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The map label for this gene is efpA [H]

Identifier: 121638726

GI number: 121638726

Start: 3107025

End: 3108617

Strand: Reverse

Name: efpA [H]

Synonym: BCG_2866c

Alternate gene names: 121638726

Gene position: 3108617-3107025 (Counterclockwise)

Preceding gene: 121638727

Following gene: 121638725

Centisome position: 71.06

GC content: 64.97

Gene sequence:

>1593_bases
ATGACGGCTCTCAACGACACAGAGCGGGCGGTCCGTAACTGGAGGGCCGGACGCCCACACCGTCCGGCCCCGATGCGCCC
GCCGCGCTCGGAGGAGACCGCTTCAGAGCGCCCCAGCAGGTACTACCCGACTTGGCTGCCCTCGCGCAGCTTTATCGCTG
CGGTTATTGCTATCGGCGGGATGCAGCTGCTGGCGACCATGGACAGCACCGTCGCCATCGTCGCGCTACCTAAGATTCAA
AACGAGCTGAGCTTGTCTGATGCCGGCCGCAGCTGGGTGATCACCGCCTACGTGCTGACCTTCGGCGGGCTGATGCTGCT
CGGCGGCCGGCTTGGCGACACCATCGGGCGCAAACGCACCTTCATTGTTGGCGTTGCGCTATTCACCATCTCGTCGGTGC
TGTGCGCGGTCGCCTGGGACGAGGCGACGTTGGTGATCGCCCGGTTGTCCCAGGGTGTGGGGTCGGCCATCGCATCTCCG
ACCGGTCTGGCGCTGGTGGCGACCACGTTCCCCAAGGGACCTGCCCGCAACGCCGCGACGGCGGTGTTCGCCGCGATGAC
CGCGATCGGGTCGGTGATGGGGCTGGTGGTCGGCGGAGCACTGACCGAGGTGTCATGGCGGTGGGCGTTCCTGGTGAACG
TGCCGATCGGGCTGGTGATGATCTACCTGGCCCGCACCGCCCTACGGGAAACCAACAAAGAACGGATGAAGCTCGACGCC
ACCGGGGCCATACTGGCCACGCTGGCATGCACCGCGGCGGTTTTCGCCTTCTCGATCGGTCCTGAAAAGGGCTGGATGTC
AGGCATTACCATCGGTTCGGGCCTGGTGGCCTTGGCGGCCGCTGTCGCGTTTGTCATCGTGGAGCGCACTGCCGAGAACC
CCGTCGTGCCGTTCCACTTGTTCCGCGACCGCAACCGGTTGGTCACGTTCAGCGCGATCCTGTTGGCCGGCGGCGTCATG
TTCAGCCTGACCGTCTGCATCGGCCTGTACGTGCAGGACATCTTGGGCTACAGCGCGCTACGCGCGGGCGTAGGTTTCAT
CCCGTTCGTCATCGCGATGGGAATCGGCCTAGGTGTGTCCTCGCAGCTGGTGTCCCGGTTTTCGCCACGGGTGTTGACCA
TCGGCGGCGGATATCTGCTATTCGGCGCCATGCTGTACGGCTCATTTTTCATGCACCGTGGTGTGCCCTACTTCCCCAAC
CTGGTCATGCCGATCGTCGTCGGCGGGATTGGCATCGGCATGGCCGTCGTCCCGCTGACTCTGTCGGCGATCGCTGGCGT
CGGCTTCGACCAGATCGGTCCGGTATCGGCAATTGCGCTGATGCTGCAGAGCCTGGGCGGTCCGCTGGTGCTCGCCGTCA
TCCAGGCTGTGATCACGTCGCGCACGCTGTACCTGGGCGGTACCACCGGTCCGGTGAAGTTCATGAACGACGTGCAGTTG
GCCGCGCTTGACCACGCCTACACCTACGGCCTGCTGTGGGTGGCCGGAGCGGCCATCATCGTCGGCGGTATGGCGCTGTT
TATCGGGTATACGCCGCAGCAGGTTGCCCATGCGCAGGAGGTCAAGGAAGCGATCGACGCCGGCGAGCTGTAA

Upstream 100 bases:

>100_bases
GGGATCCGACCTCCCGCGATCATCGTGATCGGGGCTGTAGTCGGCCTGAGCGGCGTTCGGGGTTTAAACAATTCTTAAGA
ATACTGTAAGGTAACCCGCT

Downstream 100 bases:

>100_bases
CCCTTCCCGCCGAGCAGTCATAAAAGCTCCCCTTTTCGGGCAGACCTGGGCGCTTTTGCGTCTGCTCGGCGAATTAGGCT
TGCCGCCTGTGATCACCCGG

Product: putative integral membrane efflux protein efpA

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: Efflux protein A [H]

Number of amino acids: Translated: 530; Mature: 529

Protein sequence:

>530_residues
MTALNDTERAVRNWRAGRPHRPAPMRPPRSEETASERPSRYYPTWLPSRSFIAAVIAIGGMQLLATMDSTVAIVALPKIQ
NELSLSDAGRSWVITAYVLTFGGLMLLGGRLGDTIGRKRTFIVGVALFTISSVLCAVAWDEATLVIARLSQGVGSAIASP
TGLALVATTFPKGPARNAATAVFAAMTAIGSVMGLVVGGALTEVSWRWAFLVNVPIGLVMIYLARTALRETNKERMKLDA
TGAILATLACTAAVFAFSIGPEKGWMSGITIGSGLVALAAAVAFVIVERTAENPVVPFHLFRDRNRLVTFSAILLAGGVM
FSLTVCIGLYVQDILGYSALRAGVGFIPFVIAMGIGLGVSSQLVSRFSPRVLTIGGGYLLFGAMLYGSFFMHRGVPYFPN
LVMPIVVGGIGIGMAVVPLTLSAIAGVGFDQIGPVSAIALMLQSLGGPLVLAVIQAVITSRTLYLGGTTGPVKFMNDVQL
AALDHAYTYGLLWVAGAAIIVGGMALFIGYTPQQVAHAQEVKEAIDAGEL

Sequences:

>Translated_530_residues
MTALNDTERAVRNWRAGRPHRPAPMRPPRSEETASERPSRYYPTWLPSRSFIAAVIAIGGMQLLATMDSTVAIVALPKIQ
NELSLSDAGRSWVITAYVLTFGGLMLLGGRLGDTIGRKRTFIVGVALFTISSVLCAVAWDEATLVIARLSQGVGSAIASP
TGLALVATTFPKGPARNAATAVFAAMTAIGSVMGLVVGGALTEVSWRWAFLVNVPIGLVMIYLARTALRETNKERMKLDA
TGAILATLACTAAVFAFSIGPEKGWMSGITIGSGLVALAAAVAFVIVERTAENPVVPFHLFRDRNRLVTFSAILLAGGVM
FSLTVCIGLYVQDILGYSALRAGVGFIPFVIAMGIGLGVSSQLVSRFSPRVLTIGGGYLLFGAMLYGSFFMHRGVPYFPN
LVMPIVVGGIGIGMAVVPLTLSAIAGVGFDQIGPVSAIALMLQSLGGPLVLAVIQAVITSRTLYLGGTTGPVKFMNDVQL
AALDHAYTYGLLWVAGAAIIVGGMALFIGYTPQQVAHAQEVKEAIDAGEL
>Mature_529_residues
TALNDTERAVRNWRAGRPHRPAPMRPPRSEETASERPSRYYPTWLPSRSFIAAVIAIGGMQLLATMDSTVAIVALPKIQN
ELSLSDAGRSWVITAYVLTFGGLMLLGGRLGDTIGRKRTFIVGVALFTISSVLCAVAWDEATLVIARLSQGVGSAIASPT
GLALVATTFPKGPARNAATAVFAAMTAIGSVMGLVVGGALTEVSWRWAFLVNVPIGLVMIYLARTALRETNKERMKLDAT
GAILATLACTAAVFAFSIGPEKGWMSGITIGSGLVALAAAVAFVIVERTAENPVVPFHLFRDRNRLVTFSAILLAGGVMF
SLTVCIGLYVQDILGYSALRAGVGFIPFVIAMGIGLGVSSQLVSRFSPRVLTIGGGYLLFGAMLYGSFFMHRGVPYFPNL
VMPIVVGGIGIGMAVVPLTLSAIAGVGFDQIGPVSAIALMLQSLGGPLVLAVIQAVITSRTLYLGGTTGPVKFMNDVQLA
ALDHAYTYGLLWVAGAAIIVGGMALFIGYTPQQVAHAQEVKEAIDAGEL

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily [H]

Homologues:

Organism=Escherichia coli, GI1788710, Length=406, Percent_Identity=26.3546798029557, Blast_Score=127, Evalue=2e-30,
Organism=Escherichia coli, GI1789042, Length=420, Percent_Identity=26.6666666666667, Blast_Score=119, Evalue=5e-28,
Organism=Escherichia coli, GI1790195, Length=406, Percent_Identity=27.0935960591133, Blast_Score=113, Evalue=2e-26,
Organism=Escherichia coli, GI87081983, Length=401, Percent_Identity=24.1895261845387, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1788392, Length=318, Percent_Identity=29.2452830188679, Blast_Score=93, Evalue=5e-20,
Organism=Escherichia coli, GI87081723, Length=157, Percent_Identity=35.031847133758, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1790146, Length=318, Percent_Identity=25.1572327044025, Blast_Score=62, Evalue=7e-11,
Organism=Saccharomyces cerevisiae, GI6323520, Length=366, Percent_Identity=24.3169398907104, Blast_Score=100, Evalue=6e-22,
Organism=Saccharomyces cerevisiae, GI6324954, Length=308, Percent_Identity=25.6493506493506, Blast_Score=88, Evalue=4e-18,
Organism=Saccharomyces cerevisiae, GI6323935, Length=460, Percent_Identity=25, Blast_Score=78, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6323735, Length=312, Percent_Identity=24.6794871794872, Blast_Score=72, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6325455, Length=139, Percent_Identity=35.2517985611511, Blast_Score=70, Evalue=7e-13,
Organism=Saccharomyces cerevisiae, GI6322958, Length=310, Percent_Identity=25.1612903225806, Blast_Score=70, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6321663, Length=135, Percent_Identity=34.8148148148148, Blast_Score=67, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 55635; Mature: 55504

Theoretical pI: Translated: 9.92; Mature: 9.92

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTALNDTERAVRNWRAGRPHRPAPMRPPRSEETASERPSRYYPTWLPSRSFIAAVIAIGG
CCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCHHHHHHHHHHHH
MQLLATMDSTVAIVALPKIQNELSLSDAGRSWVITAYVLTFGGLMLLGGRLGDTIGRKRT
HHHHHHCCCCEEEEEECHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHCCCHH
FIVGVALFTISSVLCAVAWDEATLVIARLSQGVGSAIASPTGLALVATTFPKGPARNAAT
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCHHHH
AVFAAMTAIGSVMGLVVGGALTEVSWRWAFLVNVPIGLVMIYLARTALRETNKERMKLDA
HHHHHHHHHHHHHHHHHCCHHHHHHEEEEEEECCHHHHHHHHHHHHHHHHCCHHHEEECH
TGAILATLACTAAVFAFSIGPEKGWMSGITIGSGLVALAAAVAFVIVERTAENPVVPFHL
HHHHHHHHHHHHHHHHHCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHCCCCCCCEEHE
FRDRNRLVTFSAILLAGGVMFSLTVCIGLYVQDILGYSALRAGVGFIPFVIAMGIGLGVS
ECCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCH
SQLVSRFSPRVLTIGGGYLLFGAMLYGSFFMHRGVPYFPNLVMPIVVGGIGIGMAVVPLT
HHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHH
LSAIAGVGFDQIGPVSAIALMLQSLGGPLVLAVIQAVITSRTLYLGGTTGPVKFMNDVQL
HHHHHCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHCCEEEECCCCCCHHHHCCHHH
AALDHAYTYGLLWVAGAAIIVGGMALFIGYTPQQVAHAQEVKEAIDAGEL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
TALNDTERAVRNWRAGRPHRPAPMRPPRSEETASERPSRYYPTWLPSRSFIAAVIAIGG
CCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCHHHHHHHHHHHH
MQLLATMDSTVAIVALPKIQNELSLSDAGRSWVITAYVLTFGGLMLLGGRLGDTIGRKRT
HHHHHHCCCCEEEEEECHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHCCCHH
FIVGVALFTISSVLCAVAWDEATLVIARLSQGVGSAIASPTGLALVATTFPKGPARNAAT
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCHHHH
AVFAAMTAIGSVMGLVVGGALTEVSWRWAFLVNVPIGLVMIYLARTALRETNKERMKLDA
HHHHHHHHHHHHHHHHHCCHHHHHHEEEEEEECCHHHHHHHHHHHHHHHHCCHHHEEECH
TGAILATLACTAAVFAFSIGPEKGWMSGITIGSGLVALAAAVAFVIVERTAENPVVPFHL
HHHHHHHHHHHHHHHHHCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHCCCCCCCEEHE
FRDRNRLVTFSAILLAGGVMFSLTVCIGLYVQDILGYSALRAGVGFIPFVIAMGIGLGVS
ECCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCH
SQLVSRFSPRVLTIGGGYLLFGAMLYGSFFMHRGVPYFPNLVMPIVVGGIGIGMAVVPLT
HHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHH
LSAIAGVGFDQIGPVSAIALMLQSLGGPLVLAVIQAVITSRTLYLGGTTGPVKFMNDVQL
HHHHHCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHCCEEEECCCCCCHHHHCCHHH
AALDHAYTYGLLWVAGAAIIVGGMALFIGYTPQQVAHAQEVKEAIDAGEL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]