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The map label for this gene is pth

Identifier: 121997778

GI number: 121997778

Start: 1059925

End: 1060509

Strand: Reverse

Name: pth

Synonym: Hhal_0987

Alternate gene names: 121997778

Gene position: 1060509-1059925 (Counterclockwise)

Preceding gene: 121997779

Following gene: 121997777

Centisome position: 39.59

GC content: 69.23

Gene sequence:

>585_bases
GTGGCCGGCCGGGAAGGTCATTTCCGGCTCATCGCCGGCCTCGGCAACCCTGGCAGCAAGTACGCGGGAACCCGGCACAA
TGCCGGGTTCTGGCTTGTTGATGAGCTGGTCCGGCGCTACGGCGGTGAGCTGCGGGAGGAGCCCAAGTTCCGCGGCGACT
GTGCCCGTGTGCTCATCGATGGCTACGACTGTCGGCTGGTCAAGCCGATGACTTACATGAACCACAGTGGCCAGGCAGTC
GGCGCGCTGGCGAACTTCTTCAAGATCCCGCCCGAGGCGATCCTGGTCGCCCACGACGAGATCGACCTGCCCCCGGGCAG
CGTCCGCCTCAAGCGCGGCGGCGGGCACGGCGGGCACAACGGCCTGCGCCATATCCAGTCGACCCTCGGTACCCCCGATT
TCGCCCGGCTGCGCCTCGGCGTCGGCCACCCGGGGCACAAGGATCAGGTGGTCCCGCACGTCCTCTCCCGTCCGTCCCCC
GATGAGCTGCGCCAGCTTGAGCGGGCCATTGACGACGCGGCCGACCAGATACCGCGGCTGCTTGCCGGGGAGTGGGACCG
CGCCTGCCAGCAGCTCCACGCCTAG

Upstream 100 bases:

>100_bases
GAGTACGATGCGCCTGTGGTCTCGGTTCAGGCAACTCGTAAGACGCGAGGTGCCAGCAGCGACGACGAGGCCGAGTCCTC
CGAGTCCGAGTAACGCCGAA

Downstream 100 bases:

>100_bases
CCGACGCGGGCCGGCGCGCCGGATTGCGGCGCCACCGTCCAGCCACCCAACCTCTTTCAGGATCGCGCCATGGGCTTTAA
CTGCGGCATTGTCGGGCTCC

Product: peptidyl-tRNA hydrolase

Products: NA

Alternate protein names: PTH

Number of amino acids: Translated: 194; Mature: 193

Protein sequence:

>194_residues
MAGREGHFRLIAGLGNPGSKYAGTRHNAGFWLVDELVRRYGGELREEPKFRGDCARVLIDGYDCRLVKPMTYMNHSGQAV
GALANFFKIPPEAILVAHDEIDLPPGSVRLKRGGGHGGHNGLRHIQSTLGTPDFARLRLGVGHPGHKDQVVPHVLSRPSP
DELRQLERAIDDAADQIPRLLAGEWDRACQQLHA

Sequences:

>Translated_194_residues
MAGREGHFRLIAGLGNPGSKYAGTRHNAGFWLVDELVRRYGGELREEPKFRGDCARVLIDGYDCRLVKPMTYMNHSGQAV
GALANFFKIPPEAILVAHDEIDLPPGSVRLKRGGGHGGHNGLRHIQSTLGTPDFARLRLGVGHPGHKDQVVPHVLSRPSP
DELRQLERAIDDAADQIPRLLAGEWDRACQQLHA
>Mature_193_residues
AGREGHFRLIAGLGNPGSKYAGTRHNAGFWLVDELVRRYGGELREEPKFRGDCARVLIDGYDCRLVKPMTYMNHSGQAVG
ALANFFKIPPEAILVAHDEIDLPPGSVRLKRGGGHGGHNGLRHIQSTLGTPDFARLRLGVGHPGHKDQVVPHVLSRPSPD
ELRQLERAIDDAADQIPRLLAGEWDRACQQLHA

Specific function: The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis

COG id: COG0193

COG function: function code J; Peptidyl-tRNA hydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PTH family

Homologues:

Organism=Homo sapiens, GI50897284, Length=170, Percent_Identity=37.0588235294118, Blast_Score=100, Evalue=5e-22,
Organism=Escherichia coli, GI1787455, Length=188, Percent_Identity=53.1914893617021, Blast_Score=176, Evalue=1e-45,
Organism=Saccharomyces cerevisiae, GI6321983, Length=180, Percent_Identity=32.2222222222222, Blast_Score=71, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PTH_HALHL (A1WVQ1)

Other databases:

- EMBL:   CP000544
- RefSeq:   YP_001002565.1
- ProteinModelPortal:   A1WVQ1
- SMR:   A1WVQ1
- STRING:   A1WVQ1
- GeneID:   4709553
- GenomeReviews:   CP000544_GR
- KEGG:   hha:Hhal_0987
- eggNOG:   COG0193
- HOGENOM:   HBG610927
- OMA:   SHAGHNG
- PhylomeDB:   A1WVQ1
- ProtClustDB:   PRK05426
- BioCyc:   HHAL349124:HHAL_0987-MONOMER
- GO:   GO:0005737
- GO:   GO:0006412
- HAMAP:   MF_00083
- InterPro:   IPR001328
- InterPro:   IPR018171
- Gene3D:   G3DSA:3.40.50.1470
- PANTHER:   PTHR17224
- TIGRFAMs:   TIGR00447

Pfam domain/function: PF01195 Pept_tRNA_hydro; SSF53178 Pept_tRNA_hydro

EC number: =3.1.1.29

Molecular weight: Translated: 21326; Mature: 21194

Theoretical pI: Translated: 8.51; Mature: 8.51

Prosite motif: PS01195 PEPT_TRNA_HYDROL_1; PS01196 PEPT_TRNA_HYDROL_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAGREGHFRLIAGLGNPGSKYAGTRHNAGFWLVDELVRRYGGELREEPKFRGDCARVLID
CCCCCCCEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHCCHHHCCCCCCCHHHHHHHC
GYDCRLVKPMTYMNHSGQAVGALANFFKIPPEAILVAHDEIDLPPGSVRLKRGGGHGGHN
CCCCEEECCHHHHCCCCHHHHHHHHHHHCCCHHEEEECCCCCCCCCCEEEECCCCCCCHH
GLRHIQSTLGTPDFARLRLGVGHPGHKDQVVPHVLSRPSPDELRQLERAIDDAADQIPRL
HHHHHHHHHCCCCHHHEEECCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
LAGEWDRACQQLHA
HCCCHHHHHHHHCC
>Mature Secondary Structure 
AGREGHFRLIAGLGNPGSKYAGTRHNAGFWLVDELVRRYGGELREEPKFRGDCARVLID
CCCCCCEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHCCHHHCCCCCCCHHHHHHHC
GYDCRLVKPMTYMNHSGQAVGALANFFKIPPEAILVAHDEIDLPPGSVRLKRGGGHGGHN
CCCCEEECCHHHHCCCCHHHHHHHHHHHCCCHHEEEECCCCCCCCCCEEEECCCCCCCHH
GLRHIQSTLGTPDFARLRLGVGHPGHKDQVVPHVLSRPSPDELRQLERAIDDAADQIPRL
HHHHHHHHHCCCCHHHEEECCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
LAGEWDRACQQLHA
HCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA