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The map label for this gene is nuoN [H]

Identifier: 121997603

GI number: 121997603

Start: 895441

End: 896952

Strand: Reverse

Name: nuoN [H]

Synonym: Hhal_0812

Alternate gene names: 121997603

Gene position: 896952-895441 (Counterclockwise)

Preceding gene: 121997604

Following gene: 121997602

Centisome position: 33.49

GC content: 71.36

Gene sequence:

>1512_bases
ATGATCGATACACTCCACGCGCTGCTGCCGCTGTGGGCGCTGCTGGCCTCGCTGCTCACCGCGGTGATCATCTTCGCCCT
GCGCGACGAGCGCCGCCGCCAGCGCACCTTCTGGAACCTCTTCGGTGCCAGCGTCAAGCTGATCCTGGTGGCCCTGCTGG
TCCACGGCTTCGTCCAGGGGCAGAGCTACGTGGTGGCCTGGGAGATCCTCCCCGGCGTGACCTTCCGCCTGGCGGCGGAT
CCGCTGGCGTTGCTCTTCGCCATGCTCTCGGCGGTGCTGTGGCTGGTGACCACCGTCTACGCCGTCGCCTACCTGGAGAA
CTCGGCGCAGCGGGCGCGCTTCTTCGGCTTCTTCTCGCTGTGCGTGGCCGCCACCTTCGGCATCGCCCTGGCCGGCAACC
TGTTCACCTTCCTGCTCTTCTACGAGGCGCTGACCCTGGCCACCTACCCGCTGGTGGTCCACCGCGGTCACCCGGCGGCG
CTGAGCGCCGGGCGCACCTACCTGGCCTACACCCTCGGCGGCGGCATGGCGCTGCTCGCCGGCACCGTGGCGCTCTACGC
CGCGGTGGGCGATCAGCCCTTCACCCCGGGCGGGGTGGCGGCGGTGGCCGAGTGGGCAGGGCAGGCGCCGGGGGCCGCCA
CCGCGGTGCTGGGGCTGCTGCTCGCCGGGGTGGCGGTCAAGGCGGCGCTCTTCCCGCTGCAGGCGTGGCTGCCCATCGCC
ATGGTGGCGCCGGCGCCGGTCAGTGCGCTGCTCCACGCCGTGGCCGTGGTCAAGGCCGGCGCCTTCGGCGTGGTGCGCAT
CGTCCAGGACGTCTTCGGCCACACCGTGGCCACCGATCTCCACGTCACCCCGGTGCTGGCCGTGCTGGCGGCGGTGACCA
TCCTCTACGGCTCGGTGCGCGCCCTGGCCCAGGTGGAGATCAAGCGTCGCCTGGCCTTCTCCACGGTCAGTCAGGTCTCG
TTCATCACCCTGGGCGTGGCCATGGGCGGGCCGCTGGCGCTCATTGGCGGGCTGGTGCACCTGGTCCACCAGGGGCTGAT
GAAGATCACCCTGTTCTTCTGCGCCGGCAACTACGCCGAGACCCTGGACATCCACCGCATCGGGTCGCTCAACGGCGTCG
GCCGGCGCATGCCGCTGACCTCCATCGCCTTTACCATCGGCGCCCTGGGGATGATCGGCTTCCCGCCCATCGCCGGGTTC
ATCAGCAAGTGGCACCTGGGGCTGGGTGCGCTGGCCCAGGAGCTCTACTGGGTGCTGGCGGTGCTGGTGGCCAGCACCCT
GCTCAACGCCGCCTACTTCCTGCCGGTGCTCCGGCGCATCTGGCTGCTGCCGGAACCGGCCGGCGGCCCCGGCGGGGTGG
GGACGAGCAGTAGCGCCGAGACCCACCGCTGGCTGCTCTATCCGGCGCTGTTCACCGCCGCGGCGGCGCTGCTCGCCGGC
GTCCTGGCGGCGGCGGAGTTCTCGCCGCTGAGCTGGGCTGTGCGCATCGTCGAACAGGAGTACCTGCCGTGA

Upstream 100 bases:

>100_bases
AGTGGGTGCCGCTGCTGCTGGTGCTGGTGGTCTACGCCCTGGGGATCAGCGCCATGCCGGCGCTGGGGCTGCTCGAGCAG
GGCGCACCGGAGGGGCTGGA

Downstream 100 bases:

