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The map label for this gene is rnhA

Identifier: 121998364

GI number: 121998364

Start: 1724408

End: 1724857

Strand: Reverse

Name: rnhA

Synonym: Hhal_1585

Alternate gene names: 121998364

Gene position: 1724857-1724408 (Counterclockwise)

Preceding gene: 121998365

Following gene: 121998363

Centisome position: 64.4

GC content: 68.22

Gene sequence:

>450_bases
GTGACCGAGCAGCGCGGCGTGGTGGAGGCATTCACGGATGGGGCCTGTCGAGGTAATCCGGGCCCCGGAGGGTGGGGCGT
GCTGCTACGCTACGGCGAGCATGAGCGAGAGCTCTACGGTGGGGAGCCGGAGACCACCAACAACCGCATGGAACTAACCG
CGGCGATCCGCGCCCTGGAGGCCTTGGATCGGCCCTGCCGGGTGGTGCTGACCACCGACTCCCAGTACGTACGTCGCGGG
ATCACCGAGTGGCTGGAGGGCTGGAAGCGCCGGGGCTGGCGCACCGCATCGCGCAAGCCGGTGCTCAACCAGGACCTGTG
GCAACGGCTCGATGAGCTGGCCGCGTACCACCAGGTCGACTGGCACTGGGTGCGTGGCCACGCCGGTCATGCGGAGAATG
AGCGTGCCGATGCTCTGGCCAACCAGGGGATCGACGAGCTGGTTGCCTAG

Upstream 100 bases:

>100_bases
GGAAAACCCGGGTCGAGCGCTTAGGTCGAGGCGTCCCCGTCGGGGCTGCGCACCCGGTGGGCCGGATCTGCGCGCAGGCC
CAGAAGCGAGGAGGTAGTGC

Downstream 100 bases:

>100_bases
GCTCGCTGCCCGTCCCTGGCGGGCCTGGGATAGAATCGGGACGGCCAACCTAGAACCTGAAACAAATCGGAGAGTAGCGC
ATGAACAAAGCCGATCTGGC

Product: ribonuclease H

Products: NA

Alternate protein names: RNase H

Number of amino acids: Translated: 149; Mature: 148

Protein sequence:

>149_residues
MTEQRGVVEAFTDGACRGNPGPGGWGVLLRYGEHERELYGGEPETTNNRMELTAAIRALEALDRPCRVVLTTDSQYVRRG
ITEWLEGWKRRGWRTASRKPVLNQDLWQRLDELAAYHQVDWHWVRGHAGHAENERADALANQGIDELVA

Sequences:

>Translated_149_residues
MTEQRGVVEAFTDGACRGNPGPGGWGVLLRYGEHERELYGGEPETTNNRMELTAAIRALEALDRPCRVVLTTDSQYVRRG
ITEWLEGWKRRGWRTASRKPVLNQDLWQRLDELAAYHQVDWHWVRGHAGHAENERADALANQGIDELVA
>Mature_148_residues
TEQRGVVEAFTDGACRGNPGPGGWGVLLRYGEHERELYGGEPETTNNRMELTAAIRALEALDRPCRVVLTTDSQYVRRGI
TEWLEGWKRRGWRTASRKPVLNQDLWQRLDELAAYHQVDWHWVRGHAGHAENERADALANQGIDELVA

Specific function: Endonuclease that specifically degrades the RNA of RNA- DNA hybrids

COG id: COG0328

COG function: function code L; Ribonuclease HI

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase H domain

Homologues:

Organism=Homo sapiens, GI21359816, Length=103, Percent_Identity=38.8349514563107, Blast_Score=78, Evalue=3e-15,
Organism=Escherichia coli, GI1786408, Length=133, Percent_Identity=63.9097744360902, Blast_Score=185, Evalue=1e-48,
Organism=Caenorhabditis elegans, GI115532542, Length=143, Percent_Identity=38.4615384615385, Blast_Score=95, Evalue=1e-20,
Organism=Drosophila melanogaster, GI45552509, Length=148, Percent_Identity=38.5135135135135, Blast_Score=86, Evalue=7e-18,
Organism=Drosophila melanogaster, GI17137476, Length=148, Percent_Identity=38.5135135135135, Blast_Score=86, Evalue=7e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RNH_HALHL (A1WXD7)

Other databases:

- EMBL:   CP000544
- RefSeq:   YP_001003151.1
- ProteinModelPortal:   A1WXD7
- SMR:   A1WXD7
- STRING:   A1WXD7
- GeneID:   4709237
- GenomeReviews:   CP000544_GR
- KEGG:   hha:Hhal_1585
- eggNOG:   COG0328
- HOGENOM:   HBG742437
- OMA:   NGWRTAD
- PhylomeDB:   A1WXD7
- ProtClustDB:   PRK00203
- BioCyc:   HHAL349124:HHAL_1585-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00042
- InterPro:   IPR022892
- InterPro:   IPR012337
- InterPro:   IPR002156

Pfam domain/function: PF00075 RnaseH; SSF53098 RNaseH_fold

EC number: =3.1.26.4

Molecular weight: Translated: 16962; Mature: 16831

Theoretical pI: Translated: 6.02; Mature: 6.02

Prosite motif: PS50879 RNASE_H

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEQRGVVEAFTDGACRGNPGPGGWGVLLRYGEHERELYGGEPETTNNRMELTAAIRALE
CCCCCCHHHHHCCCCCCCCCCCCCCEEEEECCCCHHHHCCCCCCCCCCHHHHHHHHHHHH
ALDRPCRVVLTTDSQYVRRGITEWLEGWKRRGWRTASRKPVLNQDLWQRLDELAAYHQVD
HCCCCCEEEEECCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHCCC
WHWVRGHAGHAENERADALANQGIDELVA
CEEECCCCCCCCCHHHHHHHHCCHHHHCC
>Mature Secondary Structure 
TEQRGVVEAFTDGACRGNPGPGGWGVLLRYGEHERELYGGEPETTNNRMELTAAIRALE
CCCCCHHHHHCCCCCCCCCCCCCCEEEEECCCCHHHHCCCCCCCCCCHHHHHHHHHHHH
ALDRPCRVVLTTDSQYVRRGITEWLEGWKRRGWRTASRKPVLNQDLWQRLDELAAYHQVD
HCCCCCEEEEECCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHCCC
WHWVRGHAGHAENERADALANQGIDELVA
CEEECCCCCCCCCHHHHHHHHCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA