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The map label for this gene is cbs [H]

Identifier: 121998473

GI number: 121998473

Start: 1850260

End: 1851255

Strand: Reverse

Name: cbs [H]

Synonym: Hhal_1694

Alternate gene names: 121998473

Gene position: 1851255-1850260 (Counterclockwise)

Preceding gene: 121998474

Following gene: 121998472

Centisome position: 69.12

GC content: 66.47

Gene sequence:

>996_bases
ATGTCAAGCAAGCGGGAGTCGAGCATGTCGATCTGCGATGGATTCGTCGGCGCGATCGGGAACACGCCGCTGATTCGCCT
GCCGCGGCTGAGCGAGGAGACCGGCTGCGAGATCCTCGGCAAGGCCGAGTTCATGAACCCCGGCGGGTCTGTGAAGGATC
GGGCCGCGCTGGCCATCGTCCAGGCCGCGGAACGCAGTGGCGAGCTGCGTCCTGGTGGAACGGTGGTGGAGGGCACCGCC
GGCAACACCGGCATCGGGTTGGCCCATATCTGTAATGCGCGCGGCTACCGCTGCGTGATTGTGATCCCGGAGACCCAGAG
CCAGGAGAAGATCGACCTGCTCCGCACCCTCGGTGCCGAGGTCCATGCGGTTCCTGCCGCGCCCTACCGCGACCCGGGGA
ACTACCAGAAGGTGGCCGGCCGCATGGCGGCGGAGATGGACAACGCGGTCTGGGCCAACCAGTTCGATAACACCGCCAAC
CGCCTTGGCCACTACCGCACCACTGGGCCGGAGGTCTGGGCGCAGACCGGCGGTCGGGTCGACGCGTTCGTTGCCGCCAC
CGGCACGGGCGGCACGCTGGCCGGGGTCTCTCGGGCGCTCAAGGAGCGCTCCCCGGATACCCGCATCTACCTGGCCGACC
CTTCGGGCAGCGCCCTCTATAACTTCGTGCGCGATGGCGAGCCGGCGCCCACTGCGGGCAATTCCATCACCGAAGGGATT
GGCAGCAGCCGTGTAACAGCTAATCTTCAGGGTACGGACATCGATGACGCGTTTTGCATATCGGACGCCGAATCGGTGCC
GATGGTCTACCGGCTCCTGAGGGAAGAGGGGCTATTCCTGGGCAGTTCTTCGGGGGTCAATGTGTGCGGGGCCGTGCGTG
CCGCCGAGGAATTGGGGCCCGGGCACACGGTGGTGACGATCCTCTGCGATGGAGGGGGCCGCTATTACTCGAGACTCTTC
AATGAAGCCTGGCTGGCGGAGCGGGGACTCGCCTGA

Upstream 100 bases:

>100_bases
GCCCCCCGGGGGCTAGCCGCGAGACTTCCTTGCCAACCTCCCGCTGATTTCCGAGACGACTCCGCGCTATGCTGTCTTCT
CGCGCCCTGGGGATTGGGCT

Downstream 100 bases:

>100_bases
TCCCGTCCGCCGGCCGGGGCCGGCCGCCTCCCGCTCGGGCGCGCGCCCGGACGTTCCCGCCGACGGAGTGCGACCCGCTT
TGCCTTTCTTCCGGAACATT

Product: cysteine synthase A

Products: NA

Alternate protein names: Beta-thionase; Serine sulfhydrase [H]

Number of amino acids: Translated: 331; Mature: 330

Protein sequence:

>331_residues
MSSKRESSMSICDGFVGAIGNTPLIRLPRLSEETGCEILGKAEFMNPGGSVKDRAALAIVQAAERSGELRPGGTVVEGTA
GNTGIGLAHICNARGYRCVIVIPETQSQEKIDLLRTLGAEVHAVPAAPYRDPGNYQKVAGRMAAEMDNAVWANQFDNTAN
RLGHYRTTGPEVWAQTGGRVDAFVAATGTGGTLAGVSRALKERSPDTRIYLADPSGSALYNFVRDGEPAPTAGNSITEGI
GSSRVTANLQGTDIDDAFCISDAESVPMVYRLLREEGLFLGSSSGVNVCGAVRAAEELGPGHTVVTILCDGGGRYYSRLF
NEAWLAERGLA

Sequences:

>Translated_331_residues
MSSKRESSMSICDGFVGAIGNTPLIRLPRLSEETGCEILGKAEFMNPGGSVKDRAALAIVQAAERSGELRPGGTVVEGTA
GNTGIGLAHICNARGYRCVIVIPETQSQEKIDLLRTLGAEVHAVPAAPYRDPGNYQKVAGRMAAEMDNAVWANQFDNTAN
RLGHYRTTGPEVWAQTGGRVDAFVAATGTGGTLAGVSRALKERSPDTRIYLADPSGSALYNFVRDGEPAPTAGNSITEGI
GSSRVTANLQGTDIDDAFCISDAESVPMVYRLLREEGLFLGSSSGVNVCGAVRAAEELGPGHTVVTILCDGGGRYYSRLF
NEAWLAERGLA
>Mature_330_residues
SSKRESSMSICDGFVGAIGNTPLIRLPRLSEETGCEILGKAEFMNPGGSVKDRAALAIVQAAERSGELRPGGTVVEGTAG
NTGIGLAHICNARGYRCVIVIPETQSQEKIDLLRTLGAEVHAVPAAPYRDPGNYQKVAGRMAAEMDNAVWANQFDNTANR
LGHYRTTGPEVWAQTGGRVDAFVAATGTGGTLAGVSRALKERSPDTRIYLADPSGSALYNFVRDGEPAPTAGNSITEGIG
SSRVTANLQGTDIDDAFCISDAESVPMVYRLLREEGLFLGSSSGVNVCGAVRAAEELGPGHTVVTILCDGGGRYYSRLFN
EAWLAERGLA

Specific function: Two Cysteine Synthase Enzymes Are Found. Both Catalyze The Same Reaction. Cysteine Synthase B Can Also Use Thiosulfate In Place Of Sulfide To Give Cysteine Thiosulfonate As A Product. [C]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=331, Percent_Identity=40.785498489426, Blast_Score=247, Evalue=1e-65,
Organism=Homo sapiens, GI295821200, Length=331, Percent_Identity=40.785498489426, Blast_Score=247, Evalue=1e-65,
Organism=Homo sapiens, GI4557415, Length=331, Percent_Identity=40.785498489426, Blast_Score=247, Evalue=1e-65,
Organism=Homo sapiens, GI11345492, Length=305, Percent_Identity=26.2295081967213, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI2367138, Length=314, Percent_Identity=39.171974522293, Blast_Score=189, Evalue=3e-49,
Organism=Escherichia coli, GI1788754, Length=317, Percent_Identity=37.8548895899054, Blast_Score=163, Evalue=1e-41,
Organism=Caenorhabditis elegans, GI17562970, Length=313, Percent_Identity=40.2555910543131, Blast_Score=191, Evalue=3e-49,
Organism=Caenorhabditis elegans, GI17535051, Length=305, Percent_Identity=38.0327868852459, Blast_Score=191, Evalue=5e-49,
Organism=Caenorhabditis elegans, GI32566674, Length=300, Percent_Identity=40.6666666666667, Blast_Score=188, Evalue=3e-48,
Organism=Caenorhabditis elegans, GI115535073, Length=314, Percent_Identity=40.1273885350318, Blast_Score=183, Evalue=9e-47,
Organism=Caenorhabditis elegans, GI17534315, Length=334, Percent_Identity=35.6287425149701, Blast_Score=176, Evalue=2e-44,
Organism=Caenorhabditis elegans, GI25147552, Length=328, Percent_Identity=36.5853658536585, Blast_Score=174, Evalue=6e-44,
Organism=Caenorhabditis elegans, GI17561720, Length=313, Percent_Identity=36.741214057508, Blast_Score=166, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI32566672, Length=228, Percent_Identity=36.4035087719298, Blast_Score=112, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI71996324, Length=344, Percent_Identity=26.1627906976744, Blast_Score=92, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI17539640, Length=340, Percent_Identity=25.5882352941176, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17539800, Length=347, Percent_Identity=23.6311239193084, Blast_Score=79, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17508781, Length=214, Percent_Identity=24.7663551401869, Blast_Score=68, Evalue=7e-12,
Organism=Saccharomyces cerevisiae, GI6321449, Length=332, Percent_Identity=41.8674698795181, Blast_Score=231, Evalue=1e-61,
Organism=Saccharomyces cerevisiae, GI6321594, Length=344, Percent_Identity=36.046511627907, Blast_Score=189, Evalue=4e-49,
Organism=Drosophila melanogaster, GI24643623, Length=328, Percent_Identity=38.719512195122, Blast_Score=206, Evalue=2e-53,
Organism=Drosophila melanogaster, GI20129101, Length=328, Percent_Identity=38.719512195122, Blast_Score=206, Evalue=2e-53,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR005857
- InterPro:   IPR000644
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00571 CBS; PF00291 PALP [H]