>100_bases
GCATCGATCCGGCCGTCGGCCTGCTCGTGCCCGTGCTGATGCCGCTGCTGGCGGTGGCGCTGCTCGGTGGCCGTGCCCGT
GCCCTGGGGGCCGGGCTGCT

Product: NADH dehydrogenase (quinone)

Products: NA

Alternate protein names: NADH dehydrogenase I subunit N; NDH-1 subunit N [H]

Number of amino acids: Translated: 503; Mature: 503

Protein sequence:

>503_residues
MIDTLHALLPLWALLASLLTAVIIFALRDERRRQRTFWNLFGASVKLILVALLVHGFVQGQSYVVAWEILPGVTFRLAAD
PLALLFAMLSAVLWLVTTVYAVAYLENSAQRARFFGFFSLCVAATFGIALAGNLFTFLLFYEALTLATYPLVVHRGHPAA
LSAGRTYLAYTLGGGMALLAGTVALYAAVGDQPFTPGGVAAVAEWAGQAPGAATAVLGLLLAGVAVKAALFPLQAWLPIA
MVAPAPVSALLHAVAVVKAGAFGVVRIVQDVFGHTVATDLHVTPVLAVLAAVTILYGSVRALAQVEIKRRLAFSTVSQVS
FITLGVAMGGPLALIGGLVHLVHQGLMKITLFFCAGNYAETLDIHRIGSLNGVGRRMPLTSIAFTIGALGMIGFPPIAGF
ISKWHLGLGALAQELYWVLAVLVASTLLNAAYFLPVLRRIWLLPEPAGGPGGVGTSSSAETHRWLLYPALFTAAAALLAG
VLAAAEFSPLSWAVRIVEQEYLP

Sequences:

>Translated_503_residues
MIDTLHALLPLWALLASLLTAVIIFALRDERRRQRTFWNLFGASVKLILVALLVHGFVQGQSYVVAWEILPGVTFRLAAD
PLALLFAMLSAVLWLVTTVYAVAYLENSAQRARFFGFFSLCVAATFGIALAGNLFTFLLFYEALTLATYPLVVHRGHPAA
LSAGRTYLAYTLGGGMALLAGTVALYAAVGDQPFTPGGVAAVAEWAGQAPGAATAVLGLLLAGVAVKAALFPLQAWLPIA
MVAPAPVSALLHAVAVVKAGAFGVVRIVQDVFGHTVATDLHVTPVLAVLAAVTILYGSVRALAQVEIKRRLAFSTVSQVS
FITLGVAMGGPLALIGGLVHLVHQGLMKITLFFCAGNYAETLDIHRIGSLNGVGRRMPLTSIAFTIGALGMIGFPPIAGF
ISKWHLGLGALAQELYWVLAVLVASTLLNAAYFLPVLRRIWLLPEPAGGPGGVGTSSSAETHRWLLYPALFTAAAALLAG
VLAAAEFSPLSWAVRIVEQEYLP
>Mature_503_residues
MIDTLHALLPLWALLASLLTAVIIFALRDERRRQRTFWNLFGASVKLILVALLVHGFVQGQSYVVAWEILPGVTFRLAAD
PLALLFAMLSAVLWLVTTVYAVAYLENSAQRARFFGFFSLCVAATFGIALAGNLFTFLLFYEALTLATYPLVVHRGHPAA
LSAGRTYLAYTLGGGMALLAGTVALYAAVGDQPFTPGGVAAVAEWAGQAPGAATAVLGLLLAGVAVKAALFPLQAWLPIA
MVAPAPVSALLHAVAVVKAGAFGVVRIVQDVFGHTVATDLHVTPVLAVLAAVTILYGSVRALAQVEIKRRLAFSTVSQVS
FITLGVAMGGPLALIGGLVHLVHQGLMKITLFFCAGNYAETLDIHRIGSLNGVGRRMPLTSIAFTIGALGMIGFPPIAGF
ISKWHLGLGALAQELYWVLAVLVASTLLNAAYFLPVLRRIWLLPEPAGGPGGVGTSSSAETHRWLLYPALFTAAAALLAG
VLAAAEFSPLSWAVRIVEQEYLP

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translo

COG id: COG0651

COG function: function code CP; Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 2 family [H]

Homologues:

Organism=Homo sapiens, GI251831117, Length=271, Percent_Identity=33.9483394833948, Blast_Score=119, Evalue=7e-27,
Organism=Escherichia coli, GI1788827, Length=323, Percent_Identity=31.8885448916409, Blast_Score=134, Evalue=2e-32,
Organism=Escherichia coli, GI1788829, Length=402, Percent_Identity=29.1044776119403, Blast_Score=133, Evalue=3e-32,
Organism=Escherichia coli, GI1788614, Length=349, Percent_Identity=31.2320916905444, Blast_Score=111, Evalue=1e-25,
Organism=Escherichia coli, GI1788613, Length=355, Percent_Identity=27.887323943662, Blast_Score=105, Evalue=7e-24,
Organism=Escherichia coli, GI1788831, Length=398, Percent_Identity=27.8894472361809, Blast_Score=105, Evalue=8e-24,
Organism=Escherichia coli, GI145693160, Length=392, Percent_Identity=26.530612244898, Blast_Score=75, Evalue=9e-15,
Organism=Escherichia coli, GI2367154, Length=130, Percent_Identity=35.3846153846154, Blast_Score=75, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010096
- InterPro:   IPR001750
- InterPro:   IPR003918 [H]

Pfam domain/function: PF00361 Oxidored_q1 [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 53052; Mature: 53052

Theoretical pI: Translated: 9.67; Mature: 9.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDTLHALLPLWALLASLLTAVIIFALRDERRRQRTFWNLFGASVKLILVALLVHGFVQG
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
QSYVVAWEILPGVTFRLAADPLALLFAMLSAVLWLVTTVYAVAYLENSAQRARFFGFFSL
CCEEEEEEECCCCEEHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
CVAATFGIALAGNLFTFLLFYEALTLATYPLVVHRGHPAALSAGRTYLAYTLGGGMALLA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCHHHCCCEEEEEEECCHHHHHH
GTVALYAAVGDQPFTPGGVAAVAEWAGQAPGAATAVLGLLLAGVAVKAALFPLQAWLPIA
HHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MVAPAPVSALLHAVAVVKAGAFGVVRIVQDVFGHTVATDLHVTPVLAVLAAVTILYGSVR
HCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHCCHHHCCCHHHHHHHHHHHHHHHHHHHH
ALAQVEIKRRLAFSTVSQVSFITLGVAMGGPLALIGGLVHLVHQGLMKITLFFCAGNYAE
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
TLDIHRIGSLNGVGRRMPLTSIAFTIGALGMIGFPPIAGFISKWHLGLGALAQELYWVLA
HHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
VLVASTLLNAAYFLPVLRRIWLLPEPAGGPGGVGTSSSAETHRWLLYPALFTAAAALLAG
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
VLAAAEFSPLSWAVRIVEQEYLP
HHHHHCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure
MIDTLHALLPLWALLASLLTAVIIFALRDERRRQRTFWNLFGASVKLILVALLVHGFVQG
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
QSYVVAWEILPGVTFRLAADPLALLFAMLSAVLWLVTTVYAVAYLENSAQRARFFGFFSL
CCEEEEEEECCCCEEHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
CVAATFGIALAGNLFTFLLFYEALTLATYPLVVHRGHPAALSAGRTYLAYTLGGGMALLA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCHHHCCCEEEEEEECCHHHHHH
GTVALYAAVGDQPFTPGGVAAVAEWAGQAPGAATAVLGLLLAGVAVKAALFPLQAWLPIA
HHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MVAPAPVSALLHAVAVVKAGAFGVVRIVQDVFGHTVATDLHVTPVLAVLAAVTILYGSVR
HCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHCCHHHCCCHHHHHHHHHHHHHHHHHHHH
ALAQVEIKRRLAFSTVSQVSFITLGVAMGGPLALIGGLVHLVHQGLMKITLFFCAGNYAE
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
TLDIHRIGSLNGVGRRMPLTSIAFTIGALGMIGFPPIAGFISKWHLGLGALAQELYWVLA
HHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
VLVASTLLNAAYFLPVLRRIWLLPEPAGGPGGVGTSSSAETHRWLLYPALFTAAAALLAG
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
VLAAAEFSPLSWAVRIVEQEYLP
HHHHHCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA