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The map label for this gene is hisS

Identifier: 121998567

GI number: 121998567

Start: 1961847

End: 1963118

Strand: Reverse

Name: hisS

Synonym: Hhal_1788

Alternate gene names: 121998567

Gene position: 1963118-1961847 (Counterclockwise)

Preceding gene: 121998568

Following gene: 121998566

Centisome position: 73.29

GC content: 67.53

Gene sequence:

>1272_bases
TTGTCGAACAAGGGGATTCAAAGCATTCGCGGGTTCTCGGATATCCTTCCGGAAGAAAGCCCGTTGTGGCAGTACGCCGA
GTCGGCGATTCGTCGGGTCCTGGAGTCGTACGGGTACCGCGAGATCCGTCTGCCGGTGCTCGAACGCACCGAGCTCTTCA
GCCGGTCCATCGGCGAGGTGACCGACATCGTCGAGAAGGAGATGTACACCTTCGACGATCGCAATGGCGACAGCGTTACG
CTGCGCCCTGAGGGCACGGCCGGCTGTGTCCGGGCCGGGATCCAGTCCGGCTTGCTGCACAATGCCGAGCCGCGGCTGTG
GTACGCCGGCCCGATGTTTCGCCATGAACGCCCGCAGAAGGGGCGGCTGCGGCAGTTCCACCAGGTCGGCGCCGAGGTCT
TCGGCATCCCGGAGCCCGAGCTGGATGCCGAGATGATCATCATGACCGCGCGTATGCTGCGCGAGTTGGGGCTTTCCGAC
GTGCGGCTGCAGCTCAACTCGTTGGGTACCCCCGAGAGCCGTGCGGCGCACCGCGAACAGCTGGTGGCCTACCTGCGCCG
CCACGAGGACCGCCTGGACGAGGATGCGCGGCGGCGTCTGGAGACGAATCCGCTGCGGATCTTCGACAGCAAGAACCCGC
AAGTGCAGCAGGTCATGGCCGATGCGCCCCGCCTGATGGACTGTCTCGACAGCGTCTCGGCGGAGCACTTCACCGTGGTC
CGGAACCTGCTGGAGCGGGCCGGCGTCGAATACGAGGTGAACCCGTCGCTGGTGCGGGGGCTCGATTACTATACGCGCAC
GGTCTTCGAGTGGGTGACGGATCGCCTGGGGGCGCAGGGTACCGTCTGTGCCGGTGGGCGTTTCGACGGTCTGGTCGAAC
AGCTCGGCGGTCGGCCGACTCCGGCGATCGGCTTCGCTCTGGGGCTGGAGCGGTTGGTCGCGCTGCTTGAGGATCAGGGT
ACCCCGGGGCAGGGTGGGGCGCCCCACGCCTACCTGGTGGTGGCTACCGAGGCCGGGGCCGGGCTGGAGATGGCCGAGGC
CCTGCGGGACGCGCTGCCGGCGTTGCGGGTACAGATGCACGCGGGCGGAGGCGGTTTCAAAGCGCAGCTCAAGCGTGCCG
ATCGCAGCGGCGCCCGCGTGGCCCTGATCCTTGGCGATGATGAGCAGGCGGCCGGGGCGCTGACGATCAAGGATCTGCGT
GGCGAGGATGGGCAGCAACGGCTGCCCTTGGACGACGCGGTGACGTATCTGCGAGGGCTGATCGGGGCGTAG

Upstream 100 bases:

>100_bases
CCGGGCGAGGAAACGGGCCAGCCCCCGGAGTCCGCAAGCGAGCAGTCGGGCACGCCGAGCACCGGTGTGCGTCGGACGTC
GATGGATTCGGAGTAGCGTT

Downstream 100 bases:

>100_bases
CCCCGGTCGCTGGCAAGGGGAATAGAGATGGAGCGCAGCGACGACGAACAGCTTCAGCAGCTCAAGGATTGGTGGCAGCG
CAATGGGGGCTCGATCCTCC

Product: histidyl-tRNA synthetase

Products: NA

Alternate protein names: Histidine--tRNA ligase; HisRS

Number of amino acids: Translated: 423; Mature: 422

Protein sequence:

>423_residues
MSNKGIQSIRGFSDILPEESPLWQYAESAIRRVLESYGYREIRLPVLERTELFSRSIGEVTDIVEKEMYTFDDRNGDSVT
LRPEGTAGCVRAGIQSGLLHNAEPRLWYAGPMFRHERPQKGRLRQFHQVGAEVFGIPEPELDAEMIIMTARMLRELGLSD
VRLQLNSLGTPESRAAHREQLVAYLRRHEDRLDEDARRRLETNPLRIFDSKNPQVQQVMADAPRLMDCLDSVSAEHFTVV
RNLLERAGVEYEVNPSLVRGLDYYTRTVFEWVTDRLGAQGTVCAGGRFDGLVEQLGGRPTPAIGFALGLERLVALLEDQG
TPGQGGAPHAYLVVATEAGAGLEMAEALRDALPALRVQMHAGGGGFKAQLKRADRSGARVALILGDDEQAAGALTIKDLR
GEDGQQRLPLDDAVTYLRGLIGA

Sequences:

>Translated_423_residues
MSNKGIQSIRGFSDILPEESPLWQYAESAIRRVLESYGYREIRLPVLERTELFSRSIGEVTDIVEKEMYTFDDRNGDSVT
LRPEGTAGCVRAGIQSGLLHNAEPRLWYAGPMFRHERPQKGRLRQFHQVGAEVFGIPEPELDAEMIIMTARMLRELGLSD
VRLQLNSLGTPESRAAHREQLVAYLRRHEDRLDEDARRRLETNPLRIFDSKNPQVQQVMADAPRLMDCLDSVSAEHFTVV
RNLLERAGVEYEVNPSLVRGLDYYTRTVFEWVTDRLGAQGTVCAGGRFDGLVEQLGGRPTPAIGFALGLERLVALLEDQG
TPGQGGAPHAYLVVATEAGAGLEMAEALRDALPALRVQMHAGGGGFKAQLKRADRSGARVALILGDDEQAAGALTIKDLR
GEDGQQRLPLDDAVTYLRGLIGA
>Mature_422_residues
SNKGIQSIRGFSDILPEESPLWQYAESAIRRVLESYGYREIRLPVLERTELFSRSIGEVTDIVEKEMYTFDDRNGDSVTL
RPEGTAGCVRAGIQSGLLHNAEPRLWYAGPMFRHERPQKGRLRQFHQVGAEVFGIPEPELDAEMIIMTARMLRELGLSDV
RLQLNSLGTPESRAAHREQLVAYLRRHEDRLDEDARRRLETNPLRIFDSKNPQVQQVMADAPRLMDCLDSVSAEHFTVVR
NLLERAGVEYEVNPSLVRGLDYYTRTVFEWVTDRLGAQGTVCAGGRFDGLVEQLGGRPTPAIGFALGLERLVALLEDQGT
PGQGGAPHAYLVVATEAGAGLEMAEALRDALPALRVQMHAGGGGFKAQLKRADRSGARVALILGDDEQAAGALTIKDLRG
EDGQQRLPLDDAVTYLRGLIGA

Specific function: Unknown

COG id: COG0124

COG function: function code J; Histidyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family

Homologues:

Organism=Escherichia coli, GI1788861, Length=424, Percent_Identity=59.6698113207547, Blast_Score=508, Evalue=1e-145,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SYH_HALHL (A1WXZ0)

Other databases:

- EMBL:   CP000544
- RefSeq:   YP_001003354.1
- ProteinModelPortal:   A1WXZ0
- SMR:   A1WXZ0
- STRING:   A1WXZ0
- GeneID:   4710917
- GenomeReviews:   CP000544_GR
- KEGG:   hha:Hhal_1788
- eggNOG:   COG0124
- HOGENOM:   HBG616575
- OMA:   VFEWVTT
- PhylomeDB:   A1WXZ0
- ProtClustDB:   PRK00037
- BioCyc:   HHAL349124:HHAL_1788-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00127
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004154
- InterPro:   IPR015807
- InterPro:   IPR004516
- Gene3D:   G3DSA:3.40.50.800
- PANTHER:   PTHR11476
- PIRSF:   PIRSF001549
- TIGRFAMs:   TIGR00442

Pfam domain/function: PF03129 HGTP_anticodon; PF00587 tRNA-synt_2b; SSF52954 Anticodon_bd

EC number: =6.1.1.21

Molecular weight: Translated: 46797; Mature: 46666

Theoretical pI: Translated: 5.26; Mature: 5.26

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNKGIQSIRGFSDILPEESPLWQYAESAIRRVLESYGYREIRLPVLERTELFSRSIGEV
CCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCEEEECCHHHHHHHHHHHHHHH
TDIVEKEMYTFDDRNGDSVTLRPEGTAGCVRAGIQSGLLHNAEPRLWYAGPMFRHERPQK
HHHHHHHHHHCCCCCCCEEEECCCCCHHHHHHHHHHCCCCCCCCCEEECCCCHHCCCCCH
GRLRQFHQVGAEVFGIPEPELDAEMIIMTARMLRELGLSDVRLQLNSLGTPESRAAHREQ
HHHHHHHHHCHHHCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHCCCCCHHHHHHHHH
LVAYLRRHEDRLDEDARRRLETNPLRIFDSKNPQVQQVMADAPRLMDCLDSVSAEHFTVV
HHHHHHHHHHHCCHHHHHHHCCCCEEEECCCCHHHHHHHHCCHHHHHHHHHHCHHHHHHH
RNLLERAGVEYEVNPSLVRGLDYYTRTVFEWVTDRLGAQGTVCAGGRFDGLVEQLGGRPT
HHHHHHCCCCEECCHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCHHHHHHHHCCCCC
PAIGFALGLERLVALLEDQGTPGQGGAPHAYLVVATEAGAGLEMAEALRDALPALRVQMH
CHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHEEEEE
AGGGGFKAQLKRADRSGARVALILGDDEQAAGALTIKDLRGEDGQQRLPLDDAVTYLRGL
CCCCCHHHHHHHHCCCCCEEEEEECCCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHH
IGA
HCC
>Mature Secondary Structure 
SNKGIQSIRGFSDILPEESPLWQYAESAIRRVLESYGYREIRLPVLERTELFSRSIGEV
CCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCEEEECCHHHHHHHHHHHHHHH
TDIVEKEMYTFDDRNGDSVTLRPEGTAGCVRAGIQSGLLHNAEPRLWYAGPMFRHERPQK
HHHHHHHHHHCCCCCCCEEEECCCCCHHHHHHHHHHCCCCCCCCCEEECCCCHHCCCCCH
GRLRQFHQVGAEVFGIPEPELDAEMIIMTARMLRELGLSDVRLQLNSLGTPESRAAHREQ
HHHHHHHHHCHHHCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHCCCCCHHHHHHHHH
LVAYLRRHEDRLDEDARRRLETNPLRIFDSKNPQVQQVMADAPRLMDCLDSVSAEHFTVV
HHHHHHHHHHHCCHHHHHHHCCCCEEEECCCCHHHHHHHHCCHHHHHHHHHHCHHHHHHH
RNLLERAGVEYEVNPSLVRGLDYYTRTVFEWVTDRLGAQGTVCAGGRFDGLVEQLGGRPT
HHHHHHCCCCEECCHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCHHHHHHHHCCCCC
PAIGFALGLERLVALLEDQGTPGQGGAPHAYLVVATEAGAGLEMAEALRDALPALRVQMH
CHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHEEEEE
AGGGGFKAQLKRADRSGARVALILGDDEQAAGALTIKDLRGEDGQQRLPLDDAVTYLRGL
CCCCCHHHHHHHHCCCCCEEEEEECCCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHH
IGA
HCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA