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The map label for this gene is 121638561

Identifier: 121638561

GI number: 121638561

Start: 2956965

End: 2957723

Strand: Reverse

Name: 121638561

Synonym: BCG_2699c

Alternate gene names: NA

Gene position: 2957723-2956965 (Counterclockwise)

Preceding gene: 121638562

Following gene: 121638557

Centisome position: 67.61

GC content: 63.9

Gene sequence:

>759_bases
GTGAGAGCGATATCGAGCCTTGCGGGCCCACGGGCGTTGGCCGCGTTCGGCCGCAACGACATTCGAGGCACCTACCGCGA
TCCGCTGCTGGTCATGCTCGTCATCGCACCGGTCATCTGGACCACCGGAGTCGCGCTGCTCACGCCGCTGTTCACCGAGA
TGCTGGCGCGGCGTTATGGATTCGACCTGGTCGGATACTACCCACTGATCCTCACCGCGTTCCTGTTGTTGACCAGCATC
ATCGTCGCCGGTGCGCTGGCCGCGTTCTTGGTGCTGGACGACGTAGACGCGGGCACGATGACGGCGCTGCGAGTAACCCC
GGTGCCGCTGTCGGTCTTTTTCGGCTATCGTGCGGCCACCGTGATGGTGGTGACCACCATCTACGTCGTCGCGACGATGT
CGTGCAGCGGGATCCTCGAACCGGGCCTGGTGTCTTCACTGATTCCCATCGGACTGGTGGCCGGCCTGTCGGCGGTGGTC
ACGCTGCTGCTGATTCTTGCGGTGGCGAACAACAAGATTCAGGGCCTGGCGATGGTCCGTGCGCTGGGCATGCTCATCGC
CGGGCTGCCCTGCCTGCCGTGGTTCATCAGTTCCAACTGGAACCTCGCGTTCGGCGTCTTACCACCGTACTGGGCTGCCA
AGGCATTTTGGGTCGCCAGCGATCACGGCACCTGGTGGCCGTATCTCGTCGGGGGTGCCGTCTACAACCTGGCCATCGTC
TGGGTGCTGTTTCGGCGCTTTCGCGCTAAGCACGCGTGA

Upstream 100 bases:

>100_bases
TCGGGTATGCGGTGGTCTACCCAATCGTGTGTGCGGCGGGATTGTGCCGGGCGGCCAAGGCGCTATTCGGCCGTTATGTC
GTGCAAAGATCGGGTGTGCT

Downstream 100 bases:

>100_bases
GCGTTGGCGCTTAGCCGAACACGAAGTACCGCAGCCACAGGTAGACCGCCGACAACACGAGCGAGACCGCGGTCACCACC
GCGCCCTTGCGGGTGAACTT

Product: putative antibiotic-transport integral membrane leucine and alanine and valine rich protein ABC transporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 252; Mature: 252

Protein sequence:

>252_residues
MRAISSLAGPRALAAFGRNDIRGTYRDPLLVMLVIAPVIWTTGVALLTPLFTEMLARRYGFDLVGYYPLILTAFLLLTSI
IVAGALAAFLVLDDVDAGTMTALRVTPVPLSVFFGYRAATVMVVTTIYVVATMSCSGILEPGLVSSLIPIGLVAGLSAVV
TLLLILAVANNKIQGLAMVRALGMLIAGLPCLPWFISSNWNLAFGVLPPYWAAKAFWVASDHGTWWPYLVGGAVYNLAIV
WVLFRRFRAKHA

Sequences:

>Translated_252_residues
MRAISSLAGPRALAAFGRNDIRGTYRDPLLVMLVIAPVIWTTGVALLTPLFTEMLARRYGFDLVGYYPLILTAFLLLTSI
IVAGALAAFLVLDDVDAGTMTALRVTPVPLSVFFGYRAATVMVVTTIYVVATMSCSGILEPGLVSSLIPIGLVAGLSAVV
TLLLILAVANNKIQGLAMVRALGMLIAGLPCLPWFISSNWNLAFGVLPPYWAAKAFWVASDHGTWWPYLVGGAVYNLAIV
WVLFRRFRAKHA
>Mature_252_residues
MRAISSLAGPRALAAFGRNDIRGTYRDPLLVMLVIAPVIWTTGVALLTPLFTEMLARRYGFDLVGYYPLILTAFLLLTSI
IVAGALAAFLVLDDVDAGTMTALRVTPVPLSVFFGYRAATVMVVTTIYVVATMSCSGILEPGLVSSLIPIGLVAGLSAVV
TLLLILAVANNKIQGLAMVRALGMLIAGLPCLPWFISSNWNLAFGVLPPYWAAKAFWVASDHGTWWPYLVGGAVYNLAIV
WVLFRRFRAKHA

Specific function: Part of the ABC transporter complex Rv2686c/Rv2687c/Rv2688c involved in fluoroquinolones export. Confers resistance to ciprofloxacin and, to a lesser extent, norfloxacin, moxifloxacin and sparfloxacin. Probably responsible for the translocation of the sub

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FLQE2_MYCTU (O07188)

Other databases:

- EMBL:   BX842580
- EMBL:   AE000516
- PIR:   A70529
- RefSeq:   NP_217202.1
- RefSeq:   NP_337261.1
- ProteinModelPortal:   O07188
- EnsemblBacteria:   EBMYCT00000001911
- EnsemblBacteria:   EBMYCT00000069646
- GeneID:   888360
- GeneID:   925537
- GenomeReviews:   AE000516_GR
- GenomeReviews:   AL123456_GR
- KEGG:   mtc:MT2760
- KEGG:   mtu:Rv2686c
- TIGR:   MT2760
- TubercuList:   Rv2686c
- GeneTree:   EBGT00050000017649
- HOGENOM:   HBG565284
- OMA:   VPYYPLV
- ProtClustDB:   CLSK872094

Pfam domain/function: NA

EC number: NA

Molecular weight: Translated: 27144; Mature: 27144

Theoretical pI: Translated: 9.95; Mature: 9.95

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x1773c3a8)-; HASH(0x174edacc)-; HASH(0x179e3b38)-; HASH(0x17cafbe4)-; HASH(0x1787d8f8)-; HASH(0x17ca2a30)-;

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRAISSLAGPRALAAFGRNDIRGTYRDPLLVMLVIAPVIWTTGVALLTPLFTEMLARRYG
CCCHHHHCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
FDLVGYYPLILTAFLLLTSIIVAGALAAFLVLDDVDAGTMTALRVTPVPLSVFFGYRAAT
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHH
VMVVTTIYVVATMSCSGILEPGLVSSLIPIGLVAGLSAVVTLLLILAVANNKIQGLAMVR
HHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
ALGMLIAGLPCLPWFISSNWNLAFGVLPPYWAAKAFWVASDHGTWWPYLVGGAVYNLAIV
HHHHHHHCCCHHHHHHCCCCCEEEECCCCHHHHHEEEEECCCCCCHHHHHHHHHHHHHHH
WVLFRRFRAKHA
HHHHHHHHHCCH
>Mature Secondary Structure
MRAISSLAGPRALAAFGRNDIRGTYRDPLLVMLVIAPVIWTTGVALLTPLFTEMLARRYG
CCCHHHHCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
FDLVGYYPLILTAFLLLTSIIVAGALAAFLVLDDVDAGTMTALRVTPVPLSVFFGYRAAT
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHH
VMVVTTIYVVATMSCSGILEPGLVSSLIPIGLVAGLSAVVTLLLILAVANNKIQGLAMVR
HHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
ALGMLIAGLPCLPWFISSNWNLAFGVLPPYWAAKAFWVASDHGTWWPYLVGGAVYNLAIV
HHHHHHHCCCHHHHHHCCCCCEEEECCCCHHHHHEEEEECCCCCCHHHHHHHHHHHHHHH
WVLFRRFRAKHA
HHHHHHHHHCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036