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The map label for this gene is PPE42 [H]

Identifier: 121638495

GI number: 121638495

Start: 2899492

End: 2901234

Strand: Direct

Name: PPE42 [H]

Synonym: BCG_2633

Alternate gene names: 121638495

Gene position: 2899492-2901234 (Clockwise)

Preceding gene: 121638494

Following gene: 121638502

Centisome position: 66.28

GC content: 65.17

Gene sequence:

>1743_bases
ATGAATTTCGCCGTTTTGCCGCCGGAGGTGAATTCGGCGCGCATATTCGCCGGTGCGGGCCTGGGCCCAATGCTGGCGGC
GGCGTCGGCCTGGGACGGGTTGGCCGAGGAGTTGCATGCCGCGGCGGGCTCGTTCGCGTCGGTGACCACCGGGTTGGCGG
GCGACGCGTGGCATGGTCCGGCGTCGCTGGCGATGACCCGCGCGGCCAGCCCGTATGTGGGGTGGTTGAACACGGCGGCG
GGTCAGGCCGCGCAGGCGGCCGGCCAGGCGCGGCTAGCGGCGAGCGCGTTCGAGGCGACGCTGGCGGCCACCGTGTCTCC
AGCGATGGTCGCGGCCAACCGGACACGGCTGGCGTCGCTGGTGGCAGCCAACTTGCTGGGCCAGAACGCCCCGGCGATCG
CGGCCGCGGAGGCTGAATACGAGCAGATATGGGCCCAGGACGTGGCCGCGATGTTCGGCTATCACTCCGCCGCGTCGGCG
GTGGCCACGCAGCTGGCGCCTATTCAAGAGGGTTTGCAGCAGCAGCTGCAAAACGTGCTGGCCCAGTTGGCTAGCGGGAA
CCTGGGCAGCGGAAATGTGGGCGTCGGCAACATCGGCAACGACAACATTGGCAACGCAAACATCGGCTTCGGAAATCGAG
GCGACGCCAACATCGGCATCGGGAATATCGGCGACAGAAACCTCGGCATTGGGAACACCGGCAATTGGAATATCGGCATC
GGCATCACCGGCAACGGACAAATCGGCTTCGGCAAGCCTGCCAACCCCGACGTCTTGGTGGTGGGCAACGGCGGCCCGGG
AGTAACCGCGTTGGTCATGGGCGGCACCGACAGCCTACTGTCGCTGCCCAACATCCCCTTACTCGAGTACGCTGCGCGGT
TCATCACCCCCGTGCATCCCGGATACACCGCTACGTTCCTGGAAACGCCATCGCAGTTTTTCCCATTCACCGGGCTGAAT
AGCCTGACCTATGACGTCTCCGTGGCCCAGGGCGTAACGAATCTGCACACCGCGATCATGGCGCAACTCGCGGCGGGAAA
CGAAGTCGTCGTCTTCGGCACCTCCCAAAGCGCCACGATAGCCACCTTCGAAATGCGCTATCTGCAATCCCTGCCAGCAC
ACCTGCGTCCGGGTCTCGACGAATTGTCCTTTACGTTGACCGGCAATCCCAACCGGCCCGACGGTGGCATTCTTACGCGT
TTTGGCTTCTCCATACCGCAGTTGGGTTTCACATTGTCCGGCGCGACGCCCGCCGACGCCTACCCCACCGTCGATTACGC
GTTCCAGTACGACGGCGTCAACGACTTCCCCAAATACCCGCTGAATGTCTTCGCGACCGCCAACGCGATCGCGGGCATCC
TTTTCCTGCACTCCGGGTTGATTGCGTTGCCGCCCGATCTTGCCTCGGGCGTGGTTCAACCGGTGTCCTCACCGGACGTC
CTGACCACCTACATCCTGCTGCCCAGCCAAGATCTGCCGCTGCTGGTCCCGCTGCGTGCTATCCCCCTGCTGGGAAACCC
GCTTGCCGACCTCATCCAGCCGGACTTGCGGGTGCTCGTCGAGTTGGGTTATGACCGCACCGCCCACCAGGACGTGCCCA
GCCCGTTCGGACTGTTTCCGGACGTCGATTGGGCCGAGGTGGCCGCGGACCTGCAGCAAGGCGCCGTGCAAGGCGTCAAC
GACGCCCTGTCCGGACTGGGGCTGCCGCCGCCGTGGCAGCCGGCGCTACCCCGACTTTTCTAA

Upstream 100 bases:

>100_bases
TTTGACCGGAATGCCCGCTGACCCGTGACGACGCGGTCACCGGGGATACCCGCCGCGGTGGTGGCCAACCGATAACGGCC
AACCGAGAAAGTACACAGCG

Downstream 100 bases:

>100_bases
GCGGTCCACAAACCGTGCACGTCAGCGGATGGGCTGAGGAACGCCGGCATCGCGCGCGGCTCCGTTGTCCAGCGCGACGT
CCACCAGCCGGTTGGCTGCC

Product: PPE family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 580; Mature: 580

Protein sequence:

>580_residues
MNFAVLPPEVNSARIFAGAGLGPMLAAASAWDGLAEELHAAAGSFASVTTGLAGDAWHGPASLAMTRAASPYVGWLNTAA
GQAAQAAGQARLAASAFEATLAATVSPAMVAANRTRLASLVAANLLGQNAPAIAAAEAEYEQIWAQDVAAMFGYHSAASA
VATQLAPIQEGLQQQLQNVLAQLASGNLGSGNVGVGNIGNDNIGNANIGFGNRGDANIGIGNIGDRNLGIGNTGNWNIGI
GITGNGQIGFGKPANPDVLVVGNGGPGVTALVMGGTDSLLSLPNIPLLEYAARFITPVHPGYTATFLETPSQFFPFTGLN
SLTYDVSVAQGVTNLHTAIMAQLAAGNEVVVFGTSQSATIATFEMRYLQSLPAHLRPGLDELSFTLTGNPNRPDGGILTR
FGFSIPQLGFTLSGATPADAYPTVDYAFQYDGVNDFPKYPLNVFATANAIAGILFLHSGLIALPPDLASGVVQPVSSPDV
LTTYILLPSQDLPLLVPLRAIPLLGNPLADLIQPDLRVLVELGYDRTAHQDVPSPFGLFPDVDWAEVAADLQQGAVQGVN
DALSGLGLPPPWQPALPRLF

Sequences:

>Translated_580_residues
MNFAVLPPEVNSARIFAGAGLGPMLAAASAWDGLAEELHAAAGSFASVTTGLAGDAWHGPASLAMTRAASPYVGWLNTAA
GQAAQAAGQARLAASAFEATLAATVSPAMVAANRTRLASLVAANLLGQNAPAIAAAEAEYEQIWAQDVAAMFGYHSAASA
VATQLAPIQEGLQQQLQNVLAQLASGNLGSGNVGVGNIGNDNIGNANIGFGNRGDANIGIGNIGDRNLGIGNTGNWNIGI
GITGNGQIGFGKPANPDVLVVGNGGPGVTALVMGGTDSLLSLPNIPLLEYAARFITPVHPGYTATFLETPSQFFPFTGLN
SLTYDVSVAQGVTNLHTAIMAQLAAGNEVVVFGTSQSATIATFEMRYLQSLPAHLRPGLDELSFTLTGNPNRPDGGILTR
FGFSIPQLGFTLSGATPADAYPTVDYAFQYDGVNDFPKYPLNVFATANAIAGILFLHSGLIALPPDLASGVVQPVSSPDV
LTTYILLPSQDLPLLVPLRAIPLLGNPLADLIQPDLRVLVELGYDRTAHQDVPSPFGLFPDVDWAEVAADLQQGAVQGVN
DALSGLGLPPPWQPALPRLF
>Mature_580_residues
MNFAVLPPEVNSARIFAGAGLGPMLAAASAWDGLAEELHAAAGSFASVTTGLAGDAWHGPASLAMTRAASPYVGWLNTAA
GQAAQAAGQARLAASAFEATLAATVSPAMVAANRTRLASLVAANLLGQNAPAIAAAEAEYEQIWAQDVAAMFGYHSAASA
VATQLAPIQEGLQQQLQNVLAQLASGNLGSGNVGVGNIGNDNIGNANIGFGNRGDANIGIGNIGDRNLGIGNTGNWNIGI
GITGNGQIGFGKPANPDVLVVGNGGPGVTALVMGGTDSLLSLPNIPLLEYAARFITPVHPGYTATFLETPSQFFPFTGLN
SLTYDVSVAQGVTNLHTAIMAQLAAGNEVVVFGTSQSATIATFEMRYLQSLPAHLRPGLDELSFTLTGNPNRPDGGILTR
FGFSIPQLGFTLSGATPADAYPTVDYAFQYDGVNDFPKYPLNVFATANAIAGILFLHSGLIALPPDLASGVVQPVSSPDV
LTTYILLPSQDLPLLVPLRAIPLLGNPLADLIQPDLRVLVELGYDRTAHQDVPSPFGLFPDVDWAEVAADLQQGAVQGVN
DALSGLGLPPPWQPALPRLF

Specific function: Elicits a high humoral and a low T cell response. Could be involved in directing the host toward development of a more humoral type of immune response [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mycobacterial PPE family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002989
- InterPro:   IPR013228
- InterPro:   IPR000030 [H]

Pfam domain/function: PF08237 PE-PPE; PF01469 Pentapeptide_2; PF00823 PPE [H]

EC number: NA

Molecular weight: Translated: 59665; Mature: 59665

Theoretical pI: Translated: 4.22; Mature: 4.22

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNFAVLPPEVNSARIFAGAGLGPMLAAASAWDGLAEELHAAAGSFASVTTGLAGDAWHGP
CCCEECCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCCCCC
ASLAMTRAASPYVGWLNTAAGQAAQAAGQARLAASAFEATLAATVSPAMVAANRTRLASL
HHHHHHHCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
VAANLLGQNAPAIAAAEAEYEQIWAQDVAAMFGYHSAASAVATQLAPIQEGLQQQLQNVL
HHHHHHCCCCCCEEECHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHH
AQLASGNLGSGNVGVGNIGNDNIGNANIGFGNRGDANIGIGNIGDRNLGIGNTGNWNIGI
HHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEE
GITGNGQIGFGKPANPDVLVVGNGGPGVTALVMGGTDSLLSLPNIPLLEYAARFITPVHP
EEECCCCCCCCCCCCCCEEEEECCCCCEEEEEECCCHHHHCCCCCCHHHHHHHHHCCCCC
GYTATFLETPSQFFPFTGLNSLTYDVSVAQGVTNLHTAIMAQLAAGNEVVVFGTSQSATI
CCEEEEECCCHHHCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCEE
ATFEMRYLQSLPAHLRPGLDELSFTLTGNPNRPDGGILTRFGFSIPQLGFTLSGATPADA
EHHHHHHHHHCCHHHCCCCCCEEEEEECCCCCCCCCEEECCCCCCCCCCEEECCCCCCCC
YPTVDYAFQYDGVNDFPKYPLNVFATANAIAGILFLHSGLIALPPDLASGVVQPVSSPDV
CCCCEEEEEECCCCCCCCCCCEEEEHHHHHHHHHHHHCCCEECCHHHHHHHHCCCCCCCE
LTTYILLPSQDLPLLVPLRAIPLLGNPLADLIQPDLRVLVELGYDRTAHQDVPSPFGLFP
EEEEEEECCCCCCEEECHHHHCCCCCCHHHHHCHHHHHHHHHCCCCCCCCCCCCCCCCCC
DVDWAEVAADLQQGAVQGVNDALSGLGLPPPWQPALPRLF
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MNFAVLPPEVNSARIFAGAGLGPMLAAASAWDGLAEELHAAAGSFASVTTGLAGDAWHGP
CCCEECCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCCCCC
ASLAMTRAASPYVGWLNTAAGQAAQAAGQARLAASAFEATLAATVSPAMVAANRTRLASL
HHHHHHHCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
VAANLLGQNAPAIAAAEAEYEQIWAQDVAAMFGYHSAASAVATQLAPIQEGLQQQLQNVL
HHHHHHCCCCCCEEECHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHH
AQLASGNLGSGNVGVGNIGNDNIGNANIGFGNRGDANIGIGNIGDRNLGIGNTGNWNIGI
HHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEE
GITGNGQIGFGKPANPDVLVVGNGGPGVTALVMGGTDSLLSLPNIPLLEYAARFITPVHP
EEECCCCCCCCCCCCCCEEEEECCCCCEEEEEECCCHHHHCCCCCCHHHHHHHHHCCCCC
GYTATFLETPSQFFPFTGLNSLTYDVSVAQGVTNLHTAIMAQLAAGNEVVVFGTSQSATI
CCEEEEECCCHHHCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCEE
ATFEMRYLQSLPAHLRPGLDELSFTLTGNPNRPDGGILTRFGFSIPQLGFTLSGATPADA
EHHHHHHHHHCCHHHCCCCCCEEEEEECCCCCCCCCEEECCCCCCCCCCEEECCCCCCCC
YPTVDYAFQYDGVNDFPKYPLNVFATANAIAGILFLHSGLIALPPDLASGVVQPVSSPDV
CCCCEEEEEECCCCCCCCCCCEEEEHHHHHHHHHHHHCCCEECCHHHHHHHHCCCCCCCE
LTTYILLPSQDLPLLVPLRAIPLLGNPLADLIQPDLRVLVELGYDRTAHQDVPSPFGLFP
EEEEEEECCCCCCEEECHHHHCCCCCCHHHHHCHHHHHHHHHCCCCCCCCCCCCCCCCCC
DVDWAEVAADLQQGAVQGVNDALSGLGLPPPWQPALPRLF
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]