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The map label for this gene is devS [H]

Identifier: 121639015

GI number: 121639015

Start: 3449239

End: 3450975

Strand: Reverse

Name: devS [H]

Synonym: BCG_3155c

Alternate gene names: 121639015

Gene position: 3450975-3449239 (Counterclockwise)

Preceding gene: 121639016

Following gene: 121639013

Centisome position: 78.89

GC content: 64.02

Gene sequence:

>1737_bases
ATGACAACAGGGGGCCTCGTCGACGAAAACGACGGCGCCGCAATGCGTCCACTGCGTCACACGCTCTCCCAACTACGCCT
GCACGAGCTGCTGGTCGAGGTGCAGGACCGGGTCGAGCAGATCGTCGAGGGCCGGGACCGCCTCGATGGTCTGGTGGAGG
CCATGCTCGTGGTCACAGCGGGCCTGGACCTGGAGGCAACCCTACGCGCTATCGTGCATTCAGCGACCAGCCTTGTCGAT
GCGCGCTATGGCGCTATGGAGGTGCACGACCGGCAGCATCGGGTATTGCACTTTGTCTATGAAGGCATCGACGAGGAGAC
CGTTCGGCGGATCGGCCACCTACCGAAAGGCCTAGGCGTCATCGGGCTGCTCATCGAAGATCCCAAACCGTTACGGCTGG
ACGATGTTTCTGCGCACCCGGCCTCGATTGGTTTTCCGCCGTATCATCCGCCGATGCGTACCTTCCTCGGGGTACCGGTT
CGGGTGCGCGATGAATCGTTCGGCACTCTGTACCTGACTGACAAGACCAACGGGCAACCGTTCAGCGACGACGACGAGGT
TCTGGTCCAGGCGCTGGCGGCCGCCGCGGGTATCGCAGTCGCGAATGCCCGGCTCTACCAGCAGGCTAAGGCGCGTCAGT
CGTGGATCGAGGCCACCCGTGACATCGCCACCGAGTTGTTGTCCGGCACCGAACCCGCGACGGTGTTCCGGCTTGTCGCC
GCGGAGGCGCTCAAGCTGACGGCGGCTGACGCTGCCCTGGTAGCCGTTCCCGTCGACGAGGACATGCCTGCCGCTGACGT
GGGGGAGCTGCTGGTGATTGAAACAGTCGGCAGCGCTGTGGCTTCCACTGTTGGGCGAACGATTCCGGTGGCGGGCGCGG
TGCTGCGGGAGGTCTTCGTCAACGGCATTCCGCGACGGGTCGACCGGGTCGATTTGGAAGGCCTGGACGAACTGGCCGAC
GCAGGTCCGGCGCTGCTGTTGCCGCTGCGGGCCAGAGGTACCGTAGCGGGTGTCGTTGTTGTGCTGAGTCAAGGCGGTCC
AGGGGCTTTCACCGACGAACAACTCGAGATGATGGCCGCGTTCGCCGACCAGGCCGCGCTGGCTTGGCAATTGGCCACTT
CGCAACGTCGGATGCGCGAACTCGACGTACTGACCGACCGGGATCGTATCGCCCGTGACCTCCATGACCATGTCATCCAG
CGGCTCTTCGCGATTGGCCTGGCTTTGCAGGGTGCTGTCCCGCACGAACGTAATCCTGAAGTGCAGCAACGACTCTCGGA
CGTGGTAGACGATCTGCAAGACGTTATACAGGAAATCCGGACCACCATTTATGACCTGCACGGAGCATCGCAGGGTATCA
CTCGGCTCCGGCAGCGAATCGATGCGGCCGTAGCCCAATTTGCCGACTCGGGGTTGCGCACCAGCGTTCAATTCGTGGGT
CCATTGTCGGTGGTCGACAGCGCGCTCGCCGATCAGGCCGAGGCGGTGGTTCGGGAAGCGGTCAGCAACGCGGTTCGCCA
TGCGAAGGCCAGCACGTTGACCGTCCGGGTCAAAGTCGACGACGACTTGTGCATCGAGGTGACCGACAACGGCCGCGGGC
TGCCCGACGAGTTCACCGGAAGCGGCTTAACGAACCTGCGGCAGCGGGCAGAGCAGGCCGGCGGCGAATTCACCCTCGCG
AGCGTACCGGGCGCGAGCGGAACAGTGCTGCGATGGTCAGCACCGTTGTCGCAGTAG

Upstream 100 bases:

>100_bases
ACGTGTCGCGGTTGCTGGCCAAGCTGGGCATGGAACGTCGGACGCAAGCCGCGGTATTCGCGACGGAGTTGAAGCGCTCG
CGGCCACCCGGTGATGGACC

Downstream 100 bases:

>100_bases
CTCTTCCGGCCACTCAACGACCTGGGACAGTTCGCGCCGTGGCGTCGGTGGCAACGGGTCGGCATTGATCGGTGCCCAAC
CCACTCGCAGCAGCATCTGG

Product: two component sensor histidine kinase devS

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 578; Mature: 577

Protein sequence:

>578_residues
MTTGGLVDENDGAAMRPLRHTLSQLRLHELLVEVQDRVEQIVEGRDRLDGLVEAMLVVTAGLDLEATLRAIVHSATSLVD
ARYGAMEVHDRQHRVLHFVYEGIDEETVRRIGHLPKGLGVIGLLIEDPKPLRLDDVSAHPASIGFPPYHPPMRTFLGVPV
RVRDESFGTLYLTDKTNGQPFSDDDEVLVQALAAAAGIAVANARLYQQAKARQSWIEATRDIATELLSGTEPATVFRLVA
AEALKLTAADAALVAVPVDEDMPAADVGELLVIETVGSAVASTVGRTIPVAGAVLREVFVNGIPRRVDRVDLEGLDELAD
AGPALLLPLRARGTVAGVVVVLSQGGPGAFTDEQLEMMAAFADQAALAWQLATSQRRMRELDVLTDRDRIARDLHDHVIQ
RLFAIGLALQGAVPHERNPEVQQRLSDVVDDLQDVIQEIRTTIYDLHGASQGITRLRQRIDAAVAQFADSGLRTSVQFVG
PLSVVDSALADQAEAVVREAVSNAVRHAKASTLTVRVKVDDDLCIEVTDNGRGLPDEFTGSGLTNLRQRAEQAGGEFTLA
SVPGASGTVLRWSAPLSQ

Sequences:

>Translated_578_residues
MTTGGLVDENDGAAMRPLRHTLSQLRLHELLVEVQDRVEQIVEGRDRLDGLVEAMLVVTAGLDLEATLRAIVHSATSLVD
ARYGAMEVHDRQHRVLHFVYEGIDEETVRRIGHLPKGLGVIGLLIEDPKPLRLDDVSAHPASIGFPPYHPPMRTFLGVPV
RVRDESFGTLYLTDKTNGQPFSDDDEVLVQALAAAAGIAVANARLYQQAKARQSWIEATRDIATELLSGTEPATVFRLVA
AEALKLTAADAALVAVPVDEDMPAADVGELLVIETVGSAVASTVGRTIPVAGAVLREVFVNGIPRRVDRVDLEGLDELAD
AGPALLLPLRARGTVAGVVVVLSQGGPGAFTDEQLEMMAAFADQAALAWQLATSQRRMRELDVLTDRDRIARDLHDHVIQ
RLFAIGLALQGAVPHERNPEVQQRLSDVVDDLQDVIQEIRTTIYDLHGASQGITRLRQRIDAAVAQFADSGLRTSVQFVG
PLSVVDSALADQAEAVVREAVSNAVRHAKASTLTVRVKVDDDLCIEVTDNGRGLPDEFTGSGLTNLRQRAEQAGGEFTLA
SVPGASGTVLRWSAPLSQ
>Mature_577_residues
TTGGLVDENDGAAMRPLRHTLSQLRLHELLVEVQDRVEQIVEGRDRLDGLVEAMLVVTAGLDLEATLRAIVHSATSLVDA
RYGAMEVHDRQHRVLHFVYEGIDEETVRRIGHLPKGLGVIGLLIEDPKPLRLDDVSAHPASIGFPPYHPPMRTFLGVPVR
VRDESFGTLYLTDKTNGQPFSDDDEVLVQALAAAAGIAVANARLYQQAKARQSWIEATRDIATELLSGTEPATVFRLVAA
EALKLTAADAALVAVPVDEDMPAADVGELLVIETVGSAVASTVGRTIPVAGAVLREVFVNGIPRRVDRVDLEGLDELADA
GPALLLPLRARGTVAGVVVVLSQGGPGAFTDEQLEMMAAFADQAALAWQLATSQRRMRELDVLTDRDRIARDLHDHVIQR
LFAIGLALQGAVPHERNPEVQQRLSDVVDDLQDVIQEIRTTIYDLHGASQGITRLRQRIDAAVAQFADSGLRTSVQFVGP
LSVVDSALADQAEAVVREAVSNAVRHAKASTLTVRVKVDDDLCIEVTDNGRGLPDEFTGSGLTNLRQRAEQAGGEFTLAS
VPGASGTVLRWSAPLSQ

Specific function: Member of the two-component regulatory system devR/devS (dosR/dosS) involved in onset of the dormancy response. May act as a redox sensor (rather than a direct hypoxia sensor); the normal (aerobic growth) state is the Fe(3+) form, while the reduced (anaer

COG id: COG2203

COG function: function code T; FOG: GAF domain

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1788812, Length=208, Percent_Identity=28.3653846153846, Blast_Score=68, Evalue=2e-12,
Organism=Escherichia coli, GI1787474, Length=256, Percent_Identity=27.734375, Blast_Score=67, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016030
- InterPro:   IPR003594
- InterPro:   IPR003018
- InterPro:   IPR011712
- InterPro:   IPR005467 [H]

Pfam domain/function: PF01590 GAF; PF02518 HATPase_c; PF07730 HisKA_3 [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 62229; Mature: 62098

Theoretical pI: Translated: 4.68; Mature: 4.68

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTGGLVDENDGAAMRPLRHTLSQLRLHELLVEVQDRVEQIVEGRDRLDGLVEAMLVVTA
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GLDLEATLRAIVHSATSLVDARYGAMEVHDRQHRVLHFVYEGIDEETVRRIGHLPKGLGV
CCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCE
IGLLIEDPKPLRLDDVSAHPASIGFPPYHPPMRTFLGVPVRVRDESFGTLYLTDKTNGQP
EEEEECCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCEEEECCCCCEEEEEECCCCCC
FSDDDEVLVQALAAAAGIAVANARLYQQAKARQSWIEATRDIATELLSGTEPATVFRLVA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
AEALKLTAADAALVAVPVDEDMPAADVGELLVIETVGSAVASTVGRTIPVAGAVLREVFV
HHHHHHEECCCEEEEEECCCCCCCCCCCCEEEHHHHHHHHHHHHCCCCHHHHHHHHHHHH
NGIPRRVDRVDLEGLDELADAGPALLLPLRARGTVAGVVVVLSQGGPGAFTDEQLEMMAA
CCCCHHHHHCCCCCHHHHHCCCCEEEEEECCCCCEEEEEEEEECCCCCCCCHHHHHHHHH
FADQAALAWQLATSQRRMRELDVLTDRDRIARDLHDHVIQRLFAIGLALQGAVPHERNPE
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHH
VQQRLSDVVDDLQDVIQEIRTTIYDLHGASQGITRLRQRIDAAVAQFADSGLRTSVQFVG
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHC
PLSVVDSALADQAEAVVREAVSNAVRHAKASTLTVRVKVDDDLCIEVTDNGRGLPDEFTG
CHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCEEEEECCCCCCCCCCCCC
SGLTNLRQRAEQAGGEFTLASVPGASGTVLRWSAPLSQ
CCHHHHHHHHHHCCCCEEEEECCCCCCCEEEECCCCCC
>Mature Secondary Structure 
TTGGLVDENDGAAMRPLRHTLSQLRLHELLVEVQDRVEQIVEGRDRLDGLVEAMLVVTA
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GLDLEATLRAIVHSATSLVDARYGAMEVHDRQHRVLHFVYEGIDEETVRRIGHLPKGLGV
CCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCE
IGLLIEDPKPLRLDDVSAHPASIGFPPYHPPMRTFLGVPVRVRDESFGTLYLTDKTNGQP
EEEEECCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCEEEECCCCCEEEEEECCCCCC
FSDDDEVLVQALAAAAGIAVANARLYQQAKARQSWIEATRDIATELLSGTEPATVFRLVA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
AEALKLTAADAALVAVPVDEDMPAADVGELLVIETVGSAVASTVGRTIPVAGAVLREVFV
HHHHHHEECCCEEEEEECCCCCCCCCCCCEEEHHHHHHHHHHHHCCCCHHHHHHHHHHHH
NGIPRRVDRVDLEGLDELADAGPALLLPLRARGTVAGVVVVLSQGGPGAFTDEQLEMMAA
CCCCHHHHHCCCCCHHHHHCCCCEEEEEECCCCCEEEEEEEEECCCCCCCCHHHHHHHHH
FADQAALAWQLATSQRRMRELDVLTDRDRIARDLHDHVIQRLFAIGLALQGAVPHERNPE
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHH
VQQRLSDVVDDLQDVIQEIRTTIYDLHGASQGITRLRQRIDAAVAQFADSGLRTSVQFVG
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHC
PLSVVDSALADQAEAVVREAVSNAVRHAKASTLTVRVKVDDDLCIEVTDNGRGLPDEFTG
CHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCEEEEECCCCCCCCCCCCC
SGLTNLRQRAEQAGGEFTLASVPGASGTVLRWSAPLSQ
CCHHHHHHHHHHCCCCEEEEECCCCCCCEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]