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The map label for this gene is degP1 [H]

Identifier: 121997515

GI number: 121997515

Start: 802972

End: 804246

Strand: Reverse

Name: degP1 [H]

Synonym: Hhal_0718

Alternate gene names: 121997515

Gene position: 804246-802972 (Counterclockwise)

Preceding gene: 121997522

Following gene: 121997513

Centisome position: 30.03

GC content: 70.2

Gene sequence:

>1275_bases
ATGACGGTAGCACACGCGATGCAGCATCGACGCGCGCCGCGGATGGTGGTGGCGGCGCTGGCGACCGCTCTGATCGGCCT
GGTGGCCACCCCGGCGCTGGCCGACGACCTGGAGCACCTCCAGCCGGATGAGCGCAACACGGTGGAGATCTTCCAGCGCT
ACGGCCCCTCGGTGGTGGCCATCGAGGTCGAGGTCCGCGGCGAGCGGGTCGACCCCTTCGACCGCATCCCCGAAGGGATG
CTCCCGCGGGAATTCCGCGAGTTCTTCGAGCGCCGGCAGCAGCCCCGCGAGGACTCGCCCCGCCGCCAGGGCGCCGGGAG
TGGCTTTCTGGTCGATGATGCGGGGCATATCGTCACCAACTACCACGTCATCCGCAACGCCCTGGAGGAGGAGAGCGTGG
ATCTGCGCGAGGGCGCTTCCCTGAAGCTCAGCTTCGCCGAGCACGAAGCGGTGCCGGCCCGAGTGGTGGGCGCCAACGCG
CTCTACGACCTGGCCCTGCTCAAGCCCGAGGATCCGGACAGCATCCCGGACGGCGCCGAGCCGCTGCCGCTGGCCGACTC
GGATCAGACCCTGGTGGGCCAGAAGACCATCGCCATCGGCAACCCCTTCGGGCTGAGCTCTACGGTGACCACGGGGATTG
TCTCCGGTGTCGGCCGGGATCTGCCGGGGATCGGGCAGATCGAGATCCCCATGATCCAGACCGATGCGGCGATCAATCCG
GGCAACTCCGGCGGGCCGCTGCTCAACTCCGCCGGAGAGGTGATCGGTGTGAACACCGCCATCGTGCCGGGCGGCGGCGG
GCTGACCGGCCGGGGCGGCTCGGTGGGCGTGGGCTTTGCCGTGCCCAGCAATCTGCTCCAGGAGAGCCTGGACGAGATGG
AGGAGGGCGGTCTGACGGATCTGACCTCCCGGGCCCGTCTGGGGGTGATGGTGGCCGGTCTGCAGGGCTATCCGGAGGGG
GTCCGCGAGCGGCTGAATCTCCCGGAGCGCGGGGTGATGGTGGTGGATGTCGAGTCGGGCAGTCCGGCCGAGGAGGCGGG
GCTGCAGGGGGCGTCGTTCGAGGTGAGTGTCGAAGGGCGTGCCATGCCGGCCGACGGGGATGTCATCACCCACGTGAACG
GTGAGGCGGTGTCGGAGCCGCGGGAGTTGCAGCGGTTGGTCTTCGCCCGTCGGGCGGGGGATGCGGTGACGCTGACGGTC
CTGCGCGACGGTGAGGAGCGGAAGTTCGAGGTGGAGCTCCGTGAGGTGCCGCGGGAGCAGCAGCGGCGCCGGTAG

Upstream 100 bases:

>100_bases
TGTTGGAAATCGGTGGCTTGATCCGTTACGAACAGGGTGAACTTAACACCCTAGCCTTGTTGTCCACTACTTGATGAACA
ACCCACAGGTAGAAAGCCTT

Downstream 100 bases:

>100_bases
ATCGGGGCCGCGGTTCCGGGGCGCAGTTCCGGGGCGCAGTTCCGGGGCCGTGTAGGCCGTCGTGGGGCGGGGACCGGGTG
CCCTTTTGAGCGTGCCGAGC

Product: peptidase S1 and S6, chymotrypsin/Hap

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 424; Mature: 423

Protein sequence:

>424_residues
MTVAHAMQHRRAPRMVVAALATALIGLVATPALADDLEHLQPDERNTVEIFQRYGPSVVAIEVEVRGERVDPFDRIPEGM
LPREFREFFERRQQPREDSPRRQGAGSGFLVDDAGHIVTNYHVIRNALEEESVDLREGASLKLSFAEHEAVPARVVGANA
LYDLALLKPEDPDSIPDGAEPLPLADSDQTLVGQKTIAIGNPFGLSSTVTTGIVSGVGRDLPGIGQIEIPMIQTDAAINP
GNSGGPLLNSAGEVIGVNTAIVPGGGGLTGRGGSVGVGFAVPSNLLQESLDEMEEGGLTDLTSRARLGVMVAGLQGYPEG
VRERLNLPERGVMVVDVESGSPAEEAGLQGASFEVSVEGRAMPADGDVITHVNGEAVSEPRELQRLVFARRAGDAVTLTV
LRDGEERKFEVELREVPREQQRRR

Sequences:

>Translated_424_residues
MTVAHAMQHRRAPRMVVAALATALIGLVATPALADDLEHLQPDERNTVEIFQRYGPSVVAIEVEVRGERVDPFDRIPEGM
LPREFREFFERRQQPREDSPRRQGAGSGFLVDDAGHIVTNYHVIRNALEEESVDLREGASLKLSFAEHEAVPARVVGANA
LYDLALLKPEDPDSIPDGAEPLPLADSDQTLVGQKTIAIGNPFGLSSTVTTGIVSGVGRDLPGIGQIEIPMIQTDAAINP
GNSGGPLLNSAGEVIGVNTAIVPGGGGLTGRGGSVGVGFAVPSNLLQESLDEMEEGGLTDLTSRARLGVMVAGLQGYPEG
VRERLNLPERGVMVVDVESGSPAEEAGLQGASFEVSVEGRAMPADGDVITHVNGEAVSEPRELQRLVFARRAGDAVTLTV
LRDGEERKFEVELREVPREQQRRR
>Mature_423_residues
TVAHAMQHRRAPRMVVAALATALIGLVATPALADDLEHLQPDERNTVEIFQRYGPSVVAIEVEVRGERVDPFDRIPEGML
PREFREFFERRQQPREDSPRRQGAGSGFLVDDAGHIVTNYHVIRNALEEESVDLREGASLKLSFAEHEAVPARVVGANAL
YDLALLKPEDPDSIPDGAEPLPLADSDQTLVGQKTIAIGNPFGLSSTVTTGIVSGVGRDLPGIGQIEIPMIQTDAAINPG
NSGGPLLNSAGEVIGVNTAIVPGGGGLTGRGGSVGVGFAVPSNLLQESLDEMEEGGLTDLTSRARLGVMVAGLQGYPEGV
RERLNLPERGVMVVDVESGSPAEEAGLQGASFEVSVEGRAMPADGDVITHVNGEAVSEPRELQRLVFARRAGDAVTLTVL
RDGEERKFEVELREVPREQQRRR

Specific function: Serine Protease That Is Required At High Temperature. Involved In The Degradation Of Damaged Proteins. It Can Degrade Icia, Ada, Casein And Globin. Shared Specificity With Degq. [C]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PDZ (DHR) domains [H]

Homologues:

Organism=Homo sapiens, GI4506141, Length=378, Percent_Identity=29.3650793650794, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI22129776, Length=313, Percent_Identity=31.9488817891374, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI24308541, Length=307, Percent_Identity=31.5960912052117, Blast_Score=112, Evalue=5e-25,
Organism=Homo sapiens, GI7019477, Length=313, Percent_Identity=34.185303514377, Blast_Score=109, Evalue=5e-24,
Organism=Escherichia coli, GI1786356, Length=393, Percent_Identity=33.587786259542, Blast_Score=175, Evalue=4e-45,
Organism=Escherichia coli, GI1789629, Length=371, Percent_Identity=32.6145552560647, Blast_Score=158, Evalue=7e-40,
Organism=Escherichia coli, GI1789630, Length=317, Percent_Identity=30.9148264984227, Blast_Score=110, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24646839, Length=317, Percent_Identity=27.7602523659306, Blast_Score=99, Evalue=7e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR011782
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 45323; Mature: 45191

Theoretical pI: Translated: 4.46; Mature: 4.46

Prosite motif: PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVAHAMQHRRAPRMVVAALATALIGLVATPALADDLEHLQPDERNTVEIFQRYGPSVVA
CCHHHHHHHCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCHHHHHHHHCCEEEE
IEVEVRGERVDPFDRIPEGMLPREFREFFERRQQPREDSPRRQGAGSGFLVDDAGHIVTN
EEEEECCCCCCHHHHCCCCCCCHHHHHHHHHHCCCCCCCCHHCCCCCCEEEECCCCHHHH
YHVIRNALEEESVDLREGASLKLSFAEHEAVPARVVGANALYDLALLKPEDPDSIPDGAE
HHHHHHHHHHHCCCHHCCCCEEEEEHHCCCCCEEEECCCHHEEEEEECCCCCCCCCCCCC
PLPLADSDQTLVGQKTIAIGNPFGLSSTVTTGIVSGVGRDLPGIGQIEIPMIQTDAAINP
CCCCCCCCCEEECCEEEEECCCCCCCHHHHHHHHHHHCCCCCCCCCEEEEEEEECCCCCC
GNSGGPLLNSAGEVIGVNTAIVPGGGGLTGRGGSVGVGFAVPSNLLQESLDEMEEGGLTD
CCCCCCCCCCCCCEEECCEEEECCCCCCCCCCCCEEEEHHCCHHHHHHHHHHHHHCCCHH
LTSRARLGVMVAGLQGYPEGVRERLNLPERGVMVVDVESGSPAEEAGLQGASFEVSVEGR
HHHHHHHEEEEECCCCCCHHHHHHCCCCCCCEEEEEECCCCCHHHHCCCCCCEEEEECCC
AMPADGDVITHVNGEAVSEPRELQRLVFARRAGDAVTLTVLRDGEERKFEVELREVPREQ
CCCCCCCEEEECCCHHHCCHHHHHHHHHHHCCCCEEEEEEEECCCCCEEEEHHHHCCHHH
QRRR
HHCC
>Mature Secondary Structure 
TVAHAMQHRRAPRMVVAALATALIGLVATPALADDLEHLQPDERNTVEIFQRYGPSVVA
CHHHHHHHCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCHHHHHHHHCCEEEE
IEVEVRGERVDPFDRIPEGMLPREFREFFERRQQPREDSPRRQGAGSGFLVDDAGHIVTN
EEEEECCCCCCHHHHCCCCCCCHHHHHHHHHHCCCCCCCCHHCCCCCCEEEECCCCHHHH
YHVIRNALEEESVDLREGASLKLSFAEHEAVPARVVGANALYDLALLKPEDPDSIPDGAE
HHHHHHHHHHHCCCHHCCCCEEEEEHHCCCCCEEEECCCHHEEEEEECCCCCCCCCCCCC
PLPLADSDQTLVGQKTIAIGNPFGLSSTVTTGIVSGVGRDLPGIGQIEIPMIQTDAAINP
CCCCCCCCCEEECCEEEEECCCCCCCHHHHHHHHHHHCCCCCCCCCEEEEEEEECCCCCC
GNSGGPLLNSAGEVIGVNTAIVPGGGGLTGRGGSVGVGFAVPSNLLQESLDEMEEGGLTD
CCCCCCCCCCCCCEEECCEEEECCCCCCCCCCCCEEEEHHCCHHHHHHHHHHHHHCCCHH
LTSRARLGVMVAGLQGYPEGVRERLNLPERGVMVVDVESGSPAEEAGLQGASFEVSVEGR
HHHHHHHEEEEECCCCCCHHHHHHCCCCCCCEEEEEECCCCCHHHHCCCCCCEEEEECCC
AMPADGDVITHVNGEAVSEPRELQRLVFARRAGDAVTLTVLRDGEERKFEVELREVPREQ
CCCCCCCEEEECCCHHHCCHHHHHHHHHHHCCCCEEEEEEEECCCCCEEEEHHHHCCHHH
QRRR
HHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: Serine endopeptidases [C]

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8550509; 11481430 [H]