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The map label for this gene is glpK [H]

Identifier: 121639610

GI number: 121639610

Start: 4111315

End: 4112871

Strand: Reverse

Name: glpK [H]

Synonym: BCG_3755c

Alternate gene names: 121639610

Gene position: 4112871-4111315 (Counterclockwise)

Preceding gene: 121639611

Following gene: 121639608

Centisome position: 94.02

GC content: 64.42

Gene sequence:

>1557_bases
GTGTCCGACGCCATCCTAGGAGAGCAATTGGCCGAGTCCTCGGATTTCATAGCCGCCATCGACCAGGGCACCACCAGCAC
CCGCTGCATGATCTTCGATCACCACGGTGCCGAGGTGGCCCGCCACCAGCTCGAGCACGAGCAGATCCTGCCCCGGGCCG
GCTGGGTGGAGCACAACCCGGTCGAGATCTGGGAGCGCACCGCGTCGGTGTTGATCTCGGTGCTCAACGCCACCAACCTA
TCGCCGAAAGATATTGCCGCGTTGGGGATTACCAACCAACGTGAGACGACGCTGGTATGGAATCGGCACACCGGACGGCC
CTACTACAACGCGATTGTATGGCAGGATACCCGCACCGACCGCATCGCGTCGGCGCTGGATCGAGACGGTCGTGGAAACC
TGATCCGCCGCAAGGCGGGCCTGCCGCCGGCAACTTATTTCTCTGGCGGCAAGCTGCAGTGGATCCTGGAAAATGTCGAT
GGAGTCCGCGCGGCCGCCGAGAACGGCGACGCATTGTTCGGCACACCGGACACCTGGGTGTTGTGGAATCTGACCGGCGG
GCCGCGGGGGGGGGGTGTGCATGTCACCGATGTAACCAACGCCAGCCGGACCATGTTGATGGATCTAGAGACGCTGGACT
GGGACGACGAGCTGTTGTCGTTGTTTTCGATACCTCGGGCCATGCTGCCCGAGATCGCATCGTCGGCGCCGTCGGAGCCT
TACGGTGTCACGCTGGCGACCGGGCCTGTCGGCGGTGAGGTGCCGATCACCGGAGTTCTCGGTGATCAGCATGCGGCCAT
GGTCGGTCAAGTCTGTCTGGCCCCAGGGGAGGCGAAAAACACCTATGGGACCGGCAATTTTCTGCTGCTGAACACCGGTG
AAACGATCGTGCGATCGAATAACGGCCTGCTAACCACGGTGTGCTACCAATTCGGGAACGCTAAACCCGTGTACGCGCTT
GAAGGTTCGATCGCGGTGACCGGCTCGGCGGTGCAGTGGCTACGCGATCAGCTGGGCATCATCAGCGGCGCCGCACAGAG
TGAGGCGCTGGCCCGCCAGGTCCCCGACAACGGCGGCATGTATTTCGTGCCGGCGTTTTCCGGGCTGTTCGCGCCATACT
GGCGGTCCGATGCGCGCGGCGCGATCGTCGGGTTGTCGCGGTTCAACACCAACGCGCACCTGGCGCGCGCAACGCTGGAG
GCGATCTGCTACCAGAGCCGCGATGTGGTGGACGCCATGGAAGCAGACTCCGGTGTTCGCCTGCAGGTGTTGAAGGTGGA
TGGCGGGATCACCGGCAACGACCTGTGTATGCAGATCCAGGCCGACGTGTTGGGTGTGGATGTGGTGCGGCCGGTGGTCG
CCGAGACCACCGCACTAGGTGCGGCCTACGCGGCGGGCTTGGCGGTCGGGTTCTGGGCGGCTCCGTCCGATCTGCGGGCC
AACTGGCGAGAGGACAAGCGGTGGACACCGACGTGGGACGACGACGAGCGTGCCGCGGGTTATGCCGGCTGGCGCAAGGC
GGTGCAGCGGACCCTGGATTGGGTTGACGTGTCCTAG

Upstream 100 bases:

>100_bases
GACTTCCGCAAGTTCGAGGGCATTAGAATTCGCGACCCCTTCTCCGGCTGACGGCGTCGGACCCGCCGCTGCGGTGGACC
ATCATGGACGATTACATGCA

Downstream 100 bases:

>100_bases
CTTTCGCTGTGCGCCTGAACATGTCCGCACGCTCGGGGGATCCGGCGCAGCGAAGACTAGCTGCTAGCCCGGCGGCGAGA
ATCCCGGGCCGTCCGGCGCC

Product: glycerol kinase

Products: NA

Alternate protein names: ATP:glycerol 3-phosphotransferase; Glycerokinase; GK [H]

Number of amino acids: Translated: 518; Mature: 517

Protein sequence:

>518_residues
MSDAILGEQLAESSDFIAAIDQGTTSTRCMIFDHHGAEVARHQLEHEQILPRAGWVEHNPVEIWERTASVLISVLNATNL
SPKDIAALGITNQRETTLVWNRHTGRPYYNAIVWQDTRTDRIASALDRDGRGNLIRRKAGLPPATYFSGGKLQWILENVD
GVRAAAENGDALFGTPDTWVLWNLTGGPRGGGVHVTDVTNASRTMLMDLETLDWDDELLSLFSIPRAMLPEIASSAPSEP
YGVTLATGPVGGEVPITGVLGDQHAAMVGQVCLAPGEAKNTYGTGNFLLLNTGETIVRSNNGLLTTVCYQFGNAKPVYAL
EGSIAVTGSAVQWLRDQLGIISGAAQSEALARQVPDNGGMYFVPAFSGLFAPYWRSDARGAIVGLSRFNTNAHLARATLE
AICYQSRDVVDAMEADSGVRLQVLKVDGGITGNDLCMQIQADVLGVDVVRPVVAETTALGAAYAAGLAVGFWAAPSDLRA
NWREDKRWTPTWDDDERAAGYAGWRKAVQRTLDWVDVS

Sequences:

>Translated_518_residues
MSDAILGEQLAESSDFIAAIDQGTTSTRCMIFDHHGAEVARHQLEHEQILPRAGWVEHNPVEIWERTASVLISVLNATNL
SPKDIAALGITNQRETTLVWNRHTGRPYYNAIVWQDTRTDRIASALDRDGRGNLIRRKAGLPPATYFSGGKLQWILENVD
GVRAAAENGDALFGTPDTWVLWNLTGGPRGGGVHVTDVTNASRTMLMDLETLDWDDELLSLFSIPRAMLPEIASSAPSEP
YGVTLATGPVGGEVPITGVLGDQHAAMVGQVCLAPGEAKNTYGTGNFLLLNTGETIVRSNNGLLTTVCYQFGNAKPVYAL
EGSIAVTGSAVQWLRDQLGIISGAAQSEALARQVPDNGGMYFVPAFSGLFAPYWRSDARGAIVGLSRFNTNAHLARATLE
AICYQSRDVVDAMEADSGVRLQVLKVDGGITGNDLCMQIQADVLGVDVVRPVVAETTALGAAYAAGLAVGFWAAPSDLRA
NWREDKRWTPTWDDDERAAGYAGWRKAVQRTLDWVDVS
>Mature_517_residues
SDAILGEQLAESSDFIAAIDQGTTSTRCMIFDHHGAEVARHQLEHEQILPRAGWVEHNPVEIWERTASVLISVLNATNLS
PKDIAALGITNQRETTLVWNRHTGRPYYNAIVWQDTRTDRIASALDRDGRGNLIRRKAGLPPATYFSGGKLQWILENVDG
VRAAAENGDALFGTPDTWVLWNLTGGPRGGGVHVTDVTNASRTMLMDLETLDWDDELLSLFSIPRAMLPEIASSAPSEPY
GVTLATGPVGGEVPITGVLGDQHAAMVGQVCLAPGEAKNTYGTGNFLLLNTGETIVRSNNGLLTTVCYQFGNAKPVYALE
GSIAVTGSAVQWLRDQLGIISGAAQSEALARQVPDNGGMYFVPAFSGLFAPYWRSDARGAIVGLSRFNTNAHLARATLEA
ICYQSRDVVDAMEADSGVRLQVLKVDGGITGNDLCMQIQADVLGVDVVRPVVAETTALGAAYAAGLAVGFWAAPSDLRAN
WREDKRWTPTWDDDERAAGYAGWRKAVQRTLDWVDVS

Specific function: Key enzyme in the regulation of glycerol uptake and metabolism [H]

COG id: COG0554

COG function: function code C; Glycerol kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FGGY kinase family [H]

Homologues:

Organism=Homo sapiens, GI189409120, Length=510, Percent_Identity=48.8235294117647, Blast_Score=480, Evalue=1e-135,
Organism=Homo sapiens, GI4504007, Length=510, Percent_Identity=48.8235294117647, Blast_Score=479, Evalue=1e-135,
Organism=Homo sapiens, GI42794763, Length=515, Percent_Identity=48.3495145631068, Blast_Score=479, Evalue=1e-135,
Organism=Homo sapiens, GI41393575, Length=509, Percent_Identity=47.1512770137525, Blast_Score=469, Evalue=1e-132,
Organism=Homo sapiens, GI88196792, Length=517, Percent_Identity=30.9477756286267, Blast_Score=283, Evalue=4e-76,
Organism=Escherichia coli, GI1790361, Length=503, Percent_Identity=52.0874751491054, Blast_Score=524, Evalue=1e-150,
Organism=Escherichia coli, GI1790005, Length=480, Percent_Identity=23.125, Blast_Score=92, Evalue=7e-20,
Organism=Escherichia coli, GI1789987, Length=510, Percent_Identity=24.5098039215686, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1787789, Length=552, Percent_Identity=25.5434782608696, Blast_Score=80, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17535599, Length=509, Percent_Identity=45.3831041257367, Blast_Score=424, Evalue=1e-119,
Organism=Caenorhabditis elegans, GI71986140, Length=525, Percent_Identity=23.6190476190476, Blast_Score=149, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI71986147, Length=300, Percent_Identity=26.3333333333333, Blast_Score=107, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6321755, Length=557, Percent_Identity=39.8563734290844, Blast_Score=341, Evalue=2e-94,
Organism=Drosophila melanogaster, GI17864214, Length=514, Percent_Identity=48.2490272373541, Blast_Score=456, Evalue=1e-128,
Organism=Drosophila melanogaster, GI24654573, Length=440, Percent_Identity=50.4545454545455, Blast_Score=421, Evalue=1e-118,
Organism=Drosophila melanogaster, GI24655555, Length=524, Percent_Identity=41.030534351145, Blast_Score=410, Evalue=1e-114,
Organism=Drosophila melanogaster, GI24655560, Length=524, Percent_Identity=41.030534351145, Blast_Score=410, Evalue=1e-114,
Organism=Drosophila melanogaster, GI24655570, Length=524, Percent_Identity=41.030534351145, Blast_Score=410, Evalue=1e-114,
Organism=Drosophila melanogaster, GI24655574, Length=524, Percent_Identity=41.030534351145, Blast_Score=410, Evalue=1e-114,
Organism=Drosophila melanogaster, GI24655565, Length=524, Percent_Identity=41.030534351145, Blast_Score=410, Evalue=1e-114,
Organism=Drosophila melanogaster, GI19922058, Length=539, Percent_Identity=35.621521335807, Blast_Score=308, Evalue=4e-84,
Organism=Drosophila melanogaster, GI24652871, Length=505, Percent_Identity=35.2475247524752, Blast_Score=285, Evalue=6e-77,
Organism=Drosophila melanogaster, GI24656367, Length=533, Percent_Identity=30.3939962476548, Blast_Score=225, Evalue=6e-59,
Organism=Drosophila melanogaster, GI21357867, Length=538, Percent_Identity=29.9256505576208, Blast_Score=225, Evalue=6e-59,
Organism=Drosophila melanogaster, GI24656372, Length=377, Percent_Identity=31.5649867374005, Blast_Score=170, Evalue=2e-42,
Organism=Drosophila melanogaster, GI45552909, Length=318, Percent_Identity=29.559748427673, Blast_Score=129, Evalue=5e-30,

Paralogues:

None

Copy number: 2,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000577
- InterPro:   IPR018485
- InterPro:   IPR018483
- InterPro:   IPR018484
- InterPro:   IPR005999 [H]

Pfam domain/function: PF02782 FGGY_C; PF00370 FGGY_N [H]

EC number: =2.7.1.30 [H]

