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The map label for this gene is folP [H]

Identifier: 121998548

GI number: 121998548

Start: 1942383

End: 1943243

Strand: Reverse

Name: folP [H]

Synonym: Hhal_1769

Alternate gene names: 121998548

Gene position: 1943243-1942383 (Counterclockwise)

Preceding gene: 121998549

Following gene: 121998547

Centisome position: 72.55

GC content: 70.5

Gene sequence:

>861_bases
ATGGGGGCGGCAGTCGGCGGGGCGGTTCTCCATTGCGGGGACCGCCCCCTTACGTTGGATCGGCCGCGGGTCATGGGGGT
GCTCAATATCACCCCCGACTCCTTCTCGGACGGCGGGAGCTATCTCGATCTCGATAGGGCCCGCGCACATGCCCGACAGA
TGGTCGCCGAGGGGGCCGACCTGATCGACGTCGGCGGTGAGTCGAGCCGGCCGGGGGCGCCTCCGGTCCCGCTGGATCAG
GAGCTCGAGCGCGTCATTCCGGTGGTTGAGGCCTTGGTGCGTGAGGTCGACTGCCCGATCTCGGTGGACACCTACAAGCC
TGCGGTGGCCCGCGCTGCGGTGGCGGCCGGGGCGGGGCTGATCAACGATATCCGTGCGCTGCAGGAGCCGGGTGCCCTGG
AGGCGGCCGCTGGGCTCGGTGTGCCGGTCTGCCTGATGCACATGCAGGGGCAGCCGCAGACCATGCAGGAGTCGCCGAGC
TACCACGACGTTGTCGCGGAAGTCGGTGAGTTCCTTGCCGAGCGGGTGGCGGCGGCCGAGGCGGCCGGTCTGCCCCGTGA
GCGGATAGTGCTCGATCCGGGGTTCGGCTTCGGCAAGACGCTGGCACACAACTACCAGCTGCTGAGGCACCTGGAGCGCA
TCGTGGCGCTGGGGCTGCCGGTTCTGGTAGGGATGTCGCGGAAGTCCATGGTGGGCAAGCTACTGGATCGTCCGGTGGAG
GAGCGCCTGGCGGGTAGTCTCGGCGCGGCGGCCGTGGCGGTTTTCCAGGGGGCTCGGATCATCCGCGCCCACGACGTGGG
GCCGACCGCTGACGCGGTGCGGGTGGCGGCGGCCGCCGCCACCGCCCAGGAATCGCGCTGA

Upstream 100 bases:

>100_bases
CGGGCGACGAGGGTGAGACTGCCGGGGCCGATGACCAGCCCGAGGCCGAAGGTAAAGACGGCCGCGAGGGGCCCATCGGC
GGACCTGTAGGCGAGCACTG

Downstream 100 bases:

>100_bases
AAGGAAGAAGGTCTTGGCCGAGGAAAGAAGCTACTTCGGAACCGACGGTATCCGTGGCCGGGTGGGGGAAGCCCCGATCA
CCCCGGACTTTGTCCTGCGG

Product: dihydropteroate synthase

Products: NA

Alternate protein names: DHPS; Dihydropteroate pyrophosphorylase [H]

Number of amino acids: Translated: 286; Mature: 285

Protein sequence:

>286_residues
MGAAVGGAVLHCGDRPLTLDRPRVMGVLNITPDSFSDGGSYLDLDRARAHARQMVAEGADLIDVGGESSRPGAPPVPLDQ
ELERVIPVVEALVREVDCPISVDTYKPAVARAAVAAGAGLINDIRALQEPGALEAAAGLGVPVCLMHMQGQPQTMQESPS
YHDVVAEVGEFLAERVAAAEAAGLPRERIVLDPGFGFGKTLAHNYQLLRHLERIVALGLPVLVGMSRKSMVGKLLDRPVE
ERLAGSLGAAAVAVFQGARIIRAHDVGPTADAVRVAAAAATAQESR

Sequences:

>Translated_286_residues
MGAAVGGAVLHCGDRPLTLDRPRVMGVLNITPDSFSDGGSYLDLDRARAHARQMVAEGADLIDVGGESSRPGAPPVPLDQ
ELERVIPVVEALVREVDCPISVDTYKPAVARAAVAAGAGLINDIRALQEPGALEAAAGLGVPVCLMHMQGQPQTMQESPS
YHDVVAEVGEFLAERVAAAEAAGLPRERIVLDPGFGFGKTLAHNYQLLRHLERIVALGLPVLVGMSRKSMVGKLLDRPVE
ERLAGSLGAAAVAVFQGARIIRAHDVGPTADAVRVAAAAATAQESR
>Mature_285_residues
GAAVGGAVLHCGDRPLTLDRPRVMGVLNITPDSFSDGGSYLDLDRARAHARQMVAEGADLIDVGGESSRPGAPPVPLDQE
LERVIPVVEALVREVDCPISVDTYKPAVARAAVAAGAGLINDIRALQEPGALEAAAGLGVPVCLMHMQGQPQTMQESPSY
HDVVAEVGEFLAERVAAAEAAGLPRERIVLDPGFGFGKTLAHNYQLLRHLERIVALGLPVLVGMSRKSMVGKLLDRPVEE
RLAGSLGAAAVAVFQGARIIRAHDVGPTADAVRVAAAAATAQESR

Specific function: DHPS catalyzes the formation of the immediate precursor of folic acid. It is implicated in resistance to sulfonamide [H]

COG id: COG0294

COG function: function code H; Dihydropteroate synthase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 pterin-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87082224, Length=270, Percent_Identity=57.037037037037, Blast_Score=318, Evalue=3e-88,
Organism=Saccharomyces cerevisiae, GI6324073, Length=320, Percent_Identity=26.875, Blast_Score=118, Evalue=9e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006390
- InterPro:   IPR011005
- InterPro:   IPR000489 [H]

Pfam domain/function: PF00809 Pterin_bind [H]

EC number: =2.5.1.15 [H]

Molecular weight: Translated: 29843; Mature: 29711

Theoretical pI: Translated: 5.37; Mature: 5.37

Prosite motif: PS50972 PTERIN_BINDING ; PS00792 DHPS_1 ; PS00793 DHPS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGAAVGGAVLHCGDRPLTLDRPRVMGVLNITPDSFSDGGSYLDLDRARAHARQMVAEGAD
CCCCCCCCEEEECCCCCCCCCCCEEEEEEECCCCCCCCCCEECHHHHHHHHHHHHHCCCC
LIDVGGESSRPGAPPVPLDQELERVIPVVEALVREVDCPISVDTYKPAVARAAVAAGAGL
EEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCHH
INDIRALQEPGALEAAAGLGVPVCLMHMQGQPQTMQESPSYHDVVAEVGEFLAERVAAAE
HHHHHHHHCCCCHHHHHCCCHHHHHHHCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHH
AAGLPRERIVLDPGFGFGKTLAHNYQLLRHLERIVALGLPVLVGMSRKSMVGKLLDRPVE
HHCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCHH
ERLAGSLGAAAVAVFQGARIIRAHDVGPTADAVRVAAAAATAQESR
HHHHHHHHHHHHHHHHCCEEEEECCCCCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
GAAVGGAVLHCGDRPLTLDRPRVMGVLNITPDSFSDGGSYLDLDRARAHARQMVAEGAD
CCCCCCCEEEECCCCCCCCCCCEEEEEEECCCCCCCCCCEECHHHHHHHHHHHHHCCCC
LIDVGGESSRPGAPPVPLDQELERVIPVVEALVREVDCPISVDTYKPAVARAAVAAGAGL
EEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCHH
INDIRALQEPGALEAAAGLGVPVCLMHMQGQPQTMQESPSYHDVVAEVGEFLAERVAAAE
HHHHHHHHCCCCHHHHHCCCHHHHHHHCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHH
AAGLPRERIVLDPGFGFGKTLAHNYQLLRHLERIVALGLPVLVGMSRKSMVGKLLDRPVE
HHCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCHH
ERLAGSLGAAAVAVFQGARIIRAHDVGPTADAVRVAAAAATAQESR
HHHHHHHHHHHHHHHHCCEEEEECCCCCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]