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The map label for this gene is lolC [H]

Identifier: 121998042

GI number: 121998042

Start: 1358726

End: 1359970

Strand: Reverse

Name: lolC [H]

Synonym: Hhal_1252

Alternate gene names: 121998042

Gene position: 1359970-1358726 (Counterclockwise)

Preceding gene: 121998043

Following gene: 121998041

Centisome position: 50.77

GC content: 64.26

Gene sequence:

>1245_bases
TTGTTCCGACCTGTAGAGCTGTTCATCGGCCTTCGTTACACCCGGGCCCGGCGGCGTGGGCACTTCGTCTCTTTCATCTC
GATGACCTCGATGATCGGCATCGCCCTCGGCGTTGCAGCGCTGATCACCGTGCTTTCGGTGATGAACGGTTTCGAGCGGG
AGCTGCGCGAGCGGATCCTCGGAATGGTTTCCCACGCTGAAGTCCACGGCGCTCAGCGTCAGGTGGAGGATTGGCCCGGG
GTGCTTGAGCGCGCCGAGCGGCATCCCCGCGTTGTCGGTGCCGCCCCCTTCATCGATGGCGAGGTCATGGTGACCCGTGG
GGGCCAGGTCAGCGGGACTTTGATCCGTGGCGTGGATCCCGATCTAGAACCGAGTGTCTCCGATGTCCTGGATCAGGTGA
TCGCCGGGGAGGCCAAGCTGGAGGCCGGGGAGTTCGGGCTGATCATGGGCTCGGCCCTGGCTCGCGAACTCGGTGCACGA
GTGGGTGACCGCATCACCGTGATCACCCCCGAGGCCCGTGTCTCCGTGGCCGGTGTGACGCCCCGCATGCGGCGGTTCAC
GCTGACCGGTATCTTCGAAGTGGGGATGCACGAGTACGACCGGACCTTGGCCATCGCCCACATCGAGGATATGGCGCGGG
TCAAGGGGATGGGGGATGGGGTCAGCGGGATCCGGCTCAAGCTCGACGATATGATGGCTGCCCCTTGGTTGGCCCGCGAG
GTGGCCGACGACCTGCCGGGGCAATACCGGGTGGTGGACTGGACCCGGCAGCACGCCAATTTCTTCCGCGCAGTGCAGAC
CGAGAAAACGGTCATGTTCGTCATTCTGGCGCTGATCGTCGCGGTAGCCGCCTTTAACATCGTTTCGACCCTGGTCATGG
TGGTCCGCGATAAACAGTCCGATATCGCCATATTGCGAACGGTGGGACTGAGCCCGGGCAGCGTCATGGCGGTCTTCATT
ATCCAGGGCGCGGTGATTGGCGTGGTAGGAACCCTGCTCGGGGTCGCCGGCGGTGTGTCACTGGCGCTCAATGTCGAGAA
CATCGTCCCGGCGGTGGAGCAGTTGCTCAACTTCGAGTTCCTGCCCGCCGACGTCTACTACATCAGCGATCTGCCCTCGG
AGTTGCGCGGCGAGGACGTTGGGCGGATCACGGTACTGGCACTGGCGCTGTCGCTAGTCGCTACGCTCTACCCGGCGTGG
CGGGCGGCGCGTACAGAGCCCGCGGAGGCGTTGCGTTATGAATGA

Upstream 100 bases:

>100_bases
GAGGGCGTCGAGATCCGCGCGGTCCGGCTGCATCCGAGCGCCACCGGGATCCGGCCCGATTGCGCCCTGCCGGTCCACTA
TCAAGAGGAGCCGTAATCCG

Downstream 100 bases:

>100_bases
GGCCGAGGTGGTCATCGATTGTCGGCGGGTGGCCAAACACTTCAGCGAGGGCCCACAGGAGGTTGAGGTCCTCAGCGGGG
TGGATCTCAGCGTGCGCGCC

Product: LolC/E family lipoprotein releasing system, transmembrane protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 414; Mature: 414

Protein sequence:

>414_residues
MFRPVELFIGLRYTRARRRGHFVSFISMTSMIGIALGVAALITVLSVMNGFERELRERILGMVSHAEVHGAQRQVEDWPG
VLERAERHPRVVGAAPFIDGEVMVTRGGQVSGTLIRGVDPDLEPSVSDVLDQVIAGEAKLEAGEFGLIMGSALARELGAR
VGDRITVITPEARVSVAGVTPRMRRFTLTGIFEVGMHEYDRTLAIAHIEDMARVKGMGDGVSGIRLKLDDMMAAPWLARE
VADDLPGQYRVVDWTRQHANFFRAVQTEKTVMFVILALIVAVAAFNIVSTLVMVVRDKQSDIAILRTVGLSPGSVMAVFI
IQGAVIGVVGTLLGVAGGVSLALNVENIVPAVEQLLNFEFLPADVYYISDLPSELRGEDVGRITVLALALSLVATLYPAW
RAARTEPAEALRYE

Sequences:

>Translated_414_residues
MFRPVELFIGLRYTRARRRGHFVSFISMTSMIGIALGVAALITVLSVMNGFERELRERILGMVSHAEVHGAQRQVEDWPG
VLERAERHPRVVGAAPFIDGEVMVTRGGQVSGTLIRGVDPDLEPSVSDVLDQVIAGEAKLEAGEFGLIMGSALARELGAR
VGDRITVITPEARVSVAGVTPRMRRFTLTGIFEVGMHEYDRTLAIAHIEDMARVKGMGDGVSGIRLKLDDMMAAPWLARE
VADDLPGQYRVVDWTRQHANFFRAVQTEKTVMFVILALIVAVAAFNIVSTLVMVVRDKQSDIAILRTVGLSPGSVMAVFI
IQGAVIGVVGTLLGVAGGVSLALNVENIVPAVEQLLNFEFLPADVYYISDLPSELRGEDVGRITVLALALSLVATLYPAW
RAARTEPAEALRYE
>Mature_414_residues
MFRPVELFIGLRYTRARRRGHFVSFISMTSMIGIALGVAALITVLSVMNGFERELRERILGMVSHAEVHGAQRQVEDWPG
VLERAERHPRVVGAAPFIDGEVMVTRGGQVSGTLIRGVDPDLEPSVSDVLDQVIAGEAKLEAGEFGLIMGSALARELGAR
VGDRITVITPEARVSVAGVTPRMRRFTLTGIFEVGMHEYDRTLAIAHIEDMARVKGMGDGVSGIRLKLDDMMAAPWLARE
VADDLPGQYRVVDWTRQHANFFRAVQTEKTVMFVILALIVAVAAFNIVSTLVMVVRDKQSDIAILRTVGLSPGSVMAVFI
IQGAVIGVVGTLLGVAGGVSLALNVENIVPAVEQLLNFEFLPADVYYISDLPSELRGEDVGRITVLALALSLVATLYPAW
RAARTEPAEALRYE

Specific function: Part of an ATP-dependent transport system responsible for the release of lipoproteins targeted to the outer membrane from the inner membrane. Such a release is dependent of the sorting-signal (absence of an Asp at position 2 of the mature lipoprotein) and

COG id: COG4591

COG function: function code M; ABC-type transport system, involved in lipoprotein release, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily [H]

Homologues:

Organism=Escherichia coli, GI1787362, Length=413, Percent_Identity=38.0145278450363, Blast_Score=256, Evalue=2e-69,
Organism=Escherichia coli, GI1787360, Length=419, Percent_Identity=39.1408114558473, Blast_Score=239, Evalue=2e-64,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003838
- InterPro:   IPR011925 [H]

Pfam domain/function: PF02687 FtsX [H]

EC number: NA

Molecular weight: Translated: 45012; Mature: 45012

Theoretical pI: Translated: 5.71; Mature: 5.71

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFRPVELFIGLRYTRARRRGHFVSFISMTSMIGIALGVAALITVLSVMNGFERELRERIL
CCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GMVSHAEVHGAQRQVEDWPGVLERAERHPRVVGAAPFIDGEVMVTRGGQVSGTLIRGVDP
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCEEEEECCCCCCCEEEECCCC
DLEPSVSDVLDQVIAGEAKLEAGEFGLIMGSALARELGARVGDRITVITPEARVSVAGVT
CCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEECCCCEEEEECCC
PRMRRFTLTGIFEVGMHEYDRTLAIAHIEDMARVKGMGDGVSGIRLKLDDMMAAPWLARE
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCEEEEHHHHHHCHHHHHH
VADDLPGQYRVVDWTRQHANFFRAVQTEKTVMFVILALIVAVAAFNIVSTLVMVVRDKQS
HHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
DIAILRTVGLSPGSVMAVFIIQGAVIGVVGTLLGVAGGVSLALNVENIVPAVEQLLNFEF
CEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHCCCC
LPADVYYISDLPSELRGEDVGRITVLALALSLVATLYPAWRAARTEPAEALRYE
CCCCEEEECCCCHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCC
>Mature Secondary Structure
MFRPVELFIGLRYTRARRRGHFVSFISMTSMIGIALGVAALITVLSVMNGFERELRERIL
CCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GMVSHAEVHGAQRQVEDWPGVLERAERHPRVVGAAPFIDGEVMVTRGGQVSGTLIRGVDP
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCEEEEECCCCCCCEEEECCCC
DLEPSVSDVLDQVIAGEAKLEAGEFGLIMGSALARELGARVGDRITVITPEARVSVAGVT
CCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEECCCCEEEEECCC
PRMRRFTLTGIFEVGMHEYDRTLAIAHIEDMARVKGMGDGVSGIRLKLDDMMAAPWLARE
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCEEEEHHHHHHCHHHHHH
VADDLPGQYRVVDWTRQHANFFRAVQTEKTVMFVILALIVAVAAFNIVSTLVMVVRDKQS
HHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
DIAILRTVGLSPGSVMAVFIIQGAVIGVVGTLLGVAGGVSLALNVENIVPAVEQLLNFEF
CEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHCCCC
LPADVYYISDLPSELRGEDVGRITVLALALSLVATLYPAWRAARTEPAEALRYE
CCCCEEEECCCCHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10910347 [H]