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The map label for this gene is ald_a [H]

Identifier: 121638659

GI number: 121638659

Start: 3040269

End: 3040667

Strand: Direct

Name: ald_a [H]

Synonym: BCG_2797

Alternate gene names: 121638659

Gene position: 3040269-3040667 (Clockwise)

Preceding gene: 121638654

Following gene: 121638660

Centisome position: 69.5

GC content: 62.66

Gene sequence:

>399_bases
ATGCGCGTCGGTATTCCGACCGAGACCAAAAACAACGAATTCCGGGTGGCCATCACCCCGGCCGGCGTCGCGGAACTAAC
CCGTCGTGGCCATGAGGTGCTCATCCAGGCAGGTGCCGGAGAGGGCTCGGCTATCACCGACGCGGATTTCAAGGCGGCAG
GCGCGCAACTGGTCGGCACCGCCGACCAGGTGTGGGCCGACGCTGATTTATTGCTCAAGGTCAAAGAACCGATAGCGGCG
GAATACGGCCGCCTGCGACACGGGCGATCTTGTTCACGTTCTTGCATTTGGCCGCGTCACGTGCTTGCACCGATGCGTTG
TTGGATTCCGGCACCACGTCAATTGCCTACGAGACCGTCCAGACCGCCGACGGCGCACTACCCCTGCTTGCCCCGATGA

Upstream 100 bases:

>100_bases
TTATCACGTATATGGCCTCGAAAAAGAATTATCATCAGCAATCTTGCAGATTAATCGAACTTTCTTCACACTGAAGCGTA
CAGTATCGAGAGGGGTAATC

Downstream 100 bases:

>100_bases
GCGAAGTCGCCGGTCGACTCGCCGCCCAGGTTGGCGCTTACCACCTGATGCGAACCCAAGGGGGCCGCGGTGTGCTGATG
GGCGGGGTGCCCGGCGTCGA

Product: secreted l-alanine dehydrogenase ald_a

Products: NA

Alternate protein names: 40 kDa antigen; TB43 [H]

Number of amino acids: Translated: 132; Mature: 132

Protein sequence:

>132_residues
MRVGIPTETKNNEFRVAITPAGVAELTRRGHEVLIQAGAGEGSAITDADFKAAGAQLVGTADQVWADADLLLKVKEPIAA
EYGRLRHGRSCSRSCIWPRHVLAPMRCWIPAPRQLPTRPSRPPTAHYPCLPR

Sequences:

>Translated_132_residues
MRVGIPTETKNNEFRVAITPAGVAELTRRGHEVLIQAGAGEGSAITDADFKAAGAQLVGTADQVWADADLLLKVKEPIAA
EYGRLRHGRSCSRSCIWPRHVLAPMRCWIPAPRQLPTRPSRPPTAHYPCLPR
>Mature_132_residues
MRVGIPTETKNNEFRVAITPAGVAELTRRGHEVLIQAGAGEGSAITDADFKAAGAQLVGTADQVWADADLLLKVKEPIAA
EYGRLRHGRSCSRSCIWPRHVLAPMRCWIPAPRQLPTRPSRPPTAHYPCLPR

Specific function: May play a role in cell wall synthesis as L-alanine is an important constituent of the peptidoglycan layer [H]

COG id: COG0686

COG function: function code E; Alanine dehydrogenase

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AlaDH/PNT family [H]

Homologues:

Organism=Homo sapiens, GI122939155, Length=78, Percent_Identity=44.8717948717949, Blast_Score=70, Evalue=5e-13,
Organism=Homo sapiens, GI122939153, Length=78, Percent_Identity=44.8717948717949, Blast_Score=70, Evalue=5e-13,
Organism=Escherichia coli, GI1787887, Length=98, Percent_Identity=39.7959183673469, Blast_Score=67, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007698
- InterPro:   IPR008142
- InterPro:   IPR008143
- InterPro:   IPR007886
- InterPro:   IPR008141 [H]

Pfam domain/function: PF01262 AlaDh_PNT_C; PF05222 AlaDh_PNT_N [H]

EC number: =1.4.1.1 [H]

Molecular weight: Translated: 14414; Mature: 14414

Theoretical pI: Translated: 9.88; Mature: 9.88

Prosite motif: PS00836 ALADH_PNT_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
3.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVGIPTETKNNEFRVAITPAGVAELTRRGHEVLIQAGAGEGSAITDADFKAAGAQLVGT
CCCCCCCCCCCCEEEEEECCCCHHHHHHCCCEEEEEECCCCCCEECCCCCCCCCCEEECC
ADQVWADADLLLKVKEPIAAEYGRLRHGRSCSRSCIWPRHVLAPMRCWIPAPRQLPTRPS
HHHHHCCCHHEEEECCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCC
RPPTAHYPCLPR
CCCCCCCCCCCC
>Mature Secondary Structure
MRVGIPTETKNNEFRVAITPAGVAELTRRGHEVLIQAGAGEGSAITDADFKAAGAQLVGT
CCCCCCCCCCCCEEEEEECCCCHHHHHHCCCEEEEEECCCCCCEECCCCCCCCCCEEECC
ADQVWADADLLLKVKEPIAAEYGRLRHGRSCSRSCIWPRHVLAPMRCWIPAPRQLPTRPS
HHHHHCCCHHEEEECCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCC
RPPTAHYPCLPR
CCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1587598; 9634230; 12218036; 7822223 [H]