Molecular weight: Translated: 55889; Mature: 55758

Theoretical pI: Translated: 4.69; Mature: 4.69

Prosite motif: PS00933 FGGY_KINASES_1 ; PS00445 FGGY_KINASES_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDAILGEQLAESSDFIAAIDQGTTSTRCMIFDHHGAEVARHQLEHEQILPRAGWVEHNP
CCCCHHHHHHHCCCCEEEEECCCCCCEEEEEEECCCHHHHHHHHHHHHHCCCCCCCCCCH
VEIWERTASVLISVLNATNLSPKDIAALGITNQRETTLVWNRHTGRPYYNAIVWQDTRTD
HHHHHHHHHHHHHHHHCCCCCHHHEEEEECCCCCCEEEEEECCCCCCEEEEEEECCCCHH
RIASALDRDGRGNLIRRKAGLPPATYFSGGKLQWILENVDGVRAAAENGDALFGTPDTWV
HHHHHHCCCCCCCEEEECCCCCCCCEECCCEEEEEEECCCCHHHHCCCCCEEECCCCCEE
LWNLTGGPRGGGVHVTDVTNASRTMLMDLETLDWDDELLSLFSIPRAMLPEIASSAPSEP
EEEECCCCCCCCEEEEECCCCCCEEEEEEECCCCHHHHHHHHHCCHHHHHHHHHCCCCCC
YGVTLATGPVGGEVPITGVLGDQHAAMVGQVCLAPGEAKNTYGTGNFLLLNTGETIVRSN
CEEEEEECCCCCCCEEEEEECCCHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCEEEECC
NGLLTTVCYQFGNAKPVYALEGSIAVTGSAVQWLRDQLGIISGAAQSEALARQVPDNGGM
CCEEEEEHHHCCCCCEEEEECCCEEEEHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCE
YFVPAFSGLFAPYWRSDARGAIVGLSRFNTNAHLARATLEAICYQSRDVVDAMEADSGVR
EEEECCCCHHCHHHCCCCCEEEEEEEECCCCHHHHHHHHHHHHHCCCCHHHHHHCCCCCE
LQVLKVDGGITGNDLCMQIQADVLGVDVVRPVVAETTALGAAYAAGLAVGFWAAPSDLRA
EEEEEECCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCHHHHC
NWREDKRWTPTWDDDERAAGYAGWRKAVQRTLDWVDVS
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SDAILGEQLAESSDFIAAIDQGTTSTRCMIFDHHGAEVARHQLEHEQILPRAGWVEHNP
CCCHHHHHHHCCCCEEEEECCCCCCEEEEEEECCCHHHHHHHHHHHHHCCCCCCCCCCH
VEIWERTASVLISVLNATNLSPKDIAALGITNQRETTLVWNRHTGRPYYNAIVWQDTRTD
HHHHHHHHHHHHHHHHCCCCCHHHEEEEECCCCCCEEEEEECCCCCCEEEEEEECCCCHH
RIASALDRDGRGNLIRRKAGLPPATYFSGGKLQWILENVDGVRAAAENGDALFGTPDTWV
HHHHHHCCCCCCCEEEECCCCCCCCEECCCEEEEEEECCCCHHHHCCCCCEEECCCCCEE
LWNLTGGPRGGGVHVTDVTNASRTMLMDLETLDWDDELLSLFSIPRAMLPEIASSAPSEP
EEEECCCCCCCCEEEEECCCCCCEEEEEEECCCCHHHHHHHHHCCHHHHHHHHHCCCCCC
YGVTLATGPVGGEVPITGVLGDQHAAMVGQVCLAPGEAKNTYGTGNFLLLNTGETIVRSN
CEEEEEECCCCCCCEEEEEECCCHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCEEEECC
NGLLTTVCYQFGNAKPVYALEGSIAVTGSAVQWLRDQLGIISGAAQSEALARQVPDNGGM
CCEEEEEHHHCCCCCEEEEECCCEEEEHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCE
YFVPAFSGLFAPYWRSDARGAIVGLSRFNTNAHLARATLEAICYQSRDVVDAMEADSGVR
EEEECCCCHHCHHHCCCCCEEEEEEEECCCCHHHHHHHHHHHHHCCCCHHHHHHCCCCCE
LQVLKVDGGITGNDLCMQIQADVLGVDVVRPVVAETTALGAAYAAGLAVGFWAAPSDLRA
EEEEEECCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCHHHHC
NWREDKRWTPTWDDDERAAGYAGWRKAVQRTLDWVDVS
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA