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The map label for this gene is atoC [H]

Identifier: 121998315

GI number: 121998315

Start: 1665630

End: 1666979

Strand: Reverse

Name: atoC [H]

Synonym: Hhal_1533

Alternate gene names: 121998315

Gene position: 1666979-1665630 (Counterclockwise)

Preceding gene: 121998316

Following gene: 121998312

Centisome position: 62.24

GC content: 65.26

Gene sequence:

>1350_bases
TTGGGGCACGCGAACCACCTGCTGATCGTCGAGGATGACAAGGGGCTCCAGGAACAGCTGCGCTGGTGTTTCGACGGCTA
TGAGATCGTTCCGGCCTTCGACCGCGCGGAGGCTGTTGCTTTGGCGCGGCGTTACGAGCCCGAGCTCGTCCTGCTTGATC
TCGGGCTCCCCCCGGATCCGGCCAATGCCAGCGAGGGGCTGGCGGCCCTGCAAGAGGTGCTCGCCGAGGCGCCCGAGAGC
AAGGTGATCGTGGTCACCGGTAACGATGACCGGGAGAATGCGCTCAAGGCCGTCGCGCTCGGCGCCTACGACTTCTACGG
GAAACCGGTGGATCCGGATACCCTGCGACTGCTAGTGGATCGAGCCGCACAGCTTTATAGCCTCGAGGCGGAGAACCGTC
GTCTGGCACAACAATCGGCATCGCCGCTGGAGGGGTTCCTTAGCTCGGACCCGGGGGCGCTGCAGGTCTGCCGGATGGTC
GAGCGCGTCGCCCCGGCGGATGCTACGGTCCTGCTGCGCGGGGAGAGCGGTACCGGCAAGGAGATCCTCGCCCGTGCGGT
TCATCGGCTCAGTGGCCGCCGTGAGCAGCGTTTCGTTGCCATCAACTGCGCCGCGATCCCGGAGAATCTCCTCGAGAGTG
AGCTCTTCGGGTATGAGAAGGGTGCTTTTACCGGGGCCAACCGCCAGACCATTGGCAAGATCGAATACGCCAGTGGCGGG
ACGCTGTTCCTCGACGAGATCGGCGACTTGCCCTTGAGTCTTCAGGCCAAGCTGCTTCGCTTTCTGCAAGAGCGGACCAT
CGAGCGCCTCGGGGGCCGGCAATCGATCGAGGTGGACGTGCGGGTGGTTTGTGCCACCCATCGCGATCTGGCGGAGATGA
TTCGCGACGGCGGCTTCCGCGAGGATCTTTTCTACCGCGTTGCCGAGATCGAGCTGACCATACCGCCGCTGCGCGAGCGT
CCTGGTGACGCCGTTCTCGTGGCCCACGCCCTGCTCGATCGCTTCGCCCGCGAGCAGCGCCAGCCGCGTCGCCTGTTGAC
CCCGGAGGCTATCGACGCCATCGAGGCCTACCCGTGGCCCGGCAACGTGCGGGAGATGGAGAACGTCATCCGCCGGGCGG
TGATTATGGCCGATGGCAAAAAGATTGCTGCGGAGGATCTCGCGCTGGAAGTACCGGAGGGTGGTGGCGAGGACCGGCTG
CGCCTCAAGGATGCCCGGGAGCAGGCCGAGTACCAGGCGGTCGTCCGTGCGCTAAGCCGCTCGAATGGGAATATCGCGCA
GGCCGCCGGTCTGCTGGGGATTACTCGGCCGACCTTGTACACCCTCATGGATAAATTCGCCCTGCGCTGA

Upstream 100 bases:

>100_bases
AGGCCCGGAGCCGGTACACGCTTTACGGTCCAGCTACTTGCTCGCGGCAGCGCGGAATCGTCGTTGGCCGCGGCGGGATG
ATGAGGGAGGCATAAAGACG

Downstream 100 bases:

>100_bases
CCGCTTGTAAGTGGGGTGAGTGGTCATCGCGTGTTCGTTGGAGCGCTGCCGGAAGGAAAAGAGGAGGGGGCATTTGCCCC
CTCCTCAGGCCTGCCGCGCT

Product: Fis family two component sigma-54 specific transcriptional regulator

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 449; Mature: 448

Protein sequence:

>449_residues
MGHANHLLIVEDDKGLQEQLRWCFDGYEIVPAFDRAEAVALARRYEPELVLLDLGLPPDPANASEGLAALQEVLAEAPES
KVIVVTGNDDRENALKAVALGAYDFYGKPVDPDTLRLLVDRAAQLYSLEAENRRLAQQSASPLEGFLSSDPGALQVCRMV
ERVAPADATVLLRGESGTGKEILARAVHRLSGRREQRFVAINCAAIPENLLESELFGYEKGAFTGANRQTIGKIEYASGG
TLFLDEIGDLPLSLQAKLLRFLQERTIERLGGRQSIEVDVRVVCATHRDLAEMIRDGGFREDLFYRVAEIELTIPPLRER
PGDAVLVAHALLDRFAREQRQPRRLLTPEAIDAIEAYPWPGNVREMENVIRRAVIMADGKKIAAEDLALEVPEGGGEDRL
RLKDAREQAEYQAVVRALSRSNGNIAQAAGLLGITRPTLYTLMDKFALR

Sequences:

>Translated_449_residues
MGHANHLLIVEDDKGLQEQLRWCFDGYEIVPAFDRAEAVALARRYEPELVLLDLGLPPDPANASEGLAALQEVLAEAPES
KVIVVTGNDDRENALKAVALGAYDFYGKPVDPDTLRLLVDRAAQLYSLEAENRRLAQQSASPLEGFLSSDPGALQVCRMV
ERVAPADATVLLRGESGTGKEILARAVHRLSGRREQRFVAINCAAIPENLLESELFGYEKGAFTGANRQTIGKIEYASGG
TLFLDEIGDLPLSLQAKLLRFLQERTIERLGGRQSIEVDVRVVCATHRDLAEMIRDGGFREDLFYRVAEIELTIPPLRER
PGDAVLVAHALLDRFAREQRQPRRLLTPEAIDAIEAYPWPGNVREMENVIRRAVIMADGKKIAAEDLALEVPEGGGEDRL
RLKDAREQAEYQAVVRALSRSNGNIAQAAGLLGITRPTLYTLMDKFALR
>Mature_448_residues
GHANHLLIVEDDKGLQEQLRWCFDGYEIVPAFDRAEAVALARRYEPELVLLDLGLPPDPANASEGLAALQEVLAEAPESK
VIVVTGNDDRENALKAVALGAYDFYGKPVDPDTLRLLVDRAAQLYSLEAENRRLAQQSASPLEGFLSSDPGALQVCRMVE
RVAPADATVLLRGESGTGKEILARAVHRLSGRREQRFVAINCAAIPENLLESELFGYEKGAFTGANRQTIGKIEYASGGT
LFLDEIGDLPLSLQAKLLRFLQERTIERLGGRQSIEVDVRVVCATHRDLAEMIRDGGFREDLFYRVAEIELTIPPLRERP
GDAVLVAHALLDRFAREQRQPRRLLTPEAIDAIEAYPWPGNVREMENVIRRAVIMADGKKIAAEDLALEVPEGGGEDRLR
LKDAREQAEYQAVVRALSRSNGNIAQAAGLLGITRPTLYTLMDKFALR

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=461, Percent_Identity=40.5639913232104, Blast_Score=340, Evalue=1e-94,
Organism=Escherichia coli, GI1790437, Length=451, Percent_Identity=40.7982261640798, Blast_Score=306, Evalue=2e-84,
Organism=Escherichia coli, GI1790299, Length=466, Percent_Identity=36.6952789699571, Blast_Score=275, Evalue=5e-75,
Organism=Escherichia coli, GI1788905, Length=451, Percent_Identity=37.6940133037694, Blast_Score=270, Evalue=1e-73,
Organism=Escherichia coli, GI87082117, Length=342, Percent_Identity=46.1988304093567, Blast_Score=269, Evalue=3e-73,
Organism=Escherichia coli, GI1789087, Length=307, Percent_Identity=46.2540716612378, Blast_Score=259, Evalue=3e-70,
Organism=Escherichia coli, GI1789233, Length=310, Percent_Identity=45.4838709677419, Blast_Score=250, Evalue=1e-67,
Organism=Escherichia coli, GI87082152, Length=337, Percent_Identity=39.4658753709199, Blast_Score=226, Evalue=2e-60,
Organism=Escherichia coli, GI87081872, Length=308, Percent_Identity=41.5584415584416, Blast_Score=211, Evalue=8e-56,
Organism=Escherichia coli, GI1786524, Length=316, Percent_Identity=40.5063291139241, Blast_Score=209, Evalue=3e-55,
Organism=Escherichia coli, GI1787583, Length=322, Percent_Identity=35.0931677018634, Blast_Score=199, Evalue=4e-52,
Organism=Escherichia coli, GI87081858, Length=305, Percent_Identity=31.1475409836066, Blast_Score=137, Evalue=1e-33,
Organism=Escherichia coli, GI1789828, Length=292, Percent_Identity=33.9041095890411, Blast_Score=129, Evalue=3e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 49593; Mature: 49462

Theoretical pI: Translated: 4.81; Mature: 4.81

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00675 SIGMA54_INTERACT_1 ; PS00676 SIGMA54_INTERACT_2 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGHANHLLIVEDDKGLQEQLRWCFDGYEIVPAFDRAEAVALARRYEPELVLLDLGLPPDP
CCCCCEEEEEECCCCHHHHHHHHHCCCEEEECHHHHHHHHHHHHCCCCEEEEECCCCCCC
ANASEGLAALQEVLAEAPESKVIVVTGNDDRENALKAVALGAYDFYGKPVDPDTLRLLVD
CCHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHCCCHHCCCCCCCHHHHHHHHH
RAAQLYSLEAENRRLAQQSASPLEGFLSSDPGALQVCRMVERVAPADATVLLRGESGTGK
HHHHHHHCCHHHHHHHHHCCCHHHHHHCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCCH
EILARAVHRLSGRREQRFVAINCAAIPENLLESELFGYEKGAFTGANRQTIGKIEYASGG
HHHHHHHHHHCCCCCCEEEEEEEHHCCHHHHHHHHHCCCCCCCCCCCCCEECEEEECCCC
TLFLDEIGDLPLSLQAKLLRFLQERTIERLGGRQSIEVDVRVVCATHRDLAEMIRDGGFR
EEEEHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEEECHHHHHHHHHCCCCH
EDLFYRVAEIELTIPPLRERPGDAVLVAHALLDRFAREQRQPRRLLTPEAIDAIEAYPWP
HHHHHEEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCC
GNVREMENVIRRAVIMADGKKIAAEDLALEVPEGGGEDRLRLKDAREQAEYQAVVRALSR
CCHHHHHHHHHHHHHHCCCCEEECCCCEEECCCCCCCCCEEHHHHHHHHHHHHHHHHHHC
SNGNIAQAAGLLGITRPTLYTLMDKFALR
CCCCHHHHHHHHHCCHHHHHHHHHHHHCC
>Mature Secondary Structure 
GHANHLLIVEDDKGLQEQLRWCFDGYEIVPAFDRAEAVALARRYEPELVLLDLGLPPDP
CCCCEEEEEECCCCHHHHHHHHHCCCEEEECHHHHHHHHHHHHCCCCEEEEECCCCCCC
ANASEGLAALQEVLAEAPESKVIVVTGNDDRENALKAVALGAYDFYGKPVDPDTLRLLVD
CCHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHCCCHHCCCCCCCHHHHHHHHH
RAAQLYSLEAENRRLAQQSASPLEGFLSSDPGALQVCRMVERVAPADATVLLRGESGTGK
HHHHHHHCCHHHHHHHHHCCCHHHHHHCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCCH
EILARAVHRLSGRREQRFVAINCAAIPENLLESELFGYEKGAFTGANRQTIGKIEYASGG
HHHHHHHHHHCCCCCCEEEEEEEHHCCHHHHHHHHHCCCCCCCCCCCCCEECEEEECCCC
TLFLDEIGDLPLSLQAKLLRFLQERTIERLGGRQSIEVDVRVVCATHRDLAEMIRDGGFR
EEEEHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEEECHHHHHHHHHCCCCH
EDLFYRVAEIELTIPPLRERPGDAVLVAHALLDRFAREQRQPRRLLTPEAIDAIEAYPWP
HHHHHEEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCC
GNVREMENVIRRAVIMADGKKIAAEDLALEVPEGGGEDRLRLKDAREQAEYQAVVRALSR
CCHHHHHHHHHHHHHHCCCCEEECCCCEEECCCCCCCCCEEHHHHHHHHHHHHHHHHHHC
SNGNIAQAAGLLGITRPTLYTLMDKFALR
CCCCHHHHHHHHHCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]