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The map label for this gene is hisA

Identifier: 121997883

GI number: 121997883

Start: 1185722

End: 1186462

Strand: Reverse

Name: hisA

Synonym: Hhal_1092

Alternate gene names: 121997883

Gene position: 1186462-1185722 (Counterclockwise)

Preceding gene: 121997884

Following gene: 121997882

Centisome position: 44.3

GC content: 71.12

Gene sequence:

>741_bases
GTGATCGTAATCCCCGCCATCGACCTCAAGAACGGCCACTGCGTGCGCCTGCGCCAGGGCCGGATGGACGACGAGACCAT
TTTCGACGCTGACCCCGTCGCGGTGGCCGGACGCTGGGTGGAGGCCGGCGCCGAGCGCCTCCACCTCGTGGATCTGGACG
GCGCTGTGCGGGGCGAGCCGGCCCACGAGCAGACCATCCACGCCATCGCCCGCGCCTACCCCGACACGCCGCTGCAGATC
GGCGGCGGCATTCGCAGTCGCGAGACGGCCCTGCGTTATCTGGAAGCCGGCGTGGGTTACGTCATCGTCGGGACCCGGGC
GGTGCGCGAGCCGGCCTTCGTCGAAGAGCTCTGTCGCGAGATTCCCGGGCGCGTCTGCGTTGGCCTGGACGCGCGGGGCG
GCTACGTGGCCACCGACGGCTGGGAGCAGACCTCCGAGGTGGCCGCCGTGGACTTGGCGCGCCGCTTCGAGGACGCCGGT
GTGGCGGCGCTGATCTTCACCGATATCGGTCGGGACGGAATGATGCAGGGGTGCAACGTCGAGGCCACCCGTGAGCTGGC
GCGGGCCGTCTCCATCCCGGTGATCGCCTCCGGCGGTGTCAGCAGCCTGGAGGACGTGCGCAGCCTGGCCGGTAGCCCCG
AAGGCATCGCCGGGGCGATCGTGGGCCGCGCCATCTATGACGGTGGCCTCGATCTGGCCACCGCGATCCGCACCGCGCAG
GAGGTCGGCGATGACCGCTAA

Upstream 100 bases:

>100_bases
CCGATGGCCCCTGCTTCGCCGTGCAATTCCATCCGGAGAAGAGCCAGGACGCGGGCCTGCGCCTCTATCGCAACTTCCTC
GACTGGGACGGGAGCTGGAC

Downstream 100 bases:

>100_bases
GCGCATCATCCCGTGTTTGGACGTCGACGCCGGCCGAGTGGTCAAGGGGGTGCGCTTCGTGGATATTCGCGATGCCGGCG
ACCCGGTGGAGATCGCCCGG

Product: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase

Products: NA

Alternate protein names: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase

Number of amino acids: Translated: 246; Mature: 246

Protein sequence:

>246_residues
MIVIPAIDLKNGHCVRLRQGRMDDETIFDADPVAVAGRWVEAGAERLHLVDLDGAVRGEPAHEQTIHAIARAYPDTPLQI
GGGIRSRETALRYLEAGVGYVIVGTRAVREPAFVEELCREIPGRVCVGLDARGGYVATDGWEQTSEVAAVDLARRFEDAG
VAALIFTDIGRDGMMQGCNVEATRELARAVSIPVIASGGVSSLEDVRSLAGSPEGIAGAIVGRAIYDGGLDLATAIRTAQ
EVGDDR

Sequences:

>Translated_246_residues
MIVIPAIDLKNGHCVRLRQGRMDDETIFDADPVAVAGRWVEAGAERLHLVDLDGAVRGEPAHEQTIHAIARAYPDTPLQI
GGGIRSRETALRYLEAGVGYVIVGTRAVREPAFVEELCREIPGRVCVGLDARGGYVATDGWEQTSEVAAVDLARRFEDAG
VAALIFTDIGRDGMMQGCNVEATRELARAVSIPVIASGGVSSLEDVRSLAGSPEGIAGAIVGRAIYDGGLDLATAIRTAQ
EVGDDR
>Mature_246_residues
MIVIPAIDLKNGHCVRLRQGRMDDETIFDADPVAVAGRWVEAGAERLHLVDLDGAVRGEPAHEQTIHAIARAYPDTPLQI
GGGIRSRETALRYLEAGVGYVIVGTRAVREPAFVEELCREIPGRVCVGLDARGGYVATDGWEQTSEVAAVDLARRFEDAG
VAALIFTDIGRDGMMQGCNVEATRELARAVSIPVIASGGVSSLEDVRSLAGSPEGIAGAIVGRAIYDGGLDLATAIRTAQ
EVGDDR

Specific function: Histidine biosynthesis; fourth step. [C]

COG id: COG0106

COG function: function code E; Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hisA/hisF family

Homologues:

Organism=Escherichia coli, GI87082028, Length=248, Percent_Identity=35.8870967741936, Blast_Score=124, Evalue=6e-30,
Organism=Escherichia coli, GI1788336, Length=213, Percent_Identity=23.4741784037559, Blast_Score=70, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS4_HALHL (A1WW06)

Other databases:

- EMBL:   CP000544
- RefSeq:   YP_001002670.1
- ProteinModelPortal:   A1WW06
- SMR:   A1WW06
- STRING:   A1WW06
- GeneID:   4709918
- GenomeReviews:   CP000544_GR
- KEGG:   hha:Hhal_1092
- eggNOG:   COG0106
- HOGENOM:   HBG541613
- OMA:   SIIYTDI
- PhylomeDB:   A1WW06
- BioCyc:   HHAL349124:HHAL_1092-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01014
- InterPro:   IPR013785
- InterPro:   IPR006062
- InterPro:   IPR006063
- InterPro:   IPR023016
- InterPro:   IPR011060
- Gene3D:   G3DSA:3.20.20.70
- TIGRFAMs:   TIGR00007

Pfam domain/function: PF00977 His_biosynth; SSF51366 RibP_bind_barrel

EC number: =5.3.1.16

Molecular weight: Translated: 26045; Mature: 26045

Theoretical pI: Translated: 4.52; Mature: 4.52

Prosite motif: NA

Important sites: ACT_SITE 8-8 ACT_SITE 130-130

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIVIPAIDLKNGHCVRLRQGRMDDETIFDADPVAVAGRWVEAGAERLHLVDLDGAVRGEP
CEEEEEEECCCCCEEEEECCCCCCCCEECCCCHHHHHHHHHCCCCEEEEEECCCCCCCCC
AHEQTIHAIARAYPDTPLQIGGGIRSRETALRYLEAGVGYVIVGTRAVREPAFVEELCRE
CHHHHHHHHHHHCCCCCEEECCCCCHHHHHHHHHHCCCCEEEECCHHHCCCHHHHHHHHH
IPGRVCVGLDARGGYVATDGWEQTSEVAAVDLARRFEDAGVAALIFTDIGRDGMMQGCNV
CCCCEEEEEECCCCEEEECCCHHHHHHHHHHHHHHHHHCCEEEEEEECCCCCCCCCCCCH
EATRELARAVSIPVIASGGVSSLEDVRSLAGSPEGIAGAIVGRAIYDGGLDLATAIRTAQ
HHHHHHHHHHCCCEEECCCCHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHH
EVGDDR
HHCCCC
>Mature Secondary Structure
MIVIPAIDLKNGHCVRLRQGRMDDETIFDADPVAVAGRWVEAGAERLHLVDLDGAVRGEP
CEEEEEEECCCCCEEEEECCCCCCCCEECCCCHHHHHHHHHCCCCEEEEEECCCCCCCCC
AHEQTIHAIARAYPDTPLQIGGGIRSRETALRYLEAGVGYVIVGTRAVREPAFVEELCRE
CHHHHHHHHHHHCCCCCEEECCCCCHHHHHHHHHHCCCCEEEECCHHHCCCHHHHHHHHH
IPGRVCVGLDARGGYVATDGWEQTSEVAAVDLARRFEDAGVAALIFTDIGRDGMMQGCNV
CCCCEEEEEECCCCEEEECCCHHHHHHHHHHHHHHHHHCCEEEEEEECCCCCCCCCCCCH
EATRELARAVSIPVIASGGVSSLEDVRSLAGSPEGIAGAIVGRAIYDGGLDLATAIRTAQ
HHHHHHHHHHCCCEEECCCCHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHH
EVGDDR
HHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA