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The map label for this gene is panC

Identifier: 121997471

GI number: 121997471

Start: 757065

End: 757922

Strand: Reverse

Name: panC

Synonym: Hhal_0674

Alternate gene names: 121997471

Gene position: 757922-757065 (Counterclockwise)

Preceding gene: 121997472

Following gene: 121997470

Centisome position: 28.3

GC content: 72.26

Gene sequence:

>858_bases
TTGAGGCAGGTCACCGAGCGCAACGCCATGCGGGAGCTGTCGCGCGCCTGGCGGGCGCGCGGCGAGCGCATCGGGCTGGT
GCCGACGATGGGCAACCTCCACCGCGGCCACCTGGAACTGGTCGAGCGTCTGGCCCGGCGGGTGGATCGGCTGGTGGTGT
CGATCTTCGTCAACCCGCTGCAGTTCGGCCCGGGGGAGGACTACGACGCCTATCCGCGCACGCTGGAGGCCGATCTGAAC
GCCCTGGAGGGGCGCGGTGTCGATGCGGTCTTCGCCCCCAACGCCCGCGAGATGTACCCCGGCGTCGAGCCGCCCTGGAC
CGGGGTGGACGTGCCGGCGCTGACCCAGACCCTGTGCGGTGCGGCGCGGCCGGGCCACTTCGCCGGGGTGGCGGTGGTGG
TGATCAAGCTGCTCAATATCGTCGAGCCGGATGTCGCGGCGTTCGGGCGCAAGGATTACCAGCAGCTGCAGGTGATCCGC
CGGGTGGTGGGCGACCTTGACCTGTCGGTGGAGATCGTCGAGGTGCCCATCGTGCGTGAGGCCGACGGCCTGGCGCTGAG
TTCGCGCAACGGCTACATGGACGGCGAGCAGCGCCGGCGGGCCCCGGCGCTCTACGCCACCCTCTGCGAAGTGGCCGCGG
CGCTGGAGGCCGGGCGGCGGGATTGGTCGCAGCTCGAGGCCCAGGCCTGCCGGCGCTTGGAGGCGGCCGGGTTCGACGCC
GCGGAGTACGTGGCGGTACGCCGTTGCGACGATCTCGCCGAACCGCAGGGCGACGAGCCGCGGCTAGTGTGCCTGGGCGC
GGCGCGGCTCGGCGCCGCGCGGCTGATCGACAATGTCGAGGCGCGATTGAAGCGCTGA

Upstream 100 bases:

>100_bases
CCTTCGGGGCCGAGGGCGGCGGTGTGCACGCGGCGCTGGAGGCCTACGTGGCGGCGGTACGGGCCGGAACCTTCCCAGGA
CCAGAGCACGGGTTCGAGGC

Downstream 100 bases:

>100_bases
GCAAGGGTGTGCATAATCGCTGAGCTGCCGATTGTGCAGGTGCACATGGCCGGTTCTTCAATAATCGGATCGGCATGTGA
TTTCGCGGCATAGAGGTTTG

Product: pantoate--beta-alanine ligase

Products: NA

Alternate protein names: PS; Pantoate--beta-alanine ligase; Pantoate-activating enzyme

Number of amino acids: Translated: 285; Mature: 285

Protein sequence:

>285_residues
MRQVTERNAMRELSRAWRARGERIGLVPTMGNLHRGHLELVERLARRVDRLVVSIFVNPLQFGPGEDYDAYPRTLEADLN
ALEGRGVDAVFAPNAREMYPGVEPPWTGVDVPALTQTLCGAARPGHFAGVAVVVIKLLNIVEPDVAAFGRKDYQQLQVIR
RVVGDLDLSVEIVEVPIVREADGLALSSRNGYMDGEQRRRAPALYATLCEVAAALEAGRRDWSQLEAQACRRLEAAGFDA
AEYVAVRRCDDLAEPQGDEPRLVCLGAARLGAARLIDNVEARLKR

Sequences:

>Translated_285_residues
MRQVTERNAMRELSRAWRARGERIGLVPTMGNLHRGHLELVERLARRVDRLVVSIFVNPLQFGPGEDYDAYPRTLEADLN
ALEGRGVDAVFAPNAREMYPGVEPPWTGVDVPALTQTLCGAARPGHFAGVAVVVIKLLNIVEPDVAAFGRKDYQQLQVIR
RVVGDLDLSVEIVEVPIVREADGLALSSRNGYMDGEQRRRAPALYATLCEVAAALEAGRRDWSQLEAQACRRLEAAGFDA
AEYVAVRRCDDLAEPQGDEPRLVCLGAARLGAARLIDNVEARLKR
>Mature_285_residues
MRQVTERNAMRELSRAWRARGERIGLVPTMGNLHRGHLELVERLARRVDRLVVSIFVNPLQFGPGEDYDAYPRTLEADLN
ALEGRGVDAVFAPNAREMYPGVEPPWTGVDVPALTQTLCGAARPGHFAGVAVVVIKLLNIVEPDVAAFGRKDYQQLQVIR
RVVGDLDLSVEIVEVPIVREADGLALSSRNGYMDGEQRRRAPALYATLCEVAAALEAGRRDWSQLEAQACRRLEAAGFDA
AEYVAVRRCDDLAEPQGDEPRLVCLGAARLGAARLIDNVEARLKR

Specific function: Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate

COG id: COG0414

COG function: function code H; Panthothenate synthetase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pantothenate synthetase family

Homologues:

Organism=Escherichia coli, GI1786325, Length=269, Percent_Identity=51.3011152416357, Blast_Score=268, Evalue=3e-73,
Organism=Saccharomyces cerevisiae, GI6322046, Length=205, Percent_Identity=48.2926829268293, Blast_Score=168, Evalue=1e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PANC_HALHL (A1WUU4)

Other databases:

- EMBL:   CP000544
- RefSeq:   YP_001002258.1
- ProteinModelPortal:   A1WUU4
- SMR:   A1WUU4
- STRING:   A1WUU4
- GeneID:   4710190
- GenomeReviews:   CP000544_GR
- KEGG:   hha:Hhal_0674
- eggNOG:   COG0414
- HOGENOM:   HBG428839
- OMA:   RLIDNFT
- PhylomeDB:   A1WUU4
- BioCyc:   HHAL349124:HHAL_0674-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00158
- InterPro:   IPR004821
- InterPro:   IPR003721
- InterPro:   IPR014729
- Gene3D:   G3DSA:3.40.50.620
- PANTHER:   PTHR21299:SF1
- TIGRFAMs:   TIGR00125
- TIGRFAMs:   TIGR00018

Pfam domain/function: PF02569 Pantoate_ligase

EC number: =6.3.2.1

Molecular weight: Translated: 31430; Mature: 31430

Theoretical pI: Translated: 5.87; Mature: 5.87

Prosite motif: NA

Important sites: ACT_SITE 37-37 BINDING 61-61 BINDING 61-61 BINDING 155-155 BINDING 178-178

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRQVTERNAMRELSRAWRARGERIGLVPTMGNLHRGHLELVERLARRVDRLVVSIFVNPL
CCCHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
QFGPGEDYDAYPRTLEADLNALEGRGVDAVFAPNAREMYPGVEPPWTGVDVPALTQTLCG
CCCCCCCCCCCCCHHHHHHHHHCCCCCCEEECCCCHHHCCCCCCCCCCCCHHHHHHHHHC
AARPGHFAGVAVVVIKLLNIVEPDVAAFGRKDYQQLQVIRRVVGDLDLSVEIVEVPIVRE
CCCCCHHHHHHHHHHHHHHHHCHHHHHHCCHHHHHHHHHHHHHCCCCCEEEEEEECEEEC
ADGLALSSRNGYMDGEQRRRAPALYATLCEVAAALEAGRRDWSQLEAQACRRLEAAGFDA
CCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCH
AEYVAVRRCDDLAEPQGDEPRLVCLGAARLGAARLIDNVEARLKR
HHHHHHHHHHHHCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MRQVTERNAMRELSRAWRARGERIGLVPTMGNLHRGHLELVERLARRVDRLVVSIFVNPL
CCCHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
QFGPGEDYDAYPRTLEADLNALEGRGVDAVFAPNAREMYPGVEPPWTGVDVPALTQTLCG
CCCCCCCCCCCCCHHHHHHHHHCCCCCCEEECCCCHHHCCCCCCCCCCCCHHHHHHHHHC
AARPGHFAGVAVVVIKLLNIVEPDVAAFGRKDYQQLQVIRRVVGDLDLSVEIVEVPIVRE
CCCCCHHHHHHHHHHHHHHHHCHHHHHHCCHHHHHHHHHHHHHCCCCCEEEEEEECEEEC
ADGLALSSRNGYMDGEQRRRAPALYATLCEVAAALEAGRRDWSQLEAQACRRLEAAGFDA
CCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCH
AEYVAVRRCDDLAEPQGDEPRLVCLGAARLGAARLIDNVEARLKR
HHHHHHHHHHHHCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA