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The map label for this gene is deoA [H]

Identifier: 121639238

GI number: 121639238

Start: 3690755

End: 3692038

Strand: Reverse

Name: deoA [H]

Synonym: BCG_3380c

Alternate gene names: 121639238

Gene position: 3692038-3690755 (Counterclockwise)

Preceding gene: 121639239

Following gene: 121639237

Centisome position: 84.4

GC content: 68.22

Gene sequence:

>1284_bases
GTGACCGACTTCGCATTCGACGCCCCGACCGTCATCCGCACCAAACGTGACGGCGGCCGGTTGTCCGACGCCGCCATCGA
CTGGGTCGTCAAGGCCTATACCGACGGCCGGGTCGCCGACGAACAGATGTCGGCGCTGCTGATGGCGATCGTTTGGCGGG
GCATGGACCGCGGCGAGATCGCCAGATGGACGGCGGCCATGCTGGCCTCGGGTGCCCGGCTGGATTTCACCGATCTGCCA
CTAGCGACCGTGGACAAGCATTCCACCGGCGGGGTAGGTGACAAAATCACGCTGCCATTGGTGCCCGTCGTCGCCGCCTG
CGGTGGCGCAGTGCCCCAGGCGTCGGGCCGCGGACTCGGCCACACCGGCGGCACCCTGGACAAGCTGGAATCCATCACCG
GGTTCACCGCGAATCTGTCCAACCAGCGGGTGCGCGAGCAGCTTTGCGACGTCGGCGCCGCGATCTTCGCCGCCGGCCAG
CTGGCGCCAGCCGATGCCAAGCTGTATGCGCTGCGCGACATTACCGGCACCGTCGAATCGCTGCCGTTGATCGCCAGTTC
GATTATGAGCAAGAAGCTGGCTGAGGGTGCGGGTGCACTGGTGCTCGACGTCAAGGTTGGTTCCGGGGCCTTCATGAGGT
CGCCAGTGCAGGCGCGCGAACTTGCGCACACCATGGTCGAACTGGGCGCGGCGCATGGCGTGCCCACCCGTGCCCTGCTG
ACGGAGATGAACTGCCCGCTGGGTCGAACCGTCGGCAATGCGCTCGAGGTGGCCGAGGCGCTGGAGGTGCTGGCCGGCGG
CGGACCGCCCGACGTGGTGGAGCTGACGTTGCGGCTGGCCGGCGAGATGCTCGAGCTTGCCGGGATCCACGGCCGGGACC
CGGCCCAGACGCTGCGGGACGGCACCGCAATGGACCGGTTTCGCTGGTTGGTTGCCGCGCAGGGAGGTGACTTGTCGAAA
CCGTTGCCGATCGGTTCGCATTCGGAAACCGTCACGGCGGGCGCGAGCGGCACAATGGGCGACATCGATGCGATGGCAGT
GGGGTTAGCGGCATGGCGACTCGGTGCGGGCAGGTCCCGCCCGGGCGCACGCGTACAGCACGGTGCGGGGGTGCGGATTC
ATCGCCGCCCGGGGGAGCCGGTTGTGGTCGGTGAGCCGTTGTTCACCCTCTACACGAATGCTCCCGAGCGCTTTGGTGCG
GCGCGAGCCGAGCTGGCCGGCGGTTGGAGTATCCGGGACAGTCCGCCGCAGGTGCGGCCGCTAATCGTCGATCGGATCGT
CTGA

Upstream 100 bases:

>100_bases
GGGGTTCCGAGCTACTGATCGACCATCCGGTGCGACCCCGCCGGCTCGGCGACCTGCTGCCCGACGCCTTCGGCCTCGAC
GACCTCCCCCGGGAACGCCG

Downstream 100 bases:

>100_bases
TGACCGCTGCGCCGACCCTGCAGACGATCAGGCTAGCCCCCAAGGCGTTGCTGCACGATCACCTCGACGGCGGGCTGCGG
CCGGCCACCGTGCTGGACAT

Product: thymidine phosphorylase

Products: NA

Alternate protein names: TdRPase [H]

Number of amino acids: Translated: 427; Mature: 426

Protein sequence:

>427_residues
MTDFAFDAPTVIRTKRDGGRLSDAAIDWVVKAYTDGRVADEQMSALLMAIVWRGMDRGEIARWTAAMLASGARLDFTDLP
LATVDKHSTGGVGDKITLPLVPVVAACGGAVPQASGRGLGHTGGTLDKLESITGFTANLSNQRVREQLCDVGAAIFAAGQ
LAPADAKLYALRDITGTVESLPLIASSIMSKKLAEGAGALVLDVKVGSGAFMRSPVQARELAHTMVELGAAHGVPTRALL
TEMNCPLGRTVGNALEVAEALEVLAGGGPPDVVELTLRLAGEMLELAGIHGRDPAQTLRDGTAMDRFRWLVAAQGGDLSK
PLPIGSHSETVTAGASGTMGDIDAMAVGLAAWRLGAGRSRPGARVQHGAGVRIHRRPGEPVVVGEPLFTLYTNAPERFGA
ARAELAGGWSIRDSPPQVRPLIVDRIV

Sequences:

>Translated_427_residues
MTDFAFDAPTVIRTKRDGGRLSDAAIDWVVKAYTDGRVADEQMSALLMAIVWRGMDRGEIARWTAAMLASGARLDFTDLP
LATVDKHSTGGVGDKITLPLVPVVAACGGAVPQASGRGLGHTGGTLDKLESITGFTANLSNQRVREQLCDVGAAIFAAGQ
LAPADAKLYALRDITGTVESLPLIASSIMSKKLAEGAGALVLDVKVGSGAFMRSPVQARELAHTMVELGAAHGVPTRALL
TEMNCPLGRTVGNALEVAEALEVLAGGGPPDVVELTLRLAGEMLELAGIHGRDPAQTLRDGTAMDRFRWLVAAQGGDLSK
PLPIGSHSETVTAGASGTMGDIDAMAVGLAAWRLGAGRSRPGARVQHGAGVRIHRRPGEPVVVGEPLFTLYTNAPERFGA
ARAELAGGWSIRDSPPQVRPLIVDRIV
>Mature_426_residues
TDFAFDAPTVIRTKRDGGRLSDAAIDWVVKAYTDGRVADEQMSALLMAIVWRGMDRGEIARWTAAMLASGARLDFTDLPL
ATVDKHSTGGVGDKITLPLVPVVAACGGAVPQASGRGLGHTGGTLDKLESITGFTANLSNQRVREQLCDVGAAIFAAGQL
APADAKLYALRDITGTVESLPLIASSIMSKKLAEGAGALVLDVKVGSGAFMRSPVQARELAHTMVELGAAHGVPTRALLT
EMNCPLGRTVGNALEVAEALEVLAGGGPPDVVELTLRLAGEMLELAGIHGRDPAQTLRDGTAMDRFRWLVAAQGGDLSKP
LPIGSHSETVTAGASGTMGDIDAMAVGLAAWRLGAGRSRPGARVQHGAGVRIHRRPGEPVVVGEPLFTLYTNAPERFGAA
RAELAGGWSIRDSPPQVRPLIVDRIV

Specific function: The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis [H]

COG id: COG0213

COG function: function code F; Thymidine phosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family [H]

Homologues:

Organism=Homo sapiens, GI166158925, Length=434, Percent_Identity=44.4700460829493, Blast_Score=287, Evalue=2e-77,
Organism=Homo sapiens, GI4503445, Length=434, Percent_Identity=44.4700460829493, Blast_Score=287, Evalue=2e-77,
Organism=Homo sapiens, GI166158922, Length=434, Percent_Identity=44.4700460829493, Blast_Score=287, Evalue=2e-77,
Organism=Escherichia coli, GI1790842, Length=438, Percent_Identity=41.324200913242, Blast_Score=277, Evalue=8e-76,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000312
- InterPro:   IPR017459
- InterPro:   IPR020072
- InterPro:   IPR013102
- InterPro:   IPR018090
- InterPro:   IPR000053
- InterPro:   IPR017872 [H]

Pfam domain/function: PF02885 Glycos_trans_3N; PF00591 Glycos_transf_3; PF07831 PYNP_C [H]

EC number: =2.4.2.4 [H]

Molecular weight: Translated: 44517; Mature: 44385

Theoretical pI: Translated: 6.73; Mature: 6.73

Prosite motif: PS00647 THYMID_PHOSPHORYLASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDFAFDAPTVIRTKRDGGRLSDAAIDWVVKAYTDGRVADEQMSALLMAIVWRGMDRGEI
CCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCHH
ARWTAAMLASGARLDFTDLPLATVDKHSTGGVGDKITLPLVPVVAACGGAVPQASGRGLG
HHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCEEEHHHHHHHHHCCCCCCCCCCCCCC
HTGGTLDKLESITGFTANLSNQRVREQLCDVGAAIFAAGQLAPADAKLYALRDITGTVES
CCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEHHHHHHHHH
LPLIASSIMSKKLAEGAGALVLDVKVGSGAFMRSPVQARELAHTMVELGAAHGVPTRALL
HHHHHHHHHHHHHHCCCCEEEEEEEECCCHHHCCCHHHHHHHHHHHHHHHCCCCCHHHHH
TEMNCPLGRTVGNALEVAEALEVLAGGGPPDVVELTLRLAGEMLELAGIHGRDPAQTLRD
HHCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHC
GTAMDRFRWLVAAQGGDLSKPLPIGSHSETVTAGASGTMGDIDAMAVGLAAWRLGAGRSR
CCHHHHHEEEEEECCCCCCCCCCCCCCCCEEECCCCCCCCCHHHHHHHHHHHHHCCCCCC
PGARVQHGAGVRIHRRPGEPVVVGEPLFTLYTNAPERFGAARAELAGGWSIRDSPPQVRP
CCCCEECCCCEEEEECCCCCEEECCCCEEEECCCHHHHCCHHHHHCCCCCCCCCCCCCCH
LIVDRIV
HHHHHCC
>Mature Secondary Structure 
TDFAFDAPTVIRTKRDGGRLSDAAIDWVVKAYTDGRVADEQMSALLMAIVWRGMDRGEI
CCCCCCCCCEEEECCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCHH
ARWTAAMLASGARLDFTDLPLATVDKHSTGGVGDKITLPLVPVVAACGGAVPQASGRGLG
HHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCEEEHHHHHHHHHCCCCCCCCCCCCCC
HTGGTLDKLESITGFTANLSNQRVREQLCDVGAAIFAAGQLAPADAKLYALRDITGTVES
CCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEHHHHHHHHH
LPLIASSIMSKKLAEGAGALVLDVKVGSGAFMRSPVQARELAHTMVELGAAHGVPTRALL
HHHHHHHHHHHHHHCCCCEEEEEEEECCCHHHCCCHHHHHHHHHHHHHHHCCCCCHHHHH
TEMNCPLGRTVGNALEVAEALEVLAGGGPPDVVELTLRLAGEMLELAGIHGRDPAQTLRD
HHCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHC
GTAMDRFRWLVAAQGGDLSKPLPIGSHSETVTAGASGTMGDIDAMAVGLAAWRLGAGRSR
CCHHHHHEEEEEECCCCCCCCCCCCCCCCEEECCCCCCCCCHHHHHHHHHHHHHCCCCCC
PGARVQHGAGVRIHRRPGEPVVVGEPLFTLYTNAPERFGAARAELAGGWSIRDSPPQVRP
CCCCEECCCCEEEEECCCCCEEECCCCEEEECCCHHHHCCHHHHHCCCCCCCCCCCCCCH
LIVDRIV
HHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]