACACGGTCTGGCACG
AGGGTGTGGTGGTGATGCACATGGGCGACTGGAAGGCGCCCTTCGGCATCACCCTAGTCGCCGATCTGCTCGGCGCCATC
ATGGCGGTGCTCACCGGCATCATGGGTTTCGCCACCGCCGTCTATTCGACGGCCACCACGCCGCGCGGGCACGAGCACTA
CGGCCACTGGCCGTTGCTGCACCTGCTGCTGGCCGGTGTCGCCGGCGCCTTCCTGACCGGCGACGTCTTCAACCTCTACG
TCTGGTTCGAGGTGATGCTGGTCGCCTCGTTCGCCCTGCTGATCCTCGGCGGCGAGCGGGCGCAGATGGAGGGGGCGATC
AAGTACGTCACCCTCAACCTGCTCTCCTCGATGATCTTCCTCTCGGCGGTGGGCATCACCTACGGCCTGGTCGGTACGCT
GAACATGGCCGACATGGCGGTGAAGCTCGCCGAGGTGGATCAGCCCGGCCTGGTGACGGTGCTGGCGGCCATGTACATGG
TCTCGTTCGGCATCAAGGCCGGCGCCTTCCCGCTCTTCTTCTGGCTGCCGGCGAGTTACCACACCCCGCCGATCGCCATC
TCGGCGCTGTTCGCCGGTCTGCTGACCAAGGTGGGTGTCTACGCCCTGTACCGGGTGTTCACGCTGATCTTCACCCAGGA
CGTGGCGTTCACCCACGAGATCCTGCTCTGGGCGGCCGGCTTCACCATGATCACCGGCGTGCTGGGTGCGGCGTACCACT
ACGAGATCCGCCGCATCCTGTCGTTCCACATCATCAGCCAGATCGGCTACATGATCATGGGCCTGGCGCTGTTCACGCCC
CTGGCCCTGGTCGGTGGTGTCTTCTACATCGCCCACCACATCATCGTGAAGACCAACCTGTTCCTGGTCGCCGGCGTGGC
CTACCGCATGCTGGGCAGCTACGAGCTACGCGATCTGGGCGGGCTGTACAAGCACCGGCCGTTCCTGGCCCTGCTCTTCG
CCGTGCCGGCGCTCTCCCTGGCCGGTCTGCCGCCGCTGTCCGGGTTCATCGCCAAGCTGATCGTCATCTGGGCCGCCGTC
GAGCAGGCCTCCTGGGGGATCACCTTCGTGGCCCTGCTCACGGGTCTGCTGACGCTCTACTCGATGACCAAGATCTGGCA
GGAGGCGTTCTGGCACGGGGTGCCGGAGCATGTGCAGGATACTTCGGTCCTGACCGGCGAGAAGCGCGACCCGGGGCTGT
GGGCCATGTACCTGCCCATCGCCGGGCTGGCTGTGCTGACCCTGTTCATCGGTCTCTACGCCCAGCCGCTCTACGAGCTG
GCCGAGGCCTCCGCCGAGCAGCTGCTTGACCCGCAGGTCTACATCGACGCCGTGCTGGAGGAGGGTGCGCCGTGA

Upstream 100 bases:

>100_bases
TGATCGCCTTCGGCGTACTGGCCTTTGCGCTGGTCCTGATCAACAAGGCGTATCAGGTGGTGCAGGCCGATGACCTGGAT
CAGATGAAGGATACGGACAC

Downstream 100 bases:

>100_bases
TCCCATTCGCCTGGAACGTCGTCCTGGCCATGGTCTGGGTGGTGCTGACCGCCAACTTCAGTGCGGTCAACGCCCTGTTC
GGCTTCCTGCTCGGCTATGG

Product: NADH dehydrogenase (quinone)

Products: NA

Alternate protein names: Mrp complex subunit D; Multiple resistance and pH homeostasis protein D [H]

Number of amino acids: Translated: 504; Mature: 503

Protein sequence:

>504_residues
MSLQVAIPVLLPLLLGAVSLAAHRHLTVQRWLGVLGTGALLVSTLWLLHTVWHEGVVVMHMGDWKAPFGITLVADLLGAI
MAVLTGIMGFATAVYSTATTPRGHEHYGHWPLLHLLLAGVAGAFLTGDVFNLYVWFEVMLVASFALLILGGERAQMEGAI
KYVTLNLLSSMIFLSAVGITYGLVGTLNMADMAVKLAEVDQPGLVTVLAAMYMVSFGIKAGAFPLFFWLPASYHTPPIAI
SALFAGLLTKVGVYALYRVFTLIFTQDVAFTHEILLWAAGFTMITGVLGAAYHYEIRRILSFHIISQIGYMIMGLALFTP
LALVGGVFYIAHHIIVKTNLFLVAGVAYRMLGSYELRDLGGLYKHRPFLALLFAVPALSLAGLPPLSGFIAKLIVIWAAV
EQASWGITFVALLTGLLTLYSMTKIWQEAFWHGVPEHVQDTSVLTGEKRDPGLWAMYLPIAGLAVLTLFIGLYAQPLYEL
AEASAEQLLDPQVYIDAVLEEGAP

Sequences:

>Translated_504_residues
MSLQVAIPVLLPLLLGAVSLAAHRHLTVQRWLGVLGTGALLVSTLWLLHTVWHEGVVVMHMGDWKAPFGITLVADLLGAI
MAVLTGIMGFATAVYSTATTPRGHEHYGHWPLLHLLLAGVAGAFLTGDVFNLYVWFEVMLVASFALLILGGERAQMEGAI
KYVTLNLLSSMIFLSAVGITYGLVGTLNMADMAVKLAEVDQPGLVTVLAAMYMVSFGIKAGAFPLFFWLPASYHTPPIAI
SALFAGLLTKVGVYALYRVFTLIFTQDVAFTHEILLWAAGFTMITGVLGAAYHYEIRRILSFHIISQIGYMIMGLALFTP
LALVGGVFYIAHHIIVKTNLFLVAGVAYRMLGSYELRDLGGLYKHRPFLALLFAVPALSLAGLPPLSGFIAKLIVIWAAV
EQASWGITFVALLTGLLTLYSMTKIWQEAFWHGVPEHVQDTSVLTGEKRDPGLWAMYLPIAGLAVLTLFIGLYAQPLYEL
AEASAEQLLDPQVYIDAVLEEGAP
>Mature_503_residues
SLQVAIPVLLPLLLGAVSLAAHRHLTVQRWLGVLGTGALLVSTLWLLHTVWHEGVVVMHMGDWKAPFGITLVADLLGAIM
AVLTGIMGFATAVYSTATTPRGHEHYGHWPLLHLLLAGVAGAFLTGDVFNLYVWFEVMLVASFALLILGGERAQMEGAIK
YVTLNLLSSMIFLSAVGITYGLVGTLNMADMAVKLAEVDQPGLVTVLAAMYMVSFGIKAGAFPLFFWLPASYHTPPIAIS
ALFAGLLTKVGVYALYRVFTLIFTQDVAFTHEILLWAAGFTMITGVLGAAYHYEIRRILSFHIISQIGYMIMGLALFTPL
ALVGGVFYIAHHIIVKTNLFLVAGVAYRMLGSYELRDLGGLYKHRPFLALLFAVPALSLAGLPPLSGFIAKLIVIWAAVE
QASWGITFVALLTGLLTLYSMTKIWQEAFWHGVPEHVQDTSVLTGEKRDPGLWAMYLPIAGLAVLTLFIGLYAQPLYELA
EASAEQLLDPQVYIDAVLEEGAP

Specific function: Mrp complex is a Na(+)/H(+) antiporter involved in Na(+) excretion and Na(+) resistance [H]

COG id: COG0651

COG function: function code CP; Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CPA3 antiporters (TC 2.A.63) subunit D family [H]

Homologues:

Organism=Homo sapiens, GI251831116, Length=327, Percent_Identity=23.8532110091743, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI251831117, Length=257, Percent_Identity=25.2918287937743, Blast_Score=68, Evalue=2e-11,
Organism=Escherichia coli, GI1788831, Length=412, Percent_Identity=26.4563106796117, Blast_Score=115, Evalue=5e-27,
Organism=Escherichia coli, GI1788613, Length=418, Percent_Identity=26.0765550239234, Blast_Score=106, Evalue=4e-24,
Organism=Escherichia coli, GI1788827, Length=363, Percent_Identity=26.4462809917355, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI1788829, Length=410, Percent_Identity=25.1219512195122, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI2367154, Length=404, Percent_Identity=23.7623762376238, Blast_Score=79, Evalue=5e-16,
Organism=Escherichia coli, GI145693160, Length=343, Percent_Identity=26.2390670553936, Blast_Score=79, Evalue=6e-16,
Organism=Escherichia coli, GI1788614, Length=378, Percent_Identity=26.1904761904762, Blast_Score=64, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001750
- InterPro:   IPR003918 [H]

Pfam domain/function: PF00361 Oxidored_q1 [H]

EC number: 1.-.-.- [C]

Molecular weight: Translated: 54726; Mature: 54595

Theoretical pI: Translated: 6.60; Mature: 6.60

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHCCHHHHHHHHHHCCCC
>Mature Secondary Structure 
SLQVAIPVLLPLLLGAVSLAAHRHLTVQRWLGVLGTGALLVSTLWLLHTVWHEGVVVMH
CCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEE
MGDWKAPFGITLVADLLGAIMAVLTGIMGFATAVYSTATTPRGHEHYGHWPLLHLLLAGV
ECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHH
AGAFLTGDVFNLYVWFEVMLVASFALLILGGERAQMEGAIKYVTLNLLSSMIFLSAVGIT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YGLVGTLNMADMAVKLAEVDQPGLVTVLAAMYMVSFGIKAGAFPLFFWLPASYHTPPIAI
HHHHHHCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCHHHEECCCCCCCCHHHH
SALFAGLLTKVGVYALYRVFTLIFTQDVAFTHEILLWAAGFTMITGVLGAAYHYEIRRIL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SFHIISQIGYMIMGLALFTPLALVGGVFYIAHHIIVKTNLFLVAGVAYRMLGSYELRDLG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
GLYKHRPFLALLFAVPALSLAGLPPLSGFIAKLIVIWAAVEQASWGITFVALLTGLLTLY
HHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
SMTKIWQEAFWHGVPEHVQDTSVLTGEKRDPGLWAMYLPIAGLAVLTLFIGLYAQPLYEL
HHHHHHHHHHHCCCCHHHCCCHHCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHH
AEASAEQLLDPQVYIDAVLEEGAP
HHHHHHHHCCHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11356194 [H]