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The map label for this gene is purE [H]

Identifier: 121639164

GI number: 121639164

Start: 3610585

End: 3611109

Strand: Reverse

Name: purE [H]

Synonym: BCG_3304c

Alternate gene names: 121639164

Gene position: 3611109-3610585 (Counterclockwise)

Preceding gene: 121639165

Following gene: 121639163

Centisome position: 82.55

GC content: 71.05

Gene sequence:

>525_bases
ATGACTCCTGCCGGCGAGCGGCCCCGGGTCGGGGTGATCATGGGCAGCGACAGCGACTGGCCGGTGATGGCCGACGCTGC
GGCGGCGCTGGCCGAGTTCGACATTCCGGCCGAGGTTCGGGTTGTTTCGGCCCATCGCACCCCTGAGGCGATGTTCAGTT
ATGCGCGCGGCGCGGCCGAGCGCGGTCTCGAGGTGATCATCGCCGGAGCGGGCGGGGCCGCGCACTTGCCCGGTATGGTC
GCCGCCGCGACGCCGCTGCCGGTGATCGGGGTGCCGGTACCGCTGGGCAGGCTGGACGGCCTTGACTCCCTGCTGTCGAT
CGTGCAAATGCCGGCCGGGGTTCCGGTGGCCACGGTGTCCATCGGGGGCGCCCGTAATGCCGGACTGCTGGCGGTGCGGA
TGCTGGGAGCCGCCAACCCCCAGCTGAGGGCCCGGATCGTCGCATTCCAGGACCGGCTGGCCGACGTCGTGGCGGCCAAG
GATGCGGAACTGCAGCGGCTTGCGGGTAAGTTAACCCGCGACTAG

Upstream 100 bases:

>100_bases
GGCGGTGGACTGACGGATGGGACCCACACCGCGCCAGCGACGATGCAGTGGGGGTACCACCCGCGTGCGGGGGACGAAGC
GATGAGGAGGAGCGGCGCCT

Downstream 100 bases:

>100_bases
CACGGAGATTAGGAGGGCTCCAAGATGGTTGGATGGGCCGGAAACCCGTCGTTCGATCTGTTCAAGCTGCCCGAGGAACA
CGACGAAATGCGATCGGCGA

Product: putative phosphoribosylaminoimidazole carboxylase catalytic subunit purE

Products: NA

Alternate protein names: N5-CAIR mutase; 5-(carboxyamino)imidazole ribonucleotide mutase [H]

Number of amino acids: Translated: 174; Mature: 173

Protein sequence:

>174_residues
MTPAGERPRVGVIMGSDSDWPVMADAAAALAEFDIPAEVRVVSAHRTPEAMFSYARGAAERGLEVIIAGAGGAAHLPGMV
AAATPLPVIGVPVPLGRLDGLDSLLSIVQMPAGVPVATVSIGGARNAGLLAVRMLGAANPQLRARIVAFQDRLADVVAAK
DAELQRLAGKLTRD

Sequences:

>Translated_174_residues
MTPAGERPRVGVIMGSDSDWPVMADAAAALAEFDIPAEVRVVSAHRTPEAMFSYARGAAERGLEVIIAGAGGAAHLPGMV
AAATPLPVIGVPVPLGRLDGLDSLLSIVQMPAGVPVATVSIGGARNAGLLAVRMLGAANPQLRARIVAFQDRLADVVAAK
DAELQRLAGKLTRD
>Mature_173_residues
TPAGERPRVGVIMGSDSDWPVMADAAAALAEFDIPAEVRVVSAHRTPEAMFSYARGAAERGLEVIIAGAGGAAHLPGMVA
AATPLPVIGVPVPLGRLDGLDSLLSIVQMPAGVPVATVSIGGARNAGLLAVRMLGAANPQLRARIVAFQDRLADVVAAKD
AELQRLAGKLTRD

Specific function: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) [H]

COG id: COG0041

COG function: function code F; Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR carboxylase family [H]

Homologues:

Organism=Escherichia coli, GI1786734, Length=111, Percent_Identity=59.4594594594595, Blast_Score=135, Evalue=2e-33,
Organism=Saccharomyces cerevisiae, GI6324702, Length=159, Percent_Identity=59.1194968553459, Blast_Score=177, Evalue=7e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000031 [H]

Pfam domain/function: PF00731 AIRC [H]

EC number: =5.4.99.18 [H]

Molecular weight: Translated: 17774; Mature: 17643

Theoretical pI: Translated: 6.54; Mature: 6.54

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPAGERPRVGVIMGSDSDWPVMADAAAALAEFDIPAEVRVVSAHRTPEAMFSYARGAAE
CCCCCCCCEEEEEEECCCCCCCHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHH
RGLEVIIAGAGGAAHLPGMVAAATPLPVIGVPVPLGRLDGLDSLLSIVQMPAGVPVATVS
CCEEEEEECCCCCCCCCCHHHHCCCCCEEECCCCCHHHCCHHHHHHHHHCCCCCCEEEEE
IGGARNAGLLAVRMLGAANPQLRARIVAFQDRLADVVAAKDAELQRLAGKLTRD
ECCCCCCCHHEEHHHCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCC
>Mature Secondary Structure 
TPAGERPRVGVIMGSDSDWPVMADAAAALAEFDIPAEVRVVSAHRTPEAMFSYARGAAE
CCCCCCCEEEEEEECCCCCCCHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHH
RGLEVIIAGAGGAAHLPGMVAAATPLPVIGVPVPLGRLDGLDSLLSIVQMPAGVPVATVS
CCEEEEEECCCCCCCCCCHHHHCCCCCEEECCCCCHHHCCHHHHHHHHHCCCCCCEEEEE
IGGARNAGLLAVRMLGAANPQLRARIVAFQDRLADVVAAKDAELQRLAGKLTRD
ECCCCCCCHHEEHHHCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]