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The map label for this gene is slyA [C]

Identifier: 121638768

GI number: 121638768

Start: 3150363

End: 3150782

Strand: Direct

Name: slyA [C]

Synonym: BCG_2908

Alternate gene names: 121638768

Gene position: 3150363-3150782 (Clockwise)

Preceding gene: 121638765

Following gene: 121638772

Centisome position: 72.02

GC content: 66.67

Gene sequence:

>420_bases
ATGGGTCTAGCCGATGACGCCCCGCTGGGCTATCTGCTCTACCGGGTGGGAGCCGTACTGCGGCCAGAGGTTTCCGCTGC
GCTCAGTCCACTCGGCCTGACGCTGCCTGAGTTCGTCTGCCTGAGAATGCTTTCGCAGTCACCGGGACTATCCAGCGCCG
AATTGGCCCGGCACGCAAGCGTCACACCGCAGGCGATGAACACGGTGTTGCGCAAGCTGGAAGATGCCGGTGCGGTGGCC
CGGCCCGCATCGGTGTCTTCCGGGCGTTCGCTACCGGCTACATTGACCGCTCGAGGCCGAGCCCTGGCGAAGCGCGCCGA
GGCCGTCGTACGCGCCGCCGATGCCCGCGTCCTGGCCAGGCTGACCGCGCCTCAGCAACGCGAGTTCAAACGAATGCTGG
AGAAGCTCGGGTCCGACTAG

Upstream 100 bases:

>100_bases
ATGGTTCCCGCTCAAACGACCGGCGGCACTGCCCACAAGCGCCGGGAGCGCATAGGAACGATTTACCGTTCGGCCCGGCA
CATGTGTCAGTATCCTTGAC

Downstream 100 bases:

>100_bases
ATCCGGACGCGGGCTACTCGGCGATATTTGGGGCGTGGATCCGGGCCCAGGGCCGGGCCTCTTCGAGTTCGTAAGCCAGC
TCCAGCAGCAGCGCCTCGCG

Product: putative transcriptional regulatory protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 139; Mature: 138

Protein sequence:

>139_residues
MGLADDAPLGYLLYRVGAVLRPEVSAALSPLGLTLPEFVCLRMLSQSPGLSSAELARHASVTPQAMNTVLRKLEDAGAVA
RPASVSSGRSLPATLTARGRALAKRAEAVVRAADARVLARLTAPQQREFKRMLEKLGSD

Sequences:

>Translated_139_residues
MGLADDAPLGYLLYRVGAVLRPEVSAALSPLGLTLPEFVCLRMLSQSPGLSSAELARHASVTPQAMNTVLRKLEDAGAVA
RPASVSSGRSLPATLTARGRALAKRAEAVVRAADARVLARLTAPQQREFKRMLEKLGSD
>Mature_138_residues
GLADDAPLGYLLYRVGAVLRPEVSAALSPLGLTLPEFVCLRMLSQSPGLSSAELARHASVTPQAMNTVLRKLEDAGAVAR
PASVSSGRSLPATLTARGRALAKRAEAVVRAADARVLARLTAPQQREFKRMLEKLGSD

Specific function: Transcription Factor That Activates Expression Of Genes Such As Molecular Chaperones (Grol, Gros, Dnak, Grpe, And Cbpa), Proteins Involved In Acid Resistance (Hdea, Hdeb, And Gada), The Starvation Lipoprotein Slp, Virulence Protein Hlye/Clya. Represses Ex

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH marR-type DNA-binding domain

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): Y2887_MYCTU (P67747)

Other databases:

- EMBL:   BX842581
- EMBL:   AE000516
- PIR:   B70925
- RefSeq:   NP_217403.1
- RefSeq:   NP_337466.1
- ProteinModelPortal:   P67747
- SMR:   P67747
- EnsemblBacteria:   EBMYCT00000000196
- EnsemblBacteria:   EBMYCT00000073064
- GeneID:   888563
- GeneID:   925324
- GenomeReviews:   AE000516_GR
- GenomeReviews:   AL123456_GR
- KEGG:   mtc:MT2955
- KEGG:   mtu:Rv2887
- TIGR:   MT2955
- TubercuList:   Rv2887
- GeneTree:   EBGT00050000015612
- HOGENOM:   HBG728159
- OMA:   PVHGRIQ
- ProtClustDB:   CLSK792144
- GO:   GO:0005622
- InterPro:   IPR000835
- InterPro:   IPR023187
- InterPro:   IPR011991
- Gene3D:   G3DSA:1.10.10.10
- PRINTS:   PR00598
- SMART:   SM00347

Pfam domain/function: PF01047 MarR

EC number: NA

Molecular weight: Translated: 14690; Mature: 14559

Theoretical pI: Translated: 11.09; Mature: 11.09

Prosite motif: PS01117 HTH_MARR_1; PS50995 HTH_MARR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGLADDAPLGYLLYRVGAVLRPEVSAALSPLGLTLPEFVCLRMLSQSPGLSSAELARHAS
CCCCCCCCHHHHHHHHHHHHCHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHCC
VTPQAMNTVLRKLEDAGAVARPASVSSGRSLPATLTARGRALAKRAEAVVRAADARVLAR
CCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LTAPQQREFKRMLEKLGSD
HCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure 
GLADDAPLGYLLYRVGAVLRPEVSAALSPLGLTLPEFVCLRMLSQSPGLSSAELARHAS
CCCCCCCHHHHHHHHHHHHCHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHCC
VTPQAMNTVLRKLEDAGAVARPASVSSGRSLPATLTARGRALAKRAEAVVRAADARVLAR
CCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LTAPQQREFKRMLEKLGSD
HCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036