EC number: =4.2.1.22 [H]

Molecular weight: Translated: 34827; Mature: 34696

Theoretical pI: Translated: 5.08; Mature: 5.08

Prosite motif: PS00901 CYS_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSKRESSMSICDGFVGAIGNTPLIRLPRLSEETGCEILGKAEFMNPGGSVKDRAALAIV
CCCCCHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCEEEECCEECCCCCCCHHHHHHHHH
QAAERSGELRPGGTVVEGTAGNTGIGLAHICNARGYRCVIVIPETQSQEKIDLLRTLGAE
HHHHHCCCCCCCCEEEECCCCCCCCCHHHHHCCCCCEEEEEECCCCCHHHHHHHHHCCCC
VHAVPAAPYRDPGNYQKVAGRMAAEMDNAVWANQFDNTANRLGHYRTTGPEVWAQTGGRV
EEECCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHCCHHHHHCCCCCCCCHHHHHHCCCCE
DAFVAATGTGGTLAGVSRALKERSPDTRIYLADPSGSALYNFVRDGEPAPTAGNSITEGI
EEEEEECCCCCHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHCCCCCCCCCCHHHHCC
GSSRVTANLQGTDIDDAFCISDAESVPMVYRLLREEGLFLGSSSGVNVCGAVRAAEELGP
CCCEEEEEECCCCCCCCEECCCCCCHHHHHHHHHHCCCEEECCCCCCHHHHHHHHHHCCC
GHTVVTILCDGGGRYYSRLFNEAWLAERGLA
CCEEEEEEECCCCHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SSKRESSMSICDGFVGAIGNTPLIRLPRLSEETGCEILGKAEFMNPGGSVKDRAALAIV
CCCCHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCEEEECCEECCCCCCCHHHHHHHHH
QAAERSGELRPGGTVVEGTAGNTGIGLAHICNARGYRCVIVIPETQSQEKIDLLRTLGAE
HHHHHCCCCCCCCEEEECCCCCCCCCHHHHHCCCCCEEEEEECCCCCHHHHHHHHHCCCC
VHAVPAAPYRDPGNYQKVAGRMAAEMDNAVWANQFDNTANRLGHYRTTGPEVWAQTGGRV
EEECCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHCCHHHHHCCCCCCCCHHHHHHCCCCE
DAFVAATGTGGTLAGVSRALKERSPDTRIYLADPSGSALYNFVRDGEPAPTAGNSITEGI
EEEEEECCCCCHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHCCCCCCCCCCHHHHCC
GSSRVTANLQGTDIDDAFCISDAESVPMVYRLLREEGLFLGSSSGVNVCGAVRAAEELGP
CCCEEEEEECCCCCCCCEECCCCCCHHHHHHHHHHCCCEEECCCCCCHHHHHHHHHHCCC
GHTVVTILCDGGGRYYSRLFNEAWLAERGLA
CCEEEEEEECCCCHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]