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The map label for this gene is hisE

Identifier: 121997881

GI number: 121997881

Start: 1184627

End: 1184971

Strand: Reverse

Name: hisE

Synonym: Hhal_1090

Alternate gene names: 121997881

Gene position: 1184971-1184627 (Counterclockwise)

Preceding gene: 121997882

Following gene: 121997880

Centisome position: 44.24

GC content: 68.41

Gene sequence:

>345_bases
ATGAGCAATGCCGCGAGCGAGCGAACGGCAGCCGACACCCTGCGGGCGCTGGCCGAGACCATCGAACAGCGCCGCGGCGC
GTCGGCGGATACCTCCTACGTGGCGCGGCTCCATGACAAGGGGCTGGACGCCATCCTCAAGAAGGTCGGCGAGGAGGCCA
CCGAGGCGGTGATCGCCGCCAAGGGCGGCGAGCGGGAACAGGTCGTTTATGAGACCGCCGATCTGTGGTTCCATACTCTC
GTCATGCTCTCGGCCAGCGGTGTCTCGGTCGATGAGGTGCTGGCGGAGCTGGAGCGACGCGTGGGCCGCTCGGGTCTGGA
CGAAAAGGCGGCCCGCGGCGAGTAG

Upstream 100 bases:

>100_bases
GCGCCGACGCGGTGCTGGCGGCGAGCATCTTCCATTTCGGCGATCACACCGTCGGCGAGGCCAAGGCGCACATGGCGGAA
CGGGGGATCGAGGTCCGACG

Downstream 100 bases:

>100_bases
CAACGCACAACAGAAGGCGCCTCAGGGCGTCGGAGGGTGAGGAGATGGGATTCAATATCTGGTCGTTGCTGATCATTCTG
CTGATCGTGGCGCTGCTGTT

Product: phosphoribosyl-ATP pyrophosphatase

Products: NA

Alternate protein names: PRA-PH

Number of amino acids: Translated: 114; Mature: 113

Protein sequence:

>114_residues
MSNAASERTAADTLRALAETIEQRRGASADTSYVARLHDKGLDAILKKVGEEATEAVIAAKGGEREQVVYETADLWFHTL
VMLSASGVSVDEVLAELERRVGRSGLDEKAARGE

Sequences:

>Translated_114_residues
MSNAASERTAADTLRALAETIEQRRGASADTSYVARLHDKGLDAILKKVGEEATEAVIAAKGGEREQVVYETADLWFHTL
VMLSASGVSVDEVLAELERRVGRSGLDEKAARGE
>Mature_113_residues
SNAASERTAADTLRALAETIEQRRGASADTSYVARLHDKGLDAILKKVGEEATEAVIAAKGGEREQVVYETADLWFHTLV
MLSASGVSVDEVLAELERRVGRSGLDEKAARGE

Specific function: Histidine biosynthesis; second step. Histidine biosynthesis; third step. [C]

COG id: COG0140

COG function: function code E; Phosphoribosyl-ATP pyrophosphohydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PRA-PH family

Homologues:

Organism=Escherichia coli, GI2367128, Length=87, Percent_Identity=35.632183908046, Blast_Score=60, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS2_HALHL (A1WW04)

Other databases:

- EMBL:   CP000544
- RefSeq:   YP_001002668.1
- ProteinModelPortal:   A1WW04
- SMR:   A1WW04
- STRING:   A1WW04
- GeneID:   4709942
- GenomeReviews:   CP000544_GR
- KEGG:   hha:Hhal_1090
- eggNOG:   COG0140
- HOGENOM:   HBG646527
- OMA:   ETVMAAK
- ProtClustDB:   PRK00400
- BioCyc:   HHAL349124:HHAL_1090-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01020
- InterPro:   IPR008179
- InterPro:   IPR021130
- TIGRFAMs:   TIGR03188

Pfam domain/function: PF01503 PRA-PH

EC number: =3.6.1.31

Molecular weight: Translated: 12245; Mature: 12114

Theoretical pI: Translated: 4.67; Mature: 4.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
0.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNAASERTAADTLRALAETIEQRRGASADTSYVARLHDKGLDAILKKVGEEATEAVIAA
CCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHC
KGGEREQVVYETADLWFHTLVMLSASGVSVDEVLAELERRVGRSGLDEKAARGE
CCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure 
SNAASERTAADTLRALAETIEQRRGASADTSYVARLHDKGLDAILKKVGEEATEAVIAA
CCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHC
KGGEREQVVYETADLWFHTLVMLSASGVSVDEVLAELERRVGRSGLDEKAARGE
CCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA