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The map label for this gene is yajL [H]

Identifier: 121997998

GI number: 121997998

Start: 1312826

End: 1313392

Strand: Reverse

Name: yajL [H]

Synonym: Hhal_1208

Alternate gene names: 121997998

Gene position: 1313392-1312826 (Counterclockwise)

Preceding gene: 121997999

Following gene: 121997988

Centisome position: 49.04

GC content: 70.9

Gene sequence:

>567_bases
ATGATGAGTGTACGAGTTCTGGTTCCGCTGGCCCACGGCTGTGAGGAGCTGGAGGCGGTCACGGTGATCGACCTGCTGCG
TCGGGCCGGTGCCGAGGTGGTGGTCGCCGGCCTGGAATCGGGCACGGTGCGCGCCAGCCGCGGGGTTCAACTGGTCCCGG
ATACCGAGCTGGACAGGGTCGTGGAGGAGACCTTCGACCTGATCGTGCTGCCCGGCGGGCTCGGCGGCGCCGAGCGGCTC
GAGGGGGATGCGCGCATCGCCCGCATGCTGCAGGCGCAGAACGAGCGCGGCGGCTGGATCGCCGCCATCTGCGCAGCGCC
GCGTGTGCTCGCCGAGGTAGGGGTCCTGCAGGGGCGTCGCGCCACCGCCTTCCCCACGCAGCTCGAGCGCCACGGCATCG
AGCCGGAGGACAGCGCGGTGGTGATCGACGACAACCTGATCACCTCGCGCGGGCCGGGCACAGCGATGGACTTTGCCCTG
CGCCTGATCGAGGTGGTCTACGGCGACGAGAAGGCTGCGGAGGTCGAGGGGGCCCTGCAACGCCCGCTGTCCCACCAGCG
CTACTGA

Upstream 100 bases:

>100_bases
TCGAAGAGGAATTGCCGCGGCTTCGCGAGCGGGGTGTGGCCCTGGTGCCCGCTAGCGAGTTGGTTGATGAACCGGCCACC
GATCCGTTAAAGGGAGATCG

Downstream 100 bases:

>100_bases
GCGGGCCTGCCGTGGCGGTTCAGCGCCGCCACGGCAGGGCGAGGATCAGGGCCAGCAGCCCCAGTCCGCCCAGGCCCCAG
GTGGCGGGGGGCACCTCGGC

Product: DJ-1 family protein

Products: 1-[(4-amino-2-methylpyrimidin-5-yl)methyl]pyridinium; 4-Methyl-5-(2-hydroxyethyl)-thiazole

Alternate protein names: NA

Number of amino acids: Translated: 188; Mature: 188

Protein sequence:

>188_residues
MMSVRVLVPLAHGCEELEAVTVIDLLRRAGAEVVVAGLESGTVRASRGVQLVPDTELDRVVEETFDLIVLPGGLGGAERL
EGDARIARMLQAQNERGGWIAAICAAPRVLAEVGVLQGRRATAFPTQLERHGIEPEDSAVVIDDNLITSRGPGTAMDFAL
RLIEVVYGDEKAAEVEGALQRPLSHQRY

Sequences:

>Translated_188_residues
MMSVRVLVPLAHGCEELEAVTVIDLLRRAGAEVVVAGLESGTVRASRGVQLVPDTELDRVVEETFDLIVLPGGLGGAERL
EGDARIARMLQAQNERGGWIAAICAAPRVLAEVGVLQGRRATAFPTQLERHGIEPEDSAVVIDDNLITSRGPGTAMDFAL
RLIEVVYGDEKAAEVEGALQRPLSHQRY
>Mature_188_residues
MMSVRVLVPLAHGCEELEAVTVIDLLRRAGAEVVVAGLESGTVRASRGVQLVPDTELDRVVEETFDLIVLPGGLGGAERL
EGDARIARMLQAQNERGGWIAAICAAPRVLAEVGVLQGRRATAFPTQLERHGIEPEDSAVVIDDNLITSRGPGTAMDFAL
RLIEVVYGDEKAAEVEGALQRPLSHQRY

Specific function: Involved in biogenesis of ribosomal proteins, probably as a ribosomal protein-folding chaperone. Interacts with ribosomal subunits, ribosomes and polysomes. Confers resistance to oxidative stress [H]

COG id: COG0693

COG function: function code R; Putative intracellular protease/amidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase C56 family [H]

Homologues:

Organism=Homo sapiens, GI183227678, Length=186, Percent_Identity=40.8602150537634, Blast_Score=117, Evalue=6e-27,
Organism=Homo sapiens, GI31543380, Length=186, Percent_Identity=40.8602150537634, Blast_Score=117, Evalue=6e-27,
Organism=Escherichia coli, GI87081736, Length=185, Percent_Identity=42.1621621621622, Blast_Score=113, Evalue=7e-27,
Organism=Escherichia coli, GI87082219, Length=171, Percent_Identity=32.7485380116959, Blast_Score=73, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17531319, Length=169, Percent_Identity=40.2366863905325, Blast_Score=118, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI17558714, Length=172, Percent_Identity=37.7906976744186, Blast_Score=115, Evalue=2e-26,
Organism=Drosophila melanogaster, GI28571932, Length=182, Percent_Identity=48.9010989010989, Blast_Score=160, Evalue=4e-40,
Organism=Drosophila melanogaster, GI24653499, Length=178, Percent_Identity=44.3820224719101, Blast_Score=132, Evalue=1e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006287
- InterPro:   IPR002818 [H]

Pfam domain/function: PF01965 DJ-1_PfpI [H]

EC number: 2.5.1.2

Molecular weight: Translated: 20186; Mature: 20186

Theoretical pI: Translated: 4.54; Mature: 4.54

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMSVRVLVPLAHGCEELEAVTVIDLLRRAGAEVVVAGLESGTVRASRGVQLVPDTELDRV
CCCEEEEEEHHCCHHHHHHHHHHHHHHHCCCEEEEEECCCCCEECCCCEEECCCCHHHHH
VEETFDLIVLPGGLGGAERLEGDARIARMLQAQNERGGWIAAICAAPRVLAEVGVLQGRR
HHHHHCEEEECCCCCCHHHHCHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHCCCC
ATAFPTQLERHGIEPEDSAVVIDDNLITSRGPGTAMDFALRLIEVVYGDEKAAEVEGALQ
CCCCHHHHHHCCCCCCCCEEEEECCEECCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHH
RPLSHQRY
CCCCCCCC
>Mature Secondary Structure
MMSVRVLVPLAHGCEELEAVTVIDLLRRAGAEVVVAGLESGTVRASRGVQLVPDTELDRV
CCCEEEEEEHHCCHHHHHHHHHHHHHHHCCCEEEEEECCCCCEECCCCEEECCCCHHHHH
VEETFDLIVLPGGLGGAERLEGDARIARMLQAQNERGGWIAAICAAPRVLAEVGVLQGRR
HHHHHCEEEECCCCCCHHHHCHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHCCCC
ATAFPTQLERHGIEPEDSAVVIDDNLITSRGPGTAMDFALRLIEVVYGDEKAAEVEGALQ
CCCCHHHHHHCCCCCCCCEEEEECCEECCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHH
RPLSHQRY
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: thiamine; pyridine

Specific reaction: thiamine + pyridine = 1-[(4-amino-2-methylpyrimidin-5-yl)methyl]pyridinium + 4-methyl-5-(2-hydroxyethyl)thiazole

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9278503; 9592144 [